Abstract: A medication delivery device (MDD) (e.g., injection pen, wearable pump) is paired with an external device (e.g., smart phone, iPad, computer) via wireless link or wireline connection. The MDD provides to the external device captured data from the flow sensor relating to medicine delivery to a patient to ensure complete delivery and minimize MDD misuse or malfunction or inaccuracies in dosing. The MDD can have Bluetooth™ and/or near field communication (NFC) communication circuits for proximity-based pairing and connectivity with the external device for real-time or deferred transfer of captured data to the external device, depending on memory and power availability at the MDD. The MDD or external device can use captured data and corresponding time stamps to determine flow infomatics such as flow rate, total dose delivered, and dose completion status. An LED on the MDD indicates states such as powered on, paired, delivery in progress and delivery completion.

Abstract: A manual multi-dose auto-injector structured to manually dispense multiple discrete doses of a drug is provided with a hollow housing having at least a first housing end and a second housing end. An at least partially compressible vial is disposed in the housing and contains multiple doses of the drug. The vial is in mechanical communication with both housing ends. Each housing end has a needle spring-biasedly disposed in an unactivated configuration and disposed at least partially protruding from the housing end in an activated configuration. Each needle is manually selectively in fluid communication with the vial. Pressing a housing end against a user's body causes its respective needle to move from the unactivated configuration to the activated configuration and compresses the vial to dispense a dose of the drug. Each end/needle operates independent of the other. Post-injection, each needle is locked within the housing.

Abstract: A localised transdermal iontophoretic drug delivery system which controls localised transdermal drug delivery doses, transdermal drug delivery depths and transdermal drug delivery speeds is provided. The system includes a power supply, a current driving assembly, an optional switch matrix or multiplexer, and electrode assemblies or an electrode assembly array. The localised transdermal iontophoretic drug delivery system accurately controls a drug delivery current distribution between any electrode combination, so as to locally control a transdermal drug delivery dose, a transdermal drug delivery depth and a transdermal drug delivery speed, in order to implement accurate drug delivery to a user's skin.

Abstract: Devices and methods for creating a protective gas cushion in an outwardly open volume which are useful in surgery are provided. More particularly, the invention relates to a device having a flexible hose portion having an intake end and a discharge end and a distal tip portion connected to the discharge end of the flexible hose portion. The distal tip portion comprises a rigid, porous polymer body having a pore size of 7 to 45 ?m. The distal tip portion is adapted to be positioned in the volume and the device is arranged to supply the gas to the volume through the rigid, porous polymer body, the rigid, porous polymer body being arranged to supply the volume with the gas in a substantially laminar, continuous flow to enable the formation of the protective gas cushion intended to fill the volume and prevent air from the environment from reaching the volume.