Abstract: Nitrofuryl-triazolo[4,3-b]pyridazine compounds of the formula ##SPC1##WhereinR.sub.1 is lower alkoxy radical or a saturated 5- or 6-membered heterocyclic ring attached via a cyclic nitrogen atom, which heterocyclic ring can also contain, in addition to said cyclic nitrogen atom, a cyclic oxygen atom or an optionally lower alkylated cyclic nitrogen atom and R.sub.2 is a hydrogen atom or R.sub.1 and R.sub.2 together represent an additional valency bond,Are outstandingly effective as bacteriostats and are particularly useful in the treatment of bacterial infections in the urinary tract.

Abstract: This invention provides aminopyridazine derivatives of formula I, ##SPC1##whereinR.sub.1 is amino, or an ##EQU1## group, wherein each of R.sub.3 and R.sub.4 is alkyl of 1 to 4 carbon atoms, orR.sub.3 and R.sub.4 together with the carbon atom to which they are bound, form a cycloalkylidene radical of 5 to 12 carbon atoms,R.sub.2 is hydrogen or methyl,A is a --(CH.sub.2).sub.n -- group,Whereinn is 0 or an integer from 1 to 7, or an >N--CO--R.sub.5 group,WhereinR.sub.5 is alkyl or alkenyl of 1 to 16 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, 1-adamantyl, or a --(CH.sub.2).sub.m --R.sub.6 group,Whereinm is 0 or an integer from 1 to 4, andR.sub.

Abstract: O-alkyl-S-alkyl-O[6-alkyl- or 6-halo-pyridazin-(3)-yl]-(thiono)thiolphosphoric acid esters of the formula ##SPC1##In whichR and R', which may be identical or different, are each alkyl with 1 to 4 carbon atoms,R" is alkyl with 1 to 3 carbon atoms or halogen, andX is oxygen or sulfur,Which possess insecticidal and acaricidal properties.

Abstract: A process for purifying beta-lactones, which comprises contacting a beta-lactone selected from the group consisting of alpha, alpha-dimethyl-beta-propiolactone, beta-propiolactone and a mixture of these with a solid alkaline earth metal hydroxide.

Abstract: A facile process for the production of Ftorafur [1-(tetrahydro-2-furanyl)-5-fluorouracil] which comprises reacting 2,4-bis-trimethylsilyl uracil with 2-chlorotetrahydrofuran to produce 1-tetrahydro-2-furanyluracil at low temperatures in a dry non-aqueous solvent, e.g. a halogenated hydrocarbon solvent such as methylene chloride. Subsequently the desired final product is produced by direct fluorination of the uracil ring as the last step utilizing a fluorinating agent such as trifluoromethylhypofluorite. This step is conducted in the cold and again in the presence of a halogenated hydrocarbon solvent such as chloroform. Ftorafur has been utilized as a pyrimidine analog for the management of carcinoma in the breast and large intestine and with less side effects than 5-fluorouracil (5-FU).

Abstract: Novel cephalosporin and penicillin antibiotic derivatives.

Abstract: New nitroimidazolyl-triazolo-pyridazines of the formula: ##SPC1##WhereinZ is methyl or amino which can be substituted by lower alkyl,And the pharmacologically compatible acid-addition salts thereof, exhibit outstanding anti-microbial activity against bacteria and protozoa, and also systemic effectiveness.

Abstract: New diglycidyl compounds of mononuclear, five-membered or six-membered, unsubstituted or substituted, hydroxyalkylated N-heterocyclic compounds, produced by addition of formaldehyde or acetaldehyde to mononuclear, five-membered or six-membered, unsubstituted or substituted, N-heterocyclic compounds, for example hydantoin or dihydrouracil, to monohydroxyalkyl compounds, and subsequent glycidylation of the OH group and NH group to give the corresponding glycidyl compounds.

Abstract: The d,l-phenylpropanolamine racemate is split with optically active thiazolidine-4-carboxylic acids of the formula: ##EQU1## where R.sub.1 R.sub.2 are hydrogen, alkyl of 1 to 8 carbon atoms, cycloalkyl, aryl or alkylene of at least 2 carbon atoms or R.sub.1 and R.sub.2 together form a ring of alkyl or alkylene with 4 to 12 carbon atoms and AC is acyl, especially benzoyl, tosyl, nitrophenylsulfenyl, acetyl or preferably formyl.

Abstract: 1,3-Bis(halomethyl)phenobarbitals are prepared by reacting phenobarbital with formaldehyde and a chlorine source or a bromine source at a temperature of -10.degree. to 200.degree.C in the presence of a Lewis acid catalyst, the formaldehyde and bromine or chlorine source being employed in at least approximately twice the molar amounts of phenobarbital. These compounds are useful anticonvulsant agents.

Abstract: Disclosed are novel substituted pyridazinyloxy(thio)phenyl ureas and derivatives thereof. The compounds of the instant invention are useful as herbicides and can be formulated to provide herbicidal compositions.

Abstract: In the synthesis of tetracyclines, a critical step is the stereospecific or stereoselective introduction of a hydroxyl group at the C-12(a) position, a novel method for the introduction of this critical hydroxy group is disclosed. Additionally, synthetic procedures for obtaining tetracycline precursors are discussed.

Abstract: A process for producing N.sub.1 -(dihydroxyalkyl)-5-substituted uracils of the formula: ##SPC1##WhereinR.sub.1 is hydrogen, methyl, a trihalomethyl, a halogen,R.sub.2 is 1,4-dihydroxybutyl-2,1,4-dihydroxypentyl-2,2,5-dihydroxypentyl-1,Characterized by reducing N.sub.1 -(butyrolactone)uracils of the formula: ##SPC2##WhereinR.sub.1 is hydrogen, methyl, a trihalomethyl, a halogen,A is: ##SPC3##With an alkali metal boron hydride in an aqueous or aquo-alcoholic solution at a temperature ranging from 15.degree. to 50.degree.C.

Abstract: Novel 2-substituted-1,2,4-thiadiazolo-[ 2,3-a]-benzimidazoles of the formula ##SPC1##And the pharmaceutically acceptable salts thereof; and process for their preparation. These 2-substituted-1,2,4-thiadiazole-[2,3-a]-benzimidazoles are useful as fungistatic and fungicidal agents.

Abstract: An improved process for the production of 2-mercaptoarylthiazoles comprising reacting a primary aryl amine and sulfur with selected nitrogen-containing compounds including thiourea, urea, cyanamide, metal cyanamide salts, dicyanodiamide, ammonium thiocyanate, and the like, in the presence or absence of carbon disulfide.

Abstract: Process for resolving a racemic mixture of an oxo-type prostaglandin intermediate by (a) converting the oxo compound by reaction with an optically active ephedrine to a mixture of oxazolidine diastereomers, (b) separating at least one oxazolidine diastereomer from said mixture, (c) hydrolyzing said oxazolidine to free the optically active oxo compound, and (d) recovering said optically active oxo compound.

Abstract: This invention relates to a class of phthalein indicator dyes useful as optical filter agents in photographic processes to protect a selectively exposed photosensitive material from further exposure during processing in the presence of incident light. Such dyes comprise 3,3-disubstituted phthalides and 3,3-disubstituted naphthalides wherein the 3,3 substituents are p-hydroxy carbocyclic aryl radicals wherein one or both of the radicals possess a --CH.sub.2 --NRR' group ortho to the p-hydroxy group and the --CH.sub.2 --NRR' group(s) is capable of rendering the indicator dye substantially non-diffusible in aqueous solution.

Abstract: Vitamin E orotate which is useful in medicines and cosmetics, is produced by esterifying vitamin E with an orotyl halide or orotic anhydride or with orotic acid in the presence of phosphorous oxychloride.

Abstract: Cephalosporon compounds of the formula ##SPC1##In the form of racemic mixtures or optically active isomers or in the form of their cis or trans isomers or mixtures thereof wherein R is selected from the group consisting of phenyl substituted with at least one hydroxyl and sydnone optionally substituted with phenyl, R' is selected from the group consisting of hydrogen and R", R" is an ester group easily removable by acid hydrolysis or hydrogenolysis, R.sub.1 and R.sub.2 are alkyl of 1 to 3 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms, Y is selected from the group consisting of amino and Y', Y' is hydrogen and NHCOOZ, Z is straight or branched alkyl of 1 to 5 carbon atoms and their non-toxic, pharmaceutically acceptable addition salts with organic and inorganic acids and bases where appropriate with the proviso that when Y is amino, R' is hydrogen and when Y is amino or NHCOOZ, R is phenyl which have antibacterial activity and their preparation.

Abstract: Improved process for the preparation of 2-hydrazinobenzothiazoles, comprising the reaction of corresponding 2-aminobenzothiazoles with hydrazine in the presence of acid, preferably in a selected solvent.