Patents Examined by Arlen Soderquist
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Patent number: 12214345Abstract: In an embodiment, the claimed invention includes an oral-fluid collection and testing device that. is simple to operate. The device includes a body assembly and a cap assembly that are easy to handle by a user. A collection sponge projects from an end of the body assembly for absorbing the oral fluid of a donor, A cap assembly is easily aligned with the body assembly by way of visual alignment indicators on both the body and the cap. Once the cap is aligned with the body, a user simply pushes the cap onto the ‘body, which causes a first stage fluid, flow. More specifically, a buffer fluid is released from the cap and mixes with the oral fluid collected on the sponge—After waiting a short time* the cap is rotated, then pushed again, causing a second-stage fluid flow in which the sponge is compressed such that the buffer fluid/oral fluid exits the sponge and flows toward a. pair of test strips.Type: GrantFiled: August 16, 2021Date of Patent: February 4, 2025Assignee: Premier Biotech, LLCInventors: Kevin S. Fuller, Wayde J. Altendorf, Todd Bailey
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Patent number: 12203834Abstract: A handheld medical analyzer works with different disposable application cartridges to perform a variety of interrogations on specimen samples. One application includes attaching a biological microelectromechanical systems (BioMEMS) cartridge that generates blood coagulation profiles indicative of particular forms of coagulation disorders. The device makes coagulopathy testing simpler for small hospitals, clinics, ambulances, remote locations and individuals and permits for a larger number of parallel or serial devices operating simultaneously. One insertion of a cartridge actuates an oscillating circular motion to generate a blood coagulation profile based on a change in rotational motion as blood coagulates in a sample. Change in rotational motion is analyzed through a video camera such as in a smartphone and is plotted to show an amplitude over time. Actuation of the BioMEMS can be achieved by magnetic actuation of a motor controlled by an iPhone or a smart phone to provide a specific rotational pattern.Type: GrantFiled: September 7, 2023Date of Patent: January 21, 2025Assignee: iFirst Medical Technologies, Inc.Inventors: Luke B. Joseph, Thomas A. Hasling
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Patent number: 12203945Abstract: Provided is a method for separating and detecting various hemoglobins including abnormal hemoglobins and thalassemia markers. A method for analyzing hemoglobins, comprising separating hemoglobins in a sample by cation exchange chromatography, wherein an eluent having a pH of 8.1 or more and an osmotic pressure of 40 mOsm/kg or less is used for separation of the hemoglobins.Type: GrantFiled: April 18, 2019Date of Patent: January 21, 2025Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Hiroaki Taira, Ei-Ichiro Sunamura, Kohei Matsuda, Takuya Yotani
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Patent number: 12203833Abstract: A medical analyzer and coagulation profiler performs various interrogations on specimens. A motor with reduction gearing moves and a video camera observes the samples, the cartridges or parts thereof. Changes in images are compared and recorded with a central processor that controls a display. Power supply, temperature controller, motor and gearing are mounted in a box which attaches to a smartphone. The smartphone provides the video camera, illumination and central processor that control the movement, temperature and display. The device makes testing simpler for small hospitals, clinics, ambulances, remote locations and individuals and controls a number of parallel or serial devices operating simultaneously or sequentially. A cartridge insertion actuates a circular motion to generate a blood profile based on changes. Change is analyzed with a video camera and processor such as in a smartphone and is plotted to show an amplitude and time. A smartphone provides a specific movement pattern.Type: GrantFiled: March 3, 2023Date of Patent: January 21, 2025Assignee: iFirst Medical Technologies, Inc.Inventors: Luke B. Joseph, Thomas A. Hasling
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Patent number: 12188350Abstract: A composition includes a functionalized fluorescent dye. The functionalized fluorescent dye includes an isothiocyanate-containing compound functionalized with a functional group. The functional group includes a primary amine. The functionalized fluorescent dye can be mixed with a fluid to form a tracer fluid for tracing fluid flow in a subterranean formation.Type: GrantFiled: June 8, 2022Date of Patent: January 7, 2025Assignee: Saudi Arabian Oil CompanyInventor: Wei Wang
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Patent number: 12174209Abstract: Disclosed in the present invention is a blood sample analyzer, including a sample conveying device, a first agitating device, a second agitating device and a controller, etc. When the first agitating device drives a sample container placed in a sample container accommodating hole to agitate a blood sample, a bottom of the sample container is kept lower than an opening of the sample container. In addition, the present invention further discloses a blood sample agitating device, a blood sample analysis method, a blood sample agitating method, and a computer storage medium.Type: GrantFiled: February 8, 2021Date of Patent: December 24, 2024Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.Inventors: Lijian Hu, Zixian Xie, Yuanxing Liu
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Patent number: 12153030Abstract: The present disclosure relates to an apparatus and a method for measuring miscibility in oil using back titration. The apparatus includes: a flocculation solution storage unit; a flow cell including a UV transmitting member; a dissolving agent storage unit; a UV irradiation unit; and a measurement unit, wherein: a flocculation solution is stored in the flocculation solution storage unit; the flocculation solution circulates between the flocculation solution storage unit and the flow cell; the measurement unit measures the UV transmittance of the flocculation solution while the dissolving agent in the dissolving agent storage unit is supplied to the flocculation solution storage unit; the miscibility in the oil is calculated from the amount of dissolving agent supplied and a change in the UV transmittance measured by the measurement unit; and the miscibility is calculated based on a time point when the slope of increase in the UV transmittance changes.Type: GrantFiled: December 28, 2020Date of Patent: November 26, 2024Assignee: KOREA INSTITUTE OF ENERGY RESEARCHInventors: Kang-Seok Go, Nam-Sun Nho, Kwang-Ho Kim, Eun Hee Kwon, Suk Hyun Lim, Hung Hai Pham, Anh Dung Pham
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Patent number: 12140550Abstract: A photoluminescent material can be applied to part of a substrate as part of substrate inspection. The photoluminescent material includes a conjugated polymer having a coiled macroscopic molecular shape and a meta-linkage or an ortho-linkage. The substrate is imaged using an inspection system. The conjugated polymer can be, for example, poly(m-phenylene ethynylene) (PPE) or poly(para-phenylene vinylene) (PPV).Type: GrantFiled: January 25, 2023Date of Patent: November 12, 2024Assignee: KLA CorporationInventors: Jinsang Kim, Grace Chen
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Patent number: 12130295Abstract: Disclosed are methods and systems to determine a subject's metabolic vulnerability index (MVX) score using at least one defined mathematical model of risk. The methods comprise evaluating various biomarkers to distinguish various health risks. In one embodiment, the method comprises evaluating biomarkers to determine a relative risk of premature all-cause mortality. The model may include NMR-derived measurements of GlycA, S-HDLP, branched chain amino acids (BCAAs), ketone bodies, total serum protein, and citrate in at least one biosample of the subject.Type: GrantFiled: October 22, 2021Date of Patent: October 29, 2024Assignee: LipoScience, Inc.Inventors: James D. Otvos, Irina Y. Shalaurova
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Patent number: 12130236Abstract: What is disclosed is a method for creating a database for determining a virtual reference value for a light transmission aggregometry measurement, comprising the following steps: a. providing platelet-rich plasma “PRP” (17) of a reference blood sample; b. performing a light transmission measurement with a first light wavelength and a second light wavelength (14), different from the first, on the PRP (17) of the reference blood sample; c. providing platelet-poor plasma “PPP” of the reference blood sample; d. performing a light transmission measurement on the PPP in order to determine a PPP reference value; e. assigning the measurement result of step d to the measurement results of step b in a database; f. repeating steps a to e for a plurality of reference blood samples. The database obtained using this method makes it possible to determine a virtual reference value that is an excellent estimate of the PPP reference value.Type: GrantFiled: July 22, 2022Date of Patent: October 29, 2024Assignee: Kommanditgesellschaft Behnk Elektronik GmbH & Co.Inventor: Christian Radon
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Patent number: 12130266Abstract: A jet injector for a GC that includes a body, a skirt extending away from the body; and a bore that extends through the skirt and the body to create an inlet and an outlet for the jet injector.Type: GrantFiled: May 20, 2022Date of Patent: October 29, 2024Assignee: AGILENT TECHNOLOGIES, INCInventors: Edward D. Mroz, Heng He
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Patent number: 12123884Abstract: An automatic analyzer is capable of normally maintaining a device condition and exhibiting a stable performance by automatically monitoring a cleaning implementation situation using a wash rack. The automatic analyzer includes an analysis unit, a rack loading unit into which at least a sample rack that holds the sample and a wash rack that holds a cleaning liquid are loaded. A transportation mechanism transports the sample rack and the wash rack to the analysis unit. A management control unit causes the wash rack to be transported to an analysis unit, causes a cleaning operation of the analysis unit by the cleaning liquid held by the wash rack, and causes stopping of the sample analysis operation of the analysis unit to which the wash rack has been transported until a performance of the analysis unit is determined to be normal based on the cleaning operation.Type: GrantFiled: November 14, 2019Date of Patent: October 22, 2024Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Kenichi Yagi, Masafumi Miyake, Sayaka Asada
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Patent number: 12117424Abstract: A jet injector for a GC that includes a body, a skirt extending away from the body; and a bore that extends through the skirt and the body to create an inlet and an outlet for the jet injector.Type: GrantFiled: January 13, 2020Date of Patent: October 15, 2024Assignee: AGILENT TECHNOLOGIES, INC.Inventors: Edward D. Mroz, Heng He
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Automatic analyzer with a control unit for displaying background maintenance operation notifications
Patent number: 12111327Abstract: The automatic analyzer is capable of performing other operations concurrently with a maintenance operation and notifying a user when a user action is required in executing maintenance and displaying guidance. Automatic analyzer includes analysis modules and that analyze a sample, a display device that displays information related to maintenance in the analyzer including the analysis modules and, and an overall management computer that controls a constant display area to be displayed on a display screen of the display device, in which when there is a need to notify a user of a maintenance status at a timing when the maintenance in the analyzer is executed in a background and a screen other than a maintenance screen is displayed on the display device, the overall management computer displays notification information on the screen including global areas and of the display device.Type: GrantFiled: November 13, 2019Date of Patent: October 8, 2024Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Satoru Chida, Masashi Akutsu, Chikook Ha, Satoshi Yokotsuka -
Patent number: 12085560Abstract: Provided is a biochemical reaction substrate which can achieve higher test sensitivity and shorter testing time in an allergy test, which can also reduce a required amount of blood or the like needed as a specimen and decrease the number of test steps, thereby facilitating performance of the test, and which is to be used in an allergy test in which infection risk of the test staff is reduced.Type: GrantFiled: February 1, 2019Date of Patent: September 10, 2024Assignee: NIPPON CHEMIPHAR CO., LTD.Inventors: Kenji Uemura, Norio Tanimoto, Mai Egami, Takahiro Mataki, Yumi Konishi, Motoe Shimizu, Shigenori Takahashi, Koji Sakaguchi
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Patent number: 12070745Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.Type: GrantFiled: June 30, 2022Date of Patent: August 27, 2024Assignee: BIOMERIEUX, INC.Inventors: Christopher S. Ronsick, Mark S. Wilson, John D. Walsh
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Patent number: 12061194Abstract: Embodiments described herein may be useful in the detection of analytes. The systems and methods may allow for a relatively simple and rapid way for detecting analytes such as chemical and/or biological analytes and may be useful in numerous applications including sensing, food manufacturing, medical diagnostics, performance materials, dynamic lenses, water monitoring, environmental monitoring, detection of proteins, detection of DNA, among other applications. For example, the systems and methods described herein may be used for determining the presence of a contaminant such as bacteria (e.g., detecting pathogenic bacteria in food and water samples which helps to prevent widespread infection, illness, and even death). Advantageously, the systems and methods described herein may not have the drawbacks in current detection technologies including, for example, relatively high costs, long enrichment steps and analysis times, and/or the need for extensive user training.Type: GrantFiled: December 8, 2021Date of Patent: August 13, 2024Assignee: Massachusetts Institute of TechnologyInventors: Timothy Manning Swager, Hadley Sikes Johnson, Qifan Zhang, Eric Alexander Miller, Lukas Zeininger, Ki-Joo Sung, Kosuke Yoshinaga
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Patent number: 12000853Abstract: An automated computer-controlled sampling system and related methods for collecting, processing, and analyzing agricultural samples for various chemical properties such as plant available nutrients. The sampling system allows multiple samples to be processed and analyzed for different analytes or chemical properties in a simultaneous concurrent or semi-concurrent manner. Advantageously, the system can process soil samples in the “as collected” condition without drying or grinding. The system generally includes a sample preparation sub-system which receives soil samples collected by a probe collection sub-system and produces a slurry (i.e. mixture of soil, vegetation, and/or manure and water), and a chemical analysis sub-system which processes the prepared slurry samples for quantifying multiple analytes and/or chemical properties of the sample. The sample preparation and chemical analysis sub-systems can be used to analyze soil, vegetation, and/or manure samples.Type: GrantFiled: January 7, 2021Date of Patent: June 4, 2024Assignee: Precision Planting LLCInventors: Todd Swanson, Dale Koch, Hayden Splechter, Timothy Schaefer
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Patent number: 11988601Abstract: A method and process for determining the propensity of elastomeric articles to discolor or stain is provided. The elastomeric articles tested are generally crosslinked elastomeric articles containing accelerators, such as carbamates. Residual carbamates can cause staining when contacted with metal ions, such as copper. Tests are disclosed for determining the propensity of the elastomeric articles to stain or discolor. The process can include remediation steps for preventing future articles from staining.Type: GrantFiled: June 8, 2020Date of Patent: May 21, 2024Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Priyadarshini Gadgil, Alison S. Bagwell, Maurice Thompson, Zamsari Bin Zakaria, Sumsuriya Beraheng
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Patent number: 11988608Abstract: A method for determining the presence of an acidic sulfide species in a liquid sample of an industrial or environmental material. The method includes the step of contacting the sample or an extract thereof with a composition including a metal complex dye compound in which the electromagnetic absorption spectrum of the metal complex dye compound changes upon reaction with an acidic sulfide species.Type: GrantFiled: August 6, 2018Date of Patent: May 21, 2024Assignee: INNOSPEC LIMITEDInventor: Philip Maltas