Patents Examined by Anthony Joseph Seitz
  • Inhibitors of histone deacetylase useful for the treatment or prevention of HIV infection
    Patent number: 11976069
    Abstract: The present invention relates to Compounds of Formula I and Ia and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, X, A and B are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula I or Ia, and methods of using the compounds of Formula I or Ia for treating or preventing HIV infection in a subject.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: May 7, 2024
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Wensheng Yu, Joseph A. Kozlowski, Dane James Clausen, Jian Liu, James Fells
  • Potent agelastatin derivatives as modulators for cancer invasion and metastasis
    Patent number: 11932650
    Abstract: The present disclosure relates to derivatized agelastatin compounds and methods for the treatment, prevention, or delay of cancer, comprising administering a therapeutically effect amount of the derivatized agelastatin compounds, a pharmaceutically acceptable salt thereof, or a composition thereof to a subject in need thereof. Methods for making the derivatized agelastatin compounds are also provided.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: March 19, 2024
    Assignees: Massachusetts Institute of Technology, Tufts Medical Center, Inc.
    Inventors: Mohammad Movassaghi, Alyssa H. Antropow, Rachel J. Buchsbaum, Kun Xu