Patents Examined by Arlen Soderquist
  • Patent number: 12247993
    Abstract: Disclosed is a specimen measurement method for measuring platelet aggregation of a specimen, and the specimen measurement method includes: automatically preparing a diluted reagent solution that contains a platelet-aggregating reagent diluted with a diluent; preparing a measurement sample that contains a predetermined concentration of the platelet-aggregating reagent, from the diluted reagent solution and the specimen; and performing optical measurement of the measurement sample.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: March 11, 2025
    Assignee: SYSMEX CORPORATION
    Inventors: Hiroshi Kurono, Tasuku Sakayori, Yuri Watanabe
  • Patent number: 12241849
    Abstract: Methods for determining protein and/or peptide concentration or molecular parameter, such as the extinction coefficient, and uses thereof.
    Type: Grant
    Filed: January 22, 2021
    Date of Patent: March 4, 2025
    Assignee: Eli Lilly and Company
    Inventors: Scott Allan Bradley, William F. Weiss, IV, Wesley Clinton Jackson, Jr.
  • Patent number: 12241840
    Abstract: An airborne silica detection system provides a chemiluminescence reaction for quantitative assessment of silica on an automated basis. A prefilter allows reaction to be sensitive to particle sizes relevant to chronic respiratory diseases.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: March 4, 2025
    Inventor: James E. Boulter
  • Patent number: 12228511
    Abstract: The embodiments disclose a portable microbial test kit including a plurality of organic materials configured to be processed for preservation and prevention of mold, bacteria infestations, rot, and decay and reduce and prevent any degradation, a storage facility, a plurality of hardware, and a plurality of equipment configured for storage and monitoring of the plurality of organic materials, wherein the hardware and the equipment are configured to monitor the condition of the organic materials during storage, a plurality of components coupled to the hardware and the equipment configured to electronically monitor the condition of the organic materials during storage, at least one electronic device coupled to the plurality of hardware and the plurality of equipment configured to report electronically the condition of the organic materials to the facility and customer, and a system coupled to the at least one electronic device configured for customers to automatically reorder hardware and equipment.
    Type: Grant
    Filed: September 25, 2023
    Date of Patent: February 18, 2025
    Inventor: Craig Ellins
  • Patent number: 12222360
    Abstract: An automatic analyzer includes a flow cell detector, a nozzle that is connected to the flow cell detector by a flow path and aspirates or discharges liquid, a reservoir that is provided with a table and a table driving mechanism that rotates or moves the table up and down, and a cleaning tank that is disposed on the table. A position of the nozzle is fixed, and a cleaning water discharge port discharges cleaning water used for cleaning the nozzle at an angle ? with respect to a plane perpendicular to a central axis of the nozzle. An upper part of a side wall of the cleaning tank is continuous with an upper discharge unit at a side facing a discharge outlet provided in the reservoir and a spatula-shaped part projects outward of the cleaning tank at a side facing the upper discharge unit.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: February 11, 2025
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Yoshihiro Kabe, Takenori Okusa
  • Patent number: 12214345
    Abstract: In an embodiment, the claimed invention includes an oral-fluid collection and testing device that. is simple to operate. The device includes a body assembly and a cap assembly that are easy to handle by a user. A collection sponge projects from an end of the body assembly for absorbing the oral fluid of a donor, A cap assembly is easily aligned with the body assembly by way of visual alignment indicators on both the body and the cap. Once the cap is aligned with the body, a user simply pushes the cap onto the ‘body, which causes a first stage fluid, flow. More specifically, a buffer fluid is released from the cap and mixes with the oral fluid collected on the sponge—After waiting a short time* the cap is rotated, then pushed again, causing a second-stage fluid flow in which the sponge is compressed such that the buffer fluid/oral fluid exits the sponge and flows toward a. pair of test strips.
    Type: Grant
    Filed: August 16, 2021
    Date of Patent: February 4, 2025
    Assignee: Premier Biotech, LLC
    Inventors: Kevin S. Fuller, Wayde J. Altendorf, Todd Bailey
  • Patent number: 12203834
    Abstract: A handheld medical analyzer works with different disposable application cartridges to perform a variety of interrogations on specimen samples. One application includes attaching a biological microelectromechanical systems (BioMEMS) cartridge that generates blood coagulation profiles indicative of particular forms of coagulation disorders. The device makes coagulopathy testing simpler for small hospitals, clinics, ambulances, remote locations and individuals and permits for a larger number of parallel or serial devices operating simultaneously. One insertion of a cartridge actuates an oscillating circular motion to generate a blood coagulation profile based on a change in rotational motion as blood coagulates in a sample. Change in rotational motion is analyzed through a video camera such as in a smartphone and is plotted to show an amplitude over time. Actuation of the BioMEMS can be achieved by magnetic actuation of a motor controlled by an iPhone or a smart phone to provide a specific rotational pattern.
    Type: Grant
    Filed: September 7, 2023
    Date of Patent: January 21, 2025
    Assignee: iFirst Medical Technologies, Inc.
    Inventors: Luke B. Joseph, Thomas A. Hasling
  • Patent number: 12203945
    Abstract: Provided is a method for separating and detecting various hemoglobins including abnormal hemoglobins and thalassemia markers. A method for analyzing hemoglobins, comprising separating hemoglobins in a sample by cation exchange chromatography, wherein an eluent having a pH of 8.1 or more and an osmotic pressure of 40 mOsm/kg or less is used for separation of the hemoglobins.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: January 21, 2025
    Assignee: SEKISUI MEDICAL CO., LTD.
    Inventors: Hiroaki Taira, Ei-Ichiro Sunamura, Kohei Matsuda, Takuya Yotani
  • Patent number: 12203833
    Abstract: A medical analyzer and coagulation profiler performs various interrogations on specimens. A motor with reduction gearing moves and a video camera observes the samples, the cartridges or parts thereof. Changes in images are compared and recorded with a central processor that controls a display. Power supply, temperature controller, motor and gearing are mounted in a box which attaches to a smartphone. The smartphone provides the video camera, illumination and central processor that control the movement, temperature and display. The device makes testing simpler for small hospitals, clinics, ambulances, remote locations and individuals and controls a number of parallel or serial devices operating simultaneously or sequentially. A cartridge insertion actuates a circular motion to generate a blood profile based on changes. Change is analyzed with a video camera and processor such as in a smartphone and is plotted to show an amplitude and time. A smartphone provides a specific movement pattern.
    Type: Grant
    Filed: March 3, 2023
    Date of Patent: January 21, 2025
    Assignee: iFirst Medical Technologies, Inc.
    Inventors: Luke B. Joseph, Thomas A. Hasling
  • Patent number: 12188350
    Abstract: A composition includes a functionalized fluorescent dye. The functionalized fluorescent dye includes an isothiocyanate-containing compound functionalized with a functional group. The functional group includes a primary amine. The functionalized fluorescent dye can be mixed with a fluid to form a tracer fluid for tracing fluid flow in a subterranean formation.
    Type: Grant
    Filed: June 8, 2022
    Date of Patent: January 7, 2025
    Assignee: Saudi Arabian Oil Company
    Inventor: Wei Wang
  • Patent number: 12174209
    Abstract: Disclosed in the present invention is a blood sample analyzer, including a sample conveying device, a first agitating device, a second agitating device and a controller, etc. When the first agitating device drives a sample container placed in a sample container accommodating hole to agitate a blood sample, a bottom of the sample container is kept lower than an opening of the sample container. In addition, the present invention further discloses a blood sample agitating device, a blood sample analysis method, a blood sample agitating method, and a computer storage medium.
    Type: Grant
    Filed: February 8, 2021
    Date of Patent: December 24, 2024
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Lijian Hu, Zixian Xie, Yuanxing Liu
  • Patent number: 12153030
    Abstract: The present disclosure relates to an apparatus and a method for measuring miscibility in oil using back titration. The apparatus includes: a flocculation solution storage unit; a flow cell including a UV transmitting member; a dissolving agent storage unit; a UV irradiation unit; and a measurement unit, wherein: a flocculation solution is stored in the flocculation solution storage unit; the flocculation solution circulates between the flocculation solution storage unit and the flow cell; the measurement unit measures the UV transmittance of the flocculation solution while the dissolving agent in the dissolving agent storage unit is supplied to the flocculation solution storage unit; the miscibility in the oil is calculated from the amount of dissolving agent supplied and a change in the UV transmittance measured by the measurement unit; and the miscibility is calculated based on a time point when the slope of increase in the UV transmittance changes.
    Type: Grant
    Filed: December 28, 2020
    Date of Patent: November 26, 2024
    Assignee: KOREA INSTITUTE OF ENERGY RESEARCH
    Inventors: Kang-Seok Go, Nam-Sun Nho, Kwang-Ho Kim, Eun Hee Kwon, Suk Hyun Lim, Hung Hai Pham, Anh Dung Pham
  • Patent number: 12140550
    Abstract: A photoluminescent material can be applied to part of a substrate as part of substrate inspection. The photoluminescent material includes a conjugated polymer having a coiled macroscopic molecular shape and a meta-linkage or an ortho-linkage. The substrate is imaged using an inspection system. The conjugated polymer can be, for example, poly(m-phenylene ethynylene) (PPE) or poly(para-phenylene vinylene) (PPV).
    Type: Grant
    Filed: January 25, 2023
    Date of Patent: November 12, 2024
    Assignee: KLA Corporation
    Inventors: Jinsang Kim, Grace Chen
  • Patent number: 12130295
    Abstract: Disclosed are methods and systems to determine a subject's metabolic vulnerability index (MVX) score using at least one defined mathematical model of risk. The methods comprise evaluating various biomarkers to distinguish various health risks. In one embodiment, the method comprises evaluating biomarkers to determine a relative risk of premature all-cause mortality. The model may include NMR-derived measurements of GlycA, S-HDLP, branched chain amino acids (BCAAs), ketone bodies, total serum protein, and citrate in at least one biosample of the subject.
    Type: Grant
    Filed: October 22, 2021
    Date of Patent: October 29, 2024
    Assignee: LipoScience, Inc.
    Inventors: James D. Otvos, Irina Y. Shalaurova
  • Patent number: 12130236
    Abstract: What is disclosed is a method for creating a database for determining a virtual reference value for a light transmission aggregometry measurement, comprising the following steps: a. providing platelet-rich plasma “PRP” (17) of a reference blood sample; b. performing a light transmission measurement with a first light wavelength and a second light wavelength (14), different from the first, on the PRP (17) of the reference blood sample; c. providing platelet-poor plasma “PPP” of the reference blood sample; d. performing a light transmission measurement on the PPP in order to determine a PPP reference value; e. assigning the measurement result of step d to the measurement results of step b in a database; f. repeating steps a to e for a plurality of reference blood samples. The database obtained using this method makes it possible to determine a virtual reference value that is an excellent estimate of the PPP reference value.
    Type: Grant
    Filed: July 22, 2022
    Date of Patent: October 29, 2024
    Assignee: Kommanditgesellschaft Behnk Elektronik GmbH & Co.
    Inventor: Christian Radon
  • Patent number: 12130266
    Abstract: A jet injector for a GC that includes a body, a skirt extending away from the body; and a bore that extends through the skirt and the body to create an inlet and an outlet for the jet injector.
    Type: Grant
    Filed: May 20, 2022
    Date of Patent: October 29, 2024
    Assignee: AGILENT TECHNOLOGIES, INC
    Inventors: Edward D. Mroz, Heng He
  • Patent number: 12123884
    Abstract: An automatic analyzer is capable of normally maintaining a device condition and exhibiting a stable performance by automatically monitoring a cleaning implementation situation using a wash rack. The automatic analyzer includes an analysis unit, a rack loading unit into which at least a sample rack that holds the sample and a wash rack that holds a cleaning liquid are loaded. A transportation mechanism transports the sample rack and the wash rack to the analysis unit. A management control unit causes the wash rack to be transported to an analysis unit, causes a cleaning operation of the analysis unit by the cleaning liquid held by the wash rack, and causes stopping of the sample analysis operation of the analysis unit to which the wash rack has been transported until a performance of the analysis unit is determined to be normal based on the cleaning operation.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: October 22, 2024
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Kenichi Yagi, Masafumi Miyake, Sayaka Asada
  • Patent number: 12117424
    Abstract: A jet injector for a GC that includes a body, a skirt extending away from the body; and a bore that extends through the skirt and the body to create an inlet and an outlet for the jet injector.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: October 15, 2024
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Edward D. Mroz, Heng He
  • Patent number: 12111327
    Abstract: The automatic analyzer is capable of performing other operations concurrently with a maintenance operation and notifying a user when a user action is required in executing maintenance and displaying guidance. Automatic analyzer includes analysis modules and that analyze a sample, a display device that displays information related to maintenance in the analyzer including the analysis modules and, and an overall management computer that controls a constant display area to be displayed on a display screen of the display device, in which when there is a need to notify a user of a maintenance status at a timing when the maintenance in the analyzer is executed in a background and a screen other than a maintenance screen is displayed on the display device, the overall management computer displays notification information on the screen including global areas and of the display device.
    Type: Grant
    Filed: November 13, 2019
    Date of Patent: October 8, 2024
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Satoru Chida, Masashi Akutsu, Chikook Ha, Satoshi Yokotsuka
  • Patent number: 12085560
    Abstract: Provided is a biochemical reaction substrate which can achieve higher test sensitivity and shorter testing time in an allergy test, which can also reduce a required amount of blood or the like needed as a specimen and decrease the number of test steps, thereby facilitating performance of the test, and which is to be used in an allergy test in which infection risk of the test staff is reduced.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: September 10, 2024
    Assignee: NIPPON CHEMIPHAR CO., LTD.
    Inventors: Kenji Uemura, Norio Tanimoto, Mai Egami, Takahiro Mataki, Yumi Konishi, Motoe Shimizu, Shigenori Takahashi, Koji Sakaguchi