Patents Examined by Andrew D. Kosar
  • Substituted octahydrocyclopenta[C]pyrrol-4-amines as calcium channel blockers
    Patent number: 8691865
    Abstract: The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein L1, L2, R1, R2, and R3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: April 8, 2014
    Assignee: AbbVie Inc.
    Inventors: Xenia B. Searle, Ming C. Yeung, Stanley DiDomenico, Andrew O. Stewart, Daria Darczak, Michael Schrimpf, Michael J. Rozema
  • Process for preparation of taxane derivatives
    Patent number: 8686165
    Abstract: The present disclosure relates to processes for the preparation of taxane derivatives with improved purity and enhanced stability. The taxane derivatives prepared according to the processes described herein are useful for the preparation of pharmaceutical compositions.
    Type: Grant
    Filed: November 2, 2010
    Date of Patent: April 1, 2014
    Assignee: Emcure Pharmaceuticals Limited
    Inventors: Mukund K. Gurjar, Swapnil P. Sonawane, Pankaj S. Patil, Samit S. Mehta
  • Aryl- or heteroaryl-sulfonyl compounds as acid secretion inhibitors
    Patent number: 8686010
    Abstract: The present invention provides a compound having a superior acid secretion inhibitory action, an antiulcer activity and the like.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: April 1, 2014
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Atsushi Hasuoka, Terufumi Takagi, Haruyuki Nishida
  • Tazobactam arginine compositions
    Patent number: 8685957
    Abstract: This disclosure provides compositions containing solid forms of tazobactam arginine, and methods of manufacturing and using these compositions.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: April 1, 2014
    Assignee: Cubist Pharmaceuticals, Inc.
    Inventors: Jan-Ji Lai, Jian-Qiao Gu, Pradip M. Pathare, Valdas Jurkauskas, Joseph Terracciano, Nicole Miller Damour
  • Method for producing alcohol compound
    Patent number: 8680302
    Abstract: Disclosed is a practical method for efficiently producing an alcohol compound by hydrogenating an aldehyde by using a homogeneous copper catalyst which is an easily-available low-cost metal species. Specifically disclosed is a method for producing an alcohol compound, which is characterized in that a hydrogenation reaction of an aldehyde compound is performed in the presence of a homogeneous copper catalyst and a diphosphine compound.
    Type: Grant
    Filed: December 11, 2008
    Date of Patent: March 25, 2014
    Assignee: Takasago International Corporation
    Inventor: Hideo Shimizu
  • Epoxidation catalysts
    Patent number: 8680303
    Abstract: The present invention generally relates to methods for the synthesis of catalysts, including epoxidation catalysts, and related compounds and catalyst compositions. Embodiments described herein may provide efficient processes for providing catalysts (e.g., epoxidation catalysts) in large quantities and using simplified methods.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: March 25, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy F. Jamison, Yutaka Ikeuchi
  • Organoboron compound and method for manufacturing the same
    Patent number: 8674117
    Abstract: To provide a novel organoboron compound which is useful as a reactant of organic synthesis. To provide a method for manufacturing the organoboron compound. A novel organoboron compound represented by General Formula (G1) below is provided. Note that in General Formula (G1), R1 to R9 separately represent any one of hydrogen, an alkyl group having 1 to 6 carbon atoms, and an aryl group having 6 to 16 carbon atoms. R10 and R11 separately represent hydrogen or an alkyl group having 1 to 6 carbon atoms, and R10 and R11 may be bonded with each other to form a ring. Further, X represents an oxygen atom or a sulfur atom.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: March 18, 2014
    Assignee: Semiconductor Energy Laboratory Co., Ltd.
    Inventors: Hiroki Suzuki, Sachiko Kawakami
  • One-step catalytic conversion of biomass-derived carbohydrates to liquid fuels
    Patent number: 8674150
    Abstract: The invention relates to a method for manufacture of hydrocarbon fuels and oxygenated hydrocarbon fuels such as alkyl substituted tetrahydrofurans such as 2,5-dimethyltetrahydrofuran, 2-methyltetrahydrofuran, 5-methylfurfural and mixtures thereof. The method generally entails forming a mixture of reactants that includes carbonaceous material, water, a metal catalyst and an acid reacting that mixture in the presence of hydrogen. The reaction is performed at a temperature and for a time sufficient to produce a furan type hydrocarbon fuel. The process may be adapted to provide continuous manufacture of hydrocarbon fuels such as a furan type fuel.
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: March 18, 2014
    Assignee: Penn State Research Foundation
    Inventors: Ayusman Sen, Weiran Yang
  • Cyclopamine analogs
    Patent number: 8669365
    Abstract: The invention provides novel derivatives of cyclopamine having the following formula:
    Type: Grant
    Filed: August 27, 2008
    Date of Patent: March 11, 2014
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Brian Austad, Mark L. Behnke, Alfredo C. Castro, André B. Charette, Michael J. Grogan, Somarajannair Janardanannair, Andre Lescarbeau, Stephane Peluso, Martin Tremblay
  • Process for the preparation of docetaxel, its intermediates, and methods for preparation thereof
    Patent number: 8658811
    Abstract: Described is a process for preparing docetaxel 1, including the following steps: a) hydroxyl acylation reaction of compound 2 and 3 to obtain compound 4; b) deprotection group R1 of the hydroxyl group of compound 4 obtained from step a to prepare compound 5; c) removing one tert-butoxycarbonyl of compound 5 obtained from step b to prepare compound 6; d) removing one acetyl of compound 6 obtained from step c to prepare compound 1; wherein, R1 represents tert-butyl dimethyl silyl, triethylsilyl, ethoxyethyl, tetrahydropyranyl, trichloroethoxycarbonyl or methoxymethyl, Boc is tert-butoxycarbonyl, Ac is acetyl, and Ph is phenyl. Also disclosed are intermediates of docetaxel and methods for preparation thereof.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: February 25, 2014
    Assignee: Shanghai Parling Pharma-Tech. Co., Ltd.
    Inventors: Xin Shen, Huaxing Zhan, Jidong Yang, Xiao He, Fuxing Lin, Shaohong Wu
  • PLK inhibitor salts
    Patent number: 8648078
    Abstract: The present invention relates to novel crystalline, water-soluble salts of a plk inhibitor. Such crystal salts are for example L-tartrate, succinate, phosphate, mesylate, maleate, L-malate, hydrochloride, fumarate (half mole of counterion), fumarate, citrate (half mole of counterion), benzenesulfonate and L-aspartate (half mole of counterion). New crystal forms of the base as well as solvates and hydrates of such new salt forms, a process for their preparation, their utility in therapy and to the pharmaceutical compositions containing them are also claimed and described in the present application.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: February 11, 2014
    Assignee: Nerviano Medical Sciences S.R.L.
    Inventors: Massimo Zampieri, Italo Beria, Annalisa Airoldi, Ilaria Candiani, Riccardo Frigerio
  • Compounds having phenanthroline structure
    Patent number: 8648194
    Abstract: The present invention provides a novel compound having a phenanthroline structure represented by formula (I) or a salt thereof:
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: February 11, 2014
    Assignee: B.R.A.H.M.S GmbH
    Inventors: Mikio Hoshino, Toshisada Yano
  • Co-crystal compound, method for preparing the same and oxidant of gas generator propellant
    Patent number: 8642789
    Abstract: A co-crystal compound containing ammonium nitrate and benzo-18-crown-6-ether. Ammonium nitrate and benzo-18-crown-6-ether are used to form the co-crystal compound with hydrogen bonding in a mole ratio of 1:1. A melting point of the co-crystal compound falls within a range of 124˜130° C., and the co-crystal compound can be prepared by an evaporation method or an anti-solvent method. The co-crystal compound comes with a non-hygroscopic property, a low burning rate (7 MPa, 0.58 mm/s) and a high pressure index (n>0.6), which can be used for replacing the oxidizer of a common gas generator propellant.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: February 4, 2014
    Assignee: National Central University
    Inventors: Lee Tu, Jeng-Wei Chen
  • Method for preparing taxane derivatives
    Patent number: 8633326
    Abstract: Provided is a method for preparing a taxane derivative, comprising: carrying out condensation of a phenylisoserine derivatives having a protective group introduced thereto or a mixture of isomers thereof, as a side chain, with a baccatin III derivative or 10-deacetyl-baccatin III derivative to obtain a mixture of isomers; separating the isomers via chromatography; and carrying out a reversion of the stereochemical structure of a selectively separated isomer, which is suitable for producing a taxane derivative in a large scale with high yield.
    Type: Grant
    Filed: December 3, 2009
    Date of Patent: January 21, 2014
    Assignee: Samyang Biopharmaceuticals Corporation
    Inventors: Sang-Hyun Pyo, Jin-Suk Cho, Moon-Suk Kim, Jai-Young Song, Ho-Joon Choi
  • Method of producing bicyclo[3.1.0] hexane derivative using enzyme
    Patent number: 8618312
    Abstract: Production of a bicyclo[3.1.0]hexane derivative, useful as a metabotropic glutamate receptor modulator, becomes possible by a production method that includes converting a compound represented by Formula (II) into a compound represented by Formula (III) by reaction with an acyl group donor in the presence of a microorganism-derived enzyme, without using an expensive optically active trans hydroxy ester as a starting material and without employing a fluorination reaction requiring an ultralow temperature reaction. Furthermore, since asymmetric synthesis can be carried out in a stage closer to the final product, the production method is useful as a production method that can mass produce a bicyclo[3.1.0]hexane derivative.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: December 31, 2013
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Mitsuaki Hirotsuka, Joji Sasaki, Hiroaki Kamiyama, Motoko Oshida, Takaaki Ishii
  • Use of cyclovinyl phosphine/copper complexes as arylation catalysts
    Patent number: 8604201
    Abstract: The invention relates to the use of cyclovinyl phosphine compounds in the form of complexes with copper, as catalysts for reactions leading to the formation of carbon-carbon and carbon-heteroatom bonds. The invention also relates to complexes of copper with at least one cyclovinyl phosphine, as well as to the method for creating a carbon-carbon or a carbon-heteroatom bond catalysed by a cyclovinyl phosphine/copper complex.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: December 10, 2013
    Assignee: Centre National de Recherche Scientifique (C.N.R.S.)
    Inventors: Marc Taillefer, Hamid Kaddouri, Fouad Ouazzani
  • Perimidine-based squarylium dye, dye-containing composition, and image-forming material
    Patent number: 8586736
    Abstract: A perimidine-based squarylium dye contains a compound represented by Formula (I), the compound containing an isomer A and satisfying the following formula: Pa?95(%) wherein the isomer A is an isomer of the peak shown in the longest retention time among all peaks due to isomers obtained by analysis of the compound by means of reversed-phase high-performance liquid chromatography, and Pa represents a value of the peak area of the isomer A relative to the peak area of all peaks.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: November 19, 2013
    Assignee: Fuji Xerox Co., Ltd.
    Inventors: Minquan Tian, Takashi Matsubara, Suguru Nakaso, Yuka Ito, Shinji Hasegawa, Makoto Furuki
  • Labeling reagents and methods of their use
    Patent number: 8586743
    Abstract: The present disclosure is directed to a reactive ester agent capable of conjugating a reporter molecule to a carrier molecule or solid support. The reactive ester agent has the general formula: wherein the variables are described throughout the application.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: November 19, 2013
    Assignee: Life Technologies Corporation
    Inventors: Kyle Gee, Aleksey Rukavishnikov, Diane M. Witczak
  • Use of kinase inhibitor for the treatment of thymoma
    Patent number: 8580793
    Abstract: The invention provides a low molecular weight ATP-competitive CDK inhibitor and TRKA inhibitor of formula (I) for use in the treatment of thymoma and thymic carcinoma. The compound can be administered together with one or more cytotoxic or cytostatic agents.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: November 12, 2013
    Assignee: Nerviano Medical Services S.r.l.
    Inventors: Angela Scaburri, Maria Adele Pacciarini, Marina Ciomei, Bernard Laffranchi, Silvia Comis
  • Beta-lactamase inhibitory compounds
    Patent number: 8575144
    Abstract: Inhibitors of the enzyme beta-lactamase are provided comprising compounds of formula (II) wherein R1 or R2 is a pyridyl group and R5 is a group of formula The compounds are adapted to inhibit beta-lactamase as produced by beta-lactam resistant bacterial strains. Methods of treatment of beta-lactam resistant bacterial infections in patients are provided.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: November 5, 2013
    Assignee: Southern Methodist University
    Inventors: John D. Buynak, Anjaneyulu Sheri, Sundar Ram Reddy Pagadala