Patents Examined by Anthony Bottinc - Justia Patents Search

Patents Examined by Anthony Bottinc

Asymmetric synthesis of (-)-6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1- benzoxanzin-2-one

Patent number: 5633405

Abstract: An improved synthesis of a highly potent HIV reverse transcription inhibitor is disclosed, involving an acetylide and a trifluoromethyl ketone which produces a chiral product in the presence of a chiral amino alcohol.

Type: Grant

Filed: May 25, 1995

Date of Patent: May 27, 1997

Assignee: Merck & Co., Inc.

Inventors: Andrew S. Thompson, Edward G. Corley, Edward J.J. Grabowski, Nobuyoshi Yasuda