Abstract: A method of delivering a multi-phase fluid injection to a patient via a fluid injector comprising two or more syringes includes injecting a first fluid of the fluid injection from at least a first syringe at a first predetermined flow rate, wherein the first fluid has a first viscosity; injecting an initial portion of a second fluid from at least a second syringe at an intermediate flow rate different than a second predetermined flow rate for a specified time, the second fluid having a second viscosity different from the first viscosity; and injecting a remaining portion of the second fluid of the fluid injection at a flow rate at the second predetermined flow rate. A fluid injector system configured for delivering a multi-phase fluid injection is disclosed.

Abstract: A drug delivery device includes a housing, a fluid reservoir received within the housing, a drive assembly configured to dispense fluid from the fluid reservoir, a needle hub actuator attached to the housing, and a needle hub at least partially received by the housing. The needle hub includes a hub body, a needle holder with a needle attached to the needle holder, and a cannula holder with a cannula attached to the cannula holder. The needle hub actuator is configured to move the needle holder and the cannula holder from a retracted position where the needle and the cannula are positioned within the hub body to an insertion position where the needle and the cannula are positioned within the hub body. The needle hub is detachable from the housing.

Abstract: An activation mechanism for an on-body medicament delivery device, wherein the activation mechanism comprises: an activation button structure configured to be moved between an initial position and an activation position, an activation pin sleeve, and a biased activation pin received by the activation pin sleeve, the activation pin being configured to be linearly movable from an initial retracted position relative to the activation pin sleeve to an extended position towards which the activation pin is biased, the activation button structure being configured to interact with the activation pin sleeve in the initial position to cause the activation pin sleeve to engage with and maintain the activation pin in the retracted position, and wherein the activation button structure is configured to interact with the activation pin sleeve when the activation button structure is moved linearly towards the activation position causing the activation pin sleeve to release the activation pin from the retracted position.

Abstract: An intravenous (IV) catheter system may include a catheter adapter having a proximal end and a distal end. The IV catheter system may also include a cannula extending through the catheter adapter. A proximal end of the cannula may include a notch. The IV catheter system may also include a needle hub, which may be coupled to the proximal end of the catheter adapter. The needle hub may include a flashback chamber, which may be in fluid communication with the notch when the IV catheter system is in an insertion configuration.

Abstract: The invention relates to an automatic drug delivery device (10), in particular automatic drug delivery device, for dispensing a fluid product, in particular a fluid medicament, including: a longitudinal housing (104) extending along a longitudinal axis and having a proximal end close to the dispensing site, a distal end opposite to the proximal end and a hollow interior; a removable cap (50) mountable to the proximal end of the housing (104); a syringe assembly (200) arranged a mounting position inside the housing (104) and having a hollow syringe body (204) and an injection needle (206) coupled to the hollow syringe body (204) including the fluid product; a drive mechanism (300) which can be triggered by a trigger element in order to initiate the dispensing of the fluid product; wherein the loaded drive mechanism is operatively coupled with a safety shield (102) movable within the longitudinal housing (104), wherein the safety shield (102) is biased into a proximal position in which it protrudes out of the p

Abstract: A leak detecting apparatus (1) for detecting a leak and determining the size of the leak in a suture repaired site (5) of a hollow organ (3), for example, a stomach, in a cavity (7), for example, the peritoneal cavity of a subject comprises a first insufflator (12) for insufflating the hollow organ (3) with a first gas, and a second insufflator (14) for insufflating the cavity (7) with a second gas. A gas detector (18) is provided for detecting the concentration of the first gas in gases exhausted from the cavity (7) through a communicating conduit (35). A flow meter (25) monitors the flow rate of the first gas to the hollow organ (3). First and second pressure sensors (15) and (16) monitor the static pressure of the first and second gases in the hollow organ (3) and the cavity (7), respectively. The apparatus (1) is operable in a first mode and a second mode.

Abstract: A removal device (121, 221) for removing and disposing of a pen needle (113, 213) connectable to a drug delivery device (111, 211) includes a body (123, 223) having a cavity (141, 241) for receiving the pen needle of the drug delivery device such that a patient end (116, 216) of a needle (115, 215) of the pen needle is covered by the body. An ejector (151, 251) is movably connected to the body (123, 223) for engaging the received pen needle (113, 213) and selectively ejecting the engaged pen needle from the body. The pen needle (113, 213) is securely retained within the removal device (121, 221) without exposing the needle (115, 215) of the pen needle until the pen needle (113, 213) can be properly disposed of, such as in a sharps container, thereby substantially preventing an accidental needle stick.

Abstract: A hub member for an infusion set device includes a body and pads configured to receive a squeezing force directed radially inward relative to an axis of the body. The body compresses radially inward relative to the axis in response to the squeezing force. A plurality of connection features on the body are moveable from a first position radially inward toward a second position when the hub member is compressed radially inward. The plurality of connection features engage one or more further connection features on a housing to attach the hub member to the housing when the plurality of connection features are in the first position, and disengage the one or more further connection features to release the hub member when the plurality of connection features are moved toward the second position.

Abstract: A trocar for peritoneal dialysis is disclosed herein. An example trocar includes a conduit having two parallel lumens and a head connected to a first end of the conduit. The head includes two parallel lumens that are aligned respectively with the two parallel lumens of the conduit. The trocar also includes a coupler connected to the head. The coupler includes two (or more) parallel lumens that are aligned respectively with the two parallel lumens of the head. The coupler includes a coupling mechanism for securing surgical tools in place after insertion into a patient. The trocar may also include an obturator having a shaft that is removably inserted through the coupler, the head, and the conduit to protrude from a second end of the conduit.

Abstract: A medical device includes a device body and an insufflation fitting coupled to and extending from the device body. The insufflation fitting includes an annular high-flow fitting portion and an annular low-flow fitting portion extending away from the device body from the annular high-flow fitting portion. The annular high-flow fitting portion includes a first inner surface and a radially outward sealing surface generally reverse from the first inner surface. The annular low-flow fitting portion includes an inner sealing surface and a first radially outward surface generally reverse from the inner sealing surface. The first inner surface of the annular high-flow fitting portion and the inner sealing surface of the annular low-flow fitting portion define an insufflation gas flow passageway through the insufflation fitting.

Abstract: A suction device comprising a suction tube configured to fluidly couple to a vacuum source and to provide suction at its distal end, an illumination assembly comprising at least one direct light source for emitting light to a target area, an elongated heat sink thermally coupled to the at least one light source and extending along a portion of the suction tube, and a spine extending along the suction tube and overlapping with the elongated heat sink, the spine including an integrated lens, wherein the at least one direct light source and the elongated heat sink are enclosed within a space formed between the spine and a side of the suction tube.

Abstract: A cannula to access the deep pelvic space of a patient from an incision near a patient's navel, wherein the deep pelvic space is generally inaccessible from the incision due to being obstructed by the patient's sacral promontory. The cannula is envisioned having an inner tube that slides within a rigid outer tube. The inner tube has a suction-irrigation tip located at the distal tube end and a flexible tube section interposed between the suction-irrigation tip and a rigid inner tube, which extends from the flexible tube section, outside of the proximal end of the rigid outer tube, where it is attached to a handle. The handle has an exit port centered in the handle (in communication with the suction-irrigation tip aperture), which is configured to suck fluid buildup in the deep pelvic space when the exit port is connected to a suction source via a suction tube.

Abstract: A system for treating internal bleeding via application of a heated irrigant, such that the heated irrigant is delivered at a flow rate of between 2 cc/s and 12 cc/s and at a temperature of between 46 degrees Celsius and 52 degrees Celsius.

Abstract: An integrated sheath assembly for inserting a medical device such as a percutaneous pump into a vessel can include a first sheath having a first lumen defining a first opening between proximal and distal ends of the first sheath for passage of a portion of the pump and a second sheath having a second lumen defining a second opening between proximal and distal ends of the second sheath. The second lumen is expandable to allow passage of the first sheath containing the portion of the pump. The first sheath fills a space between the second sheath and the portion of the percutaneous pump when the first sheath containing the percutaneous pump is inserted into the second lumen. The first sheath has a first hub, and the second sheath has a second hub. In some embodiments, a single sheath and a movable connector can be integrated on the medical device.

Abstract: Doxycycline injections improve the appearance of cosmetically significant lower eyelid festoons and malar edema, as well as of the jowls. The doxycycline is also useful for reducing edema of turbinates, the nasal concha or conchae shell-shaped networks of bones, vessels, and tissue within the nasal passageways that are responsible for warming, humidifying, and filtering the air as it is inhaled. The doxycline, in a concentration preferably of greater than 10 to 20 mg/ml, preferably in combination with a local anesthetic and optionally with a vasoconstrictor such as epinephrine and a pH buffering agent, is injected into the subcuticular space at the site of swelling. The high viscosity limits the spread of the doxycycline to the area to be treated. The resulting sclerosis prevents fluid accumulation. The doxycline also decreases swelling due to fat, by causing a decrease in lipomas.

Abstract: This document describes devices for in vivo drug testing in the brain. This document also describes implantable devices for long-term drug delivery to the brain parenchyma, and for access to biomarkers from the parenchyma.

Abstract: Methods, devices, and components are provided to reduce tissue resistive pressure during a subcutaneous drug delivery operation by increasing the size of the injection cavity by partially retracting the drug delivery member after inserting the drug delivery member to a subcutaneous position. The drug delivery devices described herein include a motor operably coupled to a drug delivery member. The motor can be selectively activated by a controller to retract the drug delivery member a predetermined distance to relieve pressure in an injection cavity in a patient. A force sensor can provide the controller with a drug delivery member insertion force. The controller can then estimate a tissue resistive pressure based on the drug delivery member insertion force and determine the predetermined distance for the partial drug delivery member retraction based on the tissue resistive pressure.

Abstract: An injection device comprising a housing with a receptacle for a product, a dosing mechanism for setting a product dosage to be administered and for displaying the set product dosage and a dispensing mechanism for dispensing the product. The dispensing mechanism may include a piston rod, at least one sleeve rotatable relative to the housing to eject the set product dosage, and a button moveable relative to the housing and relative to the at least one sleeve in a dispensing direction from a dosing position into a dispensing position to eject the set product dosage. The injection device can further include a first detector for detecting a position of the button relative to the housing or the at least one sleeve, a second detector for detecting rotational movement of the at least one sleeve or a component part coupled to the at least one sleeve and a feedback generator mechanism.

Abstract: An apparatus comprising a user interface configured to generate an electrical signal to start a basal insulin rate test when prompted by a user, an input configured to receive sampled blood glucose data of a patient that is obtained during a specified time duration, including a time duration during delivery of insulin according to a specified basal insulin rate pattern, and a controller communicatively coupled to the input and the user interface. The controller includes an insulin calculation module configured for determining at least one of an amount of basal insulin over-delivered and an amount of basal insulin under-delivered during the basal insulin rate test in trying to meet a target blood glucose baseline. Other devices and methods are disclosed.

Abstract: Various examples are directed to systems and methods for generating a bolus dose for a host. A bolus application may display a first bolus configuration parameter question at a user interface and receive, through the user interface, a first answer to the first bolus configuration parameter question. The first answer may describe a previous bolus determination technique of the host. The bolus application may select a second bolus configuration parameter question using the first answer and provide the second bolus configuration parameter question at the user interface. The bolus application may determine a set of at least one bolus configuration parameter using the first answer and a second answer to the second bolus configuration parameter question.