Patents Examined by Anand U Desai
  • Patent number: 12161699
    Abstract: The present specification discloses a urate oxidase-albumin conjugate, a preparation method thereof, a urate oxidase variant contained in the urate oxidase-albumin conjugate, and a preparation method thereof. The urate oxidase-albumin conjugate is characterized in that three or more albumins are conjugated to the urate oxidase variant through a linker, thereby improving half-life and reducing immunogenicity. In addition, the urate oxidase-albumin conjugate can be used to prevent or treat various diseases, disorders and/or indications caused by uric acid.
    Type: Grant
    Filed: October 28, 2022
    Date of Patent: December 10, 2024
    Assignee: Proabtech Inc.
    Inventors: Jeong Haeng Cho, Sun Oh Shin, Hyun Woo Kim, Hyeongseok Kim, Dong Ho Bak, Inchan Kwon, Byungseop Yang
  • Patent number: 12161700
    Abstract: The present disclosure provides a drug carrier, a brain-targeting nanodrug based on CRISPR gene editing technology and a preparation method and use thereof. The nanodrug contains nanoparticles prepared by coupling Cas9/sgRNA and drug carriers. The drug carrier includes a polymer mPEG-P (GPMA, FPMA) and a polymer Ang-PEG-PGPMA, wherein a structural formula of the mPEG-P (GPMA, FPMA) is: a structural formula of the polymer Ang-PEG-PGPMA is: where n is 35-45, x1 is 15-20, y is 2-4, m is 75-85, and x2=x1. The guanidino group of the drug carrier can be combined with the ribonucleoprotein complex by electrostatic action, salt bridge formation, or hydrogen bonding action. Also provided are methods of suppressing and treating tumors at a gene level using the drug carrier to transport the therapeutic drug to the lesion site.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: December 10, 2024
    Assignee: Henan University
    Inventors: Weimin Ruan, Mingzhu Jiao, Bingyang Shi, Meng Zheng
  • Patent number: 12152262
    Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
    Type: Grant
    Filed: June 23, 2023
    Date of Patent: November 26, 2024
    Assignee: HALOZYME, INC.
    Inventors: Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
  • Patent number: 12152066
    Abstract: The present disclosure provides intrabody compositions comprising i) an intrabody and ii) one or more inserts. The disclosure also provides methods for activating and deactivating intracellular and extracellular interactions utilizing the compositions, for instance via chemical and/or light.
    Type: Grant
    Filed: November 4, 2021
    Date of Patent: November 26, 2024
    Assignee: THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Yubin Zhou, Tianlu Wang
  • Patent number: 12123036
    Abstract: The present disclosure provides various insights relating to treatment of viral infection with soluble ACE2 variants, specifically including soluble human ACE2 (hACE2) variants. For example, the present disclosure teaches that decoy activity, which may intercept virus-receptor interactions, and ACE2 enzymatic activity can provide separate contributions to therapeutic efficacy; among other things, the present disclosure provides particular therapeutic regimens (e.g., relating to treatment of particular patient populations and/or to dosing regimens, combination therapies, etc.) for certain soluble ACE2 variants. Still further, the present disclosure provides certain particular ACE2 variants and methods of making and/or using them, including in accordance with particular therapeutic regimens.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: October 22, 2024
    Assignee: Northwestern University
    Inventors: Daniel Batlle, Jan Wysocki
  • Patent number: 12115241
    Abstract: Compositions and methods for darkening hair of intact skin are presented. Such compositions include defensins in concentrations that are below those that exhibit antimicrobial activity, and can be in the form of a topically applied formulation. Various formulations for such compositions, which can include various pharmaceutically acceptable stabilizers, emollients, and fragrances, are provided.
    Type: Grant
    Filed: November 16, 2021
    Date of Patent: October 15, 2024
    Inventor: Nikolay Turovets
  • Patent number: 12116400
    Abstract: The present invention relates to conjugation-competent albumins and albumin-related polypeptides, and their conjugates with at least one moiety, and to polynucleotides encoding them.
    Type: Grant
    Filed: March 28, 2022
    Date of Patent: October 15, 2024
    Assignee: SARTORIUS ALBUMEDIX LIMITED
    Inventors: Karen Ann Delahay, Christopher John Arthur Finnis, Karl Michael Nicholls
  • Patent number: 12091433
    Abstract: In various aspects, the present disclosure pertains to sorbents for isolating at least one target protein from a liquid sample, the sorbents comprising a solid support comprising attached at least one attached high affinity reagent with an affinity for the at least one target protein. Other aspects of the present disclosure include kit that contain such sorbents and methods of treating samples using the same.
    Type: Grant
    Filed: September 24, 2021
    Date of Patent: September 17, 2024
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: Laks Iyer, Beatrice W. Muriithi
  • Patent number: 12018070
    Abstract: Provided herein are methods shifting the isoelectric profile of a recombinant protein product and the use of such methods in the manufacture of recombinant protein products. Also provided are recombinant protein products produced by such methods.
    Type: Grant
    Filed: June 11, 2020
    Date of Patent: June 25, 2024
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Hunter F. Malanson, Pratik Jaluria, Rachael Alford
  • Patent number: 12018056
    Abstract: The present invention relates to a highly contracted artificial fibroin fiber including a modified fibroin, in which a contraction percentage defined by the following equation exceeds 7%.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: June 25, 2024
    Assignee: Spiber Inc.
    Inventors: Junichi Sugahara, Keisuke Morita, Hiroyuki Nakamura
  • Patent number: 12016333
    Abstract: A coat protein of Junonia coenia densovirus (JcDNV) is used to deliver attached peptide insect toxin across the gut epithelium of a fall armyworm, Spodoptera frugiperda. A fusion protein comprising VP4 attached to an insect toxin via a peptide linker is developed. A composition comprising a JcDNV coat protein attached to an insect toxin via a peptide linker can be used for insect pest control.
    Type: Grant
    Filed: September 9, 2021
    Date of Patent: June 25, 2024
    Assignees: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED, Iowa State University Research Foundation, Inc.
    Inventors: Bryony C. Bonning, Mariah Kemmerer
  • Patent number: 11987818
    Abstract: The present application provides engineered polypeptides having imine or oxime reductase activity, polynucleotides encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
    Type: Grant
    Filed: May 26, 2021
    Date of Patent: May 21, 2024
    Assignee: Codexis, Inc.
    Inventors: Margie Tabuga Borra-Garske, Oscar Alvizo, Melissa Ann Mayo, Stephan Jenne, Auric Anthony Sowell-Kantz, Carmela Molinaro
  • Patent number: 11965192
    Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
    Type: Grant
    Filed: November 30, 2021
    Date of Patent: April 23, 2024
    Assignee: Codexis, Inc.
    Inventors: Jovana Nazor, Vesna Mitchell, David Elgart, Katrina W. Lexa, Nikki Dellas, Robert Kevin Orr, Oscar Alvizo, Ravi David Garcia, Judy Victoria Antonio Viduya, Courtney Dianne Moffett
  • Patent number: 11952412
    Abstract: The present invention provides a recombinant exosome and uses thereof. More particularly, the present invention provides a recombinant exosome wherein a phagocytosis promoting protein is presented on the surface of the exosome.
    Type: Grant
    Filed: April 3, 2022
    Date of Patent: April 9, 2024
    Assignee: SHIFTBIO
    Inventors: Eun-ee Koh, Eun Jung Lee, Yoo Soo Yang, In-San Kim
  • Patent number: 11946089
    Abstract: The present invention provides for a mechanism to reduce glycerol production and increase nitrogen utilization and ethanol production of recombinant microorganisms. One aspect of this invention relates to strains of S. cerevisiae with reduced glycerol productivity that get a kinetic benefit from higher nitrogen concentration without sacrificing ethanol yield. A second aspect of the invention relates to metabolic modifications resulting in altered transport and/or intracellular metabolism of nitrogen sources present in corn mash.
    Type: Grant
    Filed: February 4, 2022
    Date of Patent: April 2, 2024
    Assignee: Lallemand Hungary Liquidity Management LLC
    Inventors: Aaron Argyros, Trisha Barrett
  • Patent number: 11939612
    Abstract: The invention provides a process for preparing sphingolipids, compositions comprising sphingolipids and further components, and for the use of the compositions.
    Type: Grant
    Filed: October 8, 2021
    Date of Patent: March 26, 2024
    Assignee: Evonik Operations GmbH
    Inventors: Marrit Friederike Eckstein, Monica Desiree van Logchem, Hans Henning Wenk, Annika Schrader, Ursula Maczkiewitz, Claudia Hierath, Sunay Karacocuk, Andreas Seifert
  • Patent number: 11898185
    Abstract: The present invention relates to a method for producing fucosylated oligosaccharides by using a recombinant prokaryotic host cell that is cultivated on a gluconeogenic substrate, as well as to the host cell and its use. The host cell is genetically modified in that the activity of a fructose-6-phosphate converting enzyme is abolished or lowered, and the transport of the produced fucosylated oligosaccharide through the cell membrane is facilitated by an exogenous transport protein.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: February 13, 2024
    Assignee: Chr Hansen HMO GmbH
    Inventors: Stefan Jennewein, Dirk Wartenberg, Katja Parschat
  • Patent number: 11884566
    Abstract: Metal bioremediation and metal mining strategies can include compositions and methods.
    Type: Grant
    Filed: September 3, 2020
    Date of Patent: January 30, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: George Le-Le Sun, Angela M. Belcher
  • Patent number: 11858972
    Abstract: The present invention relates to new peptidic compounds, more specifically to micropeptides derived from lncRNAs implicated in cancer and cellular plasticity. It also relates to the use of the said micropeptides in the treatment of proliferative diseases, more specifically in the treatment of cancer.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: January 2, 2024
    Assignee: Fundació Privada Institut d'Investigació Oncològica de Vall Hebron
    Inventors: Maria Abad Méndez, Olga Boix Sánchez, Emanuela Greco, Iñaki Merino Valverde
  • Patent number: 11858971
    Abstract: This invention relates to elastomeric protein and elastomeric protein production. In particular, the invention is directed to elastomeric protein sequences, including methods and compositions for production of elastomeric protein sequences, such as expression constructs, and host cells, and including compositions generated from the elastomeric protein sequences.
    Type: Grant
    Filed: March 31, 2021
    Date of Patent: January 2, 2024
    Assignee: BOLT THREADS, INC.
    Inventors: Joshua Kittleson, Michael Lee, David N. Breslauer, Daniel M. Widmaier