Patents Examined by Andrea S Grossman
  • Patent number: 10690686
    Abstract: Disclosed is an antibody which binds to risperidone, which can be used to detect risperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of risperidone, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone in a single lateral flow assay device.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: June 23, 2020
    Assignee: JANSSEN PHARMACEUTICA NV
    Inventors: Eric Hryhorenko, Banumathi Sankaran, Thomas R. DeCory, Theresa Tubbs, Linda Colt, Maarten Vliegen, Pieter Rik Haspeslagh
  • Patent number: 10662459
    Abstract: Disclosed are methods, devices and systems for the isolation and detection of biomolecules from a sample. The embodiments, detection of such biomolecules provides for detection of microorganisms. For example, disclosed are methods, devices and systems that use bacteriophage-based amplification of the signal in detection of bacteria and other microorganisms. The devices, systems and methods of the invention may allow for the detection of certain biomolecules peptides and ions in real time using minute amounts of sample.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: May 26, 2020
    Assignee: Laboratory Corporation of America Holdings
    Inventors: Jeff Albrecht, Andrew J. Conrad
  • Patent number: 10656149
    Abstract: This disclosure provides, among other things, a method of sample analysis, that comprises: (a) binding target analytes to capture agents that are attached to a surface of a plate, wherein the plate comprises (i) a sensing amplification layer comprises nanostructures that enhance signals and (ii) the capture agents are attached to said sensing amplification layer; (b) reading the plate with a reading device to produce an image of signals that represent individual binding events; and (c) identifying and counting individual binding events in an area of the image, thereby providing an estimate of the amount of one or more analytes in the sample. A system for performing the method is also provided.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 19, 2020
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Stephen Y. Chou, Liang-Cheng Zhou
  • Patent number: 10648970
    Abstract: The present invention lies in the field of visualization and quantification of immobilized targets in samples using immunochemical means. In particular, the invention relates to a method and reagents for detection, visualization and quantification of a molecular target in immunostained histological samples using particular compositions of the target specific binding agent. Methods and compositions of the invention are suitable for any assay that uses a target visualization system in histological samples based on detection of the target by the target specific binding agent. The methods and compositions are useful for evaluation of targets that are biomarkers of diseases in medical diagnostic.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: May 12, 2020
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Jesper Lohse, Kristian Jensen, Rikke Malene Krusenst Jerna-Hafstrom, Kirsten Damgaard Hoff, Lars Christian Jacobsen
  • Patent number: 10627401
    Abstract: The present invention provides methods, compositions, and kits associated with analyzing, enriching, and/or isolating a biomarker or analyte in a biological sample. In one aspect, for example, a method for determining a concentration of a biomarker in a biological sample can include binding any unbound biomarker with an antibody specific for the biomarker to form antibody-bound biomarker, enriching the antibody-bound biomarker and any endogenous autoantibody-bound biomarker to form an enriched fraction, identifying the biomarker in the enriched fraction, and determining the concentration of the biomarker in the biological sample. In one aspect, the concentration of the biomarker is derived from initially unbound biomarker and autoantibody-bound biomarker in the biological sample.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: April 21, 2020
    Assignee: University of Utah Research Foundation
    Inventors: Mark M. Kushnir, Alan L. Rockwood, A. Wayne Meikle
  • Patent number: 10620194
    Abstract: A microscale method for the characterization of one or more reaction variables that influence the formation or dissociation of an affinity complex comprising a ligand and a binder, which have mutual affinity for each other.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: April 14, 2020
    Assignee: GYROS Patent AB
    Inventors: Per Andersson, Mats Inganas, Gunnar Thorsén, Gunnar Kylberg
  • Patent number: 10613087
    Abstract: The present invention, in some embodiments thereof, generally relates to methods and devices for determining the health status of a subject, e.g., whether the subject has a disease or other condition. In some embodiments, a plurality or mixture of species may be differentially solubilized in a single two-phase aqueous system, or other multi-phase aqueous system. The nature or degree of the solubilization of the species may be used to determine the health status of a subject. For example, some embodiments are directed to devices and methods for determining a disease or other condition as a function of the changes to the structure of two or more species. The species may be selected based on their differential solubility behavior in a two-phase or other multi-phase aqueous system.
    Type: Grant
    Filed: August 8, 2013
    Date of Patent: April 7, 2020
    Assignee: Analiza, Inc.
    Inventors: Arnon Chait, Boris Y. Zaslavsky
  • Patent number: 10551378
    Abstract: It is an object of the present invention to provide a tissue staining method that makes it possible to observe both information on the morphology of a tissue and information on a biological substance such as an antigen molecule to be detected on a single section and in a single view field. The present invention provides a tissue staining method, including carrying out (A) a HE (hematoxylin-eosin) staining, and (B) a histochemical staining, serially on a single tissue section, wherein the histochemical staining is defined as a histochemical technique for detecting a biological substance to be detected in a tissue in a visible manner by use of a binding reaction between the biological substance to be detected and a probe biological substance capable of binding specifically to the biological substance to be detected.
    Type: Grant
    Filed: September 4, 2012
    Date of Patent: February 4, 2020
    Assignee: KONICA MINOLTA, INC.
    Inventors: Hideki Gouda, Hisatake Okada, Yasushi Nakano, Kohsuke Gonda, Noriaki Ohuchi, Mika Watanabe
  • Patent number: 10545150
    Abstract: The invention provides a method of diagnosis and/or prognosis of lung cancer, the method comprising the steps of: (a) determining the level of a C4 activation fragment in a test sample, and (b) comparing the level of the test sample with the level of a C4 activation fragment detected in a control sample, wherein if the level of C4 activation fragment is higher than the level in a reference control, it is indicative that the subject suffers lung cancer or has a bad prognosis. The present invention further provides methods for determining the risk of suffering from lung cancer as well as for deciding whether to initiate a medical regimen and to determine the efficacy of said medical regimen, based on the determination of a C4 activation fragment. C4 activation fragment, used as marker, confers high sensitivity and specificity to the methods object of the invention.
    Type: Grant
    Filed: March 20, 2013
    Date of Patent: January 28, 2020
    Assignee: PROYECTO DE BIOMEDICINA CIMA, S.L.
    Inventors: Daniel Ajona Martínez-Polo, Leticia Corrales Pecino, Luis Montuenga Badía, María José Pajares Villandiego, Rubén Pío Osés
  • Patent number: 10539559
    Abstract: Disclosed are a PIVKA-II measurement method that achieves better serum-plasma correlation than conventional methods, and a reagent and a kit therefor. The PIVKA-II measurement method according to the present invention comprises measuring PIVKA-II in a sample by an immunoassay using a mixture of an anti-F1 antibody that specifically binds to prothrombin fragment F1 or an antigen-binding fragment thereof and an anti-F2 antibody that specifically binds to prothrombin fragment F2 or an antigen-binding fragment thereof; and an anti-PIVKA-II antibody that specifically binds to PIVKA-II or an antigen-binding fragment thereof.
    Type: Grant
    Filed: August 6, 2013
    Date of Patent: January 21, 2020
    Assignees: FUJIREBIO INC., SEKISUI MEDICAL CO., LTD.
    Inventors: Kentaro Yamaguchi, Katsumi Aoyagi, Azusa Terao
  • Patent number: 10473651
    Abstract: A method for determining agglutination of a biological liquid by measuring a change in hydrodynamic resistance of the biological liquid flowing through a microfluidic channel of a microfluidic device, comprising the steps of: a) calibrating the microfluidic device; b) filling the microfluidic reaction channel with a hydrophobic continuous liquid phase, c) introducing a first reference droplet; d) causing the first reference droplet to flow; e) measuring the time of flow of the first reference droplet; f) introducing a second reference droplet followed by a sequence of test droplet(s); g) causing the second reference droplet and the sequence of test droplet(s) to flow; h) measuring the time of flow; i) calculating the hydrodynamic resistance of the sequence of the test droplet(s); and j) determining agglutination of the biological liquid by comparing the hydrodynamic resistance with the calibrated values.
    Type: Grant
    Filed: November 29, 2015
    Date of Patent: November 12, 2019
    Assignees: Geomobile Sp. z o.o
    Inventor: Sylwia Makulska
  • Patent number: 10444127
    Abstract: A device consisting activated microfibers, such as glass and cellulose, comprising the 3D network, packed in small volumes, traps and concentrates the bacteria from trace contaminated liquids rapidly. It functions for concentrating and rapid detection of microbes in <20 min. The device enables the easy recovery of concentrated bacteria, which involves the mixing and agitation of the contaminated sample, followed by the suction. The chemistry of the system involves coupling aminosilane groups such as 3-aminopropyl methyldiethoxysilane (APMDES) or carboxylated groups in 3-triethoxysilyl propylsuccinicanhydride (TESPSA) to the —OH bearing moieties on the surfaces of glass and/or cellulose microfibers, attained by solution or vapor phase techniques.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: October 15, 2019
    Inventor: Recep Avci
  • Patent number: 10444250
    Abstract: Disclosed is an antibody or a binding fragment thereof that binds to risperidone, which can be used to detect risperidone in a sample such as in a competitive immunoassay method. The antibody or fragment thereof can be used in a lateral flow assay device for point-of-care detection of risperidone, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone in a single lateral flow assay device.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: October 15, 2019
    Assignee: JANSSEN PHARMACEUTICA NV
    Inventors: Eric Hryhorenko, Banumathi Sankaran, Thomas R. DeCory, Theresa Tubbs, Linda Colt, Maarten Vliegen, Pieter Rik Haspeslagh
  • Patent number: 10436785
    Abstract: The invention provides antibodies that bind specifically to human indoleamine 2,3-dioxygenase 1 (IDO1), and methods of using the same. The antibodies are capable of binding to a sequence comprising SEQ ID NO: 1 and specifically bind to human IDO1 in formalin fixed paraffin embedded tissues. The antibodies are useful in a number of different analytical techniques, including immunohistochemistry (IHC) and immunocytochemistry (ICC).
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: October 8, 2019
    Assignee: Spring BioScience Corporation
    Inventors: Fernando Jose Rebelo do Couto, Zhiming Liao, Yifei Zhu
  • Patent number: 10436797
    Abstract: This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: October 8, 2019
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Mahalakshmi Yerramilli, Michael Randolph Atkinson, Murthy V. S. N. Yerramilli
  • Patent number: 10434037
    Abstract: The present invention relates to a kit and a probe for detecting porous dental hydroxyapatite that includes a protein capable of binding porous dental hydroxyapatite or a detector thereof. The invention also relates to a method for detecting a condition involving porous dental hydroxyapatite that includes detecting in or on a tooth or a sample of the tooth of a subject a protein bound to porous dental hydroxyapatite. The invention also relates to methods for detecting a hypomineralization developmental dental defect or detecting intact and/or broken MIH enamel, and to a kit and method for removing a protein bound to porous dental hydroxyapatite.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: October 8, 2019
    Assignee: INCISIVE TECHNOLOGIES PTY LTD
    Inventors: Michael James Hubbard, Jonathan Edward Mangum
  • Patent number: 10408789
    Abstract: An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries and includes a valve system. Analyte concentrators, having antibody-specific (or related affinity) chemistries, are stationed at the respective intersections of the transport capillary and separation capillaries to bind one or more analytes of interest. The apparatus allows the performance of two or more dimensions for the optimal separation of analytes. The apparatus may also include a plurality of valves surrounding each of the analyte concentrators to localize each of the concentrators to improve the binding of one or more analytes of interest.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: September 10, 2019
    Assignee: PRINCETON BIOCHEMICALS, INC.
    Inventor: Norberto A. Guzman
  • Patent number: 10401356
    Abstract: An object of the present invention is to provide an analyte-measuring sensor using a thermoresponsive polymer, which is a novel analyte-measuring sensor capable of quantitatively measuring a target analyte with higher sensitivity. The analyte-measuring sensor of the present invention comprises a labeled particle capable of specifically reacting with a measurement target analyte, a thermoresponsive polymer, a charged substance exhibiting a positive or negative zeta potential in a solution, and a metal particle, and said metal particle is coated with a copolymer of said labeled particle, said charged substance and said thermoresponsive polymer.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: September 3, 2019
    Assignee: JNC CORPORATION
    Inventor: Nobuo Uehara
  • Patent number: 10393631
    Abstract: A method for extracting protein from a fat sample is described comprising the steps of separating solidified fat and solid residues from a centrifuged mixture of protein, fat, other solid materials and aqueous solution of phosphate buffered saline to form an aqueous phase containing the protein. The aqueous phase is then filtered through a filter to separate a clear protein extract from the mixture.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: August 27, 2019
    Assignee: Florida State University Research Foundation, Inc.
    Inventor: Yun-Hwa Peggy Hsieh
  • Patent number: 10379110
    Abstract: The present invention relates to a method for calibrating a multiplex assay, comprising: adding a calibration reagent to a solid phase on which a plurality of capturing agents are immobilized, adding a detection molecule which has a capacity to bind to the calibration reagent, detecting bound detection molecule, thereby creating a calibration curve, wherein the calibration reagent comprises at least two different binding molecules, wherein each binding molecule has a capacity to bind specifically to a capturing agent immobilized on the solid phase and a capacity to bind to a detection molecule. Further provided is a multiplex assay system comprising such a calibration reagent.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: August 13, 2019
    Assignee: PHADIA AB
    Inventors: Göran Elfverson, Per Matsson, Mats Nystrand