Abstract: Sensor in signal communication with at least one controller measure at least blood glucose levels, galvanic skin response microsiemens, heart rate, oxygen and temperature of a subject. At least one controller induces an individualized hypoglycemic condition within a predetermined non-homeostatic blood glucose level. Controllers may be in signal communication with one or more computing devices. The controller may also be a computing device. The system fluidly controls flow control devices to control delivery of at least insulin and glucose. The fluid control devices are in signal communication with at least one microprocessor having memory A controller controls the fluid control devices for at least insulin glucose, and a treatment cocktail to keep blood glucose level (BGL) within a target non-homeostatic hypoglycemic range.

Abstract: An adhesive patch is secured to an infusion set, patch pump or other on-body medical device by an overmolding process during manufacture of the medical device, or during manufacture of a portion of the medical device, without the need for a separate adhesive. This provides a more secure connection between the patch and the medical device, and reduces the required number of adhesive layers from two (skin attachment side and device attachment side) to one (skin attachment side only), thereby simplifying the design and manufacture of the patch.

Abstract: An injection device comprises a housing with a receptacle for the product, a dosing mechanism for setting a product dosage, a dispensing mechanism for dispensing the product, at least one sleeve, which is rotatable relative to the housing in order to eject the set product dosage, and a stop wheel coupled to the at least one sleeve such that the stop wheel is rotatable relative to the housing and the at least one sleeve for setting a product dosage and together with the at least one sleeve relative to the housing in order to eject the set product dosage. The device further comprises a first detector for detecting movement of the stop wheel relative to the housing and/or the at least one sleeve and a data processing unit connected to the first detector reading, storing, processing, transmitting, and/or displaying signals received from the first detector.

Abstract: A catheter insertion device (10) includes a housing (12) with a base (14), a catheter (28), an introducer needle (30) and an actuator (26) mounted within the housing. The catheter (28) and needle (30) are coupled to the actuator (26) and movable between a first position where the catheter and needle are retracted within the housing and a second position where the catheter (28) and needle (30) extend from the housing, and where the needle retracts into the actuator when the catheter and needle reach the second position. A spring (90) is provided in the housing (12) or the actuator (26) where the spring (90) is released after deployment of the device to retract the needle (20) with respect to the catheter (28).

Abstract: Disclosed is a medical device component for delivering medication fluid to a patient. The medical device component includes a fluid infusion device to regulate delivery of medication fluid, a body-mountable base unit, and a top cover assembly that is removably couplable to the base unit and to the fluid infusion device. The base unit includes a cannula to deliver medication fluid under the control of the fluid infusion device, and a physiological analyte sensor to measure a physiological characteristic. The base unit also includes an electronics assembly electrically connected to sensor leads to obtain measurements in the analog domain, to convert measurements into digital sensor data, and to communicate conditioned digital sensor data to the fluid infusion device. The top cover assembly is configured to provide both fluid and electrical connections for the base unit, by way of an infusion tube having sensor conductors integrated therein or otherwise associated therewith.

Abstract: A syringe rolling apparatus for initial rolling of a rolling diaphragm syringe from an unrolled state to a rolled state has a pressure jacket configured for receiving an empty, unrolled rolling diaphragm syringe, a piston reciprocally movable within the pressure jacket and configured for contacting an end wall of the syringe rolling diaphragm syringe to initiate a rolling of a flexible sidewall of the rolling diaphragm syringe, and a seal assembly configured for engaging an open discharge neck of the rolling diaphragm syringe. The seal assembly is in fluid communication with a source of pressurized fluid to pressurize an interior of the rolling diaphragm syringe during a distal movement of the piston. A method for initial rolling of a rolling diaphragm syringe from an unrolled state to a rolled state is also disclosed.

Abstract: The present invention discloses a central venous catheter (CVC) extension device featuring a plate with a bore passing through it and an opening connecting to the bore, with two or more protrusion structures extending from the plate's second side. The opening's first end is linked to the bore, while its second end borders a section of the plate's outer perimeter edge. This device enhances the functionality and versatility of CVC extension devices, providing improved access and ease of use for medical professionals in various clinical settings.

Abstract: A dental anesthetic buffering system using pre-dosed dry buffering material. Liquid dental anesthetic from a standard anesthetic cartridge or carpule is injected into a dry buffering material buffering the anesthetic improving efficacy and comfort. A buffer dosing cartridge or carpule configured to fit within an anesthetic syringe is pre-dosed with a dry buffering material and injected with a liquid anesthetic from a standard anesthetic cartridge or carpule forming a buffered anesthetic cartridge or carpule. The buffered anesthetic cartridge or carpule is placed in an anesthetic syringe used to immediately administer the buffered anesthetic to a patient. Ease-of-use, effectiveness, and comfort to the patient are provided making dentistry easier.

Abstract: A hold assistance device for use with a medicament delivery device is described. The hold assistance device includes: a housing configured to be coupled to a medicament delivery device; a chamber for containing air, the chamber having a proximal end and a distal end; and a piston movable within the chamber between the proximal and distal ends of the chamber, wherein the piston is arrangeable in an activated position inside the chamber in which the piston is arranged proximate to the proximal end of the chamber such that the chamber is at least partially evacuated of air and movement of the piston towards the distal end of the chamber is resisted by a vacuum force.

Abstract: A valved needle assembly includes a connector having an inner hole, a pipe body fixed to a tip end of the connector, a valve body, and an assembly part in which an insertion part provided to one of the connector and the pipe body is inserted into another such that the connector is disposed within or about the pipe body. A locking protrusion and a locking part are provided to superposed faces of the connector and the pipe body in the assembly part for preventing the insertion part from dislodgment by mutual lock, and an inclined guide surface for guiding the locking protrusion is formed on a tip end in a direction of assembly of the connector or the pipe body to which the locking part is provided. The valve body is incorporated by being mated with the connector and the pipe body.

Abstract: An electric breast pump 1 includes a breast placement part 12 in which a breast part including a breast and a nipple of a subject is placed and suction-pressure generating units 10 and 50 that generate a suction pressure in the breast placement part. The suction-pressure generating unit generates a suction cycle including a plurality of sucking operations. The suction cycle includes basic suction and increased suction with an increased suction pressure. A suction pressure difference that increases in the increased suction is a pressure difference at a borderline at which a user perceives a change of a suction pressure. In the suction cycle, the basic suction and the increased suction are each repeated multiple times consecutively at an equal suction pressure. At least a last sucking operation in the suction cycle is extended suction having a longer suction time than those of other sucking operations.

Abstract: Described herein is a generalized injection device for delivering formulations of various mechanical properties to precise locations. Of particular interest is the manifestation intended for the application of a thermally responsive hydrogel to the tear duct for the purpose of occlusion, as a treatment for symptoms associated with dry eye syndrome. Further, a modular solution to the need for an injection device across a variety of applications, mechanism, and physical considerations is provided. This disclosure provides examples of methods for precise injection of low volumes, moisture retention in pre-filled injection devices, and actuation for automatic or manual injection, to name a few.

Abstract: A medicament delivery device comprising: a main body arranged to receive a medicament cartridge sealed with a penetrable barrier; a needle carrier carrying a needle; a cap removably coupled to the needle carrier, a pre-stressed spring connected to the needle carrier and to the main body, wherein the pre-stressed spring is held by an activation element coupled to the cap, wherein the activation element is arranged to release the spring when the cap is pulled in a distal direction from the device, thereby causing the needle carrier to move axially in a proximal direction.

Abstract: The present invention provides devices and methods for establishing aseptic connections between two or more components or subassemblies. The devices may be used in medical devices such as drug delivery pumps (10). In some embodiments, a connection is made between a drug container (50, 1050, 2050) and a fluid pathway connection assembly (300, 1300, 2300). The fluid pathway connection assembly may include a connection hub (312, 1312, 2312), a piercing member (316, 1316, 2316), and a piercing member retainer (314, 1314, 2314). The assembly may further include a first film (318, 1318, 2318) covering a cavity (312A, 1312A, 2312A), thereby maintaining the aseptic condition of the cavity. The drug container may hold a fluid drug and include a pierceable seal (326, 1326, 2326). A second film (322, 1322, 2322) may cover a recess (328, 1328, 2328) formed by the seal and thereby maintain the aseptic condition of the interior of the chamber.

Abstract: Syringe control assemblies are described herein. A syringe control assembly includes an assembly body, a first syringe, a second syringe, and a pump assembly. The first and second syringes are releasably coupled to a syringe mounting rack of the assembly body. The pump assembly includes a first pump unit and a second pump unit. Each pump unit is in fluid communication with each respective syringe. In a priming configuration, the first pump unit is configured to draw fluid flow from the first syringe cavity and the second pump unit is configured to pump fluid flow into the second syringe cavity.

Abstract: A drug delivery device (1) comprising a delivery unit (2) receiving a drug cartridge (3) containing a drug to be administered to a patient in need thereof, the delivery unit comprising a subcutaneous delivery mechanism (7) including a needle (24), a needle support (8) to which the needle is mounted, and a needle actuation mechanism (9) configured to move the needle from a retracted position within a housing (5) of the delivery unit (2), to an extended delivery position where the needle projects through a base wall (14) of the housing. The needle actuation mechanism comprises a rotary actuator (10) configured to engage an engagement lever (11) coupled to the needle support (8) for translating the needle support between retracted and extended delivery positions.

Abstract: Some embodiments of a medical device anchor system include an anchor device, a tether, and an adapter for securing a medical instrument (such as a catheter or the like) in place relative to a skin penetration point using subcutaneous anchors.

Abstract: A catheter hub assembly. The catheter hub assembly includes a catheter hub body, a septum and a septum retainer, the catheter hub body having a distal end, a proximal and an internal wall defining an internal fluid passageway therebetween, the internal wall defining a transitional step within the internal fluid passageway, the septum positioned within the internal fluid passageway such that a distal end of the septum abuts up against the transitional step, the septum retainer at least partially receivable within the internal fluid passageway and having an outer wall shaped and sized to interlock with the inner wall of the catheter hub body, the outer wall including one or more lateral ribs configured to inhibit rotation of the septum retainer relative to the catheter hub body.

Abstract: A catheter system may include a catheter adapter, which may include a body and a nose extending distally from the body. The nose may be generally cylindrical. A strain relief rib may be disposed on the nose. The strain relief rib may be constructed of a flexible material. A bump may be disposed on the strain relief rib and configured to contact a needle cover. A catheter may be secured within the catheter adapter and extend distally beyond the nose.

Abstract: Disclosed is a method of sealing a syringe barrel having a syringe tip with a collar. The syringe tip is sealed with a resilient closure. A tamper evident syringe tip cap comprising a cap member and a sleeve member separated by an annular first breaking line is then pushed over the resilient closure, to couple the proximal end of the sleeve member with the collar. The distal end of the resilient closure is accommodated in the cap member and protrudes beyond the sleeve member. The first breaking line is bridged by a coupling strip. For use of the syringe and providing access to the closure, the first breaking line is broken by pivoting the cap member away. The sleeve member remains coupled to the collar. Further tearing the cap member downward causes breaking a second breaking line provided in the sleeve member, thereby enabling removing the entire syringe tip cap.