Patents Examined by Bernard I. Dentz
  • Patent number: 6887869
    Abstract: The invention concerns novel mikanolide derivatives, their preparation method and their therapeutic uses, in particular as anti-cancer and anti-viral agents.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: May 3, 2005
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Olivier Lavergne, Christophe Lanco, Grégoire Prevost, Beng Poon Teng
  • Patent number: 5112993
    Abstract: A process for producing difluoromaleic anhydride by reacting sulfur trioxide with a fluorinated precursor selected from the group consisting of hexafluoro-2,5-dihydrofuran, hexafluoro-2,5-dihydrothiophene, difluoro-2,5-dihydrothiophene-2,5-dione and tetrafluoro-2,5-dihydrothiophene-2-one. Also disclosed are the compounds difluoro-2,5-dihydrothiophene-2,5-dione and tetrafluoro-2,5-dihydrothiophene-2-one. Difluoromaleic anhydride is useful for example as a component of fluoropolymers.
    Type: Grant
    Filed: November 14, 1989
    Date of Patent: May 12, 1992
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Carl G. Krespan
  • Patent number: 5057522
    Abstract: Fermentation of the microorganism Streptomyces sp.
    Type: Grant
    Filed: July 19, 1990
    Date of Patent: October 15, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Shieh-Shung T. Chen, George Doss
  • Patent number: 5037839
    Abstract: The invention relates to pyridine-2,4- and -2,5-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and X have the meanings given, a process for the preparation of these compounds and their use, in particular in medicaments for influencing the metabolism of collagen and collagne-like substances or the biosynthesis of Cl.sub.q.
    Type: Grant
    Filed: November 13, 1989
    Date of Patent: August 6, 1991
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Martin Bickel, Dietrich Brocks, Harald Burghard, Volkmar Gunzler, Stephan Henke, Hartmut Hanauske-Abel, Jurgen Mohr, Georg Tschank
  • Patent number: 5028710
    Abstract: The object of the invention is a process for the preparation of derivatives of 3-sulfonyl indolizine of general formula: ##STR1## in which: R is selected from hydrogen, alkyl, cycloalkyl, substituted or unsubstituted phenyl,R.sub.1 is a protecting group for hydroxyl,R.sub.2 and R.sub.3, identical or different, is each selected from hydrogen, methyl or ethyl or halogen.These compounds are intermediates which can be used for the preparation of 3-aminoalkoxyphenylsulfonyl-indolizines, which are useful in the treatment of certain diseases of the cardiovascular system.
    Type: Grant
    Filed: June 8, 1990
    Date of Patent: July 2, 1991
    Assignee: Sanofi
    Inventors: Jean Gubin, Jean Lucchetti
  • Patent number: 5026854
    Abstract: The invention concerns compounds of formula I ##STR1## or a salt thereof, wherein R.sup.1 and R.sup.2 each independently represent hydrogen, lower alkyl, lower alkoxy, carboxyloweralkyl, carboxy, hydroxyloweralkyl, halogen, haloloweralkyl, lower alkoxycarbonyl, optionally substituted aryl or optionally substituted aralkyl, n represents an integer from 3 to 6; R.sup.3 which is optionally present represents single or multiple substitution on one or more of the aliphatic carbons by one or more substituents selected from lower alkyl, optionally substituted aryl and optionally substituted aralkyl; A represents a group of formula (i) or (ii) below:--CR.sup.4 R.sup.5 --(CR.sup.6 R.sup.7).sub.m -- (i)--CX--(CR.sup.6 R.sup.7).sub.m -- (ii)in which R.sup.4, R.sup.6 and R.sup.7 each independently represent hydrogen or lower alkyl (providing that when R.sup.5 is NH.sub.2, R.sup.4 is hydrogen); m is 0 or 1; R.sup.5 represents hydrogen, NH.sub.2, OH or loweralkoxy, and X is .dbd.O, .dbd.NH or .dbd.
    Type: Grant
    Filed: August 8, 1990
    Date of Patent: June 25, 1991
    Assignee: John Wyeth & Brother Limited
    Inventor: Robin G. Shepherd
  • Patent number: 5026876
    Abstract: Crude maleic anhydride produced by catalytic oxidation is distilled and then n-propyl gallate, cuprous chloride and zinc chloride are added thereto.Alternatively, crude maleic anhydride is distilled in the presence of tridecyl phosphite. Further, these procedures can be used in combination. Thermal stability and color stability of the maleic anhydride is improved.
    Type: Grant
    Filed: January 19, 1990
    Date of Patent: June 25, 1991
    Assignee: Mitsui Toatsu Chemicals, Inc.
    Inventors: Harusige Sugawara, Takasi Okawa
  • Patent number: 5026700
    Abstract: The present invention is directed to a new class of excitatory amino acid antagonists. The compounds contain quinoline or thieno pyridine moieties.
    Type: Grant
    Filed: March 21, 1990
    Date of Patent: June 25, 1991
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Boyd L. Harrison, Bruce M. Baron
  • Patent number: 5026711
    Abstract: Compounds represented by the general formula: ##STR1## in which R.sub.1 and R.sub.2 are selected from hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkenyl , phenyl or benzyl or R.sub.1 and R.sub.2 form together with the nitrogen atom to which they are attached a C.sub.4 -C.sub.8 saturated heterocycle, R.sub.3 is selected from hydrogen, C.sub.1 -C.sub.6 alkyl, phenyl or C.sub.7 -C.sub.9 phenyl-alkyl, R.sub.4 is selected from hydrogen or C.sub.1 -C.sub.4 alkyl, R.sub.5 and R.sub.6 are selected from hydrogen or halogen, C.sub.1 -C.sub.3 or alkoxy, nitro or trifluoromethyl; Z is selected from OH, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.4 alkyl, benzyl, C.sub.4 -C.sub.6 aryl with or without a heteroatom, or NR.sub.8 R.sub.9, R.sub.8 and R.sub.9 being selected from hydrogen, C.sub.1 -C.sub.4 alkyl, phenyl or benzyl; R.sub.10 is selected from hydrogen, C.sub.1 -C.sub.
    Type: Grant
    Filed: June 6, 1989
    Date of Patent: June 25, 1991
    Assignee: Sanofi
    Inventors: Etienne Mendes, Jean-Claude Vernieres, Peter E. Keane, Andre Bachy
  • Patent number: 5025014
    Abstract: Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines having antihistaminic and serontonin-antagonistic properties which compounds are useful agents in the treatment of allergic diseases.
    Type: Grant
    Filed: December 7, 1989
    Date of Patent: June 18, 1991
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Frans E. Janssens, Joseph L. G. Torremans, Jozef F. Hens, Theophilus T. J. Van Offenwert
  • Patent number: 5025021
    Abstract: Novel compounds represented by the formula: ##STR1## wherein R represents hydrogen, optionally substituted alkyl radicals having from 1 to about 10 carbon atoms, optionally substituted alkenyl radicals having from 1 to about 10 carbon atoms, optionally substituted aryl, alkaryl and aralkyl radicals having from about 6 to about 16 carbon atoms and optionally substituted acyl and acyloxy radicals having from about 1 to about 10 carbon atoms, manifest glycosidase inhibition activity.
    Type: Grant
    Filed: July 27, 1989
    Date of Patent: June 18, 1991
    Assignee: Monsanto Company
    Inventors: Daniel P. Getman, Gary A. DeCrescenzo
  • Patent number: 5023265
    Abstract: Substituted 1H-pyrrolopyridine-3-carboxamides and their use in pharmaceutical compositions and in treating inflammation are disclosed.
    Type: Grant
    Filed: June 1, 1990
    Date of Patent: June 11, 1991
    Assignee: Schering Corporation
    Inventors: Margaret H. Scherlock, Wing C. Tom
  • Patent number: 5021588
    Abstract: The oxidation of butane to maleic anhydride in a recirculating solids reactor using a stoichiometric excess of oxygen, a vanadium-phosphorus oxide catalyst in oxidized form, and separate regeneration of the resultant reduced catalyst is disclosed.
    Type: Grant
    Filed: August 26, 1988
    Date of Patent: June 4, 1991
    Assignee: E.I. Du Pont de Nemours and Company
    Inventor: Rashmikant M. Contractor
  • Patent number: 5021078
    Abstract: There are provided novel 2-(2-imidazolin-2-yl)pyridine and quinoline compounds, a process and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual asnd perennial plant species therewith.
    Type: Grant
    Filed: February 26, 1990
    Date of Patent: June 4, 1991
    Assignee: American Cyanamid Company
    Inventor: Marinus Los
  • Patent number: 5021169
    Abstract: Alkenyl succinic anhydrides having a decreased amount of tar and color bodies are made by the reaction of an olefin with maleic anhydride in the presence of a tri-orthoalkylphenyl phosphite and optionally a hindered phenolic antioxidant such as 2,4,6-tri-(3,5-di-tert-butyl-4-hydroxybenzyl) mesitylene.
    Type: Grant
    Filed: November 13, 1989
    Date of Patent: June 4, 1991
    Assignee: Ethyl Corporation
    Inventors: Kju H. Shin, Paul S. Hale
  • Patent number: 5017581
    Abstract: A compound of the formula ##STR1## wherein R.sup.1 is hydrogen or a protecting group; R.sup.2 is C.sub.1 -C.sub.3 alkyl or C.sub.3 -C.sub.7 cycloalkyl; R.sup.3 is hydrogen, hydroxy, or amino; R.sup.4 is halogen; R.sup.5 and R.sup.6 each is identically or differently hydrogen or C.sub.1 -C.sub.3 alkyl; W is C.sub.1 -C.sub.3 alkylidene; X is N or C-Y; Y is hydrogen or halogen; or a pharmaceutically acceptable salt thereof, having a more potent antibacterial activity against G(+) and G(-) bacteria than known analogues, useful as antibacterial agents.
    Type: Grant
    Filed: September 28, 1989
    Date of Patent: May 21, 1991
    Assignee: Shionogi & Co., Ltd.
    Inventors: Yasuhiro Nishitani, Yutaka Nishino, Tadashi Irie
  • Patent number: 5017582
    Abstract: The dicarboxylic, heterocyclic and substituted benzoic acid alkylene bridged piperidyl amides and esters are serotonin M antagonists.
    Type: Grant
    Filed: January 17, 1990
    Date of Patent: May 21, 1991
    Assignee: Sandoz Ltd.
    Inventors: Peter Donatsch, Gunter Engel, Bruno Hugi, Brian P. Richardson, Paul A. Stadler, Gerald Breuleux, legal representative
  • Patent number: 5017618
    Abstract: Compounds having the formula ##STR1## and their pharmaceutically acceptable acid addition salts, wherein --X-- is --O--, --CH.sub.2 -- or --; .dbd.Y is .dbd.O or a derivatized keto group which is hydrolyzable or enzymatically convertible to a keto group; R is alkyl having from 1 to 12 carbon atoms or aralkyl having from 7 to 20 carbon atoms; and Ar is the 3-aromatic or heterocyclic residue of a 1-alkylamino-2-propanol having an aromatic or heterocyclic substituent at the 3-position and having .beta.-adrenergic blocking properties; are useful as .beta.-adrenergic blocking agents and are of particular interest in the treatment of glaucoma or for lowering intraocular pressure.
    Type: Grant
    Filed: September 18, 1989
    Date of Patent: May 21, 1991
    Assignee: University of Florida
    Inventor: Nicholas S. Bodor
  • Patent number: 5015661
    Abstract: Racemic Compounds of the formula ##STR1## A is --C.tbd.C--R.sub.6, --CH.sub.2 --CH.sub.2 --R.sub.7 or ##STR2## R.sub.1 is hydrogen or lower alkanoyl, R.sub.2, R.sub.3, and R.sub.4 independently are hydrogen or lower alkyl,R.sub.5 is lower alkyl,R.sub.6 is a heteroaromatic radical or an aromatic radical selected from phenyl, naphthyl or phenanthryl, which aromatic radical may optionally be substituted by one or more substituents selected from chlorine, fluorine, lower alkyl, lower alkoxy, phenyl lower alkoxy, lower alkanoyl, lower alkanoyloxy, hydroxy-lower alkyl, carboxy, lower alkoxycarbonyl, hydroxyimino lower alkyl, amino, amino lower alkyl, mono- or di-lower alkylamino, mono- or di-lower alkylamino-lower alkyl, lower alkanoylamino, aminocarbonyl, lower alkylaminocarbonyl, lower dialkylaminocarbonyl, trifluoroacetylamino, trifluoromethyl, hydroxy, pyridyl, or on adjacent carbons can be ##STR3## wherein R' is hydrogen, lower alkanoyl, trifluoroacetyl and R" hydrogen or lower alkyl,R.sub.
    Type: Grant
    Filed: June 16, 1989
    Date of Patent: May 14, 1991
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Armin Walser
  • Patent number: 5011945
    Abstract: A continuous process for production of maleic anhydride is disclosed wherein maleic anhydride is produced in high yield and catalyst productivity is in the range of from about 0.12 to about 0.18 pounds of maleic anyhdride produced per pound of catalyst per hour. The catalyst comprises vanadium-phosphorus-oxygen and a modifier, preferably molybdenum. The increased catalyst productivity substantially increases production rates without necessity for extensive equipment modification.
    Type: Grant
    Filed: November 22, 1989
    Date of Patent: April 30, 1991
    Assignee: Amoco Corporation
    Inventor: Hassan Taheri