Abstract: A compound having the formula: ##STR1## where R.sub.1, R.sub.2, and R.sub.3 are independently hydrogen or C.sub.1-C.sub.4 alkyl; n is 2-4; X is aryl, substituted aryl or C.sub.1-C.sub.6 alkyl; Y is selected from the group consisting of hydrogen, amino acid, dipeptide or tripeptide linked through the C-terminal carboxylic acid, and amine protecting group is presented.

Abstract: R(+)-N-propargyl-1-aminoindan, its preparation and use and pharmaceutical compositions containing it. The novel compound was found to be useful for the treatment of human patients for Parkinson's disease, memory disorders, dementia of the Alzheimer type (DAT), depression and the hyperactive syndrome.

Abstract: An arylisonitrosoalkanone is hydrogenated in the presence of a noble metal catalyst and a weak carboxylic acid to form an arylalkanolamine which is then hydrogenated in the presence of a strong mineral acid and the transition metal catalyst to form an arylalkylamine. When the arylisonitrosoalkanone is an isonitrosoacetophenone, the isonitrosoacetophenone is prepared by one of two methods.In the first method, a substituted or an unsubstituted isonitrosoacetophenone is prepared from a corresponding substituted or unsubstituted acetophenone by oxidizing the acetophenone to form a substituted or an unsubstituted phenylglyoxalacetal in a reactor, hydrolyzing the phenylglyoxal acetal in the same reactor to form a corresponding substituted or unsubstituted phenylglyoxal, and condensing the phenylglyoxal with hydroxylamine or a salt thereof in the same reactor to form the substituted or unsubstituted isonitrosoacetophenone.

Abstract: A method of preparing an .alpha.-d-phenylalkylbenzyl carbinol by the reaction of a phenylbenzyl ketone with an alkali metal enolate of an amide to form an aldol adduct, which is reduced and purified to form an .alpha.-d-phenylalkylbenzyl carbinol, wherein the carbinol so produced possesses analgesic activity. In an embodiment of the invention, a phenylbenzyl ketone is reacted with an alkali metal enolate of an amide to form an aldol adduct, which is reacted with an alkali metal salt of a secondary amine to form a dianion; the dianion is alkylated with an alkyl halide to form an .alpha.-isomer of an aldol adduct, which is reduced and purified to form an .alpha.-d-phenylalkylbenzyl carbinol possessing analgesic activity.

Abstract: The present invention is a method for rapid in vivo assessment of intravenous irritation of pharmaceutical compositions. The assessment of the vascular irritability of new pharmaceutical agents, vehicles and their pharmaceutical compositions has traditionally been limited to histological characterization of postinfusion damage. These studies utilized about 15 conscious animals and required about two weeks to complete. The method of the present invention in contrast utilizes fewer animals and can be completed in as short as only about 2-4 hr. In addition the direct observation is contemporaneous with the infusion and utilized a central vein.

Abstract: Process for the preparation of 4,4'-diaminodiphenylmethane and its derivatives.4,4'-diaminodiphenylmethane and its derivatives are prepared by the condensation of aniline, or its derivative, and aldehyde, or its precursor and/or isomerization of appropriate intermediate products. The reaction proceeds with zeolites acting as catalysts; these catalysts, which are selected in accordance with the reaction to be effected, are preferably zeolites based on Si, Al and B; Si, Al and Ti; Ti and Fe; ZSM-5; or Y zeolites.

Abstract: Crop oil concentrates are disclosed which increase the herbicidal efficacy of herbicides from diverse chemical classes. These crop oil concentrates comprise an anionic polyoxyalkylene surfactant or salt thereof, an adjuvant which is exclusively a fatty acid or its ester, and a hydrocarbon component. These crop oil concentrates are especially effective with cyclohexenone and triketone herbicides and growth regulators.

Abstract: The invention relates to novel racemic or optically active aminopropanol derivatives of formula I ##STR1## wherein R and R.sup.1 are independently hydrogen atom, halogen atom, lower alkoxy, or together represent a methylene dioxy group,R.sup.2 and R.sup.3 together represent a chemical bond or independently stand for a hydrogen atom,R.sup.4 and R.sup.5 are independently hydrogen atom, C.sub.3-7 cycloalkyl group or straight or branched, saturated or unsaturated C.sub.1-12 alkyl group optionally substituted by one or more dialkyl-aminoalkyl, dimethoxyphenyl or phenyl groups, orR.sup.4 and R.sup.5 together with the adjacent nitrogen atom form a 4 to 7 membered ring optionally comprising an oxygen, sulfur or a further nitrogen atom, which ring is optionally substituted by a phenyl, benzyl or C.sub.1-3 alkyl group and the said substituents may carry a hydroxyl group, one or two methoxy groups, halogen atoms or trifluoromethyl groups, orR.sup.4 and R.sup.

Abstract: Compounds of the formula IV for use as local anesthesia and analgesia, as well as a method for their preparation, their pharmaceutical preparations and their use.

Abstract: The present invention relates to a process for the n-alkylation and n-allylation of anilines by bringing the aniline into contact with an alkylating or allylating agent in an organic solvent in a homogeneous liquid phase in the presence of an onium ion and a stoichiometric amount of a non-quaternizable base.

Abstract: A component having the following formula I: ##STR1## wherein X represents an integer ranging from 1 to 2 or 7 to 13;Y represents an integer ranging from 0 to 5;Z represents an integer ranging from 0 to 5;R.sub.1, R.sub.2 and R.sub.3 are the same or different and represent H or a straight chain or branched lower alkyl; andR' and R" are the same or different and represent H or halogen,and pharmaceutically acceptable salts thereof. Preferably, the lower alkyl has between 1 and 4 carbon atoms and the halogen is selected from the group consisting of fluorine, chlorine, bromine and iodine. The compound is useful as a MAO-B inhibitor. Also within the scope of the present invention is a composition for the inhibition of MAO-B activity and a method for alleviating Parkinsonism, Alzheimer's disease, depression, attention deficit hyperactive disorders, aging and other neuropsychiatric disorders and for improving the quality of life.

Abstract: A controlled release and delivery system for a hydrophobic, water sensitive herbicide is produced by:(a) dissolving the herbicide in a volatile water-immiscible solvent;(b) introducing the solvent containing the herbicide dissolved therein to a latex dispersion comprising an aqueous continuous phase and polymeric discrete phase;(c) agitating the resultant mixture until the polymeric particles of the discrete phase absorb the herbicide; and(d) removing the solvent from the resultant mixture at reduced pressure.

Abstract: A rooting composition is set forth comprising a water swellable gel containing auxin in an amount effective to stimulate root growth, the gel comprising a high molecular weight organic acid, ketone or ester or combinations thereof. Root formation of a cutting is stimulated by planting the cutting in the soil with the aformentioned rooting composition adhered to the portion of the cutting proximal where it was cut from a living plant. The auxins are maintained close to the cutting whereby they are highly effective and the gel serves as an artificial root to bring water and nutrients to the cutting as it develops its own root system.

Abstract: A novel benzxoylurea derivative represented by the formula (I) described below, its production and an insecticidal and/or acaricidal composition containing it as an active ingredient: ##STR1## wherein R.sub.1 is a chlorine or fluorine atom, each of R.sub.2 and R.sub.3, wherein may be the same or different, is a fluorine or hydrogen atom, R.sub.4 is a chlorine or hydrogen atom, R.sub.5 is a halogen atom or a methyl or trifluoromethyl group, and X is an oxygen or sulfur atom.

Abstract: Disclosed are herbicidal compositions containing a combination of the compound 2-[1-(3-transchloroallyloxyimino)propyl]-5-(2-ethylthiopropyl)-3-hydroxy-2 -cyclohexene-1-one (or a herbicidally effective salt thereof) and the compound 2-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propynyl)-2H-1,4-benzoxazine-6-yl]-4,5, 6,7-tetrahydro-1H-isoindole-1,3(2H)-dione. It has been found that this combination synergistically interacts so as to accelerate the post-emergent herbicidal activity of 2-[1-(3-trans-chloroallyloxyimino)propyl]-5-(2-ethylthiopropyl)-3-hydroxy- 2-cyclohexen-1-one (or its salt) against grassy weeds.

Abstract: Crop oil concentrates are disclosed which not only increase the herbicidal efficacy of herbicides from diverse chemical classes, but moreover assist in defeating the apparent antagonism which often arises when two or more herbicides are utilized together.

Abstract: A method and composition for treating diseases having a viral etiology is provided. The method comprises administering either locally or systemically an antiviral effective, non-toxic amount of stannous fluoride. An isotonic, sterile injectable preparation of stannous fluoride for systemic administration is also disclosed.