Patents Examined by Benjamin R Whatley
  • Patent number: 11014835
    Abstract: A method of measuring concentration of dissolved organic nitrogen in sewage. The method includes: filtering a sewage sample using a filter membrane; measuring the concentrations of total dissolved nitrogen (TDN), ammonia nitrogen (NH4+), and nitric nitrogen (NO3?) in the sewage sample, respectively designated as CTDN(I), CNH4+(I) and CNO3?(I); calculating the ratios of (CNH4+(I)+CNO3?(I))/CTDN(I) and CNO3?(I)/CNH4+(I), and according to the ratios, calculating the concentration of dissolved organic nitrogen (DON) in the sewage sample.
    Type: Grant
    Filed: June 15, 2020
    Date of Patent: May 25, 2021
    Assignee: NANJING UNIVERSITY
    Inventors: Hongqiang Ren, Haidong Hu, Jinju Geng, Lili Ding, Hui Huang
  • Patent number: 11008628
    Abstract: In one embodiment, a method is provided comprising analyte testing on one or more types of samples.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: May 18, 2021
    Assignee: Labrador Diagnostics LLC
    Inventors: Elizabeth A. Holmes, Timothy Smith, Samartha Anekal, James R. Wasson, Daniel L. Young, Chinmay Pangarkar
  • Patent number: 11002715
    Abstract: In an LC/MS analysis of a sample containing various compounds, additive supply pumps 164A and 164B in a post-column adding unit 16 draw and supply different kinds of additives A and B from containers 163A and 163B, respectively. The additives are mixed into an eluate through T-joints 162 and 161. A preferable combination of the additives is the combination of DMSO which produces the effect of gathering charge states and 2-propanol which produces the effect of promoting atomization or vaporization of droplets. By mixing the two additives into the eluate while mixing them at an appropriate flow-rate ratio according to a previously determined flow-rate program, the ionization efficiency can be nearly optimized for each compound during the process of generating ions by spraying electrically charged droplets of the eluate from an ESI spray 21. Consequently, the detection sensitivity becomes higher than conventional levels.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: May 11, 2021
    Assignee: SHIMADZU CORPORATION
    Inventor: Yusaku Hioki
  • Patent number: 11002751
    Abstract: Apparatus for separation, washing and mixing of magnetic particles in at least one reaction cup, adapted to be used in an immunoanalyzer system, said at least one reaction cup containing nanometric magnetic particles (beads) binding immuno-complex antibody, antigen molecules, and liquid, comprising: a supporting dial mechanism (11) in the form of a rotating carousel , comprising an upper side with a number of holes adapted to host a corresponding number of said at least one reaction cup (1) in substantially vertical positions, and a lower side comprising a number of guide grooves (2) radially behind corresponding holes of the upper side, a number of magnet mechanisms (30) adapted to be inserted in corresponding ones of said guide grooves (2) and to slide therein, so as to radially approach to or depart from the side external surface of corresponding ones of said at least one reaction cup (1); at least one washing mechanism (40) firmly installed around said supporting dial mechanism (11), and comprising a w
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: May 11, 2021
    Assignee: Technogenetics Holdings S.r.l.
    Inventors: Chao Yu, Shenguang Su, Qingwen Tang, Luca Melillo
  • Patent number: 10996212
    Abstract: Methods of forming a chip with fluidic channels include forming (e.g., milling) at least one nanofunnel with a wide end and a narrow end into a planar substrate, the nanofunnel having a length, with width and depth dimensions that both vary over its length and forming (e.g., milling) at least one nanochannel into the planar substrate at an interface adjacent the narrow end of the nanofunnel.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: May 4, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Laurent Menard, Jinsheng Zhou, Michael Rubinstein, Sergey Panyukov
  • Patent number: 10987673
    Abstract: The invention relates to a temperature-control element (4) for a multiwell plate (1), which comprises a plurality of cavities (2) arranged in rows and columns for freezing and/or thawing biological samples. The temperature-control element (4) comprises a base body (6) which is made of a thermally conductive material and is flown through by a temperature-control fluid; and a plurality of protruding temperature-control fingers (5) arranged in rows and columns on an upper side of the base body (6), which are connected in a thermally conductive manner to the base body (6), wherein a grid spacing of the temperature control fingers (5) corresponds to a grid spacing of the cavities (2) of the multiwell plate (1). The invention further relates to a device and method for freezing biological samples, in particular for cryopreservation, and/or thawing biological samples, in particular a cryopreserved sample.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: April 27, 2021
    Assignee: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e. V.
    Inventors: Guenter R. Fuhr, Heiko Zimmermann
  • Patent number: 10989727
    Abstract: An apparatus for cup loading and unloading and a thromboelastography machine are provided. The apparatus for cup loading and unloading includes a base, a shaft, a movable cover, and a cup holder. The shaft is rotatably connected to the base about an axis of the shaft and has an end configured to engage with an inner cup. The movable cover is disposed around the shaft and slidably connected to the base along the axis of the shaft. The movable cover is provided with an elastic member therein. The cup holder is slidably connected to the base along the axis of the shaft and disposed below the base and the shaft. The cup holder has a cavity configured to engage with an outer cup, and the cavity has an open directed upward.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: April 27, 2021
    Assignee: MEDCAPTAIN MEDICAL TECHNOLOGY CO., LTD
    Inventors: Zhiguang Yu, Shuai Yin, Lintao Wu, Jun Dong
  • Patent number: 10982183
    Abstract: Disclosed herein is a cell harvesting instrument suitable for concentrating cells from a source suspension of cells and/or washing said cells, the instrument comprising: a housing for accommodating mechanical elements including at least one fluid pump, at least one valve; and a processing kit removably insertable into the housing, said kit including a generally flat frame having or supporting plural sealed fluid paths arranged in a generally flat plane and such that fluids in the paths do not contact said mechanical elements, wherein at least portions of the fluid paths comprise flexible tubes, the outer surfaces of which are manipulateable by the or each fluid pump, to provide fluid flow in one or more of the paths and/or by the or each valve to restrict fluid flow in one or more of the paths. In an embodiment, the kit comprises also a fluid processing reservoir and a filter suitable for separating cells from fluid in said paths.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: April 20, 2021
    Assignee: Global Life Sciences Solutions USA LLC
    Inventors: Dan Harris, Jim Dowling
  • Patent number: 10983105
    Abstract: An apparatus for controlling acid-rock reaction includes a first reactor, a second reactor connected to the first reactor and configured to produce a spent acid through reaction of a rock with an acid aqueous solution and to introduce the spent acid into the first reactor, the first reactor being configured to react a rock disk with the spent acid introduced from the second reactor, a sample extractor connected to the first reactor and configured to extract, from the first reactor, a predetermined amount of the spent acid reacting with the rock disk in the first reactor, and a data acquisition device configured to acquire temperature and pressure data of the first reactor and the second reactor and control the first reactor and the second reactor based on he acquired temperature and pressure data of the first reactor and the second reactor.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: April 20, 2021
    Assignee: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY
    Inventors: Jeonghwan Lee, Hyunsang Yoo
  • Patent number: 10983138
    Abstract: A sample handling device for a laboratory automation system comprising a first carousel with a disc supported on a first axis, a second carousel with a disc supported on a second axis parallel to the first axis, and a transfer element between the first and second carousels is presented. Each disc has recesses distributed radially about the disc perimeter. Each recess receives a tube carrier. The first carousel and the second carousel connect via a passage for transferring sample tube carriers between the first and second carousels. The transfer element is a track switch which when in a rest position partly closes the passage to separate the first carousel from the second carousel. The track switch is swiveled and/or rotated about a third axis parallel to the first axis out of the rest position for transferring a tube carrier from the first carousel to the second carousel via the passage.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: April 20, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Gottlieb Schacher, Beat Jaeggi, Patrik Imfeld, Harald Ferihumer
  • Patent number: 10981947
    Abstract: The invention relates to a container holder 10, comprising a main body 12 which in turn comprises a gas inlet 16; a solution liquid outlet 18; a gas control valve 20 through which a gas enters the container 100 from the gas inlet; and a sealing means 22 for the container, which sealing means includes a passageway 24 for the input of gas and output of a solution in the container via an egress tube 19; wherein when the container is connected to the container holder through the sealing means, the gas control valve opens automatically, and when the container is disconnected the gas control valve is closed automatically. The invention further relates to a container panel 50 which includes two or more container holders. Also disclosed are methods of using these containers and container panels for synthesizing a polypeptide.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: April 20, 2021
    Assignee: Cytiva Sweden AB
    Inventors: Bjorn Markus Olovsson, Mathias Osmark, Mangus Gamberg, Daniel Carlsson
  • Patent number: 10976331
    Abstract: A container containing unit includes a housing and a lid member. The lid member has a probe insertion hole and a droplet guide portion. The droplet guide portion is formed at an edge of an opening end of the probe insertion hole and has a plurality of groove portions. The plurality of groove portions extend from the edge of the opening end to an outside of a locus through which the mouth of the container is moved.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: April 13, 2021
    Assignee: JEOL Ltd.
    Inventor: Takashi Yaginuma
  • Patent number: 10975429
    Abstract: A system may include a flow cell through which a plurality of reagents may be pumped during a genetic sequencing operation, an effluent line that, in operation, is to conduct a used reagent, a used reagent valve to receive the used reagent from the effluent line and controllable to select one of a plurality of disposal paths for the used reagent, and control circuitry coupled to the used reagent valve that, in operation, is to control the used reagent valve to select a desired one of the disposal paths depending upon which reagent is being pumped though the flow cell.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: April 13, 2021
    Assignee: ILLUMINA, INC.
    Inventors: Bradley Kent Drews, Kevin James Cappa, Matthew William Hage
  • Patent number: 10976323
    Abstract: The present invention provides methods for measuring the absolute concentration of Tau, and other protein, peptide fragments and proteoforms in CSF and plasma samples collected from a subject. Such biomolecules may be implicated in one or more neurological and neurodegenerative diseases or disorders. Also provided is a method for determining whether a therapeutic agent affects the CSF or plasma concentration of a central nervous system derived biomolecule. Also provided are kits for performing the methods of the invention.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: April 13, 2021
    Assignee: C2N Diagnostics LLC
    Inventors: Kristopher Michael Kirmess, Kevin Edward Yarasheski, Matthew R. Meyer
  • Patent number: 10974248
    Abstract: An adapter for laboratory cell strainer is disclosed. The adapter includes a unitary structure having an annular top surface, an annular bottom surface, a smooth inner surface, an outer surface, and an opening extending therethrough. The adapter has a downwardly and radially inwardly sloped funnel section terminating in a cylindrical edge at the annular bottom surface with a lower section of the funnel section having a narrowed, tapered diameter. The outer surface of a middle section of the funnel section has an annular neck configured therearound with a plurality of radially protruding ribs. The unitary structure is configured for connection to the laboratory cell strainer at the annular top surface and placement inside a various sized laboratory tube for receiving filtered liquid during use.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: April 13, 2021
    Assignee: MTC Bio Inc.
    Inventors: Walter Demsia, Michael Demsia
  • Patent number: 10968155
    Abstract: A process for selecting an inert material for use in monomer production regarding the formation of heavy by-products during the reaction of propylene to acrolein and acrylic acid.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: April 6, 2021
    Assignee: Rohm and Haas Company
    Inventor: Jinsuo Xu
  • Patent number: 10968158
    Abstract: A method of determining the inertness of a material regarding the formation of heavy by-products during the reaction of propylene to acrolein and acrylic acid.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: April 6, 2021
    Assignee: Rohm and Haas Company
    Inventor: Jinsuo Xu
  • Patent number: 10966690
    Abstract: A specimen container system and methods of use are described herein for capturing, storing and accessing fluids for lab testing. A cup is removably secured to a cap assembly. The cap assembly is comprised of cover and a lid which are connected by a hinge assembly having a biasing member for maintain the lid in an open position. An aperture in the cap has two sections that in combination with the lid decreases the contamination risk compared to prior art container system.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: April 6, 2021
    Inventor: Marc Kopoian
  • Patent number: 10962558
    Abstract: An automatic analyzer is capable of ensuring sufficient nozzle cleaning and suppressing of deterioration in the accuracy of analysis. When it is judged that there remains no analysis item of the sample, a judgment is made on whether the sample dispensation quantity of the n-th sample dispensation is less than a dispensation quantity threshold value or not, and if less, a cleaning pattern is selected by making a judgment on whether or not all the sample dispensation quantities of the first through (n?1)-th sample dispensations are less than the dispensation quantity threshold value. If the sample dispensation quantity of the n-th sample dispensation is the dispensation quantity threshold value or more, another cleaning pattern selected by making the judgment on whether or not all the sample dispensation quantities of the first through (n?1)-th sample dispensations are less than the dispensation quantity threshold value.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: March 30, 2021
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Akihiro Yasui, Hitoshi Tokieda, Toshihide Orihashi, Yoshiaki Saito, Naoto Suzuki
  • Patent number: 10948507
    Abstract: A specimen transport apparatus according to an embodiment includes: a holder including first and second trenches and configured to hold a specimen; a first transporter including a first protrusion to engage with the first trench and configured to transport the holder by transferring the first protrusion engaged with the first trench in an extension direction of the second trench; a second transporter including a second protrusion to engage with the second trench and configured to transport the holder by transferring the second protrusion engaged with the second trench in an extension direction of the first trench. The first trench is formed in at least one of an upper surface and a lower surface of the holder. The second trench is formed in at least one of the upper surface and the lower surface of the holder, and is formed to extend to a lateral surface of the holder.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: March 16, 2021
    Assignee: SYSMEX CORPORATION
    Inventors: Yuto Sasaki, Kazuki Asao, Kazuyuki Iguchi, Keiichiro Shohmi, Shoichiro Asada, Hiroaki Tobimatsu, Ryutaro Shinya