Abstract: An example system includes a well plate having at least one well, an array of electrodes positioned on a surface of a bottom floor of the well, and a controller to direct electrical voltage to the electrodes to generate a non-uniform electrical field. The electrical field is to direct an object in the electrical field to a target position in the well.

Abstract: A microdevice for monitoring a target analyte is provided. The microdevice can include a field effect transistor comprising a substrate, a gate electrode, and a microfluidic channel including graphene. The microfluidic channel can be formed between drain electrodes and source electrodes on the substrate. The microdevice can also include at least one aptamer functionalized on a surface of the graphene. The at least one aptamer can be adapted for binding to the target analyte. Binding of the target analyte to the at least one aptamer can alter the conductance of the graphene.

Abstract: A system writes input data to a storage device as machine-written polynucleotides; and reads machine written polynucleotides from the storage device as output data. The storage device includes a flow cell including a plurality of storage wells in which machine written polynucleotides may be stored. The storage device may include a set of electrodes corresponding to the storage wells that allow for selective interactions with wells across the surface of a flow cell. Operation of the storage device may include receiving a read request associated with a particular location in the storage device, creating a copy of a nucleotide sequence located at the particular location in the storage device, transferring the copy of the nucleotide sequence to a read location, and reading the copy of the nucleotide sequence at the read location.

Abstract: Automatic device for the automated conduct of analyses, notably medical analyses, including: 43. a storage zone for bottles, 44. an automated sampling system for selectively sampling the content of a bottle among those present in the storage zone, 45. a loading zone for introducing a new bottle into the automatic device, 46. an unloading zone for collecting a bottle previously present in the storage zone, 47. a bottle conveyor and storage system, configured selectively and individually to transport a bottle from a location in the storage zone to the unloading zone or from the loading zone to a location in the storage zone.

Abstract: Specialized culture plates for imaging cells in a quick, high throughput manner are provided. Ideally the wells of the culture plate have triangular, square, or V-shaped wells or cell sorting walls having a plurality of vertices, and more complicated variations thereof are also possible. The plates are tilted or rotated to collect the cells at the vertex or vertices of the wells, optionally vibrated to speed the collection, then the vibration and tilt or rotation removed for some period of time, whereon the cells are imaged through the flat transparent bottom of the plate.

Abstract: A lateral flow assay device comprising a conjugate pad for receiving a quantity of fluid, and a membrane comprising a test line for determining whether the fluid comprises a target analyte. The device includes an actuator connected to a moving element comprising a shaft or a wheel. A first magnet is connected to the backing of the membrane. Second and third magnets are connected to the moving element. The actuator moves the moving element between first and second positions. In the first position, the opposite poles of the first and second magnets attract each other and maintain a gap between the membrane and the conjugate pad separate. In the second position, the similar poles of the first and third magnets repel each other and close the gap between membrane and the conjugate pad, allowing the fluid to flow from the conjugate pad into the membrane and the test line.

Abstract: Described is an interface module for robotic loading and unloading of a liquid chromatography sample manager. The module includes a transfer drawer receiving apparatus having a device track and a drawer drive system configured to transport a transfer drawer along the device track into and out from a sample tray of a sample manager. The transfer drawer receives a sample-vial carrier that holds samples to be analyzed. The module further includes a window apparatus that has a window controllable to be in an open state or a closed state. When in the open state, transport of the transfer drawer through the window into or out from the sample manager permits loading of the sample-vial carrier into the sample tray and unloading of the sample-vial carrier from the sample tray. In the closed state, the window apparatus substantially seals the internal environment of the sample manager from the ambient environment.

Abstract: Methods, devices, and kits are provided for use in washing or cryopreserving live cells or tissue, such as fat graft tissue.

Abstract: Aspects of the present disclosure include sample analysis methods and systems. According to certain embodiments, provided are methods of analyzing samples in an automated sample analysis system. The methods include introducing samples and sample preparation cartridges into the system, isolating and purifying an analyte (e.g., nucleic acids and/or proteins) present in the samples at a sample preparation station, and performing analyte detection assays in assay mixtures that include the purified analyte. Also provided are automated sample analysis systems that find use, e.g., in performing the methods of the present disclosure. In certain aspects, the methods and systems provide for continuous operator access during replenishment or removal of one or any combination of samples, bulk fluids, reagents, commodities, waste, and/or the like.

Abstract: A processing unit for automated preparation of biological samples included in specimen tubes is described herein. The processing unit includes a removable sample preparation component configured to receive specimen tubes, read identifiers associated with the biological samples contained in the specimen tubes, mix reagents included in the specimen tubes, and transfer the specimen tubes to at least one of a centrifuge or a storage compartment. The processing unit further includes a centrifuge loader for automatic loading and unloading of the specimen tubes onto a centrifuge. The automated centrifuge loader includes a magnetic brake that can stop the centrifuge rotor at a precise position to facilitate loading and unloading of a specimen tube. The centrifuge includes a swing bucket designed to pivot around an axis and slide vertically to enable moving the bucket to a position in which the swing bucket can engage with the port where the specimen tube resides.

Abstract: The present invention describes a laboratory system for automatically processing at least one sample container containing a biological sample, the laboratory system comprising a housing; laboratory instrument units for executing processing steps on the biological sample; an input station configured to receive the sample container; a transport means for transport of the sample container from the input station to the laboratory instrument units, and further to an output station; a control unit for determining whether the sample and/or the container is in a condition to be processed by the laboratory instrument units; an input-output station providing an interface between the inside and the outside of the housing; and a workbench on the outside of the housing in front of the input-output station for an operator to be in the position to manipulate the sample and/or the container.

Abstract: The invention relates to a sample acquiring device holder (3) for a housing (2) of an analysis apparatus (1). The sample acquiring device holder (3) may comprise an activating element (5) and a reception recess (11) for receiving a sample acquiring device (4). A first portion (10) of the activating element (5) may protrude into the reception recess (11), if the activating element (5) is in a non-activating position. The activating element (5) may be adapted to be moved into an activating position by the sample acquiring device (4), if the sample acquiring device (4) is inserted into an intended measurement position within the reception recess (11). The activating element (5) may be adapted to activate a measurement triggering element (15), if the activating element (5) is in its activating position, such that the measurement triggering element (15) activates a measurement of the analysis apparatus (1).

Abstract: A device for agitating and collecting biological liquid samples comprises an agitator of racks of tubes, a sampling apparatus capable of collecting a biological liquid sample in a tube, and a changer capable of gripping a tube on a rack received in the agitator and moving it to the sampling apparatus.

Abstract: Two-phase flushing systems and methods. An example method includes moving a valve to a first position to fluidly connect a first reagent reservoir containing a first reagent to a flow cell and flowing the first reagent from the first reagent reservoir to the flow cell to perform a biochemical reaction. The method includes moving the valve to a second position to fluidly connect a gas to the flow cell and flowing gas into the flow cell to expel at least a portion of the first reagent from the biochemical reaction from the flow cell. The method includes moving the valve to a third position to fluidly connect a buffer reagent reservoir containing a buffer reagent to the flow cell and flowing the buffer reagent into the flow cell.

Abstract: Surfaces contactable by a bulk liquid for use in particle isolation are described. The surfaces comprise a plurality of ribs spaced apart to capillarily retain a portion of the bulk liquid and particles of interest therebetween. Collectively, the portion of the bulk liquid retained by the plurality of ribs on the surface forms a liquid film. The one or more particles received within the space and enveloped by the liquid film may be protected from one or more forces exerted by a draining meniscus passing over the surface.

Abstract: The invention relates to a system with a seal between a manifold and a liquid container in which a sealing without an elastomer material is used, wherein the sealing properties of the seal are independent of the rotational position of the manifold in relation to the container.

Abstract: Incubation system and method for automated cell culture and/or testing. An exemplary incubation system may comprise a housing forming a chamber. A rack may define storage positions to support an array of sample holders inside the chamber. A detection robot may be configured to capture one or more images of cells contained by one or more wells of each sample holder while the sample holder remains at one of the storage positions of the rack. A fluid handling station may be configured to add fluid to, and/or remove fluid from, one or more wells of each of the sample holders inside the housing. At least one plate robot may be configured to move sample holders between the rack and the fluid handling station. A computer may control operation of the detection robot, the fluid handling station, and the at least one plate robot.

Abstract: Described is an automated reagent dispensing cap and methods of use in an automated clinical analyzer for introducing one or more reagent components housed in the reagent dispensing cap into a container enclosing another reagent component with which it is combined to achieve a reagent useful for diagnostic testing.

Abstract: A detection chip is disclosed. The detection chip includes a sample injection structure, a filter structure, and a reaction structure which are sequentially connected. The filter structure includes a first main body, and a first inlet portion and a first outlet portion respectively on two sides of the first main body. A width of the first inlet portion gradually decreases in a direction away from the first main body, and a width of the first outlet portion gradually decreases in a direction away from the first main body.

Abstract: A nasal irrigation diagnostic assembly comprising an irrigation device including a fluid collection portion structured to retain a biological sample, in the form of waste solution from the nasal cavity resulting from irrigation. A detection member disposed on said irrigation device is exposed to the biological sample and is structured to determine the existence of at least one analyte within the biological sample of the waste solution. The detection member comprises a plurality of detection zones individually structured to analyze the biological sample upon engagement therewith, wherein said plurality of zones include at least a reaction zone and a detection zone, which respectively include reagents cooperatively and collectively formulated to detect the existence of the at least one analyte within biological sample of the waste solution. A control zone may also be included to indicate the intended operability of at least the detection member.