Abstract: An edible, hardenable coating composition containing microcrystalline cellulose and carrageenan and either a strengthening polymer, a plasticizer or both. The coating composition of the present invention may be applied to pharmaceutical and veterinary solid dosage forms, confectionery, seeds, animal feed, fertilizers, pesticide tablets, and foods and provides an elegant prompt release coating which does not retard the release of active ingredients from the coated substrate.

Abstract: Novel pharmaceutical dosage forms provide for pulsatile delivery of an antiarrhythmic agent that releases the drug in spaced apart “pulses.” The dosage forms are comprised of first, second and optional third dosage units, with each dosage unit having a different drug release profile. The dosage forms may comprise capsules housing compressed tablets or drug-containing beads, granules, or particles or may comprise a single tablet with the first, second and optional third dosage units incorporated therein, or a “coated core” dosage form. Methods of treatment using the pharmaceutical dosage forms are provided as well.

Abstract: The present invention relates to a method for treatment of mammalian skin conditions where stimulated connective tissue synthesis is beneficial, comprising treating skin in need of such treatment with a safe and effective amount of 17-&agr;-estradiol.

Abstract: A hot-type compress which does not form the skin rashes on the applied region thereof. The hot-type compress is constructed so that an applying face side composed of a sticky poultice plaster body formed on one side of a substrate sheet comprises the sticky poultice plaster body and powder or extract of ginger. A stable and good warmth-feeling stimulation is exerted on the skin without having any bad effect thereon by the ginger extract.

Abstract: The present invention is directed to a solid formulation comprising the lipid-regulating agent dispersed in a hydrophilic, amorphous polymer in which said lipid-regulating agent is present as a meta-stable, amorphous phase.

Abstract: Improved methods for forming fine particles of a material have been developed, wherein the method steps include dissolving the material in a solvent to form a dilute solution, immobilizing the dilution solution, and then removing the solvent to yield particles of the material. Methods of immobilizing the dilute solution include freezing, gelation, and chelation. In a preferred embodiment, the immobilized solvent is removed by lyophilization, i.e. reducing the ambient pressure while avoiding application of sufficient heat to power a phase transition. Essentially any material and solvent for the material can be used in the methods described herein. Proteins and peptides in an aqueous solvent are the preferred systems.

Abstract: A topical composition separately containing a hydrophilic carrier and a solid which are intended to be mixed immediately before use, the solid being powdered ascorbic acid and the carrier containing an aqueous medium and at least one hydrophilic gelling agent, the carrier being capable of withstanding the introduction of an acidic compound. In a preferred embodiment, the carrier (L) is packaged in a container (1) closed with a cap (3,6) containing ascorbic acid (P), a perforable and/or detachable separator (5) being provided between the acid and the carrier.

Abstract: The present invention to a cosmetic or pharmaceutical composition for topical application to the skin which comprises a fibrous component for promoting the transfer of moisture and oil and the removal of unpleasant and unwanted moisture from the skin, especially the facial skin. The fibrous component can include wicking fibers, evaporating fibers, or a combination of both. The composition of the present invention regulate moisture and oil when applied to the skin.

Abstract: The invention relates to stable, pulverulent lycopene formulations, comprising lycopene having a degree of crystallinity of greater than 20%, processes for their preparation and their use as an additive to foodstuffs, cosmetics, pharmaceuticals and animal feedstuffs.

Abstract: A stable injectable composition includes a non-aqueous parasitic agent in a therapeutically effect amount, chosen from the group of avermectin, ivermectin, doramectin, abamectin, milbemycin and moxidecting, and an antigen in combination with a liquid carrier that also acts as an adjuvant for use with warm-blooded animals and a method for treating parasitic diseases and preventing bacterial and viral diseases in warm-blooded animals.

Abstract: The invention relates to a delivery device for the controlled release of a therapeutically active agent, especially a progestin or an estrogen, over a prolonged period of time, said device including a core which contains the therapeutically active agent, and a membrane encasing the core wherein said membrane is made of an elastomer. According to the invention, the elastomer is a siloxane-based elastomer which includes 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units.