Patents Examined by Anh-Khoa N Dinh
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Patent number: 11975199Abstract: A device may receive, from one or more electrodes, information identifying brain activity for a first time period. The device may predict, based on the information identifying the brain activity for the first time period, predicted brain activity for a second time period that is to occur after the first time period. The device may determine, based on the predicted brain activity for the second time period, a brain stimulus for the second time period, wherein the brain stimulus is associated with a frequency and a phase determined based on the predicted brain activity for the second time period. The device may cause the brain stimulus to be applied in accordance with the frequency and the phase during the second time period.Type: GrantFiled: January 31, 2020Date of Patent: May 7, 2024Assignee: The Johns Hopkins UniversityInventors: William S. Anderson, Yousef Salimpour, L. Leon Chen, Kelly Mills
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Patent number: 11975208Abstract: A computer implemented method for determining heart arrhythmias based on cardiac activity that includes under control of one or more processors of an implantable medical device (IMD) configured with specific executable instructions to obtain far field cardiac activity (CA) signals at electrodes located remote from the heart, and obtain acceleration signatures, at an accelerometer of the IMD, indicative of heart sounds generated during the cardiac beats. The IMD is also configured with specific executable instructions to declare a candidate arrhythmia based on a characteristic of at least one R-R interval from the cardiac beats, and evaluate the acceleration signatures for ventricular events (VEs) to re-assess a presence or absence of at least one R-wave from the cardiac beats and based thereon confirming or denying the candidate arrhythmia.Type: GrantFiled: January 6, 2023Date of Patent: May 7, 2024Assignee: Pacesetter, Inc.Inventors: Jong Gill, Gene Bornzin
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Patent number: 11969264Abstract: An adaptive controller used in a photoplethysmography sensing system, comprises a plurality of hardware circuits which are configured to: receive a photoplethysmography signal (hereinafter, “PPG signal”) processed; determine whether the PPG signal processed satisfies with a requirement; output the PPG signal processed if the PPG signal processed satisfies with a requirement; and adjust a gain of an amplifier for amplifying the PPG signal and/or a driving signal of a light source if the PPG signal processed does not satisfy with a requirement.Type: GrantFiled: October 16, 2020Date of Patent: April 30, 2024Assignee: Amengine CorporationInventors: Paul C. P. Chao, Tse-Yi Tu, Bo-Wei Pan, Yan-Hwa Wu
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Patent number: 11969595Abstract: An illustrative proximity detection system directs a first electrode of an electrode lead to apply a first pulse and directs a second electrode of the electrode lead to apply a second pulse concurrently with the first pulse so as to form a dipole that generates a field. The first and second electrodes are each configured as stimulating electrodes that apply stimulation to the cochlear tissue when the electrode lead is located at a resting position subsequent to a surgical insertion of the electrode lead into a cochlea of a patient. After the pulses are applied, and based on an energy magnitude of the field that is detected to reflect from cochlear tissue located within the field, the proximity detection system determines a proximity of the electrode lead to the cochlear tissue. Corresponding systems and methods are also disclosed.Type: GrantFiled: June 6, 2022Date of Patent: April 30, 2024Assignee: Advanced Bionics AGInventors: Kanthaiah Koka, Leonid M. Litvak
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Patent number: 11969606Abstract: A wearable medical monitoring (WMM) system may be worn for a long time. Some embodiments of WMM systems are wearable cardioverter defibrillator (WCD) systems. In such systems, ECG electrodes sense an ECG signal of the patient, and store it over the long-term. The stored ECG signal can be analyzed for helping long-term heart rate monitoring of the patient. The heart rate monitoring can be assisted a) by special filtering techniques that remove short-term variations inherent in patients' short-term heart rate determinations, and b) by indication techniques that indicate when conditions hampered sensing of the ECG signal too much for a reliable heart rate determination.Type: GrantFiled: May 1, 2023Date of Patent: April 30, 2024Assignee: WEST AFFUM HOLDINGS DESIGNATED ACTIVITY COMPANYInventors: Steven Postlewait, Joseph Sullivan, Gregory T. Kavounas
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Patent number: 11951312Abstract: A medical device system and method are disclosed for treating obstructive sleep apnea. The system includes a pulse generator and a medical electrical lead including multiple electrodes carried by a distal portion of an elongated lead body. The method includes advancing the distal portion within protrusor muscle tissue below the oral cavity and delivering electrical stimulation pulses via the electrodes to sustain a protruded state throughout a delivery time period to sustain a protruded state of a patient's tongue throughout the therapy delivery time period. The therapy delivery time period may span multiple respiration cycles.Type: GrantFiled: July 13, 2022Date of Patent: April 9, 2024Assignee: Medtronic, Inc.Inventor: Avram Scheiner
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Patent number: 11944460Abstract: A method for determining a sharpness index of a pulse wave signal includes receiving a pulse wave signal; determining a first reference line starting point and a second reference line starting point on the basis of a curvature of the pulse wave signal; determining a first reference line connecting the first reference line starting point and a first reference line ending point by determining the first reference line ending point by applying an intersecting tangent method to the first reference line starting point, and determining a second reference line connecting the second reference line starting point and a second reference line ending point by determining the second reference line ending point by applying the intersecting tangent method to the second reference line starting point; and determining a sharpness index by using a peak point of the pulse wave signal, the first reference line, and the second reference line.Type: GrantFiled: September 18, 2018Date of Patent: April 2, 2024Assignee: Korea Institute of Oriental MedicineInventors: Jang Han Bae, Young Ju Jeon, Jong Yeol Kim
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Patent number: 11944812Abstract: An extravascular neural interface includes a device containing electrodes for neurostimulation of a vessel. The devices are housed in flexible substrates forming two flaps, an inner flap having a spinal portion for routing leads/conductors into the device for connection to the electrodes and an outer flap that overlaps the inner flap. The inner flap supports and positions the electrodes to be inward facing, i.e., extravascular designs. The electrodes may be circular or elliptical and include a plurality of wings for securing the electrodes within a flap.Type: GrantFiled: May 9, 2022Date of Patent: April 2, 2024Assignee: GALVANI BIOELECTRONICS LIMITEDInventors: Faisal Zaidi, Sebastien Ouchouche
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Patent number: 11938315Abstract: An electrical stimulation system includes at least one electrical stimulation lead, each of the at least one electrical stimulation lead including a plurality of stimulation electrodes; and a processor coupled to the lead and configured to perform actions, including: directing delivery of at least one electrical pulse through at least one of the stimulation electrodes of the at least one electrical stimulation lead to tissue of a patient; and directing discrete or intermittent measurement of an electrical characteristic of the tissue using at least one of the stimulation electrodes of the at least one electrical stimulation lead during, and after, delivery of the at least one electrical pulse to the tissue of the patient.Type: GrantFiled: October 5, 2022Date of Patent: March 26, 2024Assignee: Boston Scientific Neuromodulation CorporationInventor: Changfang Zhu
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Patent number: 11938317Abstract: Energy is transmitted to a body lumen or passageway in the form of pulsed electric fields (PEFs) and in a manner which provides focal therapy. In some embodiments, PEFs are delivered through independent electrically active electrodes of an energy delivery body, typically in a monopolar fashion. Such delivery concentrates the electrical energy over a smaller surface area, resulting in stronger effects than delivery through an electrode extending circumferentially around the lumen or passageway. It also forces the electrical energy to be delivered in a staged regional approach, mitigating the effect of preferential current pathways through the surrounding tissue. Focal delivery of PEFs can provide increased tissue lethality by employing precise timing and sequencing of energy delivery to the electrodes.Type: GrantFiled: December 7, 2022Date of Patent: March 26, 2024Assignee: Galvanize Therapeutics, Inc.Inventors: William Sanford Krimsky, Paul Brian Friedrichs, Roman Turovskiy, Robert E. Neal, II, Jonathan Reuben Waldstreicher, Kevin James Taylor
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Patent number: 11931570Abstract: Flexible catheters adapted to be inserted into a body to deliver high-voltage, fast (e.g., microsecond, sub-microsecond, nanosecond, picosecond, etc.) electrical energy to target tissue may include a plurality of conductive layers, that may be coaxial. These catheters and method of using them to treat tissue are configured to reduce or avoid arcing.Type: GrantFiled: January 3, 2023Date of Patent: March 19, 2024Assignee: Pulse Biosciences, Inc.Inventors: David J. Danitz, Kevin L. Moss, Wesley C. Joe, Christopher J. Foster, Gary L. Boseck, Xitlalic Y. Soto-Sida, Robert Maston, John P. Lunsford
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Patent number: 11931579Abstract: Passive tissue biasing circuitry in an Implantable Pulse Generator (IPG) is disclosed to facilitate the sensing of neural responses by holding the voltage of the tissue to a common mode voltage (Vcm). The IPG's conductive case electrode, or any other electrode, is passively biased to Vcm using a capacitor, as opposed to actively driving the (case) electrode to a prescribed voltage using a voltage source. Once Vcm is established, voltages accompanying the production of stimulation pulses will be referenced to Vcm, which eases neural response sensing. An amplifier can be used to set a virtual reference voltage and to limit the amount of current that flows to the case during the production of Vcm. In other examples, circuitry can be used to monitor the virtual reference voltage as useful to enabling the sensing the neural responses, and as useful to setting a compliance voltage for the current generation circuitry.Type: GrantFiled: February 20, 2023Date of Patent: March 19, 2024Assignee: Boston Scientific Neuromodulation CorporationInventor: Goran N. Marnfeldt
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Patent number: 11931572Abstract: A noninvasive/minimally invasive neuromodulation system and method for providing therapy to a target neural tissue of a patient. In one arrangement, an example method comprises applying at least two input waveforms to respective pairs of electrodes affixed on the patient's skin or subcutaneously disposed relative to the target neural tissue, wherein the frequencies of the input waveforms are configured such that they combine, when simultaneously applied, to generate a beat waveform having a beat frequency due to interference. The beat waveform is causative of a transcutaneous/subcutaneous temporal interference (T/STI) electric field generated in the patient body, the T/STI electric field including an interference region at least partially overlapping the target neural tissue of the patient, wherein the beat frequency is of a value operative to impart a therapeutic effect to the target neural tissue.Type: GrantFiled: December 24, 2020Date of Patent: March 19, 2024Assignee: Advanced Neuromodulation Systems, Inc.Inventors: Simeng Zhang, Hyun-Joo Park, Erika Ross
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Patent number: 11925466Abstract: An electrode, the electrode including an exposed contact surface, the exposed surface comprising a contact material, the contact material comprising a MXene. A device, the device including a plurality of electrodes, each of the plurality of electrodes comprising an exposed contact surface, the exposed surface comprising a contact material, the contact material comprising a MXene. A method, the method including delivering electrical stimulation to a subject with an electrode that comprises an exposed contact surface, the exposed contact surface comprising a contact material that includes a MXene.Type: GrantFiled: September 14, 2018Date of Patent: March 12, 2024Assignees: The Trustees of the University of Pennsylvania, Drexel UniversityInventors: Flavia Vitale, Brian Litt, Nicolette Driscoll, Yury Gogotsi, Babak Anasori, Kathleen Maleski
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Patent number: 11918806Abstract: Systems and methods include a wearable device with an electrically conductive skin interface that excites the underlying nerves from a transcutaneous surface stimulator. The device may be sized for a range of user sizes with stimulation electrodes positioned to target the appropriate nerves, such as the saphenous and/or posterior tibial nerves. The therapy may be adjusted based on leg restlessness or movement.Type: GrantFiled: May 11, 2022Date of Patent: March 5, 2024Assignee: Cala Health, Inc.Inventors: Serena HanYing Wong, Kathryn H. Rosenbluth, Samuel Richard Hamner, Peter Lin, Benjamin Pless
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Patent number: 11911616Abstract: Devices, systems and methods provide forms of asymptomatic diaphragmatic stimulation (ADS) therapy that affect pressures within the intrathoracic cavity, including: 1) dual-pulse ADS therapy, during which a first ADS pulse is delivered during a diastolic phase of a cardiac cycle and a second ADS pulse is delivered during a systolic phase, 2) paired-pulse ADS therapy, during which a first ADS pulse is delivered, closely followed by a second ADS pulse, with the second ADS pulse functioning to extend or enhance a phase of a transient, partial contraction of the diaphragm, and 3) multiple-pulse ADS therapy, during which a stream of ADS pulses is delivered, wherein the time between pulses is based on heart rate. Devices, systems and methods also monitor electromyography (EMG) activity of the diaphragm relative to baseline activity to assess the health of a diaphragm subject to ADS therapy and to adjust ADS therapy parameters or sensing parameters.Type: GrantFiled: November 3, 2022Date of Patent: February 27, 2024Assignee: VisCardia, Inc.Inventors: Peter T. Bauer, Timothy Wheeler
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Patent number: 11911108Abstract: A blood flow measuring unit of a blood flow measurement apparatus of an embodiment includes an optical system for applying an OCT scan to an eye fundus and obtains blood flow information based on data acquired by the OCT scan. A movement mechanism moves the optical system. A controller applies a first movement control to the movement mechanism to move the optical system in a first direction orthogonal to an optical axis of the optical system by a predetermined distance from the optical axis. A judging unit judges occurrence of vignetting based on a detection result of return light of light incident on the eye through the optical system after the first movement control. The controller applies a second movement control to the movement mechanism to further move the optical system based on a judgement result obtained by the judging unit.Type: GrantFiled: December 26, 2018Date of Patent: February 27, 2024Assignee: TOPCON CORPORATIONInventors: Jun Sakai, Shunsuke Nakamura, Kana Nishikawa, Masahiro Akiba
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Patent number: 11896818Abstract: The invention provides a device for treating at least one of rhinitis, congestion, and/or rhinorrhea to thereby reduce or eliminate symptoms associated therewith, including, but not limited to, coughing, sneezing, nasal or throat irritation and itching, and difficulty sleeping. The device includes an elongate body, a retractable and expandable multi-segment end effector, and handle, that, as a whole, provide a high level of precise control and feedback to an operator during a procedure. The elongate body includes an electrode array provided along a length thereof configured to deliver energy to specific target sites within the nasal passage and nasal cavity in conjunction with neuromodulation provided by the multi-segment end effector.Type: GrantFiled: April 8, 2021Date of Patent: February 13, 2024Assignee: Neurent Medical LimitedInventor: David Townley
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Patent number: 11890031Abstract: A system and method used to deliver a percutaneous ventricular assist device (pVAD) or other cardiac therapeutic device to a site within the heart, such as a site at the aortic valve. A flexible device is percutaneously introduced into a vasculature of a patient and positioned to run from a femoral vein, through the heart via a transseptal puncture, and to a femoral artery. The venous-side end of the flexible device is withdrawn out the venous vasculature superior to the heart, and a pVAD is secured to the flexible device. The pVAD is pushed in a distal direction while the arterial-side end of the flexible device is pulled in the proximal direction to advance the pVAD to the target site. A left ventricle redirector aids in orienting the pVAD and preventing migration of the flexible member towards delicate structures of the heart during advancement of the pVAD.Type: GrantFiled: June 21, 2021Date of Patent: February 6, 2024Assignee: Synecor LLCInventors: Richard S. Stack, William L. Athas, Kevin Johnson
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Patent number: 11865342Abstract: Slurry electrodes can deliver direct current (DC) nerve conduction block to neural tissue. Such slurry electrodes can include an ionically conductive membrane having a first side and a second side. Slurry electrodes can also include a mechanism that is configured to encapsulate a slurry against the first side of the ionically conductive membrane. The slurry can include an ionically conductive material and a plurality of electrically conducting high surface area particles. The mechanism and the first side of the ionically conductive membrane make up a housing for the slurry. Slurry electrodes can also include a connector configured to establish an electrical connection between the slurry and the DC generator.Type: GrantFiled: August 18, 2022Date of Patent: January 9, 2024Assignee: CASE WESTERN RESERVE UNIVERSITYInventors: Tina L. Vrabec, Jesse S. Wainright, Niloy Bhadra, Kevin L. Kilgore