Abstract: Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can include immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis, maceration, and/or removal.

Abstract: Methods and devices for ophthalmic tissue closure and fixation of ophthalmic prostheses are provided. In accordance with some embodiments, devices for both grasping and clipping a plurality of ocular tissue and ocular prostheses are provided. Various device embodiments are provided for both malleable clips and delivery of normally closed clips (i.e. shape memory). The device may accommodate a plurality of clips which include, but are not limited to: malleable metals, absorbable, shape memory, drug-eluting, and adhesive dispensing. The clips may be pigmented to match the colors of associated tissue (cornea, iris, conjunctiva, sclera, retina) to serve to camouflage fixation clips for healing duration or permanently. According to one aspect, shallow angle access to anatomy may be provided by specialized angulation of device shaft and closure jaws that are intended to access the eye through a small self-healing cornea incision and/or any ocular tissue.

Abstract: A low profile intraluminal filter includes first and second wire members that define arcuate paths having only a single sigmoidal curve. Connectors join the wire members to form an opening between the wire members. Each connecting member of a plurality of connecting members is connected to the first and second wire members and extends across the opening. The plurality of connecting members provides a plurality of open cells that permit passage of fluid flow through the opening when the filter is deployed within a body vessel.

Abstract: The invention is a system and method for accurately positioning a prosthetic valve such as a prosthetic heart valve at a desired position for deployment. The invention includes extendable positioning elements which provide tactile feedback to a user to confirm proper positioning of the catheter with respect to the native valve annulus. During delivery, the extendable positioning elements lie against the catheter, over the prosthetic valve and expandable balloon, providing a low profile for advancing the catheter to the desired treatment location via small passages such as body lumens. Prior to valve deployment, the positioning elements are extended and brought into contact with tissue of the native annulus to confirm the proper positioning of the delivery system and prosthetic valve.

Abstract: Methods and devices for diagnosing, monitoring, and/or treating tissue through an opening or port through an airway wall are provided herein.

Abstract: A suture management device includes a handle defining a first elongate channel. The first elongate channel extends about a longitudinal circumference of the handle. A shaft extends distally from the handle. A suture anchor is coupled to a distal end of the shaft. A suture is configured to extend from the suture anchor proximally along the shaft and into the first elongate channel defined by the handle. A door integrally can be formed with the handle. The suture extends into an area between the door and the handle. The door is configured to maintain tension on the suture when in a closed position.

Abstract: An endoluminal needle or punch is describes wherein the distal end of the endoluminal needle is able to articulate laterally out of the longitudinal axis of the steerable endoluminal needle. The endoluminal needle further comprise a blunted distal end configuration that is minimally traumatic. Under control by the user, at the proximal end of the endoluminal needle, a sharp stylet can be advanced to punch tissue and then be retracted to maximize safety. The endoluminal needle is configured for use within an introducer.

Abstract: A surgical instrument comprising a transducer configured to produce vibrations along a longitudinal axis. The surgical instrument further comprises an ultrasonic blade extending along the longitudinal axis. The ultrasonic blade is coupled to the transducer and comprises a body and a treatment region. The body comprises a proximal end, a distal end, and a bottom surface. The distal end of the body is movable relative to the longitudinal axis by the vibrations produced by the transducer. The treatment region extends from the proximal end to the distal end. The surgical instrument further comprises a protective sheath disposed adjacent to the bottom surface of the ultrasonic blade.

Abstract: A surgical cutting instrument comprises an outer tubular member having a proximal section, an intermediate section and a central lumen. An inner tubular member is rotatably received within the central lumen and includes a distal end forming a cutting member extending distally beyond, and exposed relative to, the distal section of the outer tubular member. A bearing assembly is coupled to the outer tubular member and the inner tubular member.

Abstract: Less invasive surgical techniques for performing brain surgery are disclosed in which a dilating obturator and cannula assembly is inserted into brain tissue until the obturator tip and cannula are adjacent to the target tissue. The obturator is removed and surgery is performed through the cannula. In preferred embodiments the obturator and cannula are placed using image guidance techniques and systems to coordinate placement with pre-operative surgical planning. A stylet with associated image guidance may be inserted prior to insertion of the obturator and cannula assembly to guide insertion of the obturator and cannula assembly. Surgery preferably is performed using an endoscope partially inserted into the cannula with an image of the target tissue projected onto a monitor. Dilating obturator structures having a rounded or semi-spherical tip and/or an optical window for visualizing brain tissue during expansion are contemplated.

Abstract: Less invasive surgical techniques for performing brain surgery are disclosed in which a dilating obturator and cannula assembly is inserted into brain tissue until the obturator tip and cannula are adjacent to the target tissue. The obturator is removed and surgery is performed through the cannula. In preferred embodiments the obturator and cannula are placed using image guidance techniques and systems to coordinate placement with pre-operative surgical planning. A stylet with associated image guidance may be inserted prior to insertion of the obturator and cannula assembly to guide insertion of the obturator and cannula assembly. Surgery preferably is performed using an endoscope partially inserted into the cannula with an image of the target tissue projected onto a monitor. Dilating obturator structures having a rounded or semi-spherical tip and/or an optical window for visualizing brain tissue during expansion are contemplated.

Abstract: The present disclosure relates to a loop vascular device and a method to retrieve said device from the body vessel of a patient. The loop vascular device comprises a loop having a first portion extending distally to a splitting portion, and a second portion also extending distally to the splitting portion, defining a close state of the loop. The splitting portion may be split such that the first portion is separated from the second portion when in the body vessel, defining an open state of the loop. In the open state, the loop may be easily retrieved through ingrowth in the body vessel, reducing or eliminating possible negative effects to the vessel wall.

Abstract: A trocar adapted for insertion through a fascia layer of an abdominal wall, comprising a proximal end configured for handling by a user; a distal end configured for insertion into tissue; and a shaft extending in between the proximal end and distal end, wherein the shaft comprises a narrow portion proximal to the distal end, the narrow portion defining at least one recess shaped and sized to receive fascia tissue, the recess ending, at a distal end, with a generally proximally facing surface of the shaft configured directly below the narrow portion, the proximally facing surface and the narrow portion shaped and sized to stabilize the trocar in the abdominal wall by the fascia. In some embodiments, a trocar and external cannula assembly are provided. In some embodiments, the trocar and/or trocar and external cannula assembly are configured for deployment of one or more anchors and/or sutures in the tissue.

Abstract: A surgical tool system with a handpiece and a cutting accessory that has inner and outer hubs. The handpiece has a spring biased lock ring that abuts a complementary stop member integral with the accessory outer hub to hold the accessory to the handpiece. An RFID chip is disposed against an inner wall of the accessory outer hub. An elastomeric seal pressed against the inner wall of the accessory outer hub provides environmental protection for the RFID chip. The seal has a rib that extends around the outer perimeter of the proximal end of the outer hub so as to form a seal between the accessory and an adjacent inner wall of the handpiece. Stop tabs extend inwardly from the seal to prevent the drive hub disposed inside the outer hub from falling out.

Abstract: A device for treating a diverticulum includes a containment device and a bushing. The containment device includes an elongate conduit. The bushing is in the conduit of the containment device. The bushing includes a heat-shrink material. The bushing has a first tubular shape including a first open end and a second open end. At least a portion of the diverticulum in an inverted state is positionable into the first open end. The bushing is configured to transform from the first tubular shape toward a second shape upon heating the heat-shrink material. The second shape includes at least a portion of the bushing radially inward relative to the first tubular shape. The bushing in the second shape is configured to hold the diverticulum in a radially compressed inverted state.

Abstract: Various devices are described to provide filtering of flow from the aorta to the left carotid artery and the right carotid artery. The filters can be brought into a desired position through one or more peripheral arteries. A single filter device can provide the desired filtering or a plurality of devices can be used. In particular a single filter device can span between the brachiocephalic artery and the left carotid artery. These filter devices can be used effectively to capture emboli generated during procedures on the heart so that emboli do not travel to the patient's brain where the emboli can cause a stroke or other adverse event. In particular, these filters can be used during percutaneous procedures on the heart, such as endovascular heart valve replacement.

Abstract: A suture management device comprises a handle defining at least a first door cavity, a shaft extending distally from the handle, and a suture anchor coupled to a distal end of the shaft. The suture anchor is configured to couple one or more sutures to a bone. A first releasable door is sized and configured to fit within the first door cavity. The first releasable door is releasably coupled to the handle. The first releasable door defining a suture channel extending longitudinally about the circumference of the releasable door. The suture channel is configured to receive the one or more sutures therein.

Abstract: The invention relates to an angioplasty device for treating stenoses or occlusions that facilitates the diagnosis and visualization of the stenosis and the treatment control having a duct dedicated to the injection of the contrast product.

Abstract: A stent is disclosed, which is formed in a cylindrical shape and has a cavity portion, and is freely switched between an expanded state and a contracted state where the stent contracts to a central axis (O) side from the expanded state. The stent has an anchor portion which protrudes to a central axis (O) side relative to an inner surface surrounding the cavity portion in the contracted state, and which is displaced to the inner surface side in the expanded state relative to a protruded position in the contracted state.

Abstract: Medical devices and related methods for closing a perforation in a bodily wall are provided. The medical device generally includes an introducer device having a base defining a plurality of recesses formed therein. Visceral staples are disposed within the recesses in a delivery state and are biased toward a deployed state. A holding mechanism retains the staples in the delivery state, and the holding mechanism is moveable relative to the base to allow the staples to extend out of the recesses. The biased nature of the staples will cause them to transition into the deployed state after the staples have been released, such that the staples will thereby pierce adjacent tissue and remain closed. The holding mechanism can be retractable or pivotable out of engagement with the staples. The introducer device can include upper and lower jaws or a slidable cover relative to the base.