Patents Examined by Anoop S Singh
  • Compositions and methods for generating adeno-associated viral vectors with undetectable capsid gene contamination
    Patent number: 10415056
    Abstract: In one aspect, the present invention provides an intron-modified cap expression cassette useful for generating adeno-associated virus (AAV) vector particles. In another aspect, the present invention provides a method of reducing the immune response in a mammalian subject undergoing treatment with an AAV vector.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: September 17, 2019
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Arthur Dusty Miller, Christine L. Halbert, Michael J. Metzger