Abstract: A spine distraction implant alleviates pain associated with spinal stenosis and facet arthropathy by expanding the volume in the spine canal and/or neural foramen. The implant provides a spinal extension inhibitor while allowing freedom of spinal flexion. The implant includes an elliptically-shaped spacer for positioning between and spacing apart the spinous processes.

Abstract: A method for determining a mask-fit test pressure to be applied to a wearer's mask by ventilatory assistance apparatus includes adaptively determining the mask-fit pressure from prior use.

Abstract: A supply of gas such as oxygen is provided to a person in need of such gas supply. The delivery system includes an alarm to alert the recipient of the gas or another when and if the gas supply is disrupted. The alarm system preferably includes a reset and on-off switch that is recessed sufficiently to prevent accidental disabling of the alarm system.

Abstract: Respiratory apparatus including stowage equipment is addressed. The equipment may include a non-rigid bag covering at least part of an oxygen mask. The bag additionally may have an opening through which a portion of the mask protrudes, thereby facilitating its grasping and rapid donning by a user.

Abstract: Disclosed is a system for delivery of a drug comprising a multiple unit dosing device comprising a housing and an actuator, said device containing multiple doses of multiparticulates comprising drug particles, said device upon actuation delivering a unit dose of said multiparticulates, said drug particles having a mean diameter of greater than 10 ?m to about 1 mm such that an effective dose of said drug cannot be delivered into the lower lung of a human patient. Also disclosed are novel methods, devices and dosage forms for delivering a drug.

Abstract: A system and method of providing a wireless heads-up display for displaying the amount of breathing gas remaining in an associated breathing gas supply is provided. The system has a transmitter and a receiver. The transmitter has a pressure sensor and a controller for interpreting the sensed pressure into levels indicative of the amount of breathing gas remaining in the breathing gas supply. These levels are transmitted via radio frequency to the receiver. The receiver, which can be mounted in a breathing mask, includes a display for displaying the amount of breathing gas remaining in the associated breathing gas supply.

Abstract: A long term oxygen therapy system having an oxygen supply directly linked with a patient's lung or lungs may be utilized to more efficiently treat hypoxia caused by chronic obstructive pulmonary disease such as emphysema and chronic bronchitis. The system includes an oxygen source, one or more valves and fluid carrying conduits. The fluid carrying conduits link the oxygen source to diseased sites within the patient's lungs.

Abstract: In one embodiment, the invention provides a device for decreasing intracranial or intraocular pressures. The device comprises a housing having an inlet opening and an outlet opening that is adapted to be interfaced with a person's airway. The device further includes a valve system that is operable to regulate respiratory gas flows through the housing and into the person's lungs during spontaneous or artificial inspiration. The valve system assists in lowering intrathoracic pressures during each inspiration to repetitively lower pressures in the venous blood vessels that transport blood out of the head to thereby reduce intracranial or intraocular pressures.

Abstract: A device and method of using the device for contraception or sterilization and particularly for reversible contraception by occluding a reproductive lumen to prevent the passage of reproductive cells through the lumen for a desired period of time until the patient wishes to become fertile again and then be reopened. The occluding member preferably comprises a tubular framework formed from a shape memory material configured to be implanted in a reproductive lumen. The occluding member is implanted within a body lumen, secured to the wall of the reproductive lumen and then collapsed to collapse the wall and occlude the lumen. Alternatively, the occluding member may be collapsed upon a solid plug. The closure of the reproductive lumen may be reversed by introducing a balloon catheter and by a series of inflations of the balloon reexpanding the collapsed occluding member or by removing the plug.

Abstract: A first and second housing is joined together by a middle housing rotatable with respect to the first and second housing. The first and second housings have conduits passing through exterior walls and an annular ring on an inside wall together with an annular interior edge rotatably joined to first and second side rim channels of the middle housing. A heat-moisture exchanger material having an annular opening through which a tube passes is mounted within the middle housing so that in a first rotatable position air and moisture passes through the first and second housing conduits directly and in a second rotatable position must pass through the heat-moisture exchange material.

Abstract: A dry powder inhaler includes an actuator pivotably mounted on a base. Movement of the actuator from a first position to a second position drives the a dobber to open a blister. A dispersion engine sub-assembly has a blister hood positioned over a blister opening position. A powder pathway connects from the blister hood into a powder dispersion engine. Upon inhalation, air flow draws powder up and out of an opened blister, into the blister hood and to the powder dispersion engine. Movement of the actuator causes the dobber to shear open a blister and also to press the blister hood down over the blister. This increases air flows up and around the open blister, carrying the pharmaceutical powder up and out of the blister and into the dispersion engine.

Abstract: A new embolic agent, bioabsorbable polymeric material (BPM) is incorporated to a Guglielmi detachable coil (GDC) to improve long-term anatomic results in the endovascular treatment of intracranial aneurysms. The embolic agent, comprised at least in part of at least one biocompatible and bioabsorbable polymer and growth factors, is carried by hybrid bioactive coils and is used to accelerate histopathologic transformation of unorganized clot into fibrous connective tissue in experimental aneurysms. An endovascular cellular manipulation and inflammatory response are elicited from implantation in a vascular compartment or any intraluminal location. Thrombogenicity of the biocompatible and bioabsorbable polymer is controlled by the composition of the polymer. The coil further is comprised at least in part of a growth factor or more particularly a vascular endothelial growth factor, a basic fibroblast growth factor or other growth factors.

Abstract: An interactive pressure support system and method employing a pressure generating system that provides a pressure therapy to the pulmonary system of a patient and an interactive system associated with the pressure generating system to enable the patient to interact with the pressure support system, for example, to monitor the effectiveness of the treatment provided by the pressure support system. The interactive system includes an output device that provides first information to the patient, an input device that allows the patient to provide second information that is based on the first information and a control unit that controls the operation of the output device to present the first information and collection of the second information via the input device. In a further embodiment, the operation of the pressure generating system is controlled based on the second information provided by the patient.

Abstract: A space occupying device for deployment within a patient's stomach and methods of deploying and removing the device. The device includes an expandable member and fasteners, such as sutures, that extend to least partially through the patient's stomach wall, and that anchor the device with the patient's stomach. The device can be deployed and/or removed through transesophageal approaches and/or through a combination of transesophageal and transabdominal approaches.

Abstract: The prostheses include an endovascular member in need of repair and a patch therefore, as well as prostheses including two or more endovascular members, such as stent-grafts, which may be assembled in situ. Components of the prostheses are held together in substantially fluid tight engagement as the result of hook and loop structures which are present on the members. The hooks engage the loops to secure the components to one another. As a result, the present invention is particularly useful for the in situ repair of damaged prostheses and for the in situ assembly of bifurcated endovascular prostheses, particularly for the treatment of abdominal aortic aneurysms.

Abstract: A method of determining ventilation inhomogeneity in the lungs is provided. During the first step of the method, a lung volume series is calculated from a series of measured lung inert gas concentrations and lung inert gas volumetric change measured data series. As a second step, the series of lung volumes is completed with a series of value representing the total gas exchange efficiency in the lungs. A global inert gas dilution ratio may be used for this purpose. The gas exchange efficiency values are such that less ventilation is represented by lower numbers. As the third step, the gas exchange efficiency series is plotted as an ordinate and lung volume series as an abscissa to form a graph. From this graph both the lung volume and homogeneity of ventilation become directly apparent.

Abstract: The systems and methods of the present invention provide for soft tissue reconstruction using a fixation device that coapts two intact anatomic structures to each other. In one embodiment, these systems and methods are used to reconstruct defects or abnormalities in the female pelvic floor by using fixation devices to produce a paravaginal suspension of the affected tissues.

Abstract: There is provided a medicament dispenser comprising a medicament container having a dispensing mechanism; a container seat for receipt of the container; an anchor station; and a coupling between said container seat and said anchor station capable on deformation of moving the container seat relative to the anchor station to actuate the dispensing mechanism. The coupling is reversibly deformable in response to the application of non-mechanical energy thereto. The non-mechanical energy may comprise heat energy, electrical current energy, electrical field energy or magnetic field energy.

Abstract: An expandable structure made from an elastomer material is preformed to a desired geometry by exposure to heat and pressure. The structure undergoes controlled expansion and further distention in cancellous bone, with controlled deformation and without stress failure.

Abstract: A method for performing a bypass procedure utilizes the patient's vascular system for accessing or reaching a desired location within the patient's body. The method may also provide a direct flow path from a heart chamber to a coronary vessel via a septal passageway.