Abstract: The present invention is related to providing a non-infectious molecular clone of a mutant HIV and HIV proteins useful as immunogens and reagents for diagnostic kit.
Type:
Grant
Filed:
September 14, 1987
Date of Patent:
June 5, 1990
Assignee:
The United States of America as represented by the Department of Health and Human Services
Abstract: DNA frangments containing an alkaline cellulase K gene, which comprise about 4.0, about 2.4 and about 1.9 kilo base pairs, respectively, each having a specific restruction map, recombinant plasmids containing any of these DNA fragments, and recombinant microorganisms harboring any of said plasmids.The alkaline cellulase K gene is derived from a bacterial strain which belongs to the genus Bacillus and is alkalophilic, that is, capable of revealing an optimum growth in an alkaline pH region.