Patents Examined by Arlen Soderquist
  • Patent number: 10837971
    Abstract: Methods are provided for detecting the amount of one or more HRT panel analytes (i.e., estrone (E1), estrone sulfate (E1s), 17?-estradiol (E2a), 17?-estradiol (E2b), estradiol sulfate (E2s), estriol (E3), equilin (EQ), 17?-dihydroequilin (EQa), 17?-dihydroequilin (EQb), Equilenin (EN), 17?-dihydroequilenin (ENa), 17?-dihydroequilenin (ENb), and ?8,9-dehydroestrone (dE1)) in a sample by mass spectrometry. The methods generally involve ionizing one or more HRT panel analytes in a sample and quantifying the generated ions to determine the amount of one or more HRT panel analytes in the sample. In methods where amounts of multiple HRT panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: November 17, 2020
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Mildred Goldman, Nigel Clarke
  • Patent number: 10837972
    Abstract: The invention relates to the detection of methylmalonic acid (MMA). In a particular aspect, the invention relates to methods for detecting derivatized methylmalonic acid (MMA) by mass spectrometry.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: November 17, 2020
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Scott M. Goldman, Julie A. Neidich, Denise Salazar, Thomas Lynn
  • Patent number: 10837949
    Abstract: A filter that is used in conjunction with a non-specific gas sensor for PAA, which allows specific detection of PAA vapor in the presence of hydrogen peroxide vapor through the removal of the hydrogen peroxide vapor. The filter contains a filter catalyst that will catalyze the disproportionation of hydrogen peroxide but not react with PAA vapor, thus removing the hydrogen peroxide vapor and allowing the peracetic vapor to pass through the filter to the sensor.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: November 17, 2020
    Inventor: Piers Richard Warburton
  • Patent number: 10830780
    Abstract: The disclosure relates to systems, apparatuses, and methods for estimating a terpene level of two or more terpenes of the plurality of terpenes in the sample to generate a set of terpene levels; and/or estimating a cannabinoid level of two or more cannabinoids of the plurality of cannabinoids in the sample to generate a set of cannabinoid levels; configured to store a set of groups and classify the sample to a group of the set of groups, based on said terpene and cannabinoid levels. The present disclosure also relates to systems, apparatuses, and methods configured to generate entourage effect values and organoleptic values, based on said cannabinoid and terpene levels.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: November 10, 2020
    Assignee: Biotech Institute, LLC
    Inventors: Matthew W. Giese, Mark Anthony Lewis
  • Patent number: 10823743
    Abstract: A handheld medical analyzer works with different disposable application cartridges to perform a variety of interrogations on specimen samples. One application includes attaching a biological microelectromechanical systems (BioMEMS) cartridge that generates blood coagulation profiles indicative of particular forms of coagulation disorders. The device makes coagulopathy testing simpler for small hospitals, clinics, ambulances, remote locations and individuals and permits for a larger number of parallel or serial devices operating simultaneously. One insertion of a cartridge actuates an oscillating circular motion to generate a blood coagulation profile based on a change in rotational motion as blood coagulates in a sample. Change in rotational motion is analyzed through a video camera such as in a smartphone and is plotted to show an amplitude over time. Actuation of the BioMEMS can be achieved by magnetic actuation of a motor controlled by an iPhone or a smart phone to provide a specific rotational pattern.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: November 3, 2020
    Assignee: iFirst Medical Technologies, Inc.
    Inventors: Luke B. Joseph, Thomas A. Hasling
  • Patent number: 10821439
    Abstract: A microfluidic apparatus is provided having one or more sequestration pens configured to isolate one or more target micro-objects by changing the orientation of the microfluidic apparatus with respect to a globally active force, such as gravity. Methods of selectively directing the movements of micro-objects in such a microfluidic apparatus using gravitational forces are also provided. The micro-objects can be biological micro-objects, such as cells, or inanimate micro-objects, such as beads.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: November 3, 2020
    Assignee: Berkeley Lights, Inc.
    Inventors: Keith J. Breinlinger, Eric D. Hobbs, Daniele Malleo, J. Tanner Nevill, Mark P. White
  • Patent number: 10823715
    Abstract: This invention relates to a chemical indicator for monitoring a vaporous hydrogen peroxide sterilization process. The chemical indicator comprises a reactive composition adhered to a substrate, the reactive composition comprising a transition metal reagent, an oxidizing agent, and a resin. A test pack containing the chemical indicator and a biological indicator is disclosed. Vaporous hydrogen peroxide sterilization processes using the chemical indicator and the test pack are disclosed.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: November 3, 2020
    Assignee: American Sterilizer Company
    Inventors: Tricia Cregger, Phillip F. Franciskovich
  • Patent number: 10814320
    Abstract: A capillary transfer pipette includes a draw tube having a distal end defining a draw tube opening through which liquid is drawn via capillary action, a proximal end, and a lumen. A squeeze bulb is arranged proximally of the draw tube and defines a fluid chamber in fluid communication with the lumen, the squeeze bulb being compressible to dispense drawn liquid from the draw tube. An air vent hole is formed in at least one of the draw tube or the squeeze bulb, and is configured to vent air to facilitate drawing of liquid through the draw tube opening via capillary action. A volume indicating element may be provided on the draw tube, and the air vent hole may be located proximally of the volume indicating element. The lumen may be formed with a first diameter at the proximal end and a differing second diameter at the distal end. Methods of collecting liquid with, and of making, a capillary transfer pipette are also disclosed.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: October 27, 2020
    Assignee: Nalge Nunc International Corporation
    Inventors: Christopher Le, Ilianna Maria Escalante
  • Patent number: 10809242
    Abstract: Compositions comprising electrospun fibers and colorimetric detection encapsulated thereto are provided. Further, methods of use of said composition, including, but not limited to in-situ detection of molecules of interest, such as explosive compounds, are provided.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: October 20, 2020
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Eyal Zussman, Yuval Eshed, Reshef Gal-Oz
  • Patent number: 10799833
    Abstract: An exhaust aftertreatment system includes a diesel oxidation catalyst in exhaust gas receiving communication with an engine. A selective catalytic reduction catalyst on filter (SCR on filter) is positioned downstream of the diesel oxidation catalyst. A hydrocarbon doser is configured to inject hydrocarbons into a flow of the exhaust gas upstream of the diesel oxidation catalyst. A reductant doser is configured to inject reductant into the flow of the exhaust gas upstream of the SCR on filter and downstream of the diesel oxidation catalyst. An aftertreatment controller is operatively coupled to the hydrocarbon doser. The aftertreatment controller is configured to control a dosing rate at which the hydrocarbon doser injects hydrocarbons into the flow of the exhaust gas so as to cause regeneration of the SCR on filter.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: October 13, 2020
    Assignee: Cummins Emission Solutions Inc.
    Inventors: Richard J. Ancimer, Michael J. Cunningham, Michael Haas, Yuhui Zha, Mert Zorlu
  • Patent number: 10788404
    Abstract: A sample preparation device for electron microscopy (EM) that is configured to eliminate user-to-user variations and environment contaminations, which are often present in the conventional method of sample preparation. The device not only provides a means for evenly and reproducibly delivering a fluid or sample to an EM grid, but also provides a means for sealing the EM grid in an air-tight chamber and delivering air-sensitive samples to the EM grid. The platform may comprise readily fabricated glass chips with features integrated to preserve the integrity of the sample grid and to facilitate its extraction. The methods may eliminate the element of user dependent variability and thus improve the throughput, reproducibility and translation of these methods.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: September 29, 2020
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Michael G. Roper, Nikita Mukhitov, Scott Stagg, John Spear
  • Patent number: 10775355
    Abstract: A clinical diagnostic system is presented and comprises a sample preparation station for automatically preparing samples comprising analytes of interest, a liquid chromatography (LC) separation station comprising a plurality of LC channels and a sample preparation/LC interface for inputting prepared samples into the LC channels. The system further comprises a controller to assign samples to pre-defined sample preparation workflows each comprising a pre-defined sequence of sample preparation steps and requiring a pre-defined time for completion depending on the analytes. The controller further assigns an LC channel for each prepared sample depending on the analytes and plans an LC channel input sequence for inputting the prepared samples that allows analytes from different LC channels to elute in a non-overlapping LC eluate output sequence based on expected elution times.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: September 15, 2020
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Tobias Franz, Uwe Kobold, Peter Kupser, Roland Thiele
  • Patent number: 10768154
    Abstract: The present disclosure is directed to a sensing agent. The sensing agent comprises a quantum dot; and a dye moiety coupled to the quantum dot. The sensing agent is capable of sensing at least one analyte chosen from hydrogen sulfide (H2S) and bisulfide. Sensors made from the sensing agents are also disclosed.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: September 8, 2020
    Assignee: Colgate-Palmolive Company
    Inventors: Venda Porter Maloney, Donghui Wu, Long Pan, Preston Snee, Armen Shamirian
  • Patent number: 10739239
    Abstract: A medical analyzer and coagulation profiler performs various interrogations on specimens. A motor with reduction gearing moves and a video camera observes the samples, the cartridges or parts thereof. Changes in images are compared and recorded with a central processor that controls a display. Power supply, temperature controller, motor and gearing are mounted in a box which attaches to a smartphone. The smartphone provides the video camera, illumination and central processor that control the movement, temperature and display. The device makes testing simpler for small hospitals, clinics, ambulances, remote locations and individuals and controls a number of parallel or serial devices operating simultaneously or sequentially. A cartridge insertion actuates a circular motion to generate a blood profile based on changes. Change is analyzed with a video camera and processor such as in a smartphone and is plotted to show an amplitude and time. A smartphone provides a specific movement pattern.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: August 11, 2020
    Assignee: iFirst Medical Technologies, Inc.
    Inventors: Luke B. Joseph, Thomas A. Hasling
  • Patent number: 10736982
    Abstract: Water-based formulations comprising an indicating composition dispersed in water are described. The water-based indicating compositions include an organic Bi(III) compound, a sulfur source, a carbonate salt, and strontium hydroxide. Formulations further including a resin and/or an acidic additive are also described.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: August 11, 2020
    Assignee: 3M Innovative Properties Company
    Inventors: Wensheng Xia, Sarah J. Davis
  • Patent number: 10732173
    Abstract: Methods are provided for obtaining a sample of ? cells from an isolated donor pancreas or isolated pancreatic islets and analyzing the sample using flow cytometry to determine the percentage of ? cells in the sample that express detectable levels of ALDH1 A3. If the percentage of ALDH1 A3-expressing ? cells in the sample is about 3% or lower, then it is possible to determine that the pancreas or islets are healthy enough for implantation into a subject, and implanting the pancreas or islets. If the percentage of ALDH1 A3-expressing cells is above about 5%, then it is determined that the pancreas or islets are not suitable for implantation into the subject and discarding the pancreas or islets. Isolated non-insulin-producing or low-insulin-producing pancreatic beta cells are also provided.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: August 4, 2020
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Domenico Accili, Ja Young Kim-Muller
  • Patent number: 10724950
    Abstract: Disclosed is a method for preparing dispersion gradients and an SPR injection method for determining full kinetics and affinity analysis in the presence of a competitor molecule. The SPR injection provides a dispersion gradient of two or more samples to a SPR flow cell and detector.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: July 28, 2020
    Assignee: SARTORIUS BIOANALYTICAL INSTRUMENTS, INC.
    Inventor: Aaron David Martin
  • Patent number: 10704993
    Abstract: A Sampler and process for collecting, growing, inoculating and evaluating microbes in-situ. The Sampler may be loaded with an active or inert media to assist with the collection of microbes. It is closed and lowered to a desired depth. Sampler is opened to initiate sampling. Materials are added to the sampler to stimulate growth or change the environment. To collect and grow in situ microbes, the sampler is left open for a period of time, a trigger closes and seals the sampler capturing contents specific to that location. The sampler is lifted preserving the in-situ conditions from the collection location. The contents of the sampler can be interrogated through sealed ports at the field site or at a remote location. The sampler can also be utilized as a biologic reactor allowing researchers to connect laboratory equipment to analyze, modify, or cultivate the collected sample.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: July 7, 2020
    Assignee: United States of America as represented by the Secretary of the Department of the Interior
    Inventors: Elliott Barnhart, Robert Hyatt, Mathew Fields, Alfred B Cunningham
  • Patent number: 10705083
    Abstract: The present disclosure relates to a method for characterizing and identifying a bioparticle. The method comprises introducing the sample to a substrate having a surface comprising a plurality of binding sites whereon bioparticles can be bound, determining, for at least one temperature, data representative for the interface thermal resistance of the surface of the substrate sufficiently long to include the detachment process of the bioparticles, and deriving, for the at least one temperature, a bioparticle retention time and/or detachment rate from the data representative for the interface thermal resistance data. The present disclosure also relates to a bio-sensing device suitable for the detection and/or characterization of target bioparticles.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: July 7, 2020
    Assignee: IMEC VZW
    Inventors: Patricia Losada-PĂ©rez, Derick Yongabi, Mehran Khorshid, Ward De Ceuninck, Ronald Thoelen, Patrick Wagner
  • Patent number: 10705081
    Abstract: Methods and compositions for the detection and quantitative measurement of biomarkers and other target analytes by determining impedance in bodily fluid samples and/or environmental samples using compositions comprising a base substrate with electrodes, a nanoporous membrane placed on top of the nanoporous membrane, O-rings placed on top of the nanoporous membrane and a manifold placed on top of the O-rings. Such a composition may be placed in a testing platform to ensure the application of constant, repeatable pressure to the composition.
    Type: Grant
    Filed: September 2, 2017
    Date of Patent: July 7, 2020
    Assignee: SYMPANO, INC.
    Inventors: Thomas W. Barrett, Shalini Gautam, Rooplekha Mitra, James Thorne