Patents Examined by Ben S Michelson
  • Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
    Patent number: 9493412
    Abstract: The present invention provides compounds of Formula (I): (I), as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: November 15, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jennifer X. Qiao, Heather Finlay, Ji Jiang, John Lloyd, Carol Hui Hu, Zulan Pi, George O. Tora, James Neels, Jon J. Hangeland, Todd J. Friends
  • Methods for the synthesis of tiotropium bromide
    Patent number: 9440945
    Abstract: Present invention relates to methods for preparing (1?, 2?, 4?, 5?, 7?)-7-[(hydroxidi-2-thienllacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane-bromide.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: September 13, 2016
    Inventor: Mahmut Bilgic
  • Substituted pyrazoles as N-type calcium channel blockers
    Patent number: 9434693
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, ring A, and G are defined herein.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: September 6, 2016
    Assignee: Janssen Pharmaceutica NV
    Inventors: Mark Wall, Nalin Subasinghe, Zhihua Sui, Christopher Flores
  • 5,6-disubstituted oxindole-derivatives and use thereof for treating vasopressin-dependent diseases
    Patent number: 9434713
    Abstract: The present invention relates to novel 5,6-disubstituted oxindole derivatives and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising such derivatives, and to the use of such derivatives for the manufacture of a medicament, and methods of treating disorders in a subject in need thereof, such as vasopressin-dependent disorders, using 5,6-disubstituted oxindole derivatives.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: September 6, 2016
    Assignee: ABBVIE DEUTSCHLAND GMBH & CO. KG
    Inventors: Wilfried Braje, Thorsten Oost, Astrid Netz, Wolfgang Wernet, Liliane Unger, Wilfried Hornberger, Wilfried Lubisch
  • Peripherally acting opioid compounds
    Patent number: 9415045
    Abstract: The invention relates to a compound of Formula I, II, III, IV or a pharmaceutically acceptable ester or prodrug thereof:
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: August 16, 2016
    Assignee: Alkermes, Inc.
    Inventors: Laura Cook Blumberg, Derrick Arnelle
  • Ligands of the benzo[]quinoline class and transition metal complexes containing them and use of said complexes as catalysts
    Patent number: 9409867
    Abstract: A new class of ligands derived from benzo[h]quinoline are described and these ligands are used to prepare several novel transition metal complexes. The complexes are preferably of the group VIII transition metals iron, ruthenium or osmium, with the benzo[h]quinoline ligands acting as tridentate ligands. The complexes described are proved to be very active catalysts for the reduction of ketones and aldehydes to alcohols, via hydrogen transfer and hydrogenation reactions. These compounds hence can be usefully employed as catalysts in said reduction reactions.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: August 9, 2016
    Assignee: Universita' Degli Studi Di Udine
    Inventors: Pierluigi Rigo, Walter Baratta, Katia Siega, Giorgio Adolfo Chelucci, Maurizio Ballico, Santo Magnolia
  • Pyridinyl and fused pyridinyl triazolone derivatives
    Patent number: 9402841
    Abstract: Disclosed are compounds of Formula 1, or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating Type I hypersensitivity reactions, autoimmune diseases, inflammatory disorders, cancer, non-malignant proliferative disorders, and other conditions associated with BTK.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: August 2, 2016
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: John David Lawson, Mark Sabat, Nicholas Scorah, Christopher Smith, Phong H. Vu, Haixia Wang
  • Apoptosis signal-regulating kinase 1 inhibitors
    Patent number: 9403819
    Abstract: The present invention relates to apoptosis signal-regulating kinase 1 (“ASK1”) inhibiting compounds of the formula wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: August 2, 2016
    Assignee: Takeda Pharmaceutical Company Limited
    Inventor: Edcon Chang
  • Arginine methyltransferase inhibitors and uses thereof
    Patent number: 9394258
    Abstract: Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: July 19, 2016
    Assignee: Epizyme, Inc.
    Inventors: Richard Chesworth, Lorna Helen Mitchell, Gideon Shapiro, Kevin Wayne Kuntz
  • Enantiopure base-metal catalysts for asymmetric catalysis and bis(imino)pyridine iron alkyl complexes for catalysis
    Patent number: 9394325
    Abstract: A transition metal-containing compound having a tridentate chiral ligand bound to iron, cobalt, or nickel. The tridentate ligands are bound to the metal via nitrogen, phosphorus, and/or arsenic atoms. The tridentate ligand has a chiral group bound at least one of the nitrogen, phosphorus, and arsenic atoms, and a blocking group may be bound to another one of the nitrogen, phosphorus, and arsenic atoms. The transition metal-containing compound is useful for the catalyzing the asymmetric hydrogenation of olefins.
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: July 19, 2016
    Assignee: The Trustees of Princeton University
    Inventors: Paul J. Chirik, Sebastien Monfette, Jordan M. Hoyt, Max R. Friedfeld
  • TRPV1 antagonists including dihydroxy substituent and uses thereof
    Patent number: 9394293
    Abstract: The disclosure relates to Compounds of Formula (I): and pharmaceutically acceptable derivatives thereof wherein Ar1, Ar2, L1, L2, X, R3, R22, and m are as defined herein, compositions comprising an effective amount of a Compound of Formula (I), and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a Compound of Formula (I).
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: July 19, 2016
    Assignee: Purdue Pharma L.P.
    Inventor: Jianming Yu
  • Ni complex and its derivatives, producing method, and the use thereof as an antioxidant
    Patent number: 9388205
    Abstract: The present invention relates to a novel nickel complex and its derivatives, which mimic the active site of Ni-containing superoxide dismutase (NiSOD). The five-coordinate Ni(II) and Ni(III) complexes or their derivatives, and six-coordinate derivatives have the following structures of formula (I) and (II): The nickel complexes and their derivatives of the invention act as anti-oxidants or free radical scavengers. The invented nickel complexes can be used in the preparation of medicines, health foods or cosmetics for human, animals and plants, or can be used in environmental or soil protection.
    Type: Grant
    Filed: October 30, 2013
    Date of Patent: July 12, 2016
    Assignee: NATIONAL TAIWAN NORMAL UNIVERSITY
    Inventors: Way-Zen Lee, Chien-Wei Chiang, Tsung-Han Lin, Ting-Shen Kuo
  • 6-pyridone-2-carbamoyl-azoles and their use as herbicides
    Patent number: 9370184
    Abstract: 6-Pyridone-2-carbamoylazoles of the general formula (I) are described as herbicides. In this formula (I), W, X and Z represent radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen. Q represents a 5-membered radical such as oxadiazyl.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: June 21, 2016
    Assignee: Bayer Cropscience AG
    Inventors: Ralf Braun, Stefan Lehr, Arnim Koehn, Hansjoerg Dietrich, Elmar Gatzweiler, Christopher Hugh Rosinger, Dirk Schmutzler
  • Treatment of cancer, inflammatory disease, and autoimmune disease
    Patent number: 9359279
    Abstract: A method of treating cancer, inflammatory disease, and autoimmune disease by administering to a subject in need thereof an effective amount of one or more 1,5-dipenylpenta-1,4-dien-3-one compounds. The compounds feature either or both of the phenyl rings being substituted with hydroxyl, diethyl(2-alkoxyethyl)amine, 1-(2-alkoxyethyl)piperidine, sulfonate, phosphinate, or phosphate.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: June 7, 2016
    Assignee: Allianz Pharmascience Ltd.
    Inventors: Charles C-Y Shih, Toshio Kitamura, Qian Shi, Toshiyuki Kawashima, Hui-Kang Wang
  • Ligands for sensitizing dyes of dye-sensitized solar cells
    Patent number: 9359334
    Abstract: The present invention provides new bi- and polypyridine ligands of ruthenium dyes. The invention also provides solar cells, in particular dye-sensitized solar cells comprising the dyes.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: June 7, 2016
    Assignee: Ecole Polytechnique Federale de Lausanne (EPFL)
    Inventors: Mohammad Khaja Nazeeruddin, Michael Graetzel, Alessandro Abbotto, Chiara Marinzi, Norberto Manfredi, Filippo De Angelis
  • Multicyclic compounds and methods of use thereof
    Patent number: 9351954
    Abstract: Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. For example, disclosed herein are compounds having formula (IIa) shown below, or a pharmaceutically acceptable salt or stereoisomer thereof, wherein the variables are defined herein. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: May 31, 2016
    Assignees: Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLC.
    Inventors: Liming Shao, John Emmerson Campbell, Michael Charles Hewitt, Una Campbell, Taleen G. Hanania
  • Photoelectric conversion material, film containing the material, photoelectric conversion device, method for preparing photoelectric conversion device, method for using photoelectric conversion device, photosensor and imaging device
    Patent number: 9349965
    Abstract: There is provided a compound represented by a specific formula, which has an absorption maximum at 400 nm or more and less than 720 nm in a UV-visible absorption spectrum, wherein a molar extinction coefficient is 10,000 mol?1·l·cm?1 or more at the absorption maximum wavelength, and a difference between a melting point and a deposition temperature (a melting point?a deposition temperature) is 31° C. or more.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: May 24, 2016
    Assignee: FUJIFILM CORPORATION
    Inventors: Katsuyuki Yofu, Kimiatsu Nomura, Eiji Fukuzaki, Yuki Hirai, Mitsumasa Hamano, Tetsuro Mitsui
  • Process for making HCV protease inhibitors
    Patent number: 9346785
    Abstract: Efficient processes for making HCV protease inhibitors are described. In one embodiment, the process uses novel idazolide derivatives of vinyl-ACCA.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: May 24, 2016
    Assignee: AbbVie Inc.
    Inventor: Kirill A. Lukin
  • Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
    Patent number: 9340550
    Abstract: The present invention provides a method for the N-demethylation and N-functionalization of an N-methylated heterocycle such as a morphine alkaloid or tropane alkaloid. The method comprises reacting the heterocycle with an functionalization agent in the presence of a transition metal catalyst in air or in the presence of an oxidant.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: May 17, 2016
    Assignee: Brock University
    Inventors: Tomas Hudlicky, Robert James Carroll, Hannes Leisch, Ales Machara, Lukas Werner, Mary Ann Endoma-Arias
  • Process for preparing sulfonamidobenzofuran derivatives
    Patent number: 9334254
    Abstract: The invention relates to a process for preparing 5-sulfonamido-benzofuran derivatives of general formula: formula (I) in which R represents an alkyl or aryl group and R1 and R2 represent hydrogen or an alkyl or aryl group. According to the invention, the compounds of formula I are prepared by coupling a benzofuran derivative of general formula II, where X represents chlorine, bromine or iodine or a sulfonate group: formula (II) with a sulfonamide derivative of formula R—SO2—NH2, in the presence of a basic agent and of a catalyst system formed from a complex between a palladium compound and a ligand.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: May 10, 2016
    Assignee: SANOFI
    Inventors: Thomas Priem, Philippe Paul Vayron