Patents Examined by Anjali Ajit Hirani
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Patent number: 11969461Abstract: The present invention concerns a composition comprising (a) botulinum toxin and (b) non-crosslinked hyaluronic acid and its use of the treatment or prevention of dystonia, spasticity and/or wrinkles. Further, the present invention relates to a method for cosmetically smoothing or preventing wrinkles comprising the step of administering the present composition.Type: GrantFiled: February 28, 2017Date of Patent: April 30, 2024Assignee: MERZ PHARMA GMBH & CO. KGAAInventors: Klaus Fink, Harold Taylor, Hermann Russ, Peter Boderke
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Patent number: 11826336Abstract: This disclosure relates to nutritional formulas and uses for treating or preventing a gastrointestinal condition and/or motor-planning speech and/or coordinator difficulties. In certain embodiments, this disclosure relates to a nutritional formula comprising medium chain fatty acids, or esters thereof (such as and tri-, di-, mono-glycerides, or alkyl esters), unsaturated fatty acids, and a vitamin E and optionally other nutrients. In certain embodiments, any of the compounds or nutrients may be in alternative salt forms.Type: GrantFiled: June 1, 2021Date of Patent: November 28, 2023Assignees: Emory University, Children's Healthcare of Atlanta, Inc.Inventor: Claudia R. Morris
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Patent number: 11814757Abstract: A method of forming a substrate includes mapping a three dimensional spatial distribution of at least one structural protein fiber of extracellular matrix of biological material of interest, designing a fiber assembly pattern based on an intrinsic pattern of the at least one structural protein fiber of the extracellular matrix of the biological material, and assembling fibers based on the fiber assembly pattern to form the substrate.Type: GrantFiled: June 15, 2016Date of Patent: November 14, 2023Assignee: BIOCONIX PTY LTD.Inventor: Melissa Knothe Tate
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Patent number: 11806375Abstract: An algal biomass and supernatant derived from at least one species of algae exhibits the ability to maintain general health in humans and non-human animals and promote a healthy immune system in them. Food, feed and nutritional supplements comprising an algal biomass or supernatant derived from at least one species of algae are described. Methods of maintaining general health or promoting a healthy immune system in humans and non-human animals comprises administering to the animal in need thereof an algal biomass or supernatant derived from at least one species of algae, or an extract, derivative or homeopathic compound derived from the algae species, biomass or supernatant, or a composition thereof.Type: GrantFiled: February 15, 2017Date of Patent: November 7, 2023Assignee: Zivo Bioscience, Inc.Inventors: Andrew A. Dahl, Amy E. Steffek
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Patent number: 11759486Abstract: A method for treating an immune disease caused by a Th1/Th2 imbalance in favor of a Th2 shift in a subject including administering a composition comprising Lactobacillus plantarum CJLP133 strain KCTC 11403BP to the subject in need thereof.Type: GrantFiled: October 21, 2020Date of Patent: September 19, 2023Assignee: CJ CHEILJEDANG CORP.Inventors: Bong Joon Kim, Heon Woong Jung, Se Hee Hwang, Jin Hee Lee, Kang-Pyo Lee, Kwang Woo Hwang, Tae Joon Won
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Patent number: 11740249Abstract: Provided herein are compositions and methods for detection and analysis of intracellular binding of a bioactive agent to a cellular target. In particular, bioactive agents tethered to fluorophores, cellular targets fused to bioluminescent reporters, and methods of detecting and analyzing the interaction of bioactive agents with cellular targets therewith.Type: GrantFiled: September 4, 2018Date of Patent: August 29, 2023Assignee: Promega CorporationInventors: Carolyn W. Hitko, Thomas Kirkland, Thomas Machleidt, Rachel Friedman Ohana, Matt Robers, Keith Wood
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Patent number: 11732009Abstract: A nanoparticle activity sensor containing a reporter and at least one tuning domain that modifies a distribution or residence time of the activity sensor when administered to a patient. When administered to the patient, the activity sensor enters cells or tissue where it is cleaved by enzymes specific to a physiological state such as a disease to release a detectable analyte. The tuning domains include molecular structures that modulate distribution or decay by protecting the particle from premature cleavage and indiscriminate hydrolysis, shielding the particle from immune detection and clearance, or by targeting the particle to specific tissue, bodily fluids, or cell types.Type: GrantFiled: March 15, 2019Date of Patent: August 22, 2023Assignee: GLYMPSE BIO, INC.Inventors: Sangeeta Bhatia, Gabriel Kwong, Eric Huang, Sirshendu Roopom Banerjee, Andrew Warren, Sophie Cazanave
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Patent number: 11692207Abstract: A process for producing butanol is provided, involving: A) mixing water, lactate, an enzyme mixture comprising at least one enzyme, at least one cofactor and at least one coenzyme, to prepare a reaction mixture; B) catalytically reacting the reaction mixture for an amount of time sufficient to cause conversion of lactate into butanol; and wherein the conversion of lactate into butanol in B) is associated with a regeneration system of NAD (P)+/NAD (P) H and/or acetyl-CoA/CoA.Type: GrantFiled: May 5, 2016Date of Patent: July 4, 2023Assignee: NEWPEK S.A. DE C.V.Inventors: Claudio Garibay Orijel, Monica Maria Rios Lozano, Jessica Valeria Guerrero Torres, Ivan Alejandro de la Pena Mireles, Jose Raul Ivan Garza Rodriguez
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Patent number: 11685897Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of making a structure including nanotubes, a structure including nanotubes, methods of delivering a fluid to a cell, methods of removing a fluid to a cell, methods of accessing intracellular space, and the like.Type: GrantFiled: December 10, 2018Date of Patent: June 27, 2023Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Jules J. Vandersarl, Alexander M. Xu, Nicholas A. Melosh, Noureddine Tayebi
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Patent number: 11649429Abstract: A mutant algal strain showing upregulation of mRNA transcripts encoding urea carboxylase, ?-15-?3-desaturase and downregulation of mRNA transcripts of gene encoding triacylglycerol lipase is provided herein. The mutant algal strain of the present disclosure is tolerant to low temperature and thus can be grown over a wide temperature range. The strain shows enhanced biomass and fatty acid production and enhanced growth rate and nitrogen metabolism over a wide temperature range of about 10° C. to about 37° C., wherein the enhancement is in comparison to the wild type algal strain. A method of obtaining the mutant algal strain and a method of producing industrially relevant products such as fatty acids from the mutant algal strain also are provided herein.Type: GrantFiled: March 30, 2020Date of Patent: May 16, 2023Assignee: Reliance Industries LimitedInventors: Chitranshu Kumar, Bhaskar Bhadra, Niraja Soni, Saranya Karuppasamy, Shradha Khater, Venkata Subhash G, Aniket A. Teredesai, Navish Kumar Batchu, Gurumurthy Raja Krishna Kumar
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Patent number: 11649473Abstract: The disclosed subject matter relates generally to a method for modifying oil, and specifically to a process for increasing the concentration of polyunsaturated fatty acid in an oil composition.Type: GrantFiled: July 29, 2019Date of Patent: May 16, 2023Assignee: DSM Nutritional Products AGInventors: Jaroslav A. Kralovec, Weijie Wang, James Colin Barrow
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Patent number: 11584940Abstract: A Geomyces mutant strain and an application thereof, relating to the technical field of the screening and application of functional microorganisms; the mutant strain is obtained through a mutagenic method, capable of greatly improving the yield of red pigment; the mutant strain has been preserved in the China Center for Type Culture Collection of Wuhan University on Jan. 24, 2019, and the preservation number is CCTCC NO: M2019086; the mutant strain can be widely used in the field of natural pigment production, can reduce the production cost of red pigment, and has a bright application prospect.Type: GrantFiled: October 14, 2019Date of Patent: February 21, 2023Inventor: Long Fang
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Patent number: 11578308Abstract: The present invention is directed to a method of preparing an artificial tooth primordium in vitro, comprising the steps: a) providing isolated mesenchymal dental pulp cells; and b) culturing the mesenchymal dental pulp cells under non-adherent conditions to form a cell aggregate representing an artificial tooth primordium; as well as to an artificial tooth primordium derived therefrom.Type: GrantFiled: January 18, 2019Date of Patent: February 14, 2023Assignee: TECHNISCHE UNIVERSITAET BERLINInventors: Roland Lauster, Uwe Marx, Jennifer Binder, Mark Rosowski
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Patent number: 11529436Abstract: Disclosed are bioprinted, three-dimensional, biological skin tissues comprising: a dermal layer comprising dermal fibroblasts; and an epidermal layer comprising keratinocytes, the epidermal layer in contact with the dermal layer to form the three-dimensional, engineered, biological skin tissue. Also disclosed are arrays of engineered skin tissues and methods of making engineered skin tissues.Type: GrantFiled: November 5, 2015Date of Patent: December 20, 2022Assignees: Organovo, Inc., L'OrealInventors: Kelsey Nicole Retting, Colin M. O'Neill, Deborah Lynn Greene Nguyen, Sharon C. Presnell, Jessica Langer, Guive Balooch, Elizabeth Wu, Julien Demaude
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Patent number: 11513039Abstract: Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing neurons (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on nerve growth.Type: GrantFiled: May 25, 2016Date of Patent: November 29, 2022Assignee: Axogen CorporationInventors: Curt Deister, Kasra Tajdaran
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Patent number: 11505816Abstract: The purpose of the present invention is to provide a detection means whereby Staphylococcus aureus can be identified at a high accuracy. An aspect of the present invention relates to a medium for detecting S. aureus which comprises one or more kinds of nutrient components, a color developing agent capable of developing a color in the presence of ?-glucosidase, a color developing agent capable of developing a color in the presence of phosphatase and 0.5 mg/cm3 or more of sodium colistin methanesulfonate. Another aspect of the present invention relates to a sheet for detecting S. aureus, said sheet comprising the aforesaid medium, and a method for detecting S. aureus with the use of the medium and sheet as described above.Type: GrantFiled: September 24, 2020Date of Patent: November 22, 2022Assignee: KIKKOMAN CORPORATIONInventors: Keisuke Kazama, Rui Saitou
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Patent number: 11505510Abstract: A biological inoculant having both fertilizing and fungicidal activity is disclosed. More particularly, a bio-inoculant having the said combined effects, comprising Bradyrhizobium japonicum and specific isolates from the Trichoderma genus is disclosed. The bio-inoculant is applied to soybean crops for preventing fungi borne diseases. More particularly, the bio-inoculant of the invention is useful for protecting soybean crops against infection by Fusarium sp., Colletotrichum sp., Cercospora sp., Sclerotinia sp. and Rhizoctonia sp.Type: GrantFiled: August 7, 2019Date of Patent: November 22, 2022Assignee: YPF TECNOLOGIA S.A.Inventors: Walter Alberto Vargas, Sebastián Reinoso, María Cecilia Orsini, Sebastián Alejandro Trejo, Eliana Abrahamovich
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Patent number: 11485992Abstract: Methods of culturing and detecting a biomarker which may be associated with autoimmune diseases, in particular inflammatory bowel disease and Crohn's disease; also a screening method for substances suitable for the treatment of inflammatory bowel disease including Crohn's disease; the method including culturing a biomarker in a culture media which includes a culture broth, OADC, PANTA and Mycobactin J.Type: GrantFiled: December 14, 2016Date of Patent: November 1, 2022Inventors: John Milford Aitken, Kevin Andrew Taylor
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Patent number: 11466295Abstract: The invention is directed to a process for producing one or more fermentation product in a multi-stage process including an inoculation reactor and at least one bioreactor. The inoculation reactor is fed a C1-containing gaseous substrate containing a reduced amount of hydrogen. The hydrogen is reduced to increase the proportion of CO in the C1-containing gaseous substrate being provided to the inoculation reactor. The inoculation reactor ferments the CO-rich C1-containing gaseous substrate and produces an inoculum, which is fed to at least one bioreactor. The bioreactor receives the C1-containing gaseous substrate, which may or may not contain reduced amounts of hydrogen, to produce one or more fermentation product. By providing a CO-rich C1-containing gaseous substrate to the inoculation reactor, both the inoculation reactor and the subsequent bioreactor(s), are able to have increased stability and product selectivity.Type: GrantFiled: September 8, 2020Date of Patent: October 11, 2022Assignee: LanzaTech, Inc.Inventors: Robert John Conrado, Guy William Waters, Matthew Puglisi, Joshua Jeremy Conolly
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Patent number: 11453872Abstract: Provided herein are a device and a method for preparation of immobilized proteins, enzymes or cells on a carrier to achieve the industrial batch production of the immobilized proteins, enzymes or cells.Type: GrantFiled: October 28, 2015Date of Patent: September 27, 2022Assignee: Bioright Worldwide Company LimitedInventors: Chung Hong Cheung, Jun Wang, Junming Chen, Guilin Wang