Abstract: A prosthesis having a radially expanded configuration and a radially compressed configuration includes a frame with a plurality of infolding longitudinal segments. Each of the infolding longitudinal segments of the frame extend an entire length of the frame and is configured to deform radially inward when the prosthesis is in the radially compressed configuration such that a series of longitudinally aligned apices of each infolding longitudinal segment is disposed radially inward of the remainder of the prosthesis. In an embodiment, the frame also includes a plurality of outfolding longitudinal segments. Each of the outfolding longitudinal segments of the frame extend an entire length of the frame and is configured to deform radially outward when the prosthesis is in the radially compressed configuration such that a series of longitudinally aligned apices of each outfolding longitudinal segment is disposed radially outward of the remainder of the prosthesis.

Abstract: A prosthetic heart valve includes a frame, a valvular structure coupled to the frame, and a sealing member coupled to the frame. The frame has inflow and outflow ends and a lumen extending therebetween. The frame includes struts that form cells, and the cells are arranged in three rows. The frame is radially expandable from a collapsed state to an expanded state. The valvular structure includes a plurality of leaflets configured to allow blood flow through the lumen of the frame from the inflow end to the outflow end and to block blood flow through the lumen of the frame from the outflow end to the inflow end. The sealing skirt extends from an intermediate location of the frame disposed between the inflow and outflow ends to the inflow end of the frame. The sealing skirt covers two rows of cells to block blood flow through the cells.

Abstract: An orthopaedic system includes an insert defining an anterior-posterior centerline and including: a medial half on one side of the centerline and defining a medial shape, the medial half having a medial articular surface defining a medial dwell region; and a lateral half on an opposite side of the centerline and defining a lateral shape that differs from the medial shape, the lateral half having a lateral articular surface. A femoral component includes a medial condylar portion bearing on the medial articular surface and a lateral condylar portion bearing on the lateral articular surface. The insert is configured to substantially limit medial anterior-posterior translation on the femoral component and define a pivot axis that extends through the medial dwell region. The insert is configured such that rotation of the lateral articular surface follows an arcuate path about the pivot axis.

Abstract: A prosthetic heart valve for implant in a human. The valve includes a wireform with undulating inflow cusps and outflow commissure posts to which flexible leaflets attach and coapt in a flow area. Each leaflet may drape over the top of the wireform in the cusp area, but have tabs that each extend underneath the wireform at the commissure posts to be secured along with a tab of an adjacent leaflet. The prosthetic heart valve may also be a dual-wire wireform, with the leaflets sandwiched therebetween. One wireform may be larger than the other, with the leaflets extending over the smaller wireform. The smaller wireform may have commissures that bend radially outward from the larger wireform to provide structure to which the leaflet tabs attach.

Abstract: The present invention provides a method of making a leaflet assembly, the leaflet assembly thus made and a prosthetic valve.

Abstract: A malleable demineralized bone composition consists of cortical bone made from a first portion and a second portion. The first portion and second portion of cortical bone is made from cut pieces freeze dried then ground into particles and demineralized then freeze-dried. A volume of the second portion is placed in a solution of sterile water to create a mixture, the water volume being seven times the volume of the second portion, the mixture is autoclaved under heat and pressure to form a gelatin, and the first portion is mixed with the gelatin to form a malleable putty or paste.

Abstract: Devices, systems and/or methods for repairing soft tissue adjacent a repair site. In one embodiment, a repair device is delivered with a delivery device system configured to move a cartridge with the repair device disposed therein toward an anvil with soft tissue positioned thereon. The delivery device linearly moves the cartridge toward the anvil with a worm drive positioned within a housing by rotating a thumb wheel disposed around the worm drive. Such linear movement is provided with a finger element extending from the worm drive that is configured to cooperate with an internal surface of the thumb wheel. With this arrangement, upon rotating the thumb wheel, the worm drive rotates with the finger element engaged with the internal surface of the thumb wheel to linearly move the cartridge toward the anvil.

Abstract: A stent delivery system includes an elongate shaft including a proximal portion, a distal portion, at least one lumen extending at least partially therethrough, and a stent receiving portion on the distal portion of the elongate shaft. A stent is positioned on the stent receiving portion of the elongate shaft, the stent having a first configuration and a second configuration. A proximal constraining arrangement is engaged with a proximal end of the stent and a distal constraining arrangement is engaged with a distal end of the stent, the distal constraining arrangement including a first distal constraining member engaged with a first distal portion of the stent and a second distal constraining member engaged with a second distal portion of the stent. When the stent is in the first configuration, the proximal restraining assembly and the distal restraining assembly applies an axial mechanical force to the distal constraining member.

Abstract: A device for improving the function of a heart valve comprises: a support member formed from a shape memory material, and a restraining member providing a restraining action on a course of the support member. The support member may abut one side of the valve conforming to the shape of the valve annulus upon said shape memory material assuming an activated shape while the restraining member restrains the course of the support member. The restraining action is removable for allowing the support member to assume a desired, altered course. The restraining member may be biodegradable to be degraded within a patient or may be detachable from the support member to be withdrawn. The support member according to another embodiment presents a shape change in that an increased cross-section is associated with a shortened length of the support member. The support member according to yet another embodiment has a first and a second activated shape.

Abstract: A medical implant structure is provided comprising a substrate 10 with at least a first surface and a second surface that surfaces differ from one another with regard to at least one property in relation to biological material.

Abstract: Selectively placed implants are specifically configured and dimensioned to address pathologies of the shoulder joint arising from improper force distribution. By using appropriately sized and positioned implants as described herein, displacement of targeted connective and muscle tissues acting on the shoulder is accomplished in order to realign force vectors and/or alter moment arms loading the joint to achieve therapeutic effects without cutting bone and with minimal cutting of the connective tissues.

Abstract: Heart valve implants and methods utilizing those valves designed to reduce or eliminate the regurgitant jet associated with an incompetent atrioventricular valve. The heart valve implants, which are deployed via a transcatheter venous approach, comprise a collapsible framework connected to an anchored guide shaft, a valve portion and an apron which permits ingrowth of native heart tissue into the apron.

Abstract: A stent is disclosed that has an elongated body having a proximal end, a distal end, at least one open spiral channel formed on the exterior surface of the body to provide fluid communication between the proximal end and the distal end. The stent also has a central lumen open at the proximal and distal ends of the stent for the passage of a guide wire. A method for using the stent and a kit containing the stent are also disclosed.

Abstract: A stent is disclosed that has an elongated body composed of a bioabsorbable polymer having a proximal end, a distal end, two open spiral channels formed on the exterior surface of the body to provide fluid communication between the proximal end and the distal end. The stent has a central lumen open at the proximal and distal ends of the stent for the passage of a guide wire. The stent also has an anti-migration device used for immobilization of the stent at the target site.

Abstract: Some embodiments of the present disclosure provide a stent-valve for transcatheter implantation to replace a cardiac valve. In some embodiments, the stent valve being compressible to a compressed state for delivery, and expandable to an operative state for implantation. In some embodiments, the stent-valve comprises a stent, a plurality of leaflets for defining a prosthetic valve, an inner skirt, an outer skirt, and a paravalve seal for sealing against surrounding tissue. In some embodiments, the paravalve seal comprising material that swells in response to contact with blood or components thereof.

Abstract: Method and set of surgical instruments for fitting a shoulder prosthesis, and the shoulder prosthesis. The proposed method seeks to interpose a bone graft between the previously prepared glenoid surface (G) of a scapula (S) of a patient's shoulder and the face of a glenoid prosthetic component opposite the articular surface. The set of instruments permit the bone graft to be taken from the upper epiphysis of the humerus (H), either in situ or ex vivo.

Abstract: A device for reducing heart valve regurgitation including a plug for placing between natural heart valve leaflets, the plug shaped so that, upon systole, the natural heart leaflets coapt upon the plug, a frame attached to the plug by a bridging element, for supporting the plug between the natural heart valve leaflets, the frame having at least one dimension in a plane of the heart valve annulus which is wider than the diameter of the heart valve annulus, and a plurality of anchors attached to the device, for preventing the device from being swept upstream of the heart valve annulus upon systole. Related apparatus and methods are also described.

Abstract: A stent is disclosed that has an elongated body composed of a bioabsorbable polymer having a proximal end, a distal end, two open spiral channels formed on the exterior surface of the body to provide fluid communication between the proximal end and the distal end. The stent also has a central lumen open at the proximal and distal ends of the stent for the passage of a guide wire. A method for using the stent and a kit containing the stent are also disclosed.

Abstract: A surgical implant for total wrist replacement (TWR) includes a carpal portion and a radial portion to fully encompass both sides of the articulated joint defining wrist movement. The carpal portion is defined by a unitary structure that defines a fused form of the scaphoid, lunate and triquetrum, and bears against the radial portion for permitting articulated motion. The radial portion replaces a distal portion of the natural radius adjacent the wrist, and has the form of a “T” to combine a bearing surface with a stem adapted for implantation in the natural radius. The stem engages a receptacle or bore formed in a truncated end of the natural radius. Both the radial portion and the carpal portion patient-specific members are formed from image scans of the patient's own skeletal structures, and incorporate inverted, contralateral images of healthy structure based on an assessment of deformation in the replaced joint.

Abstract: This shoulder prosthesis glenoid component (2) has on one of its faces an articulation surface (SA) adapted to cooperate with a humeral head and having, on an opposite face (SG) adapted to be immobilized on the glenoid cavity (G) of a shoulder, a keel (4) for anchoring it in the glenoid cavity (G). This keel (4) comprises a body (5) that extends from the opposite face (SG). The keel (4) comprises at least one fin (6) projecting from the body (5) 2 which runs over at least a part of the perimeter of the body (5).