Patents Examined by Arlen Soderquist
  • Patent number: 11327065
    Abstract: The present invention relates to a process for the preparation of angiotensin receptor blockers or its pharmaceutically acceptable salts thereof containing less than 10 ppm of the azido impurities.
    Type: Grant
    Filed: August 27, 2021
    Date of Patent: May 10, 2022
    Inventors: Saji Thomas, Rajendra Shekhawat, M. Umamaheshwar Prasad, Bidyut Biswas, Rohit Chakravarthy, Chetan Balubhai Patel, Anilkumar Haribhat Lingabhat, Mohan Chikmagalur Sadashivappa, Indranil Nandi
  • Patent number: 11325117
    Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: May 10, 2022
    Inventors: Christopher S. Ronsick, Mark S. Wilson, John D. Walsh, Kirk Ririe, Ryan T. Hill
  • Patent number: 11325120
    Abstract: This specimen treatment chip includes: a first fluid module having a first flow channel for performing a first treatment step on an object component in a specimen; a second fluid module having a second flow channel for performing a second treatment step on the object component subjected to the first treatment step; a substrate; and a connection flow channel for connecting the first fluid module and the second fluid module disposed on the substrate.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: May 10, 2022
    Inventors: Ayato Tagawa, Tsuyoshi Nakano, Yasuko Kawamoto, Koya Yamawaki, Hiroaki Tobimatsu
  • Patent number: 11313803
    Abstract: An OH radical detection probe (102) includes an aromatic carboxylic acid, a polar aprotic organic solvent, and a polar protic organic solvent.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: April 26, 2022
    Inventors: Takao Kurata, Katsumi Takahashi, Kazuyuki Sakamoto
  • Patent number: 11313730
    Abstract: An ascending/descending indicator can include a sealed housing that contains a deep eutectic solvent (DES) within the housing. The DES can include two or more components and is configured to exhibit a first characteristic when at a first temperature and to assume a second characteristic when exposed to a second temperature and to substantially maintain the second characteristic even when again exposed to the first temperature.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: April 26, 2022
    Inventors: Mohannad Abdo, John Newport, John Olson
  • Patent number: 11293936
    Abstract: Cradles for draining liquid from containers are described herein. An example apparatus includes a housing having a bottom wall, a side wall and an open top. The housing is to receive a container having liquid. The example apparatus includes a probe extending upward from the bottom wall toward the open top and is to drain the liquid from the container when the probe is inserted into the container. The example apparatus also includes a sliding lock slidably disposed within the housing that receives a cap or top of the container when the container is inserted into the housing. The sliding lock includes a key slot. The sliding lock is movable when a cap or top of the container has a matching key that engages the key slot, which enables the sliding lock to move downward to expose the probe and drain the liquid from the container.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: April 5, 2022
    Assignee: Abbott Laboratories
    Inventor: Roger W. Accurso
  • Patent number: 11286771
    Abstract: The present disclosure provides methods for determining surfactant retention values in subterranean reservoirs. In particular, the methods comprise conducting at least one single well chemical tracer test and performing a straight line analysis on a saturation profile of the subterranean reservoir.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: March 29, 2022
    Assignee: ConocoPhillips Company
    Inventors: Gaoming Li, Riley B. Needham, Sriram Solairaj
  • Patent number: 11287403
    Abstract: A permeative amine/acid introduction device (PAID) is placed after a conventional KOH eluent suppressed conductometric anion chromatography (SCAC) system. The PAID converts the suppressed eluites from the acid form to the corresponding salt. For example, when the analytes are acids, they are converted to the corresponding ammonium salt (NR2H+HX?NR2H2++X?) and allows very weak acids HX (pKa?7.0) that cannot normally be detected by SCAC to be measured by a second conductivity detector following the PAID. Permeative reagent introduction is dilutionless, can be operated without pumps and provides good mixing with low band dispersion (as small as 30 ?L). An exemplary amine is diethylamine (DEA), which was chosen as the amine source due to its low pKb value (pKb 3.0), high vapor pressure, and low toxicity and low odor.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: March 29, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Purnendu K. Dasgupta, Charles Phillip Shelor, Hongzhu Liao
  • Patent number: 11249060
    Abstract: The present invention relates to a method for quantitatively analyzing Cl, remaining after synthesis, in zinc ferrite synthesized using chloride precursors such as zinc chloride and iron chloride, and provides a method capable of using, in a quantitative analysis method of Cl remaining after synthesis of an inorganic material, AQF-IC, which has been used only in the quantitative analysis of an organic sample since gaseous Cl, discharged after burning zinc ferrite in an automatic quick furnace (AQF) by using an Sn capsule and tungsten oxide (WO3), is analyzed through ion chromatography (IC).
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: February 15, 2022
    Inventors: Sangwoo Kim, Hyun Kyung Yoon, Sumin Na, Jieun Kim, Hyun Woo Nho
  • Patent number: 11243184
    Abstract: Various bioFET sensor readout circuits and their methods of operation are described. A readout circuit includes a plurality of logic gates coupled in cascade, a delay extractor, and a counting module. Each logic gate of the plurality of logic gates includes at least one bioFET sensor. The delay extractor is designed to generate a pulse-width signal based on a time difference between an output signal from the plurality of logic gates and a reference signal. The counting module is designed to receive the pulse-width signal and output a digital count corresponding to a width of the pulse-width signal.
    Type: Grant
    Filed: December 31, 2019
    Date of Patent: February 8, 2022
    Inventors: Yu-Jie Huang, Jui-Cheng Huang
  • Patent number: 11231360
    Abstract: A titration system is disclosed for determining content of an analyte in a sample. The titration system comprises: a controller; a reaction vessel; a titration vessel and an indicator vessel in fluid communication with the reaction vessel; a spectroscopy unit; a sensor for outputting a signal to the controller based on a force exerted by the reaction vessel on the sensor. The controller executes a stored program to: (i) perform titration by delivering to the reaction vessel a first mass of a first fluid comprising the sample, a second mass of a second fluid comprising indicator, and a third mass of a third fluid comprising titrant; (ii) detect color change in the mixture in the reaction vessel based on a signal from the spectroscopy unit and stop titration; and (iii) calculate content of the analyte in the sample based on the first mass, the second mass, and the third mass.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: January 25, 2022
    Inventor: Andy Kenowski
  • Patent number: 11226322
    Abstract: Gas analyzer and method for measuring nitrogen oxides in an exhaust gas, wherein to measure the nitrogen oxides, ozone is generated from oxygen, the exhaust gas is treated with the ozone generated to convert nitrogen monoxide within the exhaust gas into nitrogen dioxide, the nitrogen dioxide concentration in the treated exhaust gas is measured photometrically using a first light-emitting diode which emits with a central wavelength between 350 nm and 500 nm and output as the nitrogen oxide concentration in the exhaust gas, and the ozone concentration in the treated exhaust gas is measured photometrically using a second light-emitting diode which emits with a central wavelength between 250 nm and 265 nm, where generation of the ozone using the measured ozone concentration as an actual value is regulated to a prespecified setpoint value to enable reliable continuous measurement of nitrogen oxides in exhaust gases with a low outlay on equipment.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: January 18, 2022
    Assignee: Siemens Aktiengesellschaft
    Inventors: Camiel Heffels, Daniel RoƟfeld
  • Patent number: 11179718
    Abstract: Embodiments of the present disclosure pertain to a colorimetric system for detecting a substance, the colorimetric system that includes a first chemical container adapted for releasing a first chemical; a second chemical container adapted for releasing a second chemical; a flow modulation sheet adjacent each chemical container; and an encapsulation covering the flow modulation sheet and each chemical container, where the encapsulation comprises a window defining a target area of the filter paper such that the target area is adapted for applying the substance; where the flow modulation sheet comprises a design adapted for automatically controlling a first flow of the first chemical and a second flow of the second chemical to the target area after simultaneously releasing the first and second chemicals; and where the design comprises a first void disposed in the flow modulation sheet.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: November 23, 2021
    Assignee: DetectaChem, Inc.
    Inventors: Mark A. Kisner, Travis R. Kisner
  • Patent number: 11155779
    Abstract: Microfluidic devices are described that include a microfluidic channel, a first array of one or more magnets above the microfluidic channel, each magnet in the first array having a magnetic pole orientation opposite to a magnetic pole orientation of an adjacent magnet in the first array, and a second array of one or more magnets beneath the microfluidic channel, each magnet in the second array having a magnetic pole orientation opposite to a magnetic pole orientation of an adjacent magnet in the second array. The first array is aligned with respect to the second array such that magnetic fields emitted by the first array and second array generate a magnetic flux gradient profile extending through the channel. An absolute value of the profile includes a first maximum and a second maximum that bound a local minimum. The local minimum is located within the microfluidic channel or less than 5 mm away from a wall of the microfluidic channel. Methods of using the new devices are also described.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: October 26, 2021
    Assignee: The General Hospital Corporation
    Inventors: Philipp S. Spuhler, Kyle C. Smith, Fabio Fachin, Thomas Alan Barber, Ravi Kapur, Mehmet Toner, Vincent Pai, Nezihi Murat Karabacak
  • Patent number: 11156615
    Abstract: The present subject matter provides glucose biosensors as well as compositions, devices, and methods comprising such biosensors.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: October 26, 2021
    Assignee: Duke University
    Inventors: Homme W. Hellinga, Malin J. Allert
  • Patent number: 11156621
    Abstract: Disclosed are methods and systems to determine a subject's metabolic vulnerability index (MVX) score using at least one defined mathematical model of risk. The methods comprise evaluating various biomarkers to distinguish various health risks. In one embodiment, the method comprises evaluating biomarkers to determine a relative risk of premature all-cause mortality. The model may include NMR-derived measurements of GlycA, S-HDLP, branched chain amino acids (BCAAs), ketone bodies, total serum protein, and citrate in at least one biosample of the subject.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: October 26, 2021
    Assignee: LipoScience, Inc.
    Inventors: James D. Otvos, Irina Y. Shalaurova
  • Patent number: 11150243
    Abstract: A device for receiving and analysing a sample, wherein the analysing involves use of a solution. The device comprises: a sample receiving portion for receiving a sample to be analysed; and a solution capsule having a sealed configuration in which the solution capsule is sealed and a release configuration in which contents of the solution capsule are released via a flow path that provides fluid communication between the solution capsule and the sample receiving portion. The device further comprises a bistable release mechanism comprising an actuator wherein the bistable release mechanism releases only in the event that a force applied to the actuator reaches a threshold force and wherein actuation of the actuator results in one-way conversion of the solution capsule from the sealed configuration into the release configuration.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: October 19, 2021
    Inventors: Jonathan Johnson, Mark Hudson
  • Patent number: 11142692
    Abstract: In various embodiments the present disclosure provides a core/shell nanocrystal comprising a core and a shell formed on the core, wherein the core/shell nanocrystal is co-doped with at least one metal dopant and at least one trivalent cation. In some embodiments, the trivalent cation is a Group 13 element. Methods of making and using the core/shell nanocrystal are also described.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: October 12, 2021
    Assignee: The Regents of the University of California
    Inventors: Jin Z. Zhang, Jason K. Cooper, Sheraz Gul
  • Patent number: 11131660
    Abstract: To measure above-saturation water content of hydrocarbons, a liquid hydrocarbon sample is received from a flowline carrying the liquid hydrocarbon. The liquid hydrocarbon sample includes liquid hydrocarbon and liquid water at a concentration greater than a water saturation level. The liquid hydrocarbon sample is mixed with a solvent. The concentration of liquid water in a mixture of the solvent and the liquid hydrocarbon sample is below the water saturation level. After mixing the liquid hydrocarbon sample with the solvent, a water content in the liquid hydrocarbon sample is determined.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: September 28, 2021
    Assignee: Saudi Arabian Oil Company
    Inventors: Elaf A. Ahmed, Sebastien A. Duval, Simone Less
  • Patent number: 11105742
    Abstract: Disclosed are nucleated red blood cell warning devices and methods, and flow cytometers using the same. The devices, methods and flow cytometers can warn whether nucleated red blood cells exist in a blood sample. The warning device may obtain forward-scattered light information, side-scattered light information and fluorescence information when cells in the blood sample pass through a detection region of the flow cytometer. The warning device may generate a side-scattered light-fluorescence dot plot, so as to classify leucocytes into four groups, and may generate a forward-scattered light-fluorescence dot plot, where the forward-scattered light-fluorescence dot plot can include a leucocyte group region. The warning device may obtain a predetermined feature region located at the left side of the leucocyte group region, perform statistics on the amount of characterization cells in the predetermined feature region, and provide a warning when the number of the characterization cells exceeds a threshold value.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: August 31, 2021
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Bo Ye, Huan Qi, Cheng Qian