Patents Examined by Andrea D. Small
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Patent number: 6909013Abstract: There is disclosed a process process for producing a cyclopropanecarboxylate of formula (1): which process comprises reacting cyclopropanecarboxylic acid of formula (2): with a monohydroxy compound of formula (3): R6OH??(3), in the presence of a catalyst compound comprising an element of to Group 4 of the Periodic Table of Elements.Type: GrantFiled: January 24, 2002Date of Patent: June 21, 2005Assignee: Sumitomo Chemical Company, LimitedInventors: Hiroshi Souda, Kazunori Iwakura
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Patent number: 6903097Abstract: The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.Type: GrantFiled: December 18, 2002Date of Patent: June 7, 2005Assignee: Pharmacia & Upjohn CompanyInventors: Fred L. Ciske, John R. Palmer, Mark E. Schnute, Valerie A. Vaillancourt
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Patent number: 6890939Abstract: The present invention is directed to compounds useful as selective serine protease or dual-serine protease inhibitors, compositions thereof and methods for treating serine protease or dual-serine protease mediated disorders.Type: GrantFiled: May 16, 2003Date of Patent: May 10, 2005Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Michael N. Greco, Bruce E. Maryanoff, Michael J. Hawkins, Robert E. Boyd
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Patent number: 6861444Abstract: Compounds of the general formula (I): or a salt thereof, wherein R1 is hydrogen, hydroxyl or halogen; R2 is NHSO2CH3, SO2NHCH3 or the like; R5 and R6 each independently is hydrogen, C1-6 alkyl, optionally substituted phenyl or optionally substituted benzyl; X is NH, sulfur, oxygen or methylene; Y is oxygen, NR7, sulfur, methylene or a bond; and * represents an asymmetric carbon atom. The compounds are useful as a medicine for treating or preventing diabetes, obesity, hyperlipidemia, digestive diseases, depression or urinary disturbances.Type: GrantFiled: April 25, 2001Date of Patent: March 1, 2005Assignee: Asahi Kasei Pharma CorporationInventors: Shunichi Ikuta, Shiro Miyoshi, Kohei Ogawa
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Patent number: 6825222Abstract: The present invention is directed to compounds represented by Structural Formula I and pharmaceutically acceptable salts, solvates and hydrates thereof, and methods of making, methods of using and pharmaceutical compositions having compounds represented by Structural Formula I and pharmaceutically acceptable salts, solvates and hydrates thereof: In Structural Formula I, n is 2, 3, or 4; V is O or S; W is O, S, or SO2; R1 is H, a C1-C4 alkyl, phenyl or trifluoromethyl; R2 are each, independently, H, a C1-C6 alkyl, an aryl-C1-C6 alkyl, a cycloalkyl-C1-C4 alkyl, an aryl, a cycloalkyl, or together with the phenyl to which they are bound form naphthyl or 1,2,3,4-tetrahydronaphthyl; R3 are each, independently, H, a C1-C6 alkyl, an aryl-C1-C6 alkyl, a cycloalkyl-C1-C4 alkyl, an aryl, or a cycloalkyl; R4 are each, independently, H, a C1-C4 alkyl, an aryl, or benzyl; R5 are each, independently, H, a substituted or unsubstituted aryl or a heteroaryl, provided that at least one R5 is a substituted or uType: GrantFiled: May 7, 2003Date of Patent: November 30, 2004Assignees: Eli Lilly and Company, Ligand Pharmaceuticals, Inc.Inventors: Dawn A. Brooks, Christopher J. Rito, Anthony J. Shuker, Samuel J. Dominianni, Alan M. Warshawsky, Lynn S. Gossett, Donald P. Matthews, David A. Hay, Robert J. Ardecky, Pierre-Yves Michellys, John S. Tyhonas
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Patent number: 6806286Abstract: Novel pyrrole derivatives of formula (I) wherein X is oxygen or sulfur; R1 is C1-C4alkyl unsubstituted or substituted, with the exception of CF3; C3-C6cycloalkyl unsubstituted or substituted; or halogen; R2 is hydrogen, C1-C4alkyl unsubstituted or substituted, C1-C4alkoxy unsubstituted or substituted, cyano or halogen; R3 is C1-C4alkyl unsubstituted or substituted; and A is orthosubstituted aryl; orthosubstituted heteroaryl; bicycloaryl unsubstituted or substituted; or bicycloheteroaryl unsubstituted or substituted. The novel compounds have plant-protective properties and are suitable for protecting plants against infestations by phytopathogenic microorganisms.Type: GrantFiled: October 8, 2002Date of Patent: October 19, 2004Assignee: Syngenta Crop Protection, Inc.Inventors: Harald Walter, Hermann Schneider
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Patent number: 6797726Abstract: An N-alkoxyalkyl-N,N-dialkylamine derivative represented by the following general formula [1]: wherein the ring D represents a 5- or 6-membered heterocyclic ring or hydrocarbon ring; R3 and R4, which are the same or different, represent an unsubstituted or substituted alkyl, cycloalkyl or aralkyl group; and R1, R2, R5, R6, R7, R8, m and n are as defined in the specification, or a salt thereof has an anti-hypoxic activity, a nerve-protecting activity and a nerve regeneration promoting activity and is useful for the treatment of neurodegenerative diseases.Type: GrantFiled: December 11, 2001Date of Patent: September 28, 2004Assignee: Toyama Chemical Co., Ltd.Inventors: Satoshi Ono, Akihito Saitoh, Noboru Iwakami, Masaya Nakagawa, Sumie Yamaguchi
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Patent number: 6797825Abstract: Compounds having the formula or therapeutically acceptable salts thereof, are protein kinase inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.Type: GrantFiled: December 12, 2002Date of Patent: September 28, 2004Assignee: Abbott LaboratoriesInventors: Nan-Horng Lin, Hing L. Sham, Ping Xia
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Patent number: 6790967Abstract: The invention concerns a novel method for preparing vitamin E. More particularly, it concerns a novel method for the condensation of trimethylhydroquinone and isophytol.Type: GrantFiled: December 19, 2002Date of Patent: September 14, 2004Assignee: Adisseo France S.A.S.Inventors: Jildaz Dhainaut, Thierry Durand
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Patent number: 6787620Abstract: The invention relates to complexes of ruthenium of the structural formula I where X is an anionic ligand, Z is a monodentate to tridentate ligand which contains a metal and is nonionically bound to the ruthenium center, R1 and R2 are identical or different and are each hydrogen or/and a hydrocarbon group, but may also form a ring, and Ligand L is an N-heterocyclic carbene, and also to a process for preparing acyclic olefins having two or more carbon atoms or/and cyclic olefins having three or more carbon atoms and the use of at least one complex of the formula I in olefin metathesis.Type: GrantFiled: February 20, 2003Date of Patent: September 7, 2004Assignee: Degussa AGInventors: Wolfgang Anton Herrmann, Florian J. Kohl, Thomas Weskamp
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Patent number: 6759538Abstract: The present invention relates to substituted diphenyl heterocycle compounds and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of the compounds and/or compositions to inhibit HCV replication and/or proliferation and to treat or prevent HCV infections.Type: GrantFiled: November 1, 2002Date of Patent: July 6, 2004Assignee: Rigel Pharmaceuticals, Inc.Inventors: Rajinder Singh, Dane Goff, Henry Lu, Sarkiz D. Issankani, Thomas Sun
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Patent number: 6756394Abstract: The invention features methods for decreasing necrosis. The invention also features methods for treating a subject with a condition in which necrosis occurs. The invention further features chemical compounds used to decrease necrosis.Type: GrantFiled: October 13, 2000Date of Patent: June 29, 2004Assignee: President and Fellow of Harvard CollegeInventors: Junying Yuan, Alexei Degterev, Timothy J. Mitchison
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Patent number: 6756375Abstract: The invention provides for a non-steroidal compound having the formula wherein Re and ′Re are OH, optionally independently etherified or esterified; Z is —CH2— or —CH2CH2—; R1 is H, halogen, CF3, or (1C-4C)alkyl; R2, R3 and R4 are independently H, halogen, —CF3, —OCF3, (1C-8C)Alkyl, hydroxy, (1C-8C)alkyloxy, aryloxy, aryl(1C-8C)alkyl, halo(1C-8C)alkyl, —O(CH2)mX, wherein X is halogen or phenyl and m=2-4; —O(CH2)mNRaRb, —S(CH2)mNRaRb or —(CH2)mNRaRb, wherein m=2-4 and Ra, Rb are independently (1C-8C)alkyl, (2C-8C)alkenyl, (2C-8C)alkynyl, or aryl, optionally substituted with halogen, —CF3, —OCF3, —CN, —NO2, —OH, (1C-8C)alkoxy, aryloxy, carboxyl, (1C-8C)alkylthio, carboxylate, (1C-8C)alkyl, aryl, aryl(1C-8C)alkyl, halo(1C-8C)alkyl or Ra and Rb form a 3-8 membered ring structure, optionally substituted with halogen, —CF3, —OCF3, —CN, —NO2, hydroxy, hydroxy(1C-4C)aType: GrantFiled: July 24, 2003Date of Patent: June 29, 2004Assignee: Akzo Nobel N.V.Inventors: Gerrit Herman Veeneman, Hubert JanJozef Loozen, Jordi Mestres, Eduard Willem De Zwart
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Patent number: 6753347Abstract: This invention provides a process for the preparation of a benzimidazole derivative (I) or a pharmaceutically acceptable salt thereof, wherein R1 is C1-C6 alkyl, C1-C6 alkoxyl, etc., R2 is C1-C6 alkyl, and R3 is hydrogen or a protecting group, which exhibits excellent hyopoglycemic action, said process comprising condensation of an amine derivative (III) with a carboxylic acid derivatives (II) to afford a compound (IV), followed by cyclization of compound (IV) in the presence of an acid.Type: GrantFiled: October 16, 2002Date of Patent: June 22, 2004Assignee: Sankyo Company, LimitedInventors: Naoyuki Kishi, Yoshitaka Nakamura, Narumi Abe, Toyonori Takebayashi
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Patent number: 6750217Abstract: Benzenesulfonamides of formula (I), in which W is OR1, NR2OR1, NRARB, NR2NRARB, or NR2(CH2)2-4NRARB and the other variables as defined in the claims, are inhibitors of MEK and are effective in the treatment of proliferative diseases, cancer, stroke, heart failure, xenograft rejection, arthritis, cystic fibrosis, hepatomegaly, cardiomegaly, Alzheimer's disease, complications of diabetes, septic shock, and viral infection.Type: GrantFiled: July 18, 2002Date of Patent: June 15, 2004Assignee: Warner-Lambert CompanyInventors: Stephen Douglas Barrett, Haile Tecle, Richard John Booth
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Patent number: 6747046Abstract: Substituted N-(1,4,5,6-tetrahydro-cyclopentapyrazol-3-yl) derivatives, their production, as well as intermediate products for their production, and the use as pharmaceutical agents for treating various diseases are described.Type: GrantFiled: September 25, 2002Date of Patent: June 8, 2004Assignee: Schering AktiengesellschaftInventors: Martin Krüger, Olaf Prien, Andreas Steinmeyer, Jörg Kroll, Alexander Ernst, Gerhard Siemeister, Martin Haberey, Jens Hoffmann
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Patent number: 6746989Abstract: The invention relates to novel substituted benzoylpyrazoles of the general formula (I), in which n represents the numbers 0, 1, 2 or 3, A represents a single bond or represents alkanediyl(alkylene), R1 represents in each case optionally substituted alkyl, alkenyl, alkinyl or cycloalkyl, R2 represents hydrogen, cyano, carbamoyl, thiocarbamoyl, halogen, or represents in each case optionally substituted alkyl, alkoxy, alkylthio, alkoxycarbonyl or cycloalkyl, R3 represents hydrogen, nitro, cyano, carboxyl, carbamoyl, thiocarbamoyl, halogen, or represents in each case optionally substituted alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, dialkylamino or dialkylaminosulfonyl, R4 represents nitro, cyano, carboxyl, carbamoyl, thiocarbamoyl, halogen, or represents in each case optionally substituted alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, dialkylamino or dialkylaminosulfonyl, Y represents hydrogen or represents in each case optionally substitutedType: GrantFiled: September 26, 2001Date of Patent: June 8, 2004Assignee: Bayer AktiengesellschaftInventors: Klaus-Helmut Müller, Stefan Lehr, Otto Schallner, Hans-Georg Schwarz, Heinz-Jürgen Wroblowsky, Mark Wilhelm Drewes, Dieter Feucht, Rolf Pontzen, Ingo Wetcholowsky
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Patent number: 6747056Abstract: The present invention comprising culturing a microorganism which belongs to genus Streptomyces and has ability to produce K99-5041-C1x substance and/or K99-5041-C2x substance in a medium, accumulating K99-5041-C1x substance and/or K99-5041-C2x substance in the culture fluid, and isolating K99-5041-C1x substance and/or K99-5041-C2x substance form the cultured mass. Since the obtained K99-5041-C1x substance and/or K99-5041-C2x substance exhibit inhibitory activity against lanosterol synthase, these substances are expected to apply clinically for preventive and therapeutic agents caused by accumulation of cholesterol in humans and antifungal agents.Type: GrantFiled: February 6, 2003Date of Patent: June 8, 2004Assignee: The Kitasato InstituteInventors: Satoshi Omura, Hiroshi Tomoda, Yoko Takahashi, Yutaka Ebizuka, Masaaki Shibuya
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Patent number: 6743793Abstract: Indole derivatives represented by formula (I): (wherein all symbols are described in the description), a process for the preparation of the same and a DP receptor antagonist comprising it as an active ingredient. Since the compounds of formula (I) binds to and are antagonistic to a DP receptor, they are useful in for the prevention and/or treatment of diseases, for example, allergic diseases (allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma, food allergy, etc., systemic mastocytosis; disorders due to systemic mastocyte activation, anaphylactic shock, bronchoconstriction, urticaria, eczema, etc.), diseases accompanied with itching (atopic dermatitis, urticaria, etc.), secondary diseases caused by behaviors (scratching behaviors, beating, etc.) (cataract, retinal detachment, inflammation, infection, sleep disorder, etc.Type: GrantFiled: December 13, 2002Date of Patent: June 1, 2004Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Kazuhiko Torisu, Kaoru Kobayashi, Fumio Nambu
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Patent number: 6740153Abstract: A bipyrrolinonylidene-type compound is provided which is useful as colorants such as dyes and pigments, or other organic chemical products or intermediates thereof. A method of producing the bipyrrolinonylidene-type compound is also provided, which is suitable for large-scale industrial production with high yield. The bipyrrolinonylidene-type compound is represented by general formula (1). The bipyrrolinonylidene-type compound is obtained by oxidizing a pyrrolinone-type compound represented by the general formula (3) in the presence of an anthraquinone-type catalyst.Type: GrantFiled: March 11, 2003Date of Patent: May 25, 2004Assignee: Dainippon Ink and Chemicals, Inc.Inventor: Yuji Ohashi