Patents Examined by Andrew J Bowman
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Patent number: 10465533Abstract: A process of producing a hot gas path turbine component. The process includes forming a void in a first ceramic matrix composite ply and forming a void in a second ceramic matrix composite ply. The second ceramic matrix composite ply is positioned on the first ceramic matrix composite ply such that the positioning aligns the voids to at least partially define a cavity in the component. A third ceramic matrix composite ply is positioned on the first ceramic matrix composite ply and the first ceramic matrix composite ply, the second ceramic matrix composite ply and the third ceramic matrix composite ply are densified to form a densified body. The cavity is present in the densified body. A ceramic matrix composite having cavities therein is also disclosed.Type: GrantFiled: October 8, 2015Date of Patent: November 5, 2019Assignee: General Electric CompanyInventors: Victor John Morgan, Jacob John Kittleson, Andres Jose Garcia-Crespo, Benjamin Paul Lacy
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Patent number: 10464100Abstract: A system and method are disclosed for coating surfaces of expandable medical devices with composite coatings. Coatings are composed of various materials including, e.g., polymers and drugs. Transfer of the coatings within a patient or other host forms a drug-eluting coating that delivers time-released drugs over time for treatment of a medical condition.Type: GrantFiled: May 30, 2012Date of Patent: November 5, 2019Assignees: Micell Technologies, Inc., Battelle Memorial InstituteInventors: Dean W. Matson, Clement R. Yonker, John L. Fulton, George S. Deverman, Barbara J. Tarasevich, Wendy J. Shaw, Leonard S. Fifield, Krys Wallace, C. Douglas Taylor, James B. McClain
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Patent number: 10456227Abstract: A method of treating a tubular medical device with a biomolecule comprises the steps of: a) providing a polyolefin tubular substrate forming a tubular medical device; b) cleaning the tubular polyolefin substrate; c) exposing the tubular polyolefin substrate to a reactive gas containing at least one of acrylic acid and siloxane and to plasma energy to yield a plasma-deposited coating on at least one surface of the tubular polyolefin substrate; and d) attaching a biomolecule to the polyolefin substrate following formation of the plasma-deposited coating on at least one surface of the tubular polyolefin substrate, and wherein the biomolecule is at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, protein, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.Type: GrantFiled: July 3, 2017Date of Patent: October 29, 2019Assignee: ENSION INC.Inventors: Ali Hussain, Linda Cahalan, Greg Johnson, Mark Gartner, Patrick Cahalan, Brian J Fill, Jeffrey W. Speakman
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Patent number: 10456993Abstract: Techniques for forming a nanopore in a lipid bilayer are described herein. In one example, an agitation stimulus level such as an electrical agitation stimulus is applied to a lipid bilayer wherein the agitation stimulus level tends to facilitate the formation of nanopores in the lipid bilayer. In some embodiments, a change in an electrical property of the lipid bilayer resulting from the formation of the nanopore in the lipid bilayer is detected, and a nanopore has formed in the lipid bilayer is determined based on the detected change in the lipid bilayer electrical property.Type: GrantFiled: July 18, 2014Date of Patent: October 29, 2019Assignee: Roche Sequencing Solutions, Inc.Inventors: Roger J. A. Chen, Randy Davis
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Patent number: 10456245Abstract: Methods for applying polymeric material to a stent are disclosed. A mandrel is coupled to a stent body. The stent body comprises an inner surface defining a cavity and an outer surface opposing the internal surface. The stent body also has a length along an axis defined by the mandrel between a first end of the stent body and a second end of the stent body. An electrospun material is applied to at least a portion of the stent external surface and to at least a portion of the mandrel to form a coating sheet. A portion of the coating sheet extends from at least one of the first end or second end of the stent to the mandrel. One or both of the stent and the mandrel are moved to apply at least some of the portion of the coating sheet onto the internal surface of the stent body.Type: GrantFiled: June 1, 2017Date of Patent: October 29, 2019Assignee: Edwards Lifesciences CorporationInventors: Paul P. Nguyen, Chris McWilliams, Connor Cady, Cody Jeremiah Kratochvil, Dylan Joseph Kratochvil
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Patent number: 10456508Abstract: An improvement in drug-eluting stents, and method of their making, are disclosed. The surface of a metal stent is roughened to have a surface roughness of at least about 20 ?in (0.5 ?m) and a surface roughness range of between about 300-700 ?in (7.5-17.5 ?m). The roughened stent surface is covered with a polymer-free coating of a limus drug, to a coating thickness greater than the range of surface roughness of the roughened stent surface.Type: GrantFiled: January 13, 2017Date of Patent: October 29, 2019Assignee: Biosensors International Group, Ltd.Inventors: Douglas R. Savage, John E. Shulze, Ronald E. Betts, Sepehr Fariabi, Shih-Horng Su
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Patent number: 10441688Abstract: A method of making a solution including poly(ethylene terephthalate). The method includes dissolving poly(ethylene terephthalate) in a solvent mixture to form a solution, the solvent mixture including two solvent components. A Hansen Solubility Parameter Distance between the solvent mixture and HSP coordinates having a dispersion HSP of 18.02 MPa0.5, a polar HSP of 5.56 MPa0.5, and a hydrogen bonding HSP of 14.27 MPa0.5 is less than about 2 MPa0.5.Type: GrantFiled: April 12, 2017Date of Patent: October 15, 2019Assignee: Cardiac Pacemakers, Inc.Inventors: Joseph T. Delaney, Jr., David R. Wulfman, Adeniyi O. Aremu, Adegbola O. Adenusi
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Patent number: 10427184Abstract: Disclosed herein is a balloon coating method for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter, the balloon catheter including the balloon which is inflatable and provided on a distal portion of an elongate shaft. The balloon coating method includes: accommodating the shaft in a groove portion formed in a support base to extend rectilinearly, and closing at least part of the groove portion with a lid portion, thereby to support the shaft such that the shaft can be rotated within the groove portion; and moving a dispensing tube for supplying a coating liquid containing the drug relative to the balloon in an axial direction of the balloon, while rotating the balloon about an axis of the balloon, thereby to coat the outer surface of the balloon with the coating liquid.Type: GrantFiled: April 22, 2016Date of Patent: October 1, 2019Assignee: TERUMO KABUSHIKI KAISHAInventors: Hiroshi Gotou, Yasuo Kurosaki, Eisuke Furuichi
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Patent number: 10422766Abstract: A manufacturing device and a manufacturing method of a test strip. The manufacturing device includes a fluid push module, a fluid flow module and a fluid output module. The fluid push module includes an actuator and a transmission unit. The transmission unit has at least a fluid delivery member. The fluid flow module includes a reagent storage unit and a reagent delivery unit. The reagent storage unit has at least one reagent storage chamber. The reagent delivery unit has at least one drain chamber, at least one first infusion line, at least a second infusion line and a plurality of check valves. The fluid output module includes a plurality of reagent outlets and a reagent output unit, and one end of each of the reagent outlets is configured with an inner recess. The reagent output unit has a plurality of channels corresponding to the reagent outlets.Type: GrantFiled: July 14, 2017Date of Patent: September 24, 2019Assignee: NATIONAL TSING HUA UNIVERSITYInventor: Chao-Min Cheng
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Patent number: 10405916Abstract: A coating and devices using the coating are provided. The coating is applied in liquid form and dried or otherwise cured to form a durable adherent coating resistant to high temperatures and having optional hydrophobic properties. The coating formulation contains an aqueous formulation of silica, one or more fillers, and sufficient base, (e.g., potassium hydroxide), to have a pH exceeding about 10.5 during at least part of the formulation process. The formulation may contain a compound(s) that affects surface free energy, energy to make the cured coating hydrophobic. Such compounds include silanes containing halogens (e.g., fluorine or chlorine) and in particular silanes containing one or more hydrolyzable groups attached to at least one silicon atom and a group containing one or more halogens (e.g., chlorine or fluorine). A medical instrument (e.g., electrosurgical instrument) may be at least partially covered by a coating using the formulation.Type: GrantFiled: October 14, 2016Date of Patent: September 10, 2019Assignee: TEAM MEDICAL, LLCInventors: Warren P. Heim, James Brassell
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Patent number: 10376613Abstract: The present invention concerns a process for the production of implants with an ultrahydrophilic surface as well as the implants produced in that way and also processes for the production of loaded, so-called bioactive implant surfaces of metallic or ceramic materials, which are used for implants such as artificial bones, joints, dental implants or also very small implants, for example what are referred to as stents, as well as implants which are further produced in accordance with the processes and which as so-called “delivery devices” allow controlled liberation, for example by way of dissociation, of the bioactive molecules from the implant materials.Type: GrantFiled: November 24, 2015Date of Patent: August 13, 2019Assignee: Nobel Biocare Services AGInventor: Herbert Jennissen
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Patent number: 10376682Abstract: Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.Type: GrantFiled: October 11, 2016Date of Patent: August 13, 2019Assignee: The Johns Hopkins UniversityInventors: Chao-Wei Hwang, Hala J. Tomey, Jon R. Resar, Robert C. Matteson, III, George L. Coles, Jr., Jason J. Benkoski, Morgana M. Trexler
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Patent number: 10369257Abstract: The present invention concerns a process for the production of implants with an ultrahydrophilic surface as well as the implants produced in that way and also processes for the production of loaded, so-called bioactive implant surfaces of metallic or ceramic materials, which are used for implants such as artificial bones, joints, dental implants or also very small implants, for example what are referred to as stents, as well as implants which are further produced in accordance with the processes and which as so-called “delivery devices” allow controlled liberation, for example by way of dissociation, of the bioactive molecules from the implant materials.Type: GrantFiled: May 26, 2017Date of Patent: August 6, 2019Assignee: Nobel Biocare Services AGInventors: Herbert Jennissen, Steffen Lüers, Markus Laub
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Patent number: 10363125Abstract: An implantable medical device that is fabricated from materials that present a blood or body fluid or tissue contact surface that has controlled heterogeneities in material constitution. An endoluminal stent-graft and web-stent that is made of a monolithic material formed into differentiated regions defining structural members and web regions extending across interstitial spaces between the structural members. The endoluminal stent-graft is characterized by having controlled heterogeneities at the blood flow surface of the stent.Type: GrantFiled: September 25, 2018Date of Patent: July 30, 2019Assignee: Vactronix Scientific, LLCInventors: Julio C. Palmaz, Eugene A. Sprague, Christopher E. Banas
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Patent number: 10363370Abstract: A method and apparatus for plasma modifying a workpiece such as a syringe barrel, cartridge barrel, vial, or blood tube is described. Plasma is provided within the lumen of the workpiece. The plasma is provided under conditions effective for plasma modification of a surface of the workpiece. A magnetic field is provided in at least a portion of the lumen. The magnetic field has an orientation and field strength effective to improve the uniformity of plasma modification of the interior surface of the generally cylindrical wall. A vessel made according to the process or using the apparatus described above. A pharmaceutical package comprising the syringe barrel or vial containing a pharmaceutical preparation, secured with a closure.Type: GrantFiled: September 1, 2017Date of Patent: July 30, 2019Assignee: SiO2 Medical Products, Inc.Inventors: Christopher Weikart, Becky L. Clark, Adam Stevenson, Robert S. Abrams, John Belfance
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Patent number: 10357406Abstract: A method of applying a patterned coating of a silicone adhesive to a substrate sheet, comprising the steps of pattern coating a silicone precursor composition onto the substrate, followed by thermally curing the precursor composition coated on the substrate. The precursor composition is a viscous fluid, and the pattern coating is performed by suitably modified block printing, intaglio printing or screen printing methods. Also provided are coated substrates obtainable by the methods of the invention, and wound dressings comprising such coated substrates.Type: GrantFiled: August 1, 2016Date of Patent: July 23, 2019Assignee: KCI USA, INC.Inventors: Deborah Addison, Sally Stephens, Patrick Joseph Brosnan, Gary Street, Ian Teet, Risham Amjad
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Patent number: 10350074Abstract: A patient-specific porous metal prosthesis and a method for manufacturing the same are provided. The orthopedic prosthesis may be metallic to provide adequate strength and stability. Also, the orthopedic prosthesis may be porous to promote bone ingrowth.Type: GrantFiled: April 24, 2017Date of Patent: July 16, 2019Assignee: Zimmer, Inc.Inventors: Jia Li, Scott V. Cron, Jeffrey Bassett, Edward M. Willis
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Patent number: 10342900Abstract: A method of modifying the surface of a medical device to release a drug in a controlled way by providing a barrier layer on the surface of one or more drug coatings. The barrier layer consists of modified drug material converted to a barrier layer by irradiation by an accelerated neutral beam derived from an accelerated gas cluster ion beam. Also medical devices formed thereby.Type: GrantFiled: August 22, 2012Date of Patent: July 9, 2019Assignee: EXOGENESISInventors: Richard C. Svrluga, Sean R. Kirkpatrick, Stephen M. Blinn
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Patent number: 10343184Abstract: Provided is a drug-eluting coronary stent. In the drug-eluting coronary stent according to the present invention, electrospinning is used, thereby making it possible to precisely control a total content of an everolimus-based drug bound thereto and form a uniform layer in spite of not using a polymer causing late thrombosis, or the like.Type: GrantFiled: September 26, 2017Date of Patent: July 9, 2019Assignee: CHONNAM NATIONAL UNIVERSITY HOSPITALInventors: Dae Sung Park, In-Ho Bae, Jae Won Shim, So Youn Lee, Eun Jae Jang, Kyung Seob Lim, Jun Kyu Park, In Soo Kim, Doo Sun Sim, Myung Ho Jeong
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Patent number: 10327892Abstract: A support structure for a heart valve implant may include an expandable metallic scaffold configured to be actuated between a delivery configuration and a deployed configuration, and a seal member formed from a polymeric material, the seal member being disposed about the expandable scaffold, wherein a first portion of the seal member immediately adjacent the expandable scaffold is directly attached to the expandable scaffold and a second portion of the seal member immediately adjacent the expandable scaffold is unattached to the expandable scaffold.Type: GrantFiled: July 26, 2016Date of Patent: June 25, 2019Assignee: BOSTON SCIENTIFIC SCIMED INC.Inventors: Tim O'Connor, Pat O'Toole, Patricia Kelly, Coley Smyth