Patents Examined by Barbara Badio
  • Reactive dyes, their preparation and use
    Patent number: 5969113
    Abstract: Compounds of the formula ##STR1## in which the variables are as defined in the claims, which are suitable as fibre-reactive dyes for dyeing widely varying fibre materials, are described.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: October 19, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Rolf Deitz, Bernhard Muller, Athanassios Tzikas
  • Androstanes for inducing hypothalamic effects
    Patent number: 5969168
    Abstract: The invention relates to novel, androstane steroids which are the ligand semiochemicals which bind to neuroepithelial receptors. The steroids are useful as ligands to neuroepithelial receptors in the human vomeronasal gland to stimulate autonomic and hypothalamic activity.
    Type: Grant
    Filed: September 29, 1994
    Date of Patent: October 19, 1999
    Assignee: Pherin Corporation
    Inventors: David L. Berliner, Nathan W. Adams, Clive L. Jennings-White
  • Androstane steroids as neurochemical initators of change in human hypothalamic compositions and methods
    Patent number: 5965552
    Abstract: The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human semiochemical, e.g. an Androstane steroid, or a pharmaceutical composition containing a semiochemical, such that the ligand semiochemical binds to a specific neuroepithelial receptor. The steroid or steroids is/are preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers. Other embodiments of the invention include pharmaceutical compositions containing the steroids.
    Type: Grant
    Filed: December 15, 1998
    Date of Patent: October 12, 1999
    Assignee: Pherin Pharmaceuticals, Inc.
    Inventors: David L. Berliner, Nathan William Adams, Clive L. Jennings-White
  • 17.beta.-nitro-11.beta.-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Patent number: 5962444
    Abstract: The invention is directed to 17.beta.-nitro-11.beta.-arylsteroids of formula I: ##STR1## wherein R.sup.1, R.sup.6, R.sup.7, R.sup.12 and X are as defined by the specification. The compounds exhibit potent antiprogestational activity and are useful in the treatment of fibroids, endometriosis, cervical ripening prior to delivery, hormone replacement therapy and in the control of fertility.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: October 5, 1999
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Rupa S. Shetty, Gary S. Bartley, David Yue-wei Lee
  • Hydroxy polyamines
    Patent number: 5962533
    Abstract: Disclosed are polyamines having the formula: ##STR1## or salts or stereoisomers thereof wherein R.sub.1 -R.sub.4 and ALK.sub.1 -ALK.sub.3 are as defined in the specification. Pharmaceutical compositions and therapeutic methods of treatment utilizing the compounds are also disclosed.
    Type: Grant
    Filed: February 6, 1996
    Date of Patent: October 5, 1999
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: Raymond J. Bergeron, Jr.
  • Phosphonic acid-based cationic lipids
    Patent number: 5958901
    Abstract: The present invention provides novel phosphonic acid-based cationic lipids of the general structure: ##STR1## or a salt, or solvate, or enantiomers thereof wherein; (a) R.sub.1 is a lipophilic moiety; (b) R.sub.2 is a positively charged moiety; (c) R.sub.3 is a lipophilic moiety of 1 to about 24 carbon atoms, a positively charged moiety, or a negatively charged moiety; (d) n is an integer from 0 to 8; (e) X.sup.- is an anion or polyanion; (f) Y is N or O, and (g) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid.The present invention further provides compositions of these lipids with polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.
    Type: Grant
    Filed: June 5, 1996
    Date of Patent: September 28, 1999
    Assignee: Genta Incorporated
    Inventors: Brian Patrick Dwyer, Alexandre V. Lehedev, Bob Dale Brown, David Aaron Schwartz
  • Method for the preparation of steroid derivative ketal
    Patent number: 5955622
    Abstract: The invention relates to a method for the preparation of a compound of formula II: ##STR1## wherein a compound of formula V: ##STR2## is condensed with a compound of the formula CH.sub.3 -C(OR.sub.4 O)-(CH.sub.2).sub.3 -XHal and R.sub.1, R.sub.2, R.sub.3, R.sub.4, X and Hal are as defined by the specification.
    Type: Grant
    Filed: August 5, 1998
    Date of Patent: September 21, 1999
    Assignee: Akzo Nobel, N.V.
    Inventors: Franciscus Theodorus Leonardus Brands, Pieter Vrijhof
  • Cationic amphiphiles containing multiplesteroid lipophilic groups
    Patent number: 5952516
    Abstract: Cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles with the therapeutic molecules. Therapeutic molecules that can be delivered into cells according to the practice of the invention include DNA, RNA, and polypeptides. Representative uses of the therapeutic compositions of the invention include providing gene therapy, and delivery of antisense polynucleotides or biologically active polypeptides to cells. With respect to therapeutic compositions for gene therapy, the DNA is provided typically in the form of a plasmid for complexing with the cationic amphiphile.
    Type: Grant
    Filed: May 8, 1997
    Date of Patent: September 14, 1999
    Assignee: Genzyme Corporation
    Inventors: Craig S. Siegel, Edward R. Lee, David J. Harris
  • Androgenic steroid compounds and a method of making and using the same
    Patent number: 5952319
    Abstract: An androgenic steroid compound of the formula: ##STR1## wherein: X, Y, Z, R.sup.1, R.sup.2, R.sup.3, R.sup.5 and R.sup.6 are as defined herein.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: September 14, 1999
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • Therapeutic compound-fatty acid conjugates
    Patent number: 5952499
    Abstract: A methotrexate conjugated to 1-3 acyl groups derived from fatty acids. In particular the invention relates to altering the pharmacokinetic profile and mode of delivery of methotrexate by conjugating it to 1.2 or 3 acyl derivatives of fatty acids.
    Type: Grant
    Filed: September 25, 1997
    Date of Patent: September 14, 1999
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Robert George Whittaker, Veronika Judith Bender, Wayne Gerrard Reilly, Minoo Moghaddam
  • Cationic amphiphiles containing linkers derived from neutral or positively charged amino acids
    Patent number: 5948925
    Abstract: Cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles with the therapeutic molecules. Therapeutic molecules that can be delivered into cells according to the practice of the invention include DNA, RNA, and polypeptides. Representative uses of the therapeutic compositions of the invention include providing gene therapy, and delivery of antisense polynucleotides or biologically active polypeptides to cells. With respect to therapeutic compositions for gene therapy, the DNA is provided typically in the form of a plasmid for complexing with the cationic amphiphile.
    Type: Grant
    Filed: May 6, 1997
    Date of Patent: September 7, 1999
    Assignee: Genzyme Corporation
    Inventors: Mikaela N. Keynes, Craig S. Siegel, Edward R. Lee, David J. Harris
  • 17,20-epoxy steroid intermediates
    Patent number: 5945530
    Abstract: A compound of the formula ##STR1## wherein the A.sub.1 and B.sub.1 rings are as defined by the specification. The compounds are intermediates in the preparation of oxoetiocholenic acid.
    Type: Grant
    Filed: November 5, 1997
    Date of Patent: August 31, 1999
    Assignee: Hoechst Marion Roussel
    Inventors: Patrick Roussel, Michel Vivat
  • Cationic amphiphiles for cell transfections
    Patent number: 5942634
    Abstract: Cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles with the therapeutic molecules. Therapeutic molecules that can be delivered into cells according to the practice of the invention include DNA, RNA, and polypeptides. Representative uses of the therapeutic compositions of the invention include providing gene therapy, and delivery of antisense polynucleotides or biologically active polypeptides to cells. With respect to therapeutic compositions for gene therapy, the DNA is provided typically in the form of a plasmid for complexing with the cationic amphiphile.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: August 24, 1999
    Assignee: Genzyme Corporation
    Inventors: Craig S. Siegel, Edward R. Lee, David J. Harris
  • Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
    Patent number: 5939545
    Abstract: Methods, compositions, and compounds for modulating the GABA.sub.A receptor-chloride ionophore complex to alleviate stress, anxiety, seizures, mood disorders, PMS and PND and to induce anesthesia.
    Type: Grant
    Filed: July 2, 1997
    Date of Patent: August 17, 1999
    Assignee: CoCensys, Inc.
    Inventors: Ravindra B. Upasani, Haiji Xia, Derk Hogenkamp
  • Hypocholesterolemic agents
    Patent number: 5939398
    Abstract: This invention relates to certain steroidal glycosides useful as hypocholesterolemic agents and antiatherosclerosis agents and certain protected intermediates useful in the preparation of said steroidal glycosides.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: August 17, 1999
    Assignee: Pfizer Inc.
    Inventor: Michael Paul Deninno
  • Aralkyoxy alkoximino derivatives and their use as fungicides
    Patent number: 5935999
    Abstract: A compound of formula (I): ##STR1## wherein A is oxygen, W is CH.sub.3 O.CH.dbd.CCO.sub.2 CH.sub.3 and R.sup.1, R.sup.2, R.sup.3, X, Y and Z are as defined in the specification. The compounds are useful as plant fungicides and insecticides.
    Type: Grant
    Filed: July 31, 1995
    Date of Patent: August 10, 1999
    Assignee: Zeneca Limited
    Inventors: Paul Anthony Worthington, Ian Henry Aspinall
  • Vitamin D analogues
    Patent number: 5932565
    Abstract: The invention relates to compounds of formula (I): ##STR1## wherein Q and R are as defined in the specification. The compounds are useful in the treatment of a number of disorders including osteoporosis, inflammation and psoriasis.
    Type: Grant
    Filed: January 14, 1998
    Date of Patent: August 3, 1999
    Assignee: Leo Pharmaceutical Products Ltd. A/S (L.o slashed.vens kemiske Fabrik Produktionsaktieselskab)
    Inventor: Gunnar Grue-S.o slashed.rensen
  • Method for preparing 17.alpha.-acetoxy-11.beta.-(4-N, N-dimethylaminophyl)-19-Norpregna-4,9-diene-3, 20-dione, intermediates useful in the method, and methods for the preparation of such intermediates
    Patent number: 5929262
    Abstract: Methods for the preparation of the 19-norprogesterone of formula I ##STR1## and its intermediates, in crystalline and amorphous forms are disclosed. The process is performed by (1) protecting the hydroxyl group of a compound of formula II ##STR2## (2) reacting the protected compound with an alkali or alkaline earth metal anion radical, (3) hydrolyzing the resulting compound, (4) ketalizing the carbonyl groups, (5) epoxidizing the compound, (6) opening the epoxide ring and introducing an N,N,dimethylamino-phenyl functional group into the axial position of C.sub.11, (7) deketalizing and dehydrating the resulting compound, and (8) acetylating to provide 17.alpha.-acetoxy-11.beta.-(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-di ene-3,20-dione (I).
    Type: Grant
    Filed: March 30, 1995
    Date of Patent: July 27, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Hyun K. Kim, Pemmaraju Narasinha Rao, James E. Burdett, Jr., Carmie K. Acosta
  • Process for preparing 2-amino-1,3-alkanediol or derivative thereof, process for preparing optically active dihydrosphingosine derivative, and intermediates for optically active dihydrosphingosine derivative
    Patent number: 5925792
    Abstract: A process for preparing an optically active dihydrosphingosine derivative is disclosed, comprising reducing a (2R,3R)-2-amino-3-hydroxyalkanoic acid derivative represented by formula (III): ##STR1## wherein R.sup.3 represents a straight-chain alkyl group having 7 to 21 carbon atoms; and R.sup.4 represents an amino group protecting group, (e.g., (2R,3R)-2-benzylamino-3-hydroxyoctadecanoic acid) with sodium tetrahydroborate in the presence of an acid. The process makes it feasible to produce an optically active dihydrosphingosine at high optical purity and through a simple process that is safe and easy to industrialize.
    Type: Grant
    Filed: August 13, 1996
    Date of Patent: July 20, 1999
    Assignee: Takasago International Corporation
    Inventors: Kazutoshi Sakurai, Kenya Ishida
  • Cationic amphiphiles for intracellular delivery of therapeutic molecules
    Patent number: 5925628
    Abstract: Cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles with the therapeutic molecules. Therapeutic molecules that can be delivered into cells according to the practice of the invention include DNA, RNA, and polypeptides. Representative uses of the therapeutic compositions of the invention include providing gene therapy, and delivery of antisense polynucleotides or biologically active polypeptides to cells. With respect to therapeutic compositions for gene therapy, the DNA is provided typically in the form of a plasmid for complexing with the cationic amphiphile.
    Type: Grant
    Filed: March 31, 1997
    Date of Patent: July 20, 1999
    Assignee: Genzyme Corporation
    Inventors: Edward R. Lee, David J. Harris, Craig S. Siegel