Abstract: The present invention provides a polynucleotide which identifies and encodes a novel human leptin receptor-related protein (LRRP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding LRRP.

Abstract: Disclosed are expression vectors useful as vectors in recombinant methods to facilitate expression of exogenous genes in E. coli. Specifically, the disclosed expression vector has the following elements in operable linkage: the PL6m promoter, the TAT32 ribosome binding site and a gene encoding a heterologous polypeptide, Also disclosed are E. coli host cells transformed with this expression vector.

Abstract: Biologically active, backbone-cyclized peptides of the formula: ##STR1## wherein ?AA! or ?A.sup.1 A.sup.1 ! is a naturally occurring or synthetic amino acid residue, n or e is an integer of 1-10, m or d is 0 or an integer of 1-10, R is a naturally occurring or synthetic amino acid side-chain, E is a hydroxyl moiety or a carboxyl protecting group of a blocking group, optionally covalently attached to an insoluble polymeric support, and the circled line designates a spacer group of ##STR2## for formula I wherein M is --S--S--, --CO--NH-- or --S-- and p and q each is an integer of 2-10, or--(CH.sub.2).sub.p --(M).sub.x --Y (IV)for formula II wherein M is an amino or carboxyl group or a sulfur atom, p is an integer of 2-10, x is 0 or 1 and Y is a side-chain of a backbone amino acid. Also, processes for the preparation of these peptides and pharmaceutical compositions containing them.