Patents Examined by Arlen Soderquist
  • Patent number: 10466180
    Abstract: The present invention relates to a logic gate, comprising a metamaterial surface enhanced Raman scattering (MetaSERS) sensor, comprising (a) alphabetical metamaterials in the form of split ring resonators operating in the wavelength range of from 560 to 2200 nm; and (b) a guanine (G) and thymine (T)-rich oligonucleotide that can, upon presence of potassium cations (K+), fold into a G-quadruplex structure, and in presence of Hg2+, form a T-Hg2+-T hairpin complex that inhibits or disrupts the G-quadruplex structure formed in presence of K+, as well as methods of operating and using such a logic gate.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: November 5, 2019
    Assignee: Nanyang Technological University
    Inventors: Qihua Xiong, Cuong Cao, Jun Zhang
  • Patent number: 10444154
    Abstract: A substance detection method includes exposing a sensor chip for surface-enhanced Raman scattering having a metal microstructure and an organic molecular modification film which modifies the metal microstructure to a first gas, irradiating a first region of the sensor chip exposed to the first gas with first laser light, performing first measurement by acquiring the intensity of Raman scattered light from the first region, blocking the first laser light after the performing the first measurement, and adjusting an irradiation region where the sensor chip is irradiated with the first laser light from the first region to a second region which is different from the first region of the sensor chip after the blocking the first laser light.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: October 15, 2019
    Assignee: Seiko Epson Corporation
    Inventor: Kohei Yamada
  • Patent number: 10444229
    Abstract: This invention provides a method for measuring insulin resistance of a test subject, and a composition suitably used for the method. A method for measuring insulin resistance of a test act comprising steps (a) and (b) below, the method using a composition for measuring insulin resistance comprising, as an active ingredient, a C12-38 fatty acid labeled with at least one isotope of C, wherein the C12-38 fatty acid is converted in the body into labeled carbon dioxide that is excreted in expired air, (a) intravenously administering the composition to a test subject and collecting expired air; and (b) determining the ratio of labeled CO2 amount to unlabeled CO2 amount contained in the expired air or the ratio of labeled CO2 amount to total CO2 amount contained in the expired air.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: October 15, 2019
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Makoto Inada, Jun-ichi Kunizaki, Kazuki Tobita, Hiroshi Motonari, Tetsuya Sato
  • Patent number: 10436803
    Abstract: Methods are described for determining the amount of insulin in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying insulin in a biological sample utilizing purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: October 8, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Zhaohui Chen, Nigel Clarke
  • Patent number: 10422780
    Abstract: A sensing electrode, and an electrochemical system and method utilizing same for detecting peroxide-containing compounds in a sample, are provided. The sensing electrode is a carbon electrode having ions of a metal that promotes decomposition of a peroxide absorbed to its surface, optionally along with a solid electrolyte membrane.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: September 24, 2019
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Fernando Patolsky, Vadim Krivitsky, Boris Filanovsky
  • Patent number: 10416181
    Abstract: Cradles for draining liquid from containers are described herein. An example apparatus includes a housing having a bottom wall, a side wall and an open top. The housing is to receive a container having liquid. The example apparatus includes a probe extending upward from the bottom wall toward the open top and is to drain the liquid from the container when the probe is inserted into the container. The example apparatus also includes a sliding lock slidably disposed within the housing that receives a cap or top of the container when the container is inserted into the housing. The sliding lock includes a key slot. The sliding lock is movable when a cap or top of the container has a matching key that engages the key slot, which enables the sliding lock to move downward to expose the probe and drain the liquid from the container.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: September 17, 2019
    Inventor: Roger W. Accurso
  • Patent number: 10330603
    Abstract: A highly portable, paper and swab-based detection kit is provided for identifying chemical and biological agents. A method of mass manufacture providing low cost kits with long term commercial shelf life and a method of use is also provided.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: June 25, 2019
    Inventor: Michael D. Callahan
  • Patent number: 10315133
    Abstract: The present invention relates to a method for separating viruses from a contaminant-containing liquid medium using two adsorbents having cationic groups, wherein the viruses are adsorbed to the first adsorbent and subsequently eluted and wherein the contaminants present in the resulting eluate are subsequently adsorbed to the second adsorbent. The yield and purity of the viruses obtained as per the method according to the invention is increased by the addition of multivalent anions during the adsorption of the contaminants to the second adsorbent.
    Type: Grant
    Filed: August 16, 2011
    Date of Patent: June 11, 2019
    Inventors: Rene Faber, Martin Leuthold
  • Patent number: 10307757
    Abstract: An automatic analyzer cartridge, spinnable around a rotational axis, has aliquoting and metering chambers, a connecting duct there between, and a vent connected to the metering chamber and nearer to the rotational axis than the metering chamber. The metering chamber has side walls that taper away from a central region. Capillary action next to the side walls is greater than in the central region. A circular arc about the rotational axis passes through a duct entrance in the aliquoting chamber and a duct exit in the metering chamber. The cartridge has a downstream fluidic element which is part of a fluidic structure for processing a biological sample into the processed biological sample. A valve connects the metering chamber to the fluidic element, which is fluidically connected to the fluidic structure. The fluidic structure receives the biological sample and has a measurement structure for enabling measurement of the processed biological sample.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: June 4, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Christoph Boehm, Sascha Lutz, Juergen Spinke
  • Patent number: 10309901
    Abstract: A process of utilizing a water-sensitive fluorophore for moisture content evaluation in a hygroscopic polymer includes forming a blend that includes a hygroscopic polymer resin and a water-sensitive fluorophore. The process includes forming pellets having a particular geometry from the blend, determining fluorescence properties of at least one of the pellets, and determining moisture content of at least one of the pellets. The process also includes generating a calibration curve for the particular pellet geometry by correlating the fluorescence properties with the moisture content. The process further includes providing the calibration curve for non-destructive moisture content evaluation of a material derived from the pellets.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: June 4, 2019
    Assignee: International Business Machines Corporation
    Inventors: Eric J. Campbell, Sarah K. Czaplewski, Joseph Kuczynski, Timothy J. Tofil
  • Patent number: 10302608
    Abstract: A system and method for non-destructive testing of a monolith catalyst element includes a a piping arrangement located above and below the element that seals against a portion of the element. A test fluid passes between the piping and therefore through the portion of the sealed catalyst section. Ports located in the piping allow for sampling of the fluid before and after the catalyst section. The catalyst element may then be repositioned for testing of a second portion of the element.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: May 28, 2019
    Assignee: Catalytic Combustion Corporation
    Inventors: John W. Robinson, Jr., Don R. Verdegan, Mike J. Werner, Mark Sokolowski
  • Patent number: 10293276
    Abstract: A phase separator and associated method for removal of water from a sample containing analytes in an organic solvent including a vertically extending body portion for vertical extension into a receptacle, the body portion including at least one vertically extending membrane portion on at least one side thereof and a port for introduction of solvent.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: May 21, 2019
    Inventors: William R. Jones, David P. Cross, Lewis B. Chesno
  • Patent number: 10295554
    Abstract: Some embodiments of a blood coagulation testing system include an analyzer console device and a single-use components configured to releasably install into the console device. In some embodiments, the blood coagulation testing system can operate as an automated thromboelastometry system that is particularly useful, for example, at a point-of-care site. The systems can be configured with features such as individual actuation systems for each measurement module, and firmware for initial and ongoing calibration and error detection.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: May 21, 2019
    Assignee: C A Casyso GmbH
    Inventors: Kevin Bels, Christian Brantl, Johannes Wittmann
  • Patent number: 10241047
    Abstract: The invention relates to a method for analysing a sample comprising at least a first and a second scale inhibitor, which scale inhibitors are synthetic organic compounds comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample interact with a reagent comprising lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement. The total concentration of the first and the second scale inhibitor is determined by using the detected sample signal, and the concentration of the first scale inhibitor in the sample is determined. The concentration of the second scale inhibitor is determined mathematically by using the obtained results for the total concentration and for the first scale inhibitor concentration.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: March 26, 2019
    Assignee: Kemira Oyj
    Inventors: Vesa Nuutinen, Susanna Toivonen, James Johnstone, Harri Härmä, Mirva Lehmusto, Satu Tiittanen, Pave Väisänen, Joonas Siivonen, Paul Mundill
  • Patent number: 10227694
    Abstract: A molecular sensor includes a substrate defining a substrate plane, and a plurality of pairs of electrode sheets above or below the substrate at an angle to the substrate plane. The molecular sensor further includes a plurality of inner dielectric sheets between each electrode sheet in each pair of electrode sheets of the plurality of pairs, and an outer dielectric sheet between each pair of electrode sheets of the plurality of pairs.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: March 12, 2019
    Assignee: Roswell Biotechnologies, Inc.
    Inventors: Sungho Jin, Barry L. Merriman, Tim Geiser, Chulmin Choi, Paul Mola
  • Patent number: 10228382
    Abstract: A fluid transport system for an automated slide treatment apparatus having slide treatment modules is disclosed. The fluid transport system including a fluid dispensing robot configured by a controller to dispense a plurality of reagents to slides received in the slide treatment modules. The fluid dispensing robot includes pumping means configured by the controller to pump the reagents to be dispensed from a plurality of corresponding reagent containers; a probe having a body arranged to store one or more of the reagents pumped via the pumping means so as to prime the probe with said one or more of the reagents to be dispensed; and a well disposed on the body of the probe to store further of the reagents primed to be dispensed.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: March 12, 2019
    Inventors: Mark Brian Dockrill, Martin Limon, Michael Houston Drummond, Mark Wilcock, Brendyn Rodgers
  • Patent number: 10222345
    Abstract: An acetic acid gas sensor based on an azobenzene compound includes an interdigital electrode and a coating material. The coating material is an azobenzene compound of formula I. The coating material is plated on the interdigital electrode through a vacuum coating process, and a thickness of the coating material is 100-200 nm.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: March 5, 2019
    Inventors: Jianmei Lu, Jinghui He
  • Patent number: 10217619
    Abstract: A method for mass spectral analysis of a sample containing a plurality of biomolecule species comprises: (a) mass analyzing a plurality of first-generation ion species generated from a sample portion; (b) automatically recognizing, for each of at least one biomolecule species, a respective subset of m/z ratios corresponding to respective first-generation ion species generated from the each biomolecule species; (c) selecting, from each recognized subset, a single representative m/z ratio; (d) isolating a sub-population of ions having each representative m/z ratio from ions having other m/z ratios; and (e) fragmenting each isolated sub-population of ions so as to generate second-generation ion species.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: February 26, 2019
    Inventors: Ping F. Yip, James L. Stephenson, Jr., Oksana Gvozdyak
  • Patent number: 10202577
    Abstract: Microfluidic devices are described that include a microfluidic channel, a first array of one or more magnets above the microfluidic channel, each magnet in the first array having a magnetic pole orientation opposite to a magnetic pole orientation of an adjacent magnet in the first array, and a second array of one or more magnets beneath the microfluidic channel, each magnet in the second array having a magnetic pole orientation opposite to a magnetic pole orientation of an adjacent magnet in the second array. The first array is aligned with respect to the second array such that magnetic fields emitted by the first array and second array generate a magnetic flux gradient profile extending through the channel. An absolute value of the profile includes a first maximum and a second maximum that bound a local minimum. The local minimum is located within the microfluidic channel or less than 5 mm away from a wall of the microfluidic channel. Methods of using the new devices are also described.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: February 12, 2019
    Assignee: The General Hospital Corporation
    Inventors: Philipp S. Spuhler, Kyle C. Smith, Fabio Fachin, Thomas Alan Barber, Ravi Kapur, Mehmet Toner, Vincent Pai, Murat N. Karabacak
  • Patent number: 10184097
    Abstract: A method of creating a protective coating on an alkali metal hydroxide-containing solid is provided. The method includes providing carbon dioxide to an alkali metal hydroxide-containing solid and allowing the alkali metal hydroxide and carbon dioxide to react thereby forming a carbonate or bicarbonate-containing layer on the exterior of the solid wherein the carbonate or bicarbonate-containing layer is non-hygroscopic and water soluble, and wherein greater than 80% of the hydroxide in the hydroxide-containing solid does not react with the carbon dioxide, and further wherein the alkali metal hydroxide-containing solid is substantially free of lithium hydroxide. A method of testing for the presence of carbonate-containing coating on an alkali metal hydroxide containing solid is also provided. The method includes exposing the coated solid to 95 weight percent ethanol, collecting the ethanol effluent and testing the effluent for alkali metal hydroxide.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: January 22, 2019
    Assignee: Ecolab USA Inc.
    Inventors: Kim R. Smith, Mark P. Peterson, Keith E. Olson