Abstract: A portable device for quantitative measurement of tissue autoregulation and neurovascular coupling via portable measurement of blood flow, oxygenation, metabolism, and/or EEG signals and methods for using said device. The device may comprise a body and a plurality of legs pivotably attached to the body. The plurality of legs may comprise at least one reference electrode leg and at least one measurement electrode leg for electrical measurement, and an optical detection fiber leg and at least one optical source fiber leg for optical blood flow, oxygenation, and metabolism measurement. The present invention is additionally directed to a portable device for blood flow measurement and therapeutic photobiomodulation. The device may comprise a body and a plurality of legs. The plurality of legs may comprise at least one optical detection fiber leg and at least one optical source fiber leg, and at least one leg for therapeutic photobiomodulation.

Abstract: During Tumor Treating Fields (TTFields) therapy, one or more pairs of electrode assemblies are used to impose an alternating electric field to the tumor. However, when the cancer cells are distributed among two or more different locations within the subject's body, it can be difficult to achieve sufficient field intensities in all of the different locations. By positioning one pair of electrode assemblies on the left half of the subject's scalp and the right side of the subject's posterior thorax, and positioning another pair of electrode assemblies on the right half of the subject's scalp and the left side of the subject's posterior thorax, it becomes possible to achieve sufficient field intensities in the following three locations simultaneously: (i) an upper half of the subject's thoracic spine, (ii) the subject's cervical spine, and (iii) the subject's head.

Abstract: A system for closed-loop therapy includes memory configured to store a first set of one or more parameters for a first set of therapeutic electrical stimulation signals. The system includes processing circuitry configured to determine one or more local field potential (LFP) measurements of an LFP that is intrinsically generated, cause stimulation generation circuitry to deliver one or more electrical stimulation signals, determine one or more evoked resonant neural activity (ERNA) signals that are evoked by delivery of respective ones of the electrical stimulation signals, determine a second set of one or more parameters for a second set of therapeutic electrical stimulation signals based on the one or more evoked signals and the one or more LFP measurements, and cause the stimulation generation circuitry to deliver the second set of the one or more therapeutic electrical stimulation signals.

Abstract: A current stimulation apparatus that includes a waveform generator to output an electric signal; a control section to control the waveform generator; a set of electrodes to provide the output electric signal; and a power supply section to supply electric power to the waveform generator and the control section, where the electric signal is a fifth electric signal including: a first electric signal having an amplitude increasing from a first amplitude, the first amplitude being not zero; a second electric signal having a second amplitude and being output after the first electric signal; a third electric signal having an amplitude decreasing to a third amplitude, the third electric signal being output after the second electric signal; and a fourth electric signal having a fourth amplitude, the fourth amplitude being not zero.

Abstract: Apparatus, systems, and methods for real time monitoring of a patient's breathing utilizing automatically controlled devices and machine learning based techniques to determine a full breath of a patient and to identify splinting points, and to thereby transmit stimulation signals to the patient so as to assist the patient breathe through splinting points. In some embodiments, a wearable breathing monitoring device comprising of one or more sensors configured to monitor the user's breathing and a stimulator apparatus comprising one or more transmitters configured to transmit stimulation signals to the patient at a time corresponding to a detected splinting point is provided. The stimulator apparatus is configured to apply electrical pulses according to a stimulation schedule via the transmitters to target nerves of the user's body.

Abstract: The disclosed systems and methods provide systems and methods for rhythm recognition and the analysis of ECG signals.

Abstract: The disclosure provides systems and methods for neuromodulation using a housing that at least partially contains a stimulator assembly, wherein the stimulator assembly is configured to generate vibration by mechanical oscillation and/or using a sound wave; and wherein the vibration generated by the stimulator assembly is configured to therapeutically treat the subject by stimulating one or more nerves when the housing is placed in proximity to or on a skin surface of a subject.

Abstract: In various embodiments, systems and methods for stimulation of the spinal cord to improve and restore upper extremity motor function in a subject having paralysis due to a spinal cord injury are provided. In some embodiments, the systems and methods involve administration of transcutaneous electrical spinal cord stimulation (tSCS) to the subject at a frequency and intensity that induces improved control of movement of the upper limbs of the subject.

Abstract: A method includes providing one or more instructions to perform a first action associated with administration of a medication; obtaining first data representing a capture of a patient performing the first action based on the one or more instructions as output by the output device; extracting information about movements of the patient from the first data; presenting an image configured to induce an emotional response in the patient; obtaining second data representing capture of the patient performing one or more microexpressions in response to presentation of the image; obtaining additional data including one or more of demographic information of the patient, information of a disease associated with the patient, or one or more characteristics of the medication; and based on the extracted information about the movements, the one or more microexpressions, and the additional data, determining a medical outcome including a progression of the disease in the patient.

Abstract: A blood pump system including a blood pump, an intravascular flow cannula, and a pressure sensor. The intravascular flow cannula is in flow communication with the blood pump and has a distal end portion distally from the blood pump and a proximal end portion closer to the blood pump. The intravascular flow cannula has at least one blood flow through opening at its distal end portion for blood to enter or exit the flow cannula. The blood flow through opening has a borderline surrounding the through opening. The pressure sensor is configured radially within the flow cannula and borders a proximal portion of the borderline.

Abstract: A catheter system includes a power source, a controller, and a light guide. The power source generates a plurality of energy pulses. The controller controls the power source so that the plurality of energy pulses cooperate to produce a composite energy pulse having a composite pulse shape. The light guide receives the composite energy pulse. The light guide emits light energy in a direction away from the light guide to generate a plasma pulse away from the light guide. The power source can be a laser and the light guide can be an optical fiber. Each of the energy pulses has a pulse width, and the energy pulses are added to one another so that the composite energy pulse has a pulse width that is longer than the pulse width of any one of the energy pulses. At least two of the energy pulses can have the same wavelength as or a different wavelength from one another.

Abstract: A device used for neurostimulation includes a plurality of electrodes. In order to improve therapeutic efficacy when using a group of N electrodes equal to or larger than 3, the device is configured to deliver a number of N+1 electrical phases during one cycle via the electrodes such that during N electrical phases of the cycle each electrode of the group delivers alternating a therapeutic electric phase and a number of N?1 charge balancing electric phases. One electrode of the group delivers its specific therapeutic electric phase and the other electrodes of the group deliver a charge balancing phase having an opposite polarity of the therapeutic electric phase delivered, and such that during an additional electrical phase each electrode of the plurality of electrodes delivers an electrical phase with an amplitude that establishes charge neutrality for residual charge on each respective electrode based on phases of the N other electrical.

Abstract: A device for providing augmented reality may include a support frame supporting at least one transparent lens, an image display module displaying augmented reality content through the at least one transparent lens, a blood-pressure information detector connected to the support frame to detect at least one blood-pressure related information including a blood-pressure, a heart rate, and oxygen saturation in case that a skin of the user touches the blood-pressure information detector, a skin information detector connected to the support frame to detect at least one skin related information including a moisture level and an oil level of the user's skin in case that the user's skin touches the skin information detector, and a control module that controls the image display module to display the at least one blood-pressure related and the at least one skin related information as augmented reality contents.

Abstract: The present disclosure provides systems and methods relating to neuromodulation. In particular, the present disclosure provides systems and methods for evaluating the efficacy of neuromodulation therapy using evoked potential (EPs). The systems and methods disclosed herein facilitate the evaluation of both parameter-dependent and system-dependent changes in EPs as indicators of therapeutic efficacy.

Abstract: A method comprises driving, by a motor, a camshaft of a transmission of a telesurgically operated instrument to a first rotational state of a plurality of rotational states. The camshaft defines a longitudinal axis and rotates about the longitudinal axis. The method further comprises engaging, in the first rotational state, a first input gear of a first effector drivetrain of the transmission with a first gear of the first effector drivetrain via a first power cam of the camshaft. The method further comprises disengaging, in the first rotational state, a first locker arm of the first effector drivetrain from the first gear via a first locker cam of the camshaft.

Abstract: A network-hosted product selection system includes a first server having at least one connected data repository, the first server including a non-transitory medium coupled thereto, the non-transitory medium including instructions for the first server to accept a digitally coded patient state diagnosis model from a connected input device, parse said diagnosis model for information, compare results with information derived from individual ones of product data models, the product data models including parse able tags weighing efficacy in treatment of one or more medical conditions and or symptoms derived from the patient state diagnosis model, select one or more product data models weighing high in efficacy based on at least collective tag weight and displaying products and associated transactional data and product consumption recommendation data.

Abstract: An electronic device, method, and computer-readable recording medium execute a customizable physiological measurement schedule for measuring one or more physiological parameters of a patient. A display displays information related to the patient including physiological data, and a memory is configured to store one or more programs. The one or more processors execute the one or more programs to provide a graphical user interface (“GUI”) on the display including a customizable measurement schedule. An input is received directed to one or more measurement times and corresponding measurement intervals of the one or more physiological parameters to the customizable measurement schedule using a first selection. When the customizable measurement schedule is executed, the one or more programs when executed by the one or more processors provide a first visible indication as each measurement time and corresponding measurement interval of the customizable measurement schedule is completed.

Abstract: The various implementations described herein include methods and systems for monitoring biometric information. In one aspect, a method includes (i) capturing, via an inward-facing camera of an artificial-reality headset, a plurality of images of a region of a face of the user, the region including an eye of the user, where (a) a first image of the plurality of images includes a first position of a pupil in the eye, and (b) a second image of the plurality of images includes a second position of the pupil in the eye, the second position different than the first position; and (ii) determining heart rate information based on the plurality of images.

Abstract: An apparatus and method for subject monitoring and diagnosing with non-invasive measures are disclosed.

Abstract: A device for non-invasive light delivery to a subject. The device includes a controller disposed in the housing, the controller being electrically connected to the power source; at least one waveform electronics assembly; a plurality of laser diodes disposed in the housing, the plurality of laser diodes being configured to operate in a super-pulsed regime, the controller being configured to operate the plurality of laser diodes with a Megahertz (MHz) modulation and peak power in milliwatts (mW), the plurality of laser diodes including at least one near-infrared laser diode, at least one mid-infrared laser diode, at least one far-infrared laser diode, and at least one visible-range laser diode; a plurality of optical fibers bundled into at least one fiber bundle, a distal end of the at least one fiber bundle being arranged and configured for delivering light from the plurality of optical fibers to the subject.