Abstract: 5-isothiocyanato-2-methylquinolines, N-(2,2-dialkoxyethyl)-N'-(2-methylquinolin-5-yl)thioureas, 5-(2-mercaptoimidazol-1-yl)-2-methylquinolines, 5-(imidazol-1-yl)-2-methylquinolines, 5-(imidazol-1-yl)-1,2,3,4-tetrahydro-2-methylquinolines and dialkoxy 2-[N-(5-(imidazol-1-yl)-1,2,3,4-tetrahydro-2-methylquinolinyl)]methylenema lonates are described as intermediates for antimicrobial 6,7-dihydro-8-(imidazol-1-yl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2- carboxylic acids.

Abstract: Disclosed are heterocyclic-fused pyrazolo[3,4-d]pyridin-3-ones useful as benzodiazepine receptor modulators.

Abstract: Novel [2-[(aminopyridinyl)amino]phenyl]arylmethanones and their thioxomethyl, ketal or thioketal analogs of the formula: ##STR1## wherein; R is selected from the group consisting of hydrogen, loweralkyl, --alk.sup.1 --halo, --alk.sup.1 --NR.sup.1 --NR.sup.1 R.sup.2 or --alk.sup.1 --N.dbd.CH--OC.sub.2 H.sub.5 ;R.sup.1 and R.sup.2 are selected from the group consisting of hydrogen, loweralkyl, --C(O)O-loweralkyl or R.sup.1 and R.sup.2 taken together with the adjacent nitrogen atom may form a heterocyclic residue selected from the group consisting of 1-piperidinyl, 1-phthalimido, 1-pyrrolidinyl, 4-morpholinyl, 1-piperazinyl and 4-substituted-1-piperazinyl;B is selected from carbonyl, thioxomethyl, ketal or thioketal;Ar is selected from the group consisting of 2, 3 and 4-pyridinyl, 2 or 3-thienyl, phenyl or phenyl substituted by 1 to 3 radicals selected from halo, loweralkyl, loweralkoxy, trifluoromethyl or nitro and may be the same of different;alk.sup.

Abstract: Compounds having the formula ##STR1## in which R.sub.1 is hydrogen or C.sub.1 -C.sub.4 alkyl and R.sub.2 and R.sub.3 are C.sub.1 -C.sub.4 alkyl are insect repellents.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms or phenyl (alkyl of 1 to 6 carbon atoms);R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl (alkyl of 1 to 6 carbon atoms);R.sub.3 is hydrogen or alkyl of 1 to 6 carbon atoms; and their use as antihypertensives.

Abstract: The present invention relates to new compounds of the general formula: ##STR1## in which X represents oxygen or sulphur and R represents a linear or branched alkyl group with 1 to 7 carbon atoms,and pharmaceutically acceptable acid addition salts thereof, having valuable cardiovascular properties.

Abstract: There are disclosed novel substituted and bridged pyridines which are useful as calcium channel blockers.

Abstract: This invention relates to novel benzothiazoline derivatives of the formula [I] and salts thereof, ##STR1## wherein R.sup.1 is formyl or lower alkanoyl;R.sup.2 is hydrogen, lower alkyl, lower alkoxy or nitro;R.sup.3 is hydrogen, lower alkyl, lower alkoxy or halogen;A is lower alkylene;B is --CO--(CH.sub.2).sub.m -- or --CH(OH)--;m is 0 or 1; andwhen m is 0, R.sup.3 is not hydrogen.The compounds of this invention are useful for treatment of cardiovascular diseases.

Abstract: Cis-4a-aryl, 1, 2, 3, 4, 4A, 9B-hexahydro-benzofuro-[3,2-C]- pyridines, useful as analgesic and anticonvulsant agents are described.

Abstract: 6H-3,11b-Dihydrocarbalkoxy-5,7-dioxobenzo[6,7]cyclohepta[1,2-c]pyridine compounds represented by the formula: ##STR1## wherein G is lower alkyl or halogen; R is lower alkyl, R' is hydrogen, lower alkyl, and n is from 0 to 2 and a process for their preparation are disclosed. The compounds have the property of inhibiting calcium induced contraction of the smooth muscle.

Abstract: Trans-(.+-.)-1-permissibly-substituted-2,6-dioxodecahydroquinoline or enantiomers thereof, intermediates for preparing tautomeric trans-(.+-.)-5-permissibly substituted octahydro-1H(and 2H)pyrazolo[3,4-g]quinolines, 4aR,8aR or 4aS,8aS enantiomers thereof, for preparing trans-(.+-.)-5-permissibly substituted-octahydropyrazolo (or oxazolo)[4,5-g]quinoline, 4aR,8aR or 4aS,8aS enantiomers thereof or for preparing trans-(.+-.)-6-permissibly-substituted octahydropyrimido[4,5-g]quinolines, a 5aR,9aR or 5aS,9aS enantiomer thereof said racemic intermediates being comprised of stereoisomers of the following formulas ##STR1## wherein R is H, alkyl or C.sub.1-3 straight-chain alkyl.

Abstract: Substituted aryloxyphenoxy acylisothioureas useful as herbicides having the formula ##STR1## wherein R is CF.sub.3 or halogen; X is hydrogen or halogen; A is CH or nitrogen; R.sub.1 is hydrogen, lower alkyl, alkenyl, alkynyl, phenyl, cyanoalkyl, alkoxyalkyl, or alkoxycarbonylalkyl; R.sub.2 is hydrogen, lower alkyl, phenyl, or substituted phenyl; and R.sub.3 is acyl or halogen substituted acyl selected from the group consisting of propionyl, dichloro bromoacetyl, propionaminocarbonyl and phenylaminocarbonyl.

Abstract: 4aR,8aR-5-permissibly substituted-6-oxo-octahydro-1H(and 2H)-pyrazolo[3,4-g]quinolines. The compounds are useful as intermediates in preparing dopamine D-2 agonists.

Abstract: Trans-(.+-.) 2 and/or 5-permissibly substituted octahydrothiazolo[4,5-g]quinolines and acid addition or quaternary salts thereof and, individual enantiomers thereof, useful as dopamine agonists.

Abstract: A class of novel fused-ring, benzotricyclic, nitrogen-containing diones useful as agents in reversing electroconvulsive shock-induced amnesia. A method of preparing the compounds, pharmaceutical compositions including the compounds, and a method of reversing electroconvulsive shock-induced amnesia are disclosed.

Abstract: The invention concerns benzoquinolizines of general formula ##STR1## and their pharmaceutically acceptable acid addition salts. In formula (I), R represents hydrogen or lower alkyl, R.sup.1 and R.sup.2 which may be the same or different each represent hydrogen, lower alkyl, lower alkoxy or halogen, R.sup.3 and R.sup.4 which may be the same or different each represents lower alkyl, halo(lower)alkyl or aryl and A represents a lower alkylene group having 1 to 3 carbon atoms in the chain between the two N atoms. The compounds possess .alpha..sub.2 -adrenoceptor antagonistic activity in warm blooded animals.

Abstract: 4aR,8aS,9R-5-C.sub.1-3 straight-chain alkyl (methyl, ethyl or n-propyl) or allyl-9-hydroxy-octahydro-1H(and 2H)-pyrazolo[3,4-g]quinolines useful as hypotensives.