Abstract: An exemplary system includes a photodetector configured to generate a plurality of photodetector output pulses over time as a plurality of light pulses are applied to and scattered by a target, a TPSF generation circuit configured to generate, based on the photodetector output pulses, a TPSF representative of a light pulse response of the target, and a control circuit configured to direct the TPSF generation circuit to selectively operate in different resolution modes.

Abstract: A method for manufacturing a blood pressure measurement cuff includes preparing an outer cloth, preparing an inner cloth, and forming a bag-shaped portion. The bag-shaped portion has an opening on a peripheral edge of the bag-shaped portion. A curler is inserted into the bag-shaped portion through the opening, the curler being flexible and configured to curve and conform to the measurement site. An air bladder is formed by welding the opening of the bag-shaped portion such that the air bladder surrounds an inner side and an outer side of the curler thereby containing the curler. The outer cloth is attached to an outer surface on a first side of the air bladder configured to be opposite to the measurement site, and the inner cloth is attached to an outer surface on a second side of the air bladder configured to be towards the measurement site.

Abstract: One aspect relates to a catheter system, a use of such catheter system and a manufacturing method for such catheter system. The catheter system includes an at least partially flexible catheter body, at least a ring electrode, and at least a strain gauge. The ring electrode surrounds at least a portion of the flexible catheter body. The strain gauge is allocated to the ring electrode and the strain gauge is configured to measure a deformation of the flexible catheter body at a position allocated to the ring electrode to detect a contact between the ring electrode and tissue.

Abstract: The systems and methods described herein determine metrics of cardiac or vascular performance, such as cardiac output, and can use the metrics to determine appropriate levels of mechanical circulatory support to be provided to the patient. The systems and methods described determine cardiac performance by determining aortic pressure measurements (or other physiologic measurements) within a single heartbeat or across multiple heartbeats and using such measurements in conjunction with flow estimations or flow measurements made during the single heartbeat or multiple heartbeats to determine the cardiac performance, including determining the cardiac output. By utilizing a mechanical circulatory support system placed within the vasculature, the need to place a separate measurement device within a patient is reduced or eliminated. The system and methods described herein may characterize cardiac performance without altering the operation of the heart pump (e.g., without increasing or decreasing pump speed).

Abstract: An aspect of the disclosure pertains to a blood pressure measurement device and methods of controlling an inflation rate in a blood pressure measurement. An inflatable bladder of the blood pressure measurement device defines, at least in part, a pressurizable volume. The inflatable bladder may be inflated to pressurize a user's appendage and temporarily occlude blood flow in the user's appendage. A pressure sensor of the blood pressure measurement device is configured to obtain blood pressure measurements, and a pump of the blood pressure measurement device is configured to inflate the inflatable bladder and control an inflation rate by controlling at least one of a duty cycle, a voltage, or a drive frequency.

Abstract: Systems configured to acquire temperature signals from an Abreu Brain Thermal Tunnel (ABTT), to analyze the temperatures signals, and to determine a condition of a human body from the analysis, and a method for doing the same, are described. In addition, systems for application of thermal signals to the ABTT for treatment of conditions are described.

Abstract: A blood pressure measurement cuff is a blood pressure measurement cuff to be attached such that it wraps around a measurement site and includes: a curler that is flexible and curves so as to naturally conform to the measurement site; an air bladder containing the curler due to being wrapped around the inner side and outer side of the curler; an inner cloth attached to an outer surface on the measurement site side of the air bladder; and an outer cloth attached to an outer surface on the side opposite to the measurement site of the air bladder.

Abstract: In various examples, an apparatus facilitates attachment of an extension wire to a guidewire. The apparatus includes a body portion including a lumen sized to accommodate a distal end of the extension wire therein. A cutout is defined within a portion of a sidewall of the body portion, the cutout allowing access to the lumen. A funnel portion is disposed within a distal end of the body portion and includes an opening in the distal end of the body portion. The funnel portion includes a tapered wall converging from the opening to the lumen, wherein, with the distal end of the extension wire disposed within the lumen, the funnel portion facilitates alignment and attachment of a proximal end of the guidewire with the distal end of the extension wire. In other examples, a system or a method facilitates attachment of an extension wire to a guidewire.

Abstract: A pressurizing/depressurizing section (4) performs at least one of air feeding to a cuff (20) by way of an air way (3) and air discharging by way of the air way (3) to thereby increase or decrease an internal pressure of the cuff (20). A first controlling section (5) causes the pressurizing/depressurizing section (4) to initiate the air feeding while performing the air discharging to thereby cause the internal pressure to transit from a pressure transient state to a pressure steady state or from the pressure steady state to the pressure transient state. A determining section (6) determines Whether the internal pressure has transited to the pressure steady state by way of the pressure transient state. A second controlling section (7) causes the pressurizing/depressurizing section (4) to suppress or stop the air discharging while continuing the air feeding, in accordance with determination made by the determining section (6).

Abstract: Disclosed are systems and methods for detecting analyte levels. These systems and methods may include a sensor configured for at least partial placement in an analyte-containing medium. The sensor may include one or more transducers and one or more diffusion barriers. The diffusion barriers may be arranged to delay diffusion of analyte to one transducer relative to another transducer. This delay may be used for purposes such as calculating and/or compensating for lag between a measured analyte level and a physiological analyte level of interest.

Abstract: A system and method is provided for monitoring the fetal position and/or orientation of the fetus of an expectant mother. An acoustic sensor array is positioned over the belly. The pattern of acoustic sensor signals is processed to determine a fetal orientation and/or to determine movement over time of the fetus.

Abstract: A system for evaluating blood flow in a vessel of a patient includes a catheter containing a first pressure sensor and a second pressure sensor and configured to simultaneously measure pressure data within a vessel on either side of a stenosis. Pressure data generated by the catheter includes a first series of pressure measurements from the first pressure sensor a second series of pressure measurements from the second pressure sensor. The system further includes an FFR calculation module executable on one or more processors and configured to calculate a stability index for each of two or more portions of the pressure data, wherein each stability index indicates at least one of heart rate stability and catheter stability for the respective portion of the pressure data. An optimal time window is identified based on the stability indexes for calculation of fractional flow reserve (FFR) based on the pressure data. An FFR value is then calculated based on the pressure data in the optimal time window.

Abstract: A catastrophe-theoretic approach is provided for predicting an occurrence of an acute inflammatory condition or event (e.g., SIRS or sepsis) for a human patient based on a time series of monitored vital signs values measured from a patient, and in some instances, for providing advanced notice to clinicians or caregivers when such an acute inflammatory event is forecasted or modifying treatment for the patient, according to the predicted likelihood. In particular, an acute inflammatory condition management system is provided for determining a likelihood of near-term future significant acute inflammation in human patients. Embodiments of the disclosure described herein may provide a forecasted risk for future significant acute inflammation within a time horizon comprising a future time interval. In one embodiment, the future time interval is from 30 min to approximately 8 hours into the future, and may be dependent on the frequency of vital signs measurements.

Abstract: An aspect of the disclosure pertains to detecting a position of a blood pressure measurement device. An inflatable bladder of the blood pressure measurement device defines, at least in part, a pressurizable volume. The inflatable bladder may be inflated to pressurize a user's appendage and temporarily occlude blood flow in the user's appendage. A pump may initiate inflation of the inflatable bladder when one or more accelerometers and/or one or more proximity sensors determine that the blood pressure measurement device is within sufficient proximity or elevation to a user's heart and stationary.

Abstract: A system and method to provide guidance for diabetes therapy includes determining glycemic risks based on an analysis of glucose data. The analysis includes visualization of a glucose median, the variability of glucose in a patient, and the risk of hypoglycemia. An Advanced Daily Patterns report includes a visualization of an ambulatory glucose profile and a glucose control measure. The glucose control measure provides a highly visible and understandable display of the glucose condition of a patient visually expressed in the categories of low glucose, median glucose, and glucose variability.

Abstract: A system and method provides a glucose report for determining glycemic risk based on an ambulatory glucose profile of glucose data over a time period, a glucose control assessment based on median and variability of glucose, and indicators of high glucose variability. Time of day periods are shown at which glucose levels can be seen. A median glucose goal and a low glucose line provide coupled with glucose variability provide a view into effects that raising or lowering the median goal would have. Likelihood of low glucose, median glucose compared to goal, and variability of glucose below median provide probabilities based on glucose data. Patterns can be seen and provide guidance for treatment.

Abstract: A guidewire-guiding device, and guidewire-guiding assembly. The device comprises a main guidewire channel and guidewire-guiding channels are respectively arranged in the guiding body. The main guidewire channel and the guidewire-guiding channels respectively pass through the guiding body along axial direction, and in-vivo end openings of the guidewire-guiding channels and the in-vivo end opening of the main guidewire channel are arranged along the axial direction at intervals. The guiding body may be imbedded into a vessel in-vivo via the main guidewire penetrating through the main guidewire channel, and as the in-vivo end openings of the guidewire-guiding channels are arranged along the axial direction at intervals, the to-be-guided guidewires enter the guidewire-guiding channels while being staggered to the main guidewire on the axial direction, therefore the problem of tanglement of the main guidewire the branch guidewires and other kinds of guidewires may be avoided.

Abstract: A system and method for determining the respiratory and other physiological status of a patient. Here, an oscillometric device is mounted on a patient's limb, and oscillometric pulse waveforms are obtained as the device's cuff deflates, thus obtaining pulse wave signals and artifact signals over multiple patient breaths. A computer processor analyzes these signals, and removes artifacts according to various algorithms. The resulting signal can be viewed as containing both an amplitude modulated envelope of pulse waves (AM signals) and a frequency modulated sequence of pulses at various time intervals (FM signals). The main harmonics of the AM and FM signals contain respiratory status data, and the system analyzes both signals. Breathing depth and even pain data may also be obtained by this method. Artifacts caused by aberrant breathing can be distinguished using non-contact microphones and suitable algorithms. The final respiratory status data is output or stored in memory.

Abstract: A method is provided for characterising a gait comprising steps of: receiving a signal measuring the movement of a target subject measured beforehand; comparing (204) at least one section of the measuring signal with a plurality of reference signals, the plurality of reference signals comprising at least one movement signal measured beforehand on a reference subject different from the target subject, each comparison of the measuring signal with a reference signal producing a similarity coefficient representative of a probability of similarity between the compared signals; and selecting (208) at least one local maximum of interest among the similarity coefficients produced, wherein the plurality of reference signals comprises at least one movement signal measured beforehand on a reference subject afflicted with a gait disorder, and at least one movement signal measured beforehand on a healthy reference object.

Abstract: An electronic blood pressure monitor of the present invention includes a blood pressure measurement cuff that is to be worn on a measurement site of a measurement subject. The electronic blood pressure monitor includes a blood pressure measurement unit that measures a blood pressure value of the measurement subject using the cuff. The electronic blood pressure monitor includes an external compression detection unit that detects whether or not there was external compression on the cuff during blood pressure measurement performed by the blood pressure measurement unit.