Abstract: An application device for applying a multicomponent tissue adhesive which includes a plurality of supply reservoirs for respectively one fluid component, each supply reservoir having a front end with an opening for discharge of the respective fluid component. The front ends of the supply reservoirs are arranged within accommodating connecting pieces of a connecting headpiece. The accommodating connecting pieces are provided with projections extending radially outwards. The supply reservoirs are held by a holding device. The application device is further provided with a coupling element for releasably connecting the holding device to the connecting headpiece, the coupling element including an encompassing member with a plurality of encompassing zones for at least partially encompassing the accommodating connecting pieces and for abutment on the sides of the projections of the accommodating connecting pieces facing away from the holding device.