Abstract: Tissue localization devices and methods of localizing tissue using tissue localization devices are disclosed. The tissue localization device can comprise a handle comprising a delivery control, a delivery needle extending out from the handle, and a localization element within the delivery needle. The localization element can be deployed out of the delivery needle or retracted back into the delivery needle when the delivery control is translated in a first direction or a second direction, respectively. The localization element can be coupled to a flexible tracking wire.

Abstract: A medical instrument includes a shaft, one or more position sensors, a connector and interrogation circuitry. The shaft is configured for insertion into a body of a patient. The one or more position sensors are fitted at a distal end of the shaft. The connector is configured to receive a mating connector. The interrogation circuitry is configured to detect whether the mating connector is connected to the connector, and, if not connected, to prevent tracking a position of the distal end in the body using the one or more position sensors.

Abstract: A method includes placing a set of electrodes on a body surface of a patient's body. The method also includes digitizing locations for the electrodes across the body surface based on one or more image frames using range imaging and/or monoscopic imaging. The method also includes estimating locations for hidden ones of the electrodes on the body surface not visible during the range imaging and/or monoscopic imaging. The method also includes registering the location for the electrodes on the body surface with predetermined geometry information that includes the body surface and an anatomical envelope within the patient's body. The method also includes storing geometry data in non-transitory memory based on the registration to define spatial relationships between the electrodes and the anatomical envelope.

Abstract: The present disclosure relates to systems, devices and methods for providing visual guidance for navigating inside a patient's chest. An exemplary method includes presenting a three-dimensional (3D) model of a luminal network, generating, by an electromagnetic (EM) field generator, an EM field about the patient's chest, detecting a location of an EM sensor within the EM field, determining a position of a tool within the patient's chest based on the detected location of the EM sensor, displaying an indication of the position of the tool on the 3D model, receiving cone beam computed tomography (CBCT) image data of the patient's chest, detecting the location of the tool within the patient's chest based on the CBCT image data, and updating the indication of the position of the tool on the 3D model based on the detected location.

Abstract: A system (200) includes a first imaging system (201) that utilizes first radiation to image an interior region of interest of a subject, including a first agent in the region of interest and a second imaging system (218) that utilizes second radiation to image a second agent in the region of interest, wherein an output of the second imaging system is used to trigger the first imaging system to scan the region of interest, including the first agent in the region of interest.

Abstract: A medical imaging system for identifying a target structure (TS), e.g. a tumor, in a biological tissue. A hyperspectral camera system is used for imaging a surface area (A1) of the tissue (BT), e.g. with a limited spectral resolution, but enough to allow identification of suspicious areas where the target structure (TS) may be, e.g. such areas can be visually indicated on a display to the operator. A probe (PR), e.g. an optical surface probe, is used to provide probe measurement of a smaller surface area (A2) of the tissue, but with more information indicative of the target structure. The probe is selected to provide a higher specificity with respect to identification of the target structure than the hyperspectral camera (HSC). The hyperspectral processing algorithm (PP) is then calibrated based on probe measurement data performed within the suspicious areas, thus providing a calibrated hyperspectral processing algorithm resulting in images with an enhanced sensitivity to identify the target structure.

Abstract: Described is an apparatus for calibrating or measuring target points (1) for cerebral neuro-navigators, comprising a processor (2) comprising a video output (3) on which can be displayed a preloaded three-dimensional or two-dimensional map (4) of a brain of a patient, a rigid body (5) comprising a plurality of optical markers (6) and a supporting tip (7) designed to be rested on the head of the patient and a stereoscopic video camera (8) configured to detect a position of the optical markers (6) relative to the head of the patient at a preset point (9) of the head of the patient and sending the position to the processor (2) to allow the acquisition of the preset point (9). The stereoscopic video camera (8) is configured for detecting and sending to the processor (2) static positions and movements of the optical markers (6).

Abstract: The present invention is directed to an echogenic catheter assembly. The catheter assembly includes a catheter having a proximal end and a distal end that defines a lumen extending from the proximal end to the distal end. Further, the catheter assembly includes a coil member configured with at least a portion of the lumen of the catheter. The coil member forms a plurality of outwardly extending projections. One or more of the outwardly extending projections define a cross-sectional shape having at least one non-arcuate edge. As such, the non-arcuate edges of the outwardly extending projections are configured to enhance ultrasonic imaging of the catheter when inserted into a patient.

Abstract: Tissue localization devices and methods of localizing tissue using tissue localization devices are disclosed. The tissue localization device can comprise a handle comprising a delivery control, a delivery needle extending out from the handle, and a localization element within the delivery needle. The localization element can be deployed out of the delivery needle or retracted back into the delivery needle when the delivery control is translated in a first direction or a second direction, respectively. The localization element can be coupled to a flexible tracking wire.

Abstract: A standardized, quantitative risk assessment method and apparatus for noninvasive melanoma screening. The apparatus and methods generate a melanoma Q-Score which calculates and displays a probability that a skin lesion is melanoma.

Abstract: Devices and systems as described herein is configured to sense a signal, such as a signal from an individual. In some embodiments, a signal is a magnetic field. In some embodiments, a source of a signal is an individual's organ, such as a heart muscle. A device or system, in some embodiments, comprises one or more sensors, such as an array of sensors configured to sense the signal. A device or system, in some embodiments, comprises a shield or portion thereof to reduce noise and enhance signal collection.

Abstract: An ophthalmic machine is provided for obtaining and diagnosing fluorescence images of the retina. An excitation light having first wavelengths (e.g., between 430 nm and 490 nm) is scanned onto the retina. Light emitted by the retina, when illuminated thereby, is filtered to block light of the first wavelengths and to pass light of second (higher) wavelengths. A second filter selects a component of the passed light having second (e.g., green) wavelengths, and a third filter selects a component of the passed light having third (e.g., red) wavelengths. First and second detection means receive light transmitted by the first and second filters, respectively, and provide detection signals indicative thereof. The detection signals are processed to provide one or more images of the retina, said images of the retina comprising at least a color fluorescence image of the retina.

Abstract: A dual-modality photoacoustic remote sensing combined with optical coherence tomography (PARS-OCT) system for visualizing details in a sample, the system comprising one or more light sources configured to generate (1) one or more excitation beams configured to generate signals in the sample at one or more first locations below a surface of the sample; (2) one or more interrogation beams incident on the sample at one or more second locations; (3) a sample beam; and (4) a reference beam.

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

Abstract: Methods and apparatus is provided for use in a medical procedure for image acquisition using a high-resolution imaging system, a three dimensional imaging system and a navigation system. A 3D imaging scan of an imaged portion of the surface of the patient is acquired using the three dimensional imaging system. Then, a first high-resolution imaging scan covering a first sub-portion of the imaged portion is acquired using the high-resolution imaging system, which is tracked by the navigation system. The 3D imaging scan and the first high-resolution imaging scan are combined to create an enhanced three dimensional image having contour lines to provide a visual representation of depth derived from depth information acquired from both the three dimensional imaging system and the high-resolution imaging system. Subsequent high resolution scans may then be stitched into the image and the updated image displayed in real-time.

Abstract: A medical image diagnosis system according to one embodiment includes a gantry, a couch, a reflecting plate, and a processing circuitry. The gantry is for medical imaging having a bore. The couch movably supports a top plate. The reflecting plate reflects an image output from an image output device. The processing circuitry, in a first case where the image is shown to an observer not through the reflecting plate, outputs a first image signal relating to a first image to the image output device. While in a second case where the image is shown to the observer through the reflecting plate, The processing circuitry outputs a second image signal relating to a second image to the image output device.

Abstract: A transperinealprostate intervention device comprises a prostate intervention instrument (10), a transrectal ultrasound (TRUS) probe (12), and a mechanical or optical coordinate measurement machine (CMM) (20) attached to the TRUS probe and configured to track the prostate intervention instrument. The CMM may include an articulated arm with a plurality of encoding joints (24), an anchor end (30) attached to the TRUS probe, and a movable end (32) attached to the prostate intervention instrument. The prostate intervention instrument may, for example, be a biopsy needle, a brachytherapy seed delivery instrument, a tissue ablation instrument, or a hollow cannula. An electronic processor (40) computes a predicted trajectory (54) of the prostate intervention instrument in a frame of reference of the TRUS probe using the CMM attached to the TRUS probe. A representation (56) of the predicted trajectory is superimposed on a prostate ultrasound image (50) generated from ultrasound data collected by the TRUS probe.

Abstract: Accuracy enhancing systems, devices and methods are provided using data obtained from inertial measurement units (IMUs). IMUs are provided on one or more of a patient, surgical table, surgical instruments, imaging devices, navigation systems, and the like. Data from sensors in each IMU is collected and used to calculate absolute and relative positions of the patient, surgical table, surgical instruments, imaging devices, and navigation systems on which the IMUs are provided. The data generated by the IMUs can be coupled with medical images and camera vision, among other information, to generate and/or provide surgical navigation, alignment of imaging systems, pre-operative diagnoses and plans, intra-operative tool guidance and error correction, and post-operative assessments.

Abstract: The present disclosure is directed to combined angiography and perfusion using radial imaging and arterial spin labeling.