Patents Examined by Andrew Freistein
  • Substituted 2,5-diamidoindoles as ECE inhibitors for the treatment of cardiovascular diseases
    Patent number: 7045544
    Abstract: The invention relates to compounds of formula (I), to a method for the production thereof, and to the use of the same as pharmaceuticals for the treatment of diseases in humans and/or animals
    Type: Grant
    Filed: September 16, 2002
    Date of Patent: May 16, 2006
    Assignee: Bayer HealthCare AG
    Inventors: Jens-Kerim Ergüden, Thomas Krahn, Christian Schröder, Johannes-Peter Stasch, Stefan Weigand, Hanno Wild, Michael Brands
  • Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
    Patent number: 6995183
    Abstract: Compounds are provided having the formula (I) wherein: n is 0, 1 or 2; m is 0, 1 or 2; the sum of n+m less then or equal to 2; the dashed bonds forming a cyclopropyl ring can only be present when Y is CH; X is H or CN; Y is CH, CH2, CHF, CF2, O, S, SO, or SO2; and A is adamantyl. Further provided are methods of using such compounds for the treatment of diabetes and related diseases, and to pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: July 27, 2004
    Date of Patent: February 7, 2006
    Assignee: Bristol Myers Squibb Company
    Inventors: Lawrence G. Hamann, Ashish Khanna, Mark S. Kirby, David R. Magnin, Ligaya M. Simpkins, James C. Sutton, Jeffrey Robl