Patents Examined by Anna Skibinsky
  • Patent number: 11141106
    Abstract: Software for calculating an astigmatism treatment is operable upon execution to perform the following steps: receiving biometric information for a patient; determining based on the biometric information an astigmatic correction comprising at least one of (a) a position for one or more limbal relaxing incisions and (b) a power and an orientation for a toric intraocular lens (IOL); generating an output comprising the astigmatic correction; receiving a selection of a different ratio of astigmatic correction attributable to the one or more limbal relaxing incisions and the toric IOL; determining an updated astigmatic correction including at least one of (a) an updated position for the one or more limbal relaxing incisions and (b) an updated power and/or orientation of the toric IOL.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: October 12, 2021
    Inventors: Gautam Chaudhary, Jack T. Holladay, Melvin Sarayba, Hadi Srass
  • Patent number: 11142799
    Abstract: Methods, systems, and apparatus determine whether a first chromosomal region exhibits a deletion or an amplification associated with cancer in a sample from a subject (e.g., where the sample includes a mixture of cell-free DNA from tumor cells and non-malignant cells. Nucleic acid molecules of the biological sample are sequenced. Respective amounts of a clinically-relevant chromosomal region and of background chromosomal region(s) are determined from results of the sequencing. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether first chromosomal region exhibits a deletion or an amplification associated with cancer.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: October 12, 2021
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan
  • Patent number: 11135367
    Abstract: A medical device for providing information for glycemic control is provided, wherein the device comprises storage means arranged to store data, receiving means arranged to receive blood glucose value data and security data, data processing means arranged to execute a first processing function for modifying data retrieved from the storage means and to execute a second processing function for providing information for glycemic control based on the blood glucose value data and data retrieved from the storage means, validating means arranged to validate the received security data and to provide validation data corresponding to the validation of the received security data, and safety means arranged to control an execution of at least a predetermined function out of the first and second processing functions based on the validation data.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: October 5, 2021
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventor: Andrew Tubb
  • Patent number: 11111296
    Abstract: The invention provides compositions and methods for treating cardiac dysfunction, particularly cachexia-associated or RAGE-associated cardiac dysfunction, using an anti-RAGE agent. The invention also provides compositions and methods for identifying therapeutic agents useful for disrupting (slowing, reducing, reversing, or preventing). The methods comprise designing or identifying agents that bind to functional sites identified on the RAGE polypeptide, wherein binding of agents to the functional site(s) inhibit RAGE-mediated cachetogenic signaling.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: September 7, 2021
    Inventors: David K. Thomas, Todd R. Golub
  • Patent number: 11104952
    Abstract: The invention provides genetic markers of severe suicidal behavior, related compositions, computer systems, and methods.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: August 31, 2021
    Assignee: Centre for Addiction and Mental Health
    Inventors: Clement C. Zai, James L. Kennedy
  • Patent number: 11086970
    Abstract: Systems and methods for generating a surgical plan for altering an abnormal bone using a generic normal bone model are discussed. For example, a system for planning a surgery on an abnormal bone can include a model receiver module configured to receive a generic normal bone model. The generic normal bone model, such as a parametric model derived from statistical shape data, can include a data set representing a normal bone having an anatomical origin comparable to the abnormal bone. An input interface can be configured to receive an abnormal bone representation including a data set representing the abnormal bone. A surgical planning module can include a registration module configured to register the generic normal bone model to the abnormal bone representation by creating a registered generic model. A surgical plan formation module can be configured to identify one or more abnormal regions of the abnormal bone using the registered generic model.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: August 10, 2021
    Assignee: Blue Belt Technologies, Inc.
    Inventors: Branislav Jaramaz, Constantinos Nikou
  • Patent number: 11062790
    Abstract: A method for designing all coverage of valid primer pairs, which satisfy various filtering constraints provided by users with respect to a given sequence database and has validated specificity to given sequences, is provided. By screening all suitable primer pairs present on a given DNA sequence database without omitting any one primer pair and also screening all primers having a coverage of 1 or more as well as primers having a coverage of 1, a user can be allowed to give rankings to the primers in order to easily select the primers having a high success rate in biological experiments from the resulting primers.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: July 13, 2021
    Inventors: Min Soo Kim, Jae Hyung Koo, Hye Rin Kim, Na Na Kang, Kang Wook Chon, Seon Ho Kim
  • Patent number: 11028444
    Abstract: The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: June 8, 2021
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Arizona Board of Regents on behalf of the University of Arizona, Queen Mary University of London, Board of Regents of the University of Nebraska, Oslo University Hospital HF, Oregon Health & Science University, University of Rochester, Hospital Clinic de Barcelona, Universitat de Barcelona, British Columbia Cancer Agency Branch, Julius-Maximilians-University of Würzburg
    Inventors: Lisa M. Rimsza, Andrew T. Lister, Wing C. Chan, Dennis Weisenburger, Jan Delabie, Erlend B. Smeland, Harald Holte, Stein Kvaløy, Rita M. Braziel, Richard I. Fisher, Pedro Jares, Armando Lopez-Guillermo, Elias Campo Guerri, Elaine S. Jaffe, Georg Lenz, Wyndham H. Wilson, George W. Wright, Sandeep S. Dave, Louis M. Staudt, Randy D. Gascoyne, Joseph M. Connors, Hans-Konrad Muller-Hermelink, Andreas Rosenwald, German Ott
  • Patent number: 11016080
    Abstract: The present invention refers to a medical device (100) comprising: •a measurement unit (110) adapted to measure a value of a physiological parameter, for example a blood glucose level, •a data storage (130) adapted to store ?a plurality of measurement values of the physiological parameter, ?for each measurement value an associated event tag, ?for each measurement value an associated time stamp, ?for each at least one predefined event an associated current time range for tagging preselection, •a processor (140) adapted to ?receive from the measurement unit (110) or from the data storage (130) a new measurement value with an associated time, ?comparing the associated time stamp of the new measurement value with the stored at least one time range for tagging preselection, ?if the time stamp is within one current time range for tagging preselection the corresponding tag of the predefined event is preselected and initiated for user confirmation, ?in case one particular predefined tag of one particular predefined e
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: May 25, 2021
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Mario Esser
  • Patent number: 11002750
    Abstract: Method and apparatus for electronic detection and determination includes detecting a signal T0 in a detection zone and a signal R0 in a reference zone before a sample is added; adding a sample and detecting the signals in each of the detection zone and the reference zone at an interval of a second preset period; calculating a judgement value based on 2k immediately previous signals in each of the detection zone and the reference zone, the signal T0 in the detection zone before the sample is added, and the signal R0 in the reference zone before the sample is added, each time when k successive signals are detected in each of the detection zone and the reference zone; and determining a judgement result based on m successive judgement values and a preset result threshold corresponding to a current detection time.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: May 11, 2021
    Inventors: Haisheng Hu, Zanxun Cen, Guiyang Li, Hong Luo, Jihua Wang
  • Patent number: 10996166
    Abstract: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light detector comprising at least two optical sensors capable of determining the intensity of the light; and a computer processing output signal generated by the optical sensors and comparing a result of the processing with a known result corresponding to a known type to determine whether the object belongs to the known type.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: May 4, 2021
    Inventors: Hung-Chun Chen, Ming-Chia Li, Chang-Sheng Chu, Yu-Tang Li, Chung-Fan Chiou
  • Patent number: 10959657
    Abstract: A stress management system comprises: a first sensor that detects biological data of a user; a second sensor that detects life log data indicating an action history of the user; a generator that generates stress data using the biological data, the stress data indicating a time series variation of a stress level of the user; an estimator that, when the stress level of the user included in the stress data exceeds a first threshold, estimates whether or not stress of the user is interpersonal stress caused by contact with another person, using the life log data; and a notifier that notifies the user of a result of the estimation by the estimator and notifies a notification target person different from the user of notification content based on the result of the estimation by the estimator.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: March 30, 2021
    Inventors: Yuumi Kaneko, Atsushi Saso, Naomi Tomiyama, Takamichi Matsusako, Mikiko Matsuo, Yuichi Aoki, Motoji Ohmori
  • Patent number: 10961587
    Abstract: In certain embodiments, this application discloses methods for detecting lung cancer. The method includes characterization of cells extracted from human sputum, which is a valuable tissue surrogate and source of upper respiratory cells that become cancerous early in 5 the process of lung cancer development. The method includes the staining of extracted cells with fluorescent reporters that produce a specific pattern in the nuclei of labeled cells, which can be made visible by light microscopy. The pattern is relevant to a type of epigenetic coding of DNA known as DNA methylation, which changes in specific cells of the lung during cancer development, in comparison to normal respiratory cells.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: March 30, 2021
    Assignees: Cedars-Sinai Medical Center, The Regents of the University of California, US Govt Department of Veterans Affairs
    Inventors: Jian Tajbakhsh, Fariborz Mortazavi
  • Patent number: 10860684
    Abstract: Disclosed is a method for calculating a Polymerase Preference Index (PPI) for potential primers for DNA sequencing and/or amplification, and thereby increasing the efficiency of DNA sequencing and/or amplification performed using primers selected according to their PPI number.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: December 8, 2020
    Assignee: iRepertoire, Inc.
    Inventor: Jian Han
  • Patent number: 10861585
    Abstract: An information processing apparatus includes a memory and a processor coupled to the memory and configured to extract data having x times y bits from genome data in which a mutation pattern at each gene mutation position is represented as x bits, such that the extracted data is constituted by y data pieces each having x bits at y respective mutation positions, x and y being integers greater than or equal to 1, respectively, to refer to an addend table that stores a plurality of addend data associated with respective x-times-y-bit data to identify addend data corresponding to the extracted data, and to use an SIMD instruction to add the identified addend data to count data at positions corresponding to the y mutation positions in the genome data, the count data indicating counts of occurrences of mutation patterns in the genome data.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: December 8, 2020
    Inventors: Yoshifumi Ujibashi, Minoru Nakamura
  • Patent number: 10832796
    Abstract: An embodiment of a method of analyzing data from processed images of biological probe arrays is described that comprises receiving a plurality of files comprising a plurality of intensity values associated with a probe on a biological probe array; normalizing the intensity values in each of the data files; determining an initial assignment for a plurality of genotypes using one or more of the intensity values from each file for each assignment; estimating a distribution of cluster centers using the plurality of initial assignments; combining the normalized intensity values with the cluster centers to determine a posterior estimate for each cluster center; and assigning a plurality of genotype calls using a distance of the one or more intensity values from the posterior estimate.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: November 10, 2020
    Assignee: Affymetrix, Inc.
    Inventors: Earl A. Hubbell, Simon Cawley
  • Patent number: 10831909
    Abstract: In an example, an apparatus includes a biological analysis component and a control component. The biological analysis component is configured to obtain an expected biological sample value. The expected biological sample value indicates an expected concentration of a material biologically processed by a courier. The biological analysis component is further configured to determine whether a measured biological sample value is associated with the courier based on a comparison of the expected biological sample value to the measured biological sample value. The control component is configured to perform a first set of operations based on the result of the comparison indicating that the measured biological sample value is associated with the courier. The control component is configured to perform a second set of operations based on the result of the comparison indicating that the measured biological sample value is outside an acceptable range of the biological sample value.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: November 10, 2020
    Assignee: International Business Machines Corporation
    Inventors: Matthew S. Doyle, Joseph Kuczynski, Kevin A. Splittstoesser, Timothy J. Tofil
  • Patent number: 10809258
    Abstract: A method for determination of the amount of a specific analyte in a sample which may show a prozone effect by photometric assays, wherein the specific analyte is quantified from the change in the optical signal of the reaction mixture after the interaction of the analyte with analyte specific assay reagents. The optical signal is measured simultaneously for the specific analyte in the sample to be determined at the wavelength used for the determination of the analyte and at least at an additional specific wavelength used for the detection of the prozone effect over the complete reaction time. The reaction rate ratio R is calculated by using the signals obtained at the wavelength used for the detection of the prozone effect. By comparison of the calculated ratio value R with predetermined limit values it is judged if a prozone effect is present in the sample.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: October 20, 2020
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Ewelina Hegel, Georg Kurz, Eloisa Lopez-Calle, Josef Roedl
  • Patent number: 10803144
    Abstract: A processor-implemented method, computer program product and system are provided for predicting drug-drug interactions based on clinical side effects. The method includes constructing a drug-drug interactions training dataset that includes pharmaceutical, pharmacokinetic or pharmacodynamics drug-drug interactions from multiple data sources for each of a plurality of drugs. The method also includes constructing side effect features for each of the drugs from side effects associated with the drugs. The method further includes building, using the drug-drug interactions training dataset, a drug-drug interactions classifier that predicts adverse drug-drug interactions for drug pairs derivable from the drugs.
    Type: Grant
    Filed: May 6, 2014
    Date of Patent: October 13, 2020
    Inventors: Jianying Hu, Robert K. Sorrentino, Fei Wang, Ping Zhang
  • Patent number: 10796783
    Abstract: A method and system for selection of a primer set for a set of target sequences includes: identifying candidate fragments upon performance of a comparison operation with the set of target sequences; identifying a forward subset of unique forward candidates and a reverse subset of unique reverse candidates; reducing the forward subset and the reverse subset based on a filtering operation; performing an in silico search operation with the reduced forward subset and the reduced reverse subset; generating a set of candidate degenerate primers based on the in silico search operation and a base mismatch criterion; generating a reduced set of candidate degenerate primers upon filtering the set of candidate degenerate primers according to the set of primer criteria; and selecting forward primer subsets that amplify the set of target sequences and identifying a reverse primer subset for each of the forward primer subsets with an in silico PCR operation.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: October 6, 2020
    Assignee: PSOMAGEN, INC.
    Inventors: Daniel Almonacid, Zachary Apte, Jessica Richman