Abstract: A nasal irrigation diagnostic assembly comprising an irrigation device including a fluid collection portion structured to retain a biological sample, in the form of waste solution from the nasal cavity resulting from irrigation. A detection member disposed on said irrigation device is exposed to the biological sample and is structured to determine the existence of at least one analyte within the biological sample of the waste solution. The detection member comprises a plurality of detection zones individually structured to analyze the biological sample upon engagement therewith, wherein said plurality of zones include at least a reaction zone and a detection zone, which respectively include reagents cooperatively and collectively formulated to detect the existence of the at least one analyte within biological sample of the waste solution. A control zone may also be included to indicate the intended operability of at least the detection member.

Abstract: The extraction cell according to the invention for extracting a sample is substantially characterized by the following features: a tubular extraction body having a first end and an opposite second end which has an interior space for receiving the sample, a first closure arrangement for sealingly closing the first end of the tubular extraction body, a second closure arrangement for sealingly closing the second end of the tubular extraction body, wherein the first closure arrangement has a first fluid port for supplying or discharging a fluid and the second closure arrangement has a second fluid port for supplying or discharging a fluid. Furthermore, between the extraction body and the first closure arrangement and between the extraction body and the second closure arrangement, at least one adhesive arrangement is provided for holding the first and the second closure arrangements on the extraction body.

Abstract: A device for handling laboratory plates comprising a base platform and opposing gripping members including one or more gripping members each pivotally attached to a first side of the base platform and one or more gripping members each pivotally attached to a second side of the base platform, wherein said gripping members extend down from the base platform and include a gripping tip disposed at the end of the gripping member, and methods of using the same.

Abstract: The present invention provides methods, systems and kits for performing microwell analysis in sealed small volumes. The microwells of the invention are sealed through the pairing of microwell and bead geometry wherein the diameter of the beads is greater than the diameter of the bottom of the microwells. Loading the beads into the microwells seals samples within an analytical space between the bottom of a nested bead and the bottom of the subject microwell.

Abstract: Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.

Abstract: When washing the inside of a reactor vessel which is used repeatedly, a rough suction is performed before suctioning with a washing tip; however, unwanted washing liquid may remain that may affect analysis results. The present invention provides an automatic analysis device for analyzing a sample using light, in which the automatic analysis device is characterized in that: a washing mechanism comprises a washing liquid supply nozzle that supplies washing liquid to a reactor vessel after analysis, a washing liquid suction nozzle that suctions the supplied washing liquid, a washing tip provided to the bottom end of the washing liquid suction nozzle, and a rough suction nozzle that suctions, in advance, a liquid within the reactor vessel before suctioning with the washing tip; and after the rough suction, liquid is caused to remain so that the bottom surface of the reactor vessel is not exposed.

Abstract: A biological false bottom transport tube system includes a top section of a specimen tube body, the top section comprising a top, a semi-spherical interior floor, and a bottom below the interior floor, the top section manufactured from a material transparent to both visible and infrared light, wherein the top section may hold a sample on the interior floor; and a bottom section of the specimen tube body, the bottom section comprises a top of a diameter less than a dimeter defined by a remainder of the bottom section, the top of the bottom section fits into the bottom of the top section below the interior floor such that the top of the bottom section is secured within the bottom of the top section, the bottom section manufactured from a material that is not transparent to either visible or infrared light.

Abstract: An electrochemical sensor incorporates a ferrocenophane which is a compound with at least one bridging group covalently attached to and connecting the two cyclopentadiene rings associated with the same iron atom. This bridging group maybe tetramethylene. As compared to an equivalent sensor with ferrocene, the tolerance of elevated temperature is improved and so is the working life at ambient temperature.

Abstract: An automated analyzer includes a reagent dispensing probe that dispenses a reagent to a reaction vessel, a sample dispensing probe that dispenses a sample to the reaction vessel, a stirring rod that stirs a sample and a reagent in the reaction vessel, and a storage unit that stores special washing information including information about a condition for performing special washing to prevent sample carryover and a washing method. The automated analyzer further includes: a determination unit that determines whether the special washing is required based on information about the sample dispensed by the sample dispensing probe and the special washing information; and a controller that causes the reagent dispensing probe to dispense a wash liquid to the reaction vessel and causes the stirring rod to stir the wash liquid in the reaction vessel based on the special washing information, when the special washing is performed.

Abstract: A measurement portion includes a containment unit including a plurality of containers containing a liquid, a dispensing unit including a dispensing probe for dispensing the liquid, and a gauging portion for gauging the liquid dispensed by the dispensing unit. An excessive immersion determination portion determines whether an immersion of the dispensing probe is excessive immersion that exceeds a predetermined range. An input portion can select and set an operation of the measurement portion to be performed after the excessive immersion determination portion determines that the immersion is excessive immersion from a plurality of modes. A measurement control portion controls the measurement portion depending on a mode set by the input portion.

Abstract: A device for base calling is provided. The device includes a receptacle configured to hold a biosensor having a sample surface holding a plurality of clusters during a sequence of sampling events, an array of sensors sensing information from clusters disposed in corresponding pixel areas of the sample surface during the sampling events and generate sequences of pixel signals and a communication port configured to output the sequences of pixel signals. The device also includes a signal processor coupled to the communication port and configured to receive and process at least one pixel signal in the sequences of pixel signals that mixes light gathered from at least two clusters in a corresponding pixel area, and to base call each of the at least two clusters using the at least one pixel signal.

Abstract: A solid phase microextraction device is disclosed, including a substrate having a planar surface and a sorbent layer disposed on the planar surface. The planar surface is defined by a base edge, a spray edge disposed distal across the substrate from the base edge, the spray edge including a tapering tip extending away from the base edge, a first lateral edge extending from the base edge to the tapering tip, and a second lateral edge extending from the base edge to the tapering tip, the second lateral edge being disposed distal across the substrate from the first lateral edge. The sorbent layer extends a sampling length from the spray edge toward the base edge and includes sorbent particles. A method for forming the solid phase microextraction device is disclosed, including applying the sorbent layer on the planar surface utilizing at least one of screen printing, stencil printing, or additive manufacturing.

Abstract: The automatic analysis device 100 is provided with: a specimen dispensing mechanism 101 that dispenses subject blood plasma and/or normal blood plasma to be added to correct the coagulation time of the subject blood plasma, into a plurality of specimen containers 103; reaction containers 104 that contain the subject blood plasma and/or the normal blood plasma; a reagent dispensing mechanism 106 that dispenses a reagent into the reaction containers 104; and a detecting unit 113 which applies light from a light source 115 to the subject blood plasma and/or the normal blood plasma to which the reagent is added in the reaction containers 104, and which measures the coagulation time on the basis of the obtained scattered light and/or transmitted light.

Abstract: A device and a method for repeatedly modifying the composition of a fluid. The device includes a first module (19) modifying the composition of the fluid, a second module (21) modifying the composition of the fluid and a dwell module (20) with an inlet (8) and an outlet (10). The first module is connected in a fluid-conducting manner to the dwell module inlet and the dwell module outlet is connected in a fluid-conducting manner to the second module. Either the first or the second module is a filter unit, or the first module is a first filter unit and the second module is a second filter unit. The filter unit(s) include(s) at least one first filter medium (4, 14) delimiting a supply channel (2, 12) and a retentate channel (1, 11) and at least one second filter medium (5, 15) delimiting the retentate channel and a permeate channel (3, 13).

Abstract: A nucleic acid loading device, including a housing, a carrying module, a motion module, a liquid circuit module and a control module. The motion module includes a support platform, first and second driving mechanisms, and a carrying member. The liquid circuit module is configured to control a reagent to flow into and out of a reactor. The control module is connected with the motion module and the liquid circuit module, and the control module is configured to control the first and second driving mechanisms, the liquid circuit module and the temperature control unit. A first face of a semiconductor cooler heats or refrigerates during operation, providing heat for an accommodating seat through a heat conducting body such that the reactor can be at different ambient temperatures. The cooperation between the motion and liquid circuit modules may achieve automation and industrialization of loading a sample into the reactor.

Abstract: The present invention provides: a drawer that is supported so as to be horizontally movable in the front-rear direction between an open position and a closed position through a front-face opening; a table that allows an expendable or a processing unit used for analysis to be mounted in the drawer; and a moving-direction transforming means that, while the drawer is moved toward the rear side from the open position to the closed position, moves horizontally until the expendable or the processing unit mounted on the table passes through the front-face opening from the front side to the rear side and moves the table toward the upper side in synchronization with the horizontal movement of the drawer toward the rear side after the expendable or the processing unit mounted on the table passes through the front-face opening. This makes it possible to easily and reliably perform the work of replacing a chip rack.

Abstract: Humidified sample preparation station for serial crystallography according to one embodiment is a humidified enclosure that delivers relative humidities above 95% and preferably above 97% in standard operation, and that can allow microscope observation of samples within. Humidified sample preparation station for serial crystallography can be used for preparation of protein crystal samples for examination using X-rays and for protein structure determination by X-ray crystallography, involving addition of liquid to the sample and removal of liquid from the sample using vacuum or suction.

Abstract: An example microfluidic device includes a microfluidic network through which operational fluid is to flow and a droplet ejector. The microfluidic device includes a drive fluid storage volume to contain drive fluid, the drive fluid storage volume connected in series between the microfluidic network and the droplet ejector. When the drive fluid is ejected from the droplet ejector, the operational fluid is drawn through the microfluidic network.

Abstract: A sample extraction cassette and method are provided to test for a target in a sample. The sample is obtained on a swab. The swab is inserted into a chamber in a case and into contact with a contact portion of a membrane. The contact portion of the membrane is axially moved into sequential communication with a wash fluid and a reaction fluid. The reaction fluid reacts with the target to provide a visual display corresponding to the presence of the target.

Abstract: Provided is an automatic analysis technique that prevents liquid contained in a reaction container from locally contacting with liquid added afterward and has less occurrence frequency of equipment malfunction and high performance.