Patents Examined by Amy Hudson Bowman
  • Reprogramming fibroblasts into cardiomyocytes
    Patent number: 10144915
    Abstract: Compositions and methods are described herein for chemically inducing cells that express a single pluripotency transcription factor to change their differentiation state and become cardiac cells, cardiac progenitor cells, cardiomyocytes, or a combination thereof.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: December 4, 2018
    Assignee: THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE
    Inventors: Haixia Wang, Sheng Ding
  • Organic compositions to treat Beta-ENaC-related diseases
    Patent number: 10081811
    Abstract: The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: September 25, 2018
    Assignee: Arrowhead Pharmaceuticals, Inc.
    Inventors: Antonin De Fougerolles, John Diener, Emma Hickman, Gregory Hinkle, Stuart Milstein, Anne-Marie Pulichino, Andrew Griffin Sprague
  • Bioactive renal cells
    Patent number: 10077442
    Abstract: The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: September 18, 2018
    Assignee: inRegen
    Inventors: Timothy A. Bertram, Roger M. Ilagan, Russell W. Kelley, Sharon C. Presnell, Sumana Choudhury, Andrew T. Bruce, Christopher W. Genheimer, Bryan R. Cox, Kelly I. Guthrie, Joydeep Basu, Shay M. Wallace, Eric Werdin, Oluwatoyin A. Knight, Namrata D. Sangha, John W. Ludlow, Craig R. Halberstadt, Richard Payne, Neil F. Robins, Darell McCoy, Deepak Jain, Manuel J. Jayo, Elias A. Rivera, Thomas Spencer, Benjamin Watts
  • Bioactive renal cells
    Patent number: 10030242
    Abstract: The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: July 24, 2018
    Assignee: InRegen
    Inventors: Timothy A. Bertram, Roger M. Ilagan, Russell W. Kelley, Sharon C. Presnell, Sumana Choudhury, Andrew T. Bruce, Christopher W. Genheimer, Bryan R. Cox, Kelly I. Guthrie, Joydeep Basu, Shay M. Wallace, Eric Werdin, Oluwatoyin A. Knight, Namrata D. Sangha, John W. Ludlow, Craig R. Halberstadt, Richard Payne, Neil F. Robins, Darell McCoy, Deepak Jain, Manuel J. Jayo, Elias A. Rivera, Thomas Spencer, Benjamin Watts