Abstract: The present invention relates to wound care products, devices and methods incorporating acetic acid for the treatment of bacterial infections, in particular bacterial biofilm infections. In particular it relates to a wound care product comprising acetic acid, wherein the product comprises at least one further antibacterial compound; a delivery system comprising a container connected to a means of delivery which is connected to a pad, wherein said container comprises a composition comprising acetic acid and said pad comprises a self-adhesive material; a kit comprising a dressing and an adhesive membrane, wherein the dressing comprises a composition comprising acetic acid; a method of treating a wound comprising a) applying acetic acid to the wound and b) applying a negative pressure to the wound.

Abstract: A method and device treats cancer where blood from a cancer patient passes through an array of passageways within an interior of a chamber. The passageways include wells having porous membrane wall portions that enable a molecular-sized activating agent in a carrier fluid that enhances an immune response to pass through these porous wall portions. Pore size is such to allow the molecular-sized activating agent in the interior of the chamber to enter the wells yet prevents immune cells and cancer cells in the wells to pass through the porous wall portions into the interior of the chamber. Blood is retained in the wells so that it remains in contact with the immune cells and cancer cells for a predetermined period sufficient to enhance an immune response. Then the cells with an enhanced immune response are return to the patient.

Abstract: The invention relates to a kit for preserving a biological product including a three-dimensional bag (1) intended for holding said biological product, said bag (1) having a substantially constant three-dimensional geometry during the use thereof, as well as a casing (2) intended for packing said bag, said casing (2) including a cavity (3) arranged such as to receive said bag (1), said cavity (3) having a substantially constant three-dimensional geometry during the use thereof, and a slot (4) being provided along one edge of said cavity such as to enable said bag (1) to be inserted in said cavity (3), a front strip (5) and a rear strip (6) extending on the outside away from said slot (4), said strips being intended for being combined with one another in order to provide an airtight seal of said cavity (3) of the casing (2).

Abstract: Dry eye treatment apparatus and methods are described herein which generally comprise a patch or strip affixed to the skin of the upper and/or lower eyelids to deliver heat or other forms of energy, pressure, drugs, moisture, etc. (alone or in combination) to the one or more meibomian glands contained within the underlying skin. The treatment strip or strips include one or more strips configured to adhere to an underlying region of skin in proximity to one or both eyes of a subject such that the one or more strips allow for the subject to blink naturally without restriction from the one or more patches. Moreover, the one or more strips may be configured to emit energy to the underlying region of skin and where the one or more strips are shaped to follow a location of one or more meibomian glands contained within the underlying region of skin.

Abstract: A multi-container transfer and deliver device and methods of mixing and transferring, the device configured to allow multiple containers to transfer and mix their respective materials and for receiving of the mixed materials to a fluid delivery device. The transfer device comprises a plurality of flow conduits for fluid flow between the multiple containers and the fluid delivery device. A drug mixing kit and optional packaging comprising a multi-container housing with a plurality of flow conduits and a plurality of sections for receiving containers and a fluid transfer device is described.

Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked.

Abstract: A pressure-driven valve is disclosed. The valve includes a housing, a fluid flow channel, and a deflectable portion. The housing comprises a fluid inlet and a fluid outlet. The fluid flow channel extends between the fluid inlet and the fluid outlet. The deflectable portion is disposed within the housing, and defines a portion of the fluid flow channel. The deflectable portion is configured to deflect to increase and decrease a size of the fluid flow channel to regulate fluid flow from the fluid inlet to the fluid outlet. The deflectable portion is disposed and arranged to deflect as a result of pressure differentials between a reference pressure, a fluid flow channel pressure, and an outlet pressure representative of fluid pressure at the fluid outlet.

Abstract: Microstrain-inducing manifolds, systems, and methods are presented that involve microstrain-inducing manifolds that include a plurality of shaped projections for creating microstrain. The shaped projections may be tapered projections. A system may include a sealing member for placing over the tissue site, a microstrain-inducing manifold, and a reduced-pressure subsystem that delivers reduced pressure to the sealing member. The reduced pressure causes the shaped projections to create microstrain at the tissue site. Other methods, apparatuses, and systems are also presented.

Abstract: A tubing set suitable for use in co-operation with a machine for carrying out a hemodialysis treatment of a patient's blood includes a blood out-tube for supplying the blood from the patient to a filter, a blood in-tube for supplying the blood from the filter back to the patient, and a substitution tube connected to the blood in-tube or the blood out-tube suitable for providing a substitution fluid in the patient's blood. The substitution tube includes an insert for the infusion of drugs, with the insert being configured to cooperate with a vial. A method of delivering drugs includes use of the tubing set, including the substitution tube, the insert, and the vial.

Abstract: An eyedrop bottle holder with resilient arms formed from an inverted U-shaped band made from resilient injection molded plastic. The top middle portion of the inverted U-shape band includes a centrally located opening through which the top (dispensing portion) of a standard eyedrop bottle containing eyedrop solution may be positioned and held. The right and left arms of the U-shape band each terminate in an outwardly disposed J-shape foot, the underside of which is covered by a soft rubber-like pad. When a user inserts a standard eyedrop bottle into the holder, the dispensing tip of the eyedrop bottle may be positioned in close proximity to the user's eye. The user may cause his or her eye lid to remain open by using the fingers of one hand to squeeze the right and left arms of the holder together, then placing the pad of one arm on the upper ridge of the orbital eye socket and the pad of the second arm on the lower ridge of the orbital eye socket.

Abstract: A connection device for use in the negative pressure therapy of wounds, includes a flexible conduit having at least two lumens and being constructed for impingement with negative pressure and/or fluid media; a coupling body made of an elastomeric flexible material, and non-detachably molded onto a wound-side end section of the conduit and being constructed for arrangement on a negative pressure bandage which covers the wound and seals the wound against the atmosphere, wherein the conduit communicates with a wound space through at least one opening in the coupling body; and a fluid inlet section for insertion through an opening in the negative pressure bandage into the wound space. The fluid inlet section is formed on the coupling body and protrudes over a walling of the coupling body, which walling faces the negative pressure bandage. The fluid inlet section is fluidly connected interiorly of the coupling body with a further lumen for delivering a fluid medium.

Abstract: The present invention relates to a method of removing blood from an extracorporeal blood circuit following termination of a blood treatment session, wherein blood is concurrently removed both from an arterial conduit portion and from a venous conduit portion of the extracorporeal blood circuit. It further relates to a method for recognizing and/or eliminating air inclusions in or from an extracorporeal blood circuit and a treatment apparatus as well as a tube system.

Abstract: A liner support frame is configured to be positioned in a gastrointestinal tract of a human and to support a liner which inhibits nutrient absorption and anchor the liner in place in the gastrointestinal tract, the liner support frame includes a plurality of frame members connected to one another so that the liner support frame possesses a plurality of openings. The liner support frame includes a plurality of frame portions arranged axially and possessing different tapers.

Abstract: A connection device for use in the negative pressure therapy of wounds includes a flexible conduit which can be impinged with negative pressure and/or fluid media, the conduit having at least two lumens, a coupling body formed by an elastomeric flexible material which is non-detachably injection molded to a wound-side end section of the conduit, and being constructed for placement on a negative pressure bandage which covers and seals the wound negative pressure tight against the atmosphere, the conduit communicating through at least one opening in the coupling body with the wound space, and an end cap attached and preferably non-detachably fastened to the injection molded-on material of the coupling body, thereby sealing the coupling body tight against the outside.

Abstract: An intestinal barrier sleeve and corresponding treatments using the sleeve are provided herein. The sleeve generally includes an expanding section coupled to a tubular section at an interface there between. The expanding section is expandable from at least a first collapsed position to at least one expanded position, where the expanding section has a conical shape that when expanded retains the sleeve in the subject gastrointestinal tract. The expanding section may further include a plurality of petal-like elements extending radially from the narrow end of the conical shape and the petal-like elements may be interconnected with a webbing to form the conical shape.

Abstract: The present disclosure relates to arrangements for attaching an RFID tag to a liquid container, and particularly to a blood components container. The RFID tag may be inserted in an enclosure, such as peel tab, or in a sealed cup attached to a container port. The tag could alternately be embedded in a molded plug or component attached to a port. The RFID antenna could be painted or stamped on the surface of the container. Or the tag could be inserted into the container to float freely in the liquid components. The RFID source may be secured around the neck of a rigid or semi-rigid container, attached with a tether or attached to a connector assembled in association with a blood component or other fluid flow path.

Abstract: A paranasal sinus access implant device to provide an artificial fluid path in fluid communication with the lacrimal apparatus may be implanted through a fistula opening into the lacrimal apparatus. The implant device may have a conduit with a first longitudinal portion having a larger minimum wall thickness than a minimum wall thickness of a second a second longitudinal portion of the conduit located distal of the first longitudinal portion. Various kits may include a paranasal sinus access implant device and one of more other components for a procedure involving implantation. A method involves use of a cutting tool to cut away tissue to prepare a fistula sized for implantation.

Abstract: A modular, reduced-pressure, wound-closure system for providing a closing force on a surface would includes a flexible strap operable to be formed into a closed loop inbound and around the surface wound and a plurality of modular closing members coupled to the flexible strap. A reduced-pressure source is fluidly coupled to the plurality of modular closing members. The modular closing members are operable to generate a closing force on the surface wound. A portion of the modular closing members are releasably attached to the patient's epidermis proximate the surface wound and another portion are attached to the flexible strap. A reduced pressure from the reduced-pressure source is delivered to each modular closing member to generate the closing force on the surface wound. Methods and other systems are presented.

Abstract: A flow control and collection system includes a flow control device having a tubular member in which an inflatable balloon is positioned about the circumference of the interior side wall for closing the passageway to movement of matter and liquid when the balloon is expanded and allowing flow when the balloon is contracted against the side wall to which it is attached. The flow control device includes an adapter at the outer end of the tubular member having one or more interlocking features. A waste collection bag has a sealed body with at least one opening and a flow control device adapter at the opening having one or more counterpoising interlocking features to removably lock the adapters together and passes waste material and liquid through the flow control device into the waste collection bag.

Abstract: An extracorporeal reservoir device including a housing, a venous inlet sub-assembly, and a venous filter. The venous sub-assembly is mounted to the housing and includes a downtube and a luer port connector body. The connector body extends from the downtube and forms a passageway open to a lumen of the downtube. The connector body is arranged such that fluid flow from the passageway merges with a flow path of fluid along the primary lumen at an angle of less than 90°. Secondary blood flow through the port connector body is less likely to induce turbulent flow into venous blood flow within the downtube, and is thus less likely to break up any bubbles carried by the venous blood. For example, at port flow rates of less than 500 mL/minute, fluid flow from the port connector body does not induce turbulent flow into fluid flowing through the primary lumen.