Patents Examined by Benjamin R Whatley
  • Patent number: 11951480
    Abstract: A solid phase microextraction device is disclosed, including a substrate having a planar surface and a sorbent layer disposed on the planar surface. The planar surface is defined by a base edge, a spray edge disposed distal across the substrate from the base edge, the spray edge including a tapering tip extending away from the base edge, a first lateral edge extending from the base edge to the tapering tip, and a second lateral edge extending from the base edge to the tapering tip, the second lateral edge being disposed distal across the substrate from the first lateral edge. The sorbent layer extends a sampling length from the spray edge toward the base edge and includes sorbent particles. A method for forming the solid phase microextraction device is disclosed, including applying the sorbent layer on the planar surface utilizing at least one of screen printing, stencil printing, or additive manufacturing.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: April 9, 2024
    Assignee: RESTEK CORPORATION
    Inventors: Tracey A. Peters, German A. Gomez-Rios, Thomas E. Kane
  • Patent number: 11953464
    Abstract: A device for base calling is provided. The device includes a receptacle configured to hold a biosensor having a sample surface holding a plurality of clusters during a sequence of sampling events, an array of sensors sensing information from clusters disposed in corresponding pixel areas of the sample surface during the sampling events and generate sequences of pixel signals and a communication port configured to output the sequences of pixel signals. The device also includes a signal processor coupled to the communication port and configured to receive and process at least one pixel signal in the sequences of pixel signals that mixes light gathered from at least two clusters in a corresponding pixel area, and to base call each of the at least two clusters using the at least one pixel signal.
    Type: Grant
    Filed: June 2, 2022
    Date of Patent: April 9, 2024
    Assignee: Illumina, Inc.
    Inventors: Dietrich Dehlinger, Ali Agah, Tracy Helen Fung, Emrah Kostem
  • Patent number: 11946941
    Abstract: The automatic analysis device 100 is provided with: a specimen dispensing mechanism 101 that dispenses subject blood plasma and/or normal blood plasma to be added to correct the coagulation time of the subject blood plasma, into a plurality of specimen containers 103; reaction containers 104 that contain the subject blood plasma and/or the normal blood plasma; a reagent dispensing mechanism 106 that dispenses a reagent into the reaction containers 104; and a detecting unit 113 which applies light from a light source 115 to the subject blood plasma and/or the normal blood plasma to which the reagent is added in the reaction containers 104, and which measures the coagulation time on the basis of the obtained scattered light and/or transmitted light.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: April 2, 2024
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Chie Yabutani, Naoto Suzuki, Akihisa Makino
  • Patent number: 11933800
    Abstract: The present invention provides: a drawer that is supported so as to be horizontally movable in the front-rear direction between an open position and a closed position through a front-face opening; a table that allows an expendable or a processing unit used for analysis to be mounted in the drawer; and a moving-direction transforming means that, while the drawer is moved toward the rear side from the open position to the closed position, moves horizontally until the expendable or the processing unit mounted on the table passes through the front-face opening from the front side to the rear side and moves the table toward the upper side in synchronization with the horizontal movement of the drawer toward the rear side after the expendable or the processing unit mounted on the table passes through the front-face opening. This makes it possible to easily and reliably perform the work of replacing a chip rack.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: March 19, 2024
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Taichiro Yamashita, Takenori Okusa
  • Patent number: 11931742
    Abstract: A nucleic acid loading device, including a housing, a carrying module, a motion module, a liquid circuit module and a control module. The motion module includes a support platform, first and second driving mechanisms, and a carrying member. The liquid circuit module is configured to control a reagent to flow into and out of a reactor. The control module is connected with the motion module and the liquid circuit module, and the control module is configured to control the first and second driving mechanisms, the liquid circuit module and the temperature control unit. A first face of a semiconductor cooler heats or refrigerates during operation, providing heat for an accommodating seat through a heat conducting body such that the reactor can be at different ambient temperatures. The cooperation between the motion and liquid circuit modules may achieve automation and industrialization of loading a sample into the reactor.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: March 19, 2024
    Assignee: GENEMIND BIOSCIENCES COMPANY LIMITED
    Inventors: Songzhen Zhang, Zefei Jiang, Guangming Wang, Ping Wu, Zhiliang Zhou, Qin Yan
  • Patent number: 11931733
    Abstract: A device and a method for repeatedly modifying the composition of a fluid. The device includes a first module (19) modifying the composition of the fluid, a second module (21) modifying the composition of the fluid and a dwell module (20) with an inlet (8) and an outlet (10). The first module is connected in a fluid-conducting manner to the dwell module inlet and the dwell module outlet is connected in a fluid-conducting manner to the second module. Either the first or the second module is a filter unit, or the first module is a first filter unit and the second module is a second filter unit. The filter unit(s) include(s) at least one first filter medium (4, 14) delimiting a supply channel (2, 12) and a retentate channel (1, 11) and at least one second filter medium (5, 15) delimiting the retentate channel and a permeate channel (3, 13).
    Type: Grant
    Filed: June 4, 2021
    Date of Patent: March 19, 2024
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Martin Leuthold, Alexander Helling, Ulrich Grummert
  • Patent number: 11925932
    Abstract: An example microfluidic device includes a microfluidic network through which operational fluid is to flow and a droplet ejector. The microfluidic device includes a drive fluid storage volume to contain drive fluid, the drive fluid storage volume connected in series between the microfluidic network and the droplet ejector. When the drive fluid is ejected from the droplet ejector, the operational fluid is drawn through the microfluidic network.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: March 12, 2024
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventor: Si-lam Choy
  • Patent number: 11925931
    Abstract: Humidified sample preparation station for serial crystallography according to one embodiment is a humidified enclosure that delivers relative humidities above 95% and preferably above 97% in standard operation, and that can allow microscope observation of samples within. Humidified sample preparation station for serial crystallography can be used for preparation of protein crystal samples for examination using X-rays and for protein structure determination by X-ray crystallography, involving addition of liquid to the sample and removal of liquid from the sample using vacuum or suction.
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: March 12, 2024
    Assignee: MiTeGen, LLC
    Inventors: Richard Jayne, David Closs, Benjamin A. Apker, Robert E. Thorne
  • Patent number: 11919004
    Abstract: A sample extraction cassette and method are provided to test for a target in a sample. The sample is obtained on a swab. The swab is inserted into a chamber in a case and into contact with a contact portion of a membrane. The contact portion of the membrane is axially moved into sequential communication with a wash fluid and a reaction fluid. The reaction fluid reacts with the target to provide a visual display corresponding to the presence of the target.
    Type: Grant
    Filed: August 30, 2021
    Date of Patent: March 5, 2024
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David Beebe, Duane Juang, Terry Juang
  • Patent number: 11904313
    Abstract: The invention discloses a liquid quantifying device which comprises a base body and a liquid quantifying area arranged on the base body; the liquid quantifying area is provided with a preset volume, two ends of the liquid quantifying area are respectively provided with a liquid quantitative inlet and a liquid quantitative outlet, the liquid flows into the liquid quantifying area from the liquid quantitative inlet and reaches the liquid quantitative outlet after the liquid quantifying area is filled; and a liquid identification device is arranged at a relevant position of the liquid quantitative outlet and used for identifying the liquid reaching the liquid quantitative outlet. The invention also discloses a use of the liquid quantifying device in a microfluidic chip. The invention can improve the accuracy of quantification and detection.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: February 20, 2024
    Assignee: GUANGZHOU WONDFO BIOTECH CO., LTD.
    Inventors: Xuan Meng, Huifang Wan, Haisheng Hu, Wenmei Li
  • Patent number: 11906406
    Abstract: Provided is an automatic analysis technique that prevents liquid contained in a reaction container from locally contacting with liquid added afterward and has less occurrence frequency of equipment malfunction and high performance.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: February 20, 2024
    Assignees: Hitachi High-Tech Corporation, Roche Diagnostics Operations, Inc.
    Inventors: Daisuke Ebihara, Shinya Matsuoka, Taku Sakazume, Yuzuru Shimazaki
  • Patent number: 11896976
    Abstract: A lidded vessel assembly comprises a tubular vessel, a lid, and a latching device. The tubular vessel defines a vessel opening and comprises a vessel base, an inner wall, a sealing area and a parking area both defined on the inner wall and both positioned below the vessel opening. The lid comprises a lid base having an inside surface, and a plug projecting from the inside surface of the lid base. The plug is configured to be inserted through the vessel opening to engage the parking area to define a parking position, and configured to be further inserted through the vessel opening out of the parking area to bias against a portion of the sealing area to define a sealing position. The first latching device comprises a first latching element positioned on the inner wall of the vessel, and a second latching element positioned on the outside of the plug.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: February 13, 2024
    Assignee: Eppendorf AG
    Inventors: Michael Blumentritt, Kai Holl
  • Patent number: 11890619
    Abstract: Pipetting containers, such as reservoirs, reservoir liners, microplates, PCR plates, microtubes and PCR tubes, include anti-vacuum channels on the bottom wall of the receptacle to prevent a pipette tip vacuum engaging the wall during aspiration. The groupings of anti-vacuum channels are located on the bottom surface facing upward into the basin that holds liquid samples or reagents. The anti-vacuum channels also lower the required working volume for pipetting and reduce liquid waste.
    Type: Grant
    Filed: May 5, 2021
    Date of Patent: February 6, 2024
    Assignee: Integra Biosciences AG
    Inventors: Terrence Kelly, Jonathan Harkins, George Kalmakis, Gary Nelson
  • Patent number: 11878297
    Abstract: Provided herein is technology relating to testing fluid specimens and particularly, but not exclusively, to apparatuses, devices, methods, systems, and kits for testing a fluid specimen, e.g. urine, saliva, or other body fluids, to detect specified chemical components in the specimen.
    Type: Grant
    Filed: June 3, 2020
    Date of Patent: January 23, 2024
    Assignee: ABBOTT TOXICOLOGY LIMITED
    Inventors: Nigel John Fairbank, Jr., Barry Lillis, Timothy John Abbott, Paul Ngui
  • Patent number: 11856947
    Abstract: A device for permeation of a biological material may include a lower portion and an upper portion configured to be releasably coupled to the lower portion. The lower portion may include a groove configured to receivingly support a biological material. The lower portion and the upper portion may be coupled such that a first reservoir and a second reservoir are formed collectively by the lower portion and the upper portion. The first reservoir, the second reservoir, and the groove may be in fluid communication with each other.
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: January 2, 2024
    Assignee: COOK MEDICAL TECHNOLOGIES LLC
    Inventor: Jorge L. Jimenez-Rios
  • Patent number: 11850583
    Abstract: Devices, kits, and methods separating and metering a plasma sample from a patient's liquid test sample.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: December 26, 2023
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Aaron Kauffmann, David Ledden
  • Patent number: 11852571
    Abstract: A sample separation device to introduce a sample to be separated to an inside of the sample separation device, centrifuge the sample, and collect a desired liquid after separation, includes: a sample introducing portion introducing the sample into the sample separation device; a liquid surface defining portion connected to the sample introducing portion; a first separating portion connected to the liquid surface defining portion; a second separating portion connected to the first separating portion; a third separating portion connected to the second separating portion; and a liquid extracting portion including the third separating portion and connected to the third separating portion, in which a tubular flow path is formed by at least the first separating portion and the second separating portion, in which an opening of the sample introducing portion and an opening of the liquid extracting portion are oriented in the same direction.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: December 26, 2023
    Assignee: HITACHI, LTD.
    Inventors: Yu Ishige, Sakuichiro Adachi, Takahiro Ando
  • Patent number: 11846644
    Abstract: A conveyor assembly for transporting a carrier coupled to a receptacle to a processing station located within a housing of an instrument. The conveyor assembly includes a spur conveyor subassembly and a buffer conveyor subassembly for transporting the carrier from a host conveyor assembly to the spur conveyor subassembly. The spur conveyor subassembly includes (i) a rotatable diverter having at least one recess for receiving and moving the carrier between the buffer conveyor subassembly and the spur conveyor subassembly and (ii) a gripper configured to grasp the carrier and move it from the diverter to the processing position located within the housing of the instrument.
    Type: Grant
    Filed: May 13, 2020
    Date of Patent: December 19, 2023
    Assignee: GEN-PROBE INCORPORATED
    Inventors: George T. Walker, Matthias Merten, Gary D. Lair
  • Patent number: 11841376
    Abstract: A system includes a reagent selector valve controllable to select a reagent flow path from a plurality of reagent flow paths, and a pump coupled to the reagent flow path to draw a liquid through the reagent flow path in accordance with a prescribed test protocol. The system includes a discharge flow path to expel the drawn liquid, and a flow meter to measure liquid displaced by the pump and that outputs data representative of the measured flow. The system also includes a processor to access the data and to determine a volume of the liquid displaced by the pump.
    Type: Grant
    Filed: March 23, 2021
    Date of Patent: December 12, 2023
    Assignee: Illumina, Inc.
    Inventors: Bradley Kent Drews, Kevin James Cappa
  • Patent number: 11841310
    Abstract: In one example, a flow cell includes a substrate, an electrode positioned on the substrate, and a patterned material positioned on the electrode. In this example, the patterned material includes depressions separated by interstitial regions, and a functionalized surface of the electrode is exposed at each of the depressions. In this example, the flow cell further includes a primer grafted to the functionalized surface in each of the depressions. In another example, a flow cell includes a substrate and a patterned electrode positioned on the substrate. In this other example, the patterned electrode includes depressions separated by interstitial regions, and a functionalized surface of the substrate exposed at each of the depressions. In this other example, a primer is grafted to the functionalized surface in each of the depressions.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: December 12, 2023
    Assignee: Illumina, Inc.
    Inventors: Hayden Black, Brian D. Mather