Patents Examined by Amy Atzel, Ph.D.
  • Method of detecting amplified nucleic sequences in cells by flow cytometry
    Patent number: 5840478
    Abstract: The field of this invention is the detection and isolation of specific amplified DNA sequences by flow cytometry. More particularly, this invention relates to the detection of these specific amplified DNA sequences in cells so as to allow quantitation of viral burden of patients infected with a virus. The method is particularly adapted to detection of HIV-1 proviral DNA sequences and the assessment of activity of the virus in a cell.
    Type: Grant
    Filed: May 18, 1994
    Date of Patent: November 24, 1998
    Assignee: Northwestern University
    Inventors: Bruce Patterson, Michelle Till, Steven Wolinsky
  • Nucleic acid ligand inhibitors to DNA polymerases
    Patent number: 5693502
    Abstract: This invention discloses high-affinity oligonucleotide ligands to the thermostable Taq polymerase and Tth polymerase. Specifically, this invention discloses DNA ligands having the ability to bind to the Taq and Tth polymerases and the methods for obtaining such ligands. The ligands are capable of inhibiting polymerases at ambient temperatures.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 2, 1997
    Assignee: NeXstar Pharmaceuticals, Inc.
    Inventors: Larry Gold, Sumedha D. Jayasena