Patents Examined by Beby Jayaram
  • Integrin receptor antagonists
    Patent number: 6211191
    Abstract: The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors &agr;&ngr;&bgr;3, &agr;&ngr;&bgr;5, and/or &agr;&ngr;&bgr;6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, tumor growth, and metastasis.
    Type: Grant
    Filed: December 15, 1998
    Date of Patent: April 3, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Mark E. Duggan, James J. Perkins, Robert S. Meissner
  • Neurokinin antagonists, processes for preparing them and pharmaceutical compositions containing these compounds
    Patent number: 6103719
    Abstract: The invention relates to new compounds of general formula I ##STR1## or the pharmaceutically acceptable salts thereof, wherein X=N--R.sup.3 or CH--R.sup.4,Y=CH.sub.2 or (CH.sub.2).sub.2,Z=O or H.sub.2 ;and R.sup.1, R.sup.2, R.sup.3, R.sup.4 and Ar have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable neurokinin (tachykinin) antagonists.
    Type: Grant
    Filed: May 27, 1999
    Date of Patent: August 15, 2000
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Franz Esser, Gerd Schnorrenberg, Horst Dollinger, Sven Luettke, Birgit Jung, Georg Speck
  • Imidazopyridazines
    Patent number: 6043242
    Abstract: Compounds of formula (I) ##STR1## in which the substituents and symbols have the meanings indicated in the description, are suitable for controlling Helicobacter bacteria.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: March 28, 2000
    Assignee: Byk Gulden Lomberg Chemische Fabrik GmbH
    Inventor: Gerhard Grundler