Abstract: The present invention relates, in part, to novel compounds comprising 4-imidazolidinone-fused cyclic peptides and compositions thereof. The present invention also relates to methods of generating said compounds and compositions thereof as well as methods of inhibiting protein-protein interaction using said compounds or compositions thereof. In another aspect, the present invention relates, in part, to methods of treating or preventing a various diseases or disorders using said compounds or compositions thereof.
Abstract: The present disclosure generally relates to compositions comprising fibrin and to methods of forming such compositions. In an embodiment, a method of forming fibrin particles is provided. The method includes introducing a buffer, a fibrinogen solution, and a thrombin solution to a first end of a microfluidic device to form a mixture, the buffer comprising one or more amino acids. The method further includes contacting the mixture with a fluorocarbon oil and a surfactant to form fibrinogen-containing particles, and applying positive pressure to the microfluidic device to cause the fibrinogen-containing particles to flow towards a second end of the microfluidic device. The method further includes collecting the fibrinogen-containing particles at the second end of the microfluidic device; and polymerizing the fibrinogen-containing particles to form fibrin particles.
Abstract: The present invention relates to the field of medical technology, in particular to a composition for treating cancer and use and medicament thereof. The composition comprises an SGLT1 inhibitor and a VEGFR2 inhibitor. The present invention finds that SGLT1 interacts with VEGFR2 to promote the development and progression of tumors; the present invention also finds that a composition of a VEGFR2 targeting inhibitor and an SGLT1 inhibitor has a synergistic anti-tumor effect, and the composition of the VEGFR2 targeting inhibitor and the SGLT1 targeting inhibitor can be used in cancer treatment.
Type:
Grant
Filed:
August 19, 2020
Date of Patent:
July 9, 2024
Assignee:
NEWISH TECHNOLOGY (BEIJING) CO., LTD.
Inventors:
Zhongjie Sun, Hailong Qi, Ligong Chen, Huangfan Xie, Defang Liu, Xiao E. Yan, Weiwei Li, Xiaofang Wang
Abstract: The present disclosure provides a method of treating hemophilia A in a human subject in need thereof comprising administering to the subject a chimeric polypeptide comprising (i) a factor VIII (FVIII) protein and (ii) a von Willebrand factor (VWF) fragment comprising a D? domain of VWF and a D3 domain of VWF at a dosing interval.
Type:
Grant
Filed:
May 17, 2019
Date of Patent:
July 9, 2024
Assignee:
BIOVERATIV THERAPEUTICS INC.
Inventors:
Ekta Seth Chhabra, Alison Innes, Dan Rudin, Kara Rice, Nancy Wong, Suresh Katragadda
Abstract: A skin-penetrating carrier containing a nucleic acid complex having a novel structure which introduces a bioactive nucleic acid into cells. Composition for diagnosing, preventing or treating disease and to a skin-penetrating carrier containing a nucleic acid complex in which a bioactive nucleic acid and a carrier peptide nucleic acid are complementarily bound to each other, and having skin permeability and skin retention ability. Skin-penetrating carrier containing nucleic acid complex having structure of Structural Formula (1) has both a skin penetration function of effectively delivering a large-molecular-weight drug and in vivo effectiveness. Carrier enables bioactive nucleic acids or various compounds to pass through the epidermis and dermis of the skin, thus enables external treatment by application to the skin surface.
Type:
Grant
Filed:
January 8, 2019
Date of Patent:
June 25, 2024
Assignee:
SEASUN THERAPEUTICS, INC.
Inventors:
Hye Joo Kim, Ji-Yeon Yu, Dong In Lee, Yusun Kang, Hee Kyung Park
Abstract: Provided herein are submucosal lifting compositions and methods of using same. The submucosal lifting agents of the disclosure include a polysaccharide, a polyol, and a colorant.
Type:
Grant
Filed:
June 1, 2021
Date of Patent:
June 25, 2024
Assignee:
GI SUPPLY
Inventors:
Patrick Lee, Robert G. Whalen, Ethan Krokonko, Amy A. Cameron, Erica A. Ward
Abstract: A family of peptides which prevent and/or reduce the signs of skin aging (including chronological and/or environmental aging) and which are useful for skin firming; cosmetic compositions comprising peptides and cosmetic uses and methods of peptides or cosmetic compositions.
Type:
Grant
Filed:
January 3, 2020
Date of Patent:
June 18, 2024
Assignee:
LIPOTRUE, S.L.
Inventors:
Ariadna Grau-Campistany, Silvia Pastor, Patricia Carulla, Juan Carlos Escudero
Abstract: The present disclosure relates to solutions and methods of preparing lyophilized formulations of factor Xa (fXa) antidotes. A suitable aqueous formulation suitable for lyophilization can include a fXa antidote, a solubilizing agent, and a stabilizer, wherein the formulation does not collapse during lyophilization.
Abstract: Methods for the production of immunogenic compositions containing a non-natural amino acid are disclosed. The non-natural amino acid can be a site for attachment of antigens, such as bacterial capsular polysaccharides, to make immunogenic conjugates. Bio-orthogonal attachment chemistry incorporated into the non-natural amino acids allows for more efficient and potent antigen presentation to the immune system, simplified purification, and more well-defined structure of these semi-synthetic immunogens.
Type:
Grant
Filed:
December 29, 2017
Date of Patent:
June 4, 2024
Assignee:
Vaxcyte, Inc.
Inventors:
Jeffery Fairman, Jon H. Heinrichs, Wei Chan
Abstract: The present invention provides novel GM-CSF constructs and methods of using the same. In certain embodiments, the constructs of the invention comprise certain peptide fragments from GM-CSF. In other embodiments, the invention provides certain GM-CSF peptides that act as GM-CSF mimetics.
Type:
Grant
Filed:
January 31, 2022
Date of Patent:
May 28, 2024
Assignee:
The Regents of the University of Colorado, a body corporate
Abstract: A fusion protein according to an embodiment of the present disclosure includes a growth differentiation factor 11 and an epidermal growth factor with an enhanced anti-oxidation activity and an enhanced skin cell proliferation effect, A cosmetic composition according to an embodiment of the present disclosure includes the fusion protein as an effective component. The cosmetic composition can be advantageously used in future as a material of a functional cosmetic product.
Type:
Grant
Filed:
June 1, 2017
Date of Patent:
May 21, 2024
Assignees:
NEXGEN BIOTECHNOLOGIES, INC.
Inventors:
Sun Kyo Lee, Seong Ran Lee, Han Bong Ryu, Tae Hyun Kim
Abstract: Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.
Abstract: The present invention relates to a growth hormone receptor antagonist comprising a growth hormone variant which is modified by substitution of one or more amino acids of growth hormone. Further, the growth hormone receptor antagonist of the present invention may further comprise a long-acting carrier which is fused to the growth hormone variant. The growth hormone receptor antagonist may have strong binding potency to growth hormone receptor and may exhibit a long-lasting antagonistic action.
Type:
Grant
Filed:
December 20, 2018
Date of Patent:
May 14, 2024
Assignee:
Alteogen, Inc.
Inventors:
Soon Jae Park, Jaehyeong Ko, Sun-Ah You, Sang Hoon Yun
Abstract: Antihypertensive agents which are crystalline having a general plate shape may be difficult to formulate as they often do not exhibit good flowability properties. Addition of spray-dried riboflavin surprisingly improves flowability of these agents.
Abstract: A composition containing cyclo-hispro (CHP) and its use in preventing, alleviating, or treating bone loss diseases are disclosed. The composition contains CHP or a CHP-containing prostate extract.
Type:
Grant
Filed:
November 20, 2018
Date of Patent:
May 7, 2024
Assignee:
NovMetaPharma Co., Ltd.
Inventors:
Hoe Yune Jung, Heon Jong Lee, Do Hyun Lee
Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the disclosure and methods of using and producing same are also disclosed.
Abstract: Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: wherein R1, R2, R3, R4, R5 and R6 are as described herein.
Type:
Grant
Filed:
August 3, 2021
Date of Patent:
April 23, 2024
Assignee:
Genentech, Inc.
Inventors:
Frederick Cohen, Lewis J. Gazzard, Vickie Hsiao-Wei Tsui, John A. Flygare
Abstract: Sunscreen compositions comprising a dermatologically acceptable carrier and a polyhydroxy fullerene compound are described. The sunscreen compositions can be used to protect a substrate such as the skin of a subject from the effects of ultraviolet radiation.
Type:
Grant
Filed:
February 22, 2021
Date of Patent:
April 16, 2024
Assignee:
THE CLEVELAND CLINIC FOUNDATION
Inventors:
Vijay Krishna, Sanjay Anand, Edward Maytin, Stephen Grobmyer
Abstract: Methods for the production of immunogenic compositions containing a non-natural amino acid are disclosed. The non-natural amino acid can be a site for attachment of antigens, such as bacterial capsular polysaccharides, to make immunogenic conjugates. Bio-orthogonal attachment chemistry incorporated into the non-natural amino acids allows for more efficient and potent antigen presentation to the immune system, simplified purification, and more well-defined structure of these semi-synthetic immunogens.
Type:
Grant
Filed:
July 1, 2019
Date of Patent:
April 9, 2024
Assignee:
Vaxcyte, Inc.
Inventors:
Jeffery C. Fairman, Jon H. Heinrichs, Wei Chan
Abstract: The present invention relates to a method of increasing the bioavailability and/or prolonging ophthalmic action of a drug, the method comprising instilling into the eye an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters having a D50 value of at least 2 micrometer and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometer to 900 nanometer. The present invention further relates to an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters have a D50 value of at least 2 micrometers and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometers to 900 nanometers.
Type:
Grant
Filed:
June 17, 2021
Date of Patent:
April 9, 2024
Assignee:
SUN PHARMA ADVANCED RESEARCH COMPANY LTD.