Abstract: A method for assessing pain caused by administration of a drug solution includes: anesthetizing an experimental animal; inserting a measurement electrode into skeletal muscle of the anesthetized experimental animal; puncturing an injection needle into a predetermined part of the anesthetized experimental animal while measuring a myoelectric potential of the skeletal muscle with the measurement electrode; administering a drug solution to the anesthetized experimental animal; and (i) measuring a duration time of the myoelectric response caused by the administration of the drug solution, and/or (ii) measuring an EMG intensity obtained by integrating absolute values of myoelectric potentials during a period from occurrence of the myoelectric response by the administration of the drug solution to disappearance of the myoelectric response.

Abstract: A breast biopsy lateral arm system includes a removable gun mount which attaches to a carriage that traverses along an X-axis defined by a lateral arm in order to position a biopsy needle relative to a patient. The carriage rides along the lateral arm on self-adjusting rollers which are loaded against the lateral arm by spring members. A cam-actuated carriage slide lock can be used to secure the carriage in a desired position relative to the lateral arm. A cam-actuated removable gun mount lock allows the gun mount to be quickly changed and offset orthogonally with respect to the X-axis. An X-axis stop can be used to establish a position to which the carriage can be returned with accuracy.

Abstract: Systems and methods for diurnal curve generations, tracking, and analysis are provided. Based on a user's demographic, or a user's baseline diurnal curve, insights into a user's temperature reading can be produced. Such insights can be used to, for example, assess the probability that the user is experiencing a fever, which can be used in screening for medical diagnostic testing.

Abstract: Methods for the diagnosis, prognosis, patient stratification and prediction of pharmacological response in patients afflicted by psychiatric disorders based on electroretinography (ERG) parameters are described.

Abstract: A guide wire including a flexible first core wire which has a first plate-shaped portion having a plate shape and a first linear portion having a linear shape that is continuous to the first-plate shaped portion. The width of the first plate-shaped is larger than the width of the first linear portion. The guide wire includes a flexible second core wire which has a second plate-shaped portion having a plate shape and a second linear portion having a linear shape that is continuous to the second-plate shaped portion. The width of the second plate-shaped portion is larger than the width of the second linear portion. The second plate-shaped portion axially overlaps the first linear portion, and the second linear portion axially overlaps the first plate-shaped portion.

Abstract: A system includes an endotracheal tube having a plurality of electrodes, wherein the electrodes include at least one stimulating electrode configured to stimulate tissue of a patient and at least one monitoring electrode configured to monitor at least one nerve of a patient. The system includes a nerve integrity monitor device configured to send a stimulation signal to the at least one stimulating electrode to evoke a reflex response, and configured to receive a monitoring signal from the at least one monitoring electrode.

Abstract: The Personal Warning Temperature (PWT) is a method of determining a person's personal warning temperature that defines a fever for that person. The method includes analyzing a person's body temperature measurements taken over time when the person is healthy, in order to find the person's average temperature; standard deviation; a channel defined by an upper and lower temperature bound using the average and standard deviation, and a selected multiplier for the standard deviation, such that nearly all body temperatures fall within the channel; and a personal warning temperature similarly defined using the average, standard deviation, and another selected multiplier for the standard deviation. The method also determines a correction or interpretation of a person's body temperature based on the time of day to account for known variations associated with circadian rhythm. A person can use their personal warning temperature for improved and accelerated awareness of their health status.

Abstract: The Personal Warning Temperature (PWT) is a method of determining a person's personal warning temperature that defines a fever for that person. The method includes analyzing a person's body temperature measurements taken over time when the person is healthy, in order to find the person's average temperature; standard deviation; a channel defined by an upper and lower temperature bound using the average and standard deviation, and a selected multiplier for the standard deviation, such that nearly all body temperatures fall within the channel; and a personal warning temperature similarly defined using the average, standard deviation, and another selected multiplier for the standard deviation. The method also determines a correction or interpretation of a person's body temperature based on the time of day to account for known variations associated with circadian rhythm. A person can use their personal warning temperature for improved and accelerated awareness of their health status.

Abstract: Devices, systems, and methods for determining vein geometric and compliance profiles for venous stenting. In one device embodiment, the device comprises an elongated body configured to fit within a mammalian luminal organ, a balloon coupled to the elongated body capable of and configured for inflation and deflation within the mammalian luminal organ, at least two excitation electrodes positioned along the elongated body within the balloon, and a plurality of at least three detection electrodes positioned in between at least two of the at least two excitation electrodes, wherein a first pair of two adjacent detection electrodes of the at least three detection electrodes can detect an electric field generated by the at least two excitation electrodes and obtain a first conductance measurement within the balloon, and a second pair of two adjacent detection electrodes can detect the electric field and obtain a second conductance measurement within the balloon.

Abstract: The disclosure provides wearable cardiac arrest detection and alerting device that incorporates a non-invasive sensor based on optical and/or electrical signals transmitted into and received from human tissue containing blood vessels, and that transcutaneously quantifies the wearer's heart rate. The heart-rate quantification enables the detection of the absence of any heart beat by the wearable detection and alerting device indicative of the occurrence of a cardiac arrest, wherein the heart is no longer achieving effective blood circulation in the individual wearing the device. The display on the wearable cardiac arrest detection and alerting device may include the elapsed time since the time of detection of a heart rate that is below a predetermine lower limit value, i.e., the detected occurrence of a cardiac arrest event.

Abstract: Glaucoma is the second most common cause of blindness in the global world. It is a multifactorial disease with several risk factors, of which intraocular pressure (IOP) is the most important. IOP measurements are used for glaucoma diagnosis and patient monitoring. IOP has wide diurnal fluctuation, and is dependent on body posture, so the occasional measurements done by the eye care expert in clinic can be misleading. We provide an implantable sensor, based on microfluidic principles, which in one example has 1 mmHg limit of detection, high sensitivity and excellent reproducibility. This sensor has an optical interface, which enables IOP to be read with, for example, a cell phone camera. The design, fabrication, along with the option of self-monitoring are promising steps toward better patient care and treatment for this devastating disease.

Abstract: A system, computer-readable storage medium, and a method capable of, directly or indirectly, estimating sleep states of a user based on sensor data from movement sensors and/or optical sensors.

Abstract: Provided is to determine a walking state when a target person uses a stick. A walking state determination device according to an embodiment of the present invention includes: an acquisition unit that acquires feature information indicating a feature of a motion of a target person when using a stick, based on first measurement data acquired from a first sensor installed at the stick and second measurement data acquired from a second sensor installed at the target person; and a determination unit that determines a walking state of the target person, based on the acquired feature information.

Abstract: Embodiments herein include gas sampling catheters, systems and related methods. In an embodiment, a gas sampling catheter is included. The catheter can include a catheter shaft having a proximal end and a distal end, the catheter shaft defining a lumen therein. The catheter can include a gas sampling port providing fluid communication between the exterior of the catheter shaft adjacent the distal end of the lumen of the catheter shaft. The catheter can further include a sensor element disposed in fluid communication with the lumen, the sensor element configured to detect a component of a gaseous sample. The sensor element can include a first measurement zone comprising a plurality of discrete binding detectors. Other embodiments are also included herein.

Abstract: Method and system for monitoring an internal electrical impedance of a biological object including Internal Thoracic Impedance (ITI) comprising placing two arrays of electrodes on opposite sides of the biological object, wherein each of said two arrays comprise three equally spaced electrodes; imposing an alternating electrical current between pairs of the electrodes and obtaining voltage signals representative of a voltage drop thereon, calculating two values of internal electrical impedance of the biological object corresponding to the uttermost electrodes of said two arrays of electrodes placed on the opposite sides of the biological object.

Abstract: The present disclosure generally relates to devices, systems, and methods for Fallopian tube diagnostics. In some embodiments a tube may have a distal end, and a balloon may have a first end coupled to the distal end of the tube. The balloon may be disposed in the tube in a first, inverted position, may be movable to a second, everted position, and may be extendable a distance distal of the tube. An extending portion may have a proximal end coupled to a second end of the balloon. The extending portion may be disposed within the balloon in the first inverted position, and may be extendable from the second end of the balloon in the second everted position.

Abstract: Disclosed is a biopsy needle, medical device incorporating the biopsy needle, and method of using the biopsy needle and medical device. The biopsy needle and medical device is used to obtain a sample of tissue for further analysis and testing. The biopsy needle includes an inner stylet that is slidably engaged with an outer coaxial sheath and at least part of the distal portion of the stylet is bent or curved relative to the longitudinal axis of the coaxial sheath.

Abstract: Torque devices for use with intravascular devices and associated systems and methods are disclosed. In some embodiments, a torque device for use with an intravascular device includes a first component having a body defining a tapered opening for receiving a proximal portion of the intravascular device, a first arm extending from the body, and a second arm extending from the body; and a second component movably coupled to the first component, wherein the second component is movable relative to the first component between an open position where the torque device is configured to slidably receive the proximal portion of the flexible elongate member between the first and second arms of the first component and a closed position where the torque device fixedly engages the proximal portion of the flexible elongate member between first and second arms of the first component.

Abstract: A wrist-type body composition measuring apparatus is provided to measure body composition conveniently. The wrist-type body composition measuring apparatus includes a main body comprising a measurer configured to measure body impedance of a user, and an analyzer configured to analyze a body composition of the user based on the measured body impedance; a strap connected to the main body and configured to be flexible; a first inner electrode and a second inner electrode which are provided on a rear surface of the main body to be in direct contact with the user; and a first outer electrode and a second outer electrode which are provided on a surface of the main body to be in contact with the user during measurement of the body composition, wherein the first outer electrode and the second outer electrode are each formed as a half ring and face each other with a gap therebetween.

Abstract: An intra vaginal device (10) including an elongated hollow body (11) with side wall portions (15, 16 and 24). Secured to each wall portion (15 and 24) is a sensor (19), while secured to the wall portion (16) is a sensor (20). The sensors (19) simply measure forces directly applied by the bi-lateral contraction of the pubococcygeus, while the sensor (20) provides an indication of the puborectalis contraction forces.