Patents Examined by Blaine G Doletski
  • Patent number: 12269791
    Abstract: The present invention relates to a process for manufacturing of anhydrous methanesulfonic acid (MSA) and to methanesulfonic acid manufactured by said process and its uses.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: April 8, 2025
    Assignee: BASF SE
    Inventors: Frieder Borgmeier, Frank Piepenbreier, Andreas Kempter
  • Patent number: 12247001
    Abstract: Compound are described comprising a perfluorinated group bonded to at least one terminal photoinitiator group with an organic linking group comprising at least one amide moiety. The compound typically comprises the (e.g. Michael addition) reaction product of i) a compound comprising an acryl group and a photoinitiator group; and ii) an amino functional perfluorinated compound. Also described is a composition comprising at least one free-radically polymerizable (e.g. fluorinated) monomer, oligomer, or combination thereof; and the described fluorinated photoinitiator compound and methods.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: March 11, 2025
    Assignee: 3M Innovative Properties Company
    Inventors: Thomas P. Klun, Brandon R. Pietz, Paul J. Homnick, Christopher S. Lyons, Chad M. Amb
  • Patent number: 12234200
    Abstract: The present invention is directed to methods for the asymmetric synthesis of esketamine. The present invention is further directed to key intermediates in the asymmetric esketamine synthesis. In one embodiment, the invention is an asymmetric synthesis of esketamine comprising the conversion of (S)-2?-chloro-2-methoxy-3,4,5,6-5 tetrahydro-[1, 1?-biphenyl]-3-yl carbamate to (S)-2?-chloro-1-isocyanato-6-methoxy-1,2,3,4-tetrahydro-1,1?-biphenyl.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: February 25, 2025
    Assignee: Janssen Pharmaceutica NV
    Inventor: Cheng Yi Chen
  • Patent number: 12234254
    Abstract: Methods for preparing crystalline L-glufosinate ammonium monohydrate are disclosed. The methods include forming a mixture comprising water, a water-miscible organic solvent, ammonium hydroxide, and a glufosinate starting material containing L-glufosinate ammonium and D-glufosinate ammonium. L-Glufosinate ammonium monohydrate is crystallized and separated from the mixture, providing L-glufosinate ammonium monohydrate Form B. Compositions and methods employing the crystalline L-glufosinate ammonium monohydrate are also described.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: February 25, 2025
    Assignee: BASF SE
    Inventors: Brian Michael Green, Rachel Melissa Witek, Nadejda Pavlova, Matthew Richard Oberholzer
  • Patent number: 12227474
    Abstract: The disclosure relates to methods of producing and recovering levulinic acid.
    Type: Grant
    Filed: March 19, 2024
    Date of Patent: February 18, 2025
    Assignee: Biofine Technology, LLC
    Inventor: Stephen W. Fitzpatrick
  • Patent number: 12215074
    Abstract: Process for the production of a peroxyester involving the reaction of an anhydride with an organic hydroperoxide, separation of the formed carboxylic acid, production of an anhydride from said carboxylic acid, and recycling of the anhydride within the process.
    Type: Grant
    Filed: June 11, 2020
    Date of Patent: February 4, 2025
    Assignee: NOURYON CHEMICALS INTERNATIONAL B.V.
    Inventor: Martinus Catharinus Tammer
  • Patent number: 12209069
    Abstract: The present disclosure is directed to novel derivatives of terpenes, particularly derivatives of terpene alcohols, and methods of making them, compositions comprising them, and methods for using them.
    Type: Grant
    Filed: May 17, 2022
    Date of Patent: January 28, 2025
    Assignee: P2 SCIENCE, INC.
    Inventor: Patrick Foley
  • Patent number: 12202783
    Abstract: A method for obtaining a salt with a general formula: RxNI, wherein: RxN is an organic cation (RxN+), R represents substituents (R—) independently selected from a group consisting of organic substituents: R1—, R2—, R3— and hydrogen (H—), x is a number of the substituents R— directly linked with the nitrogen (N) atom in the organic cation RxN+, wherein x is 3 or 4, I is an iodide anion (I?). The method comprises: preparing a reaction mixture comprising the steps of: synthesizing hydrogen iodide (HI) in situ by mixing molecular iodine (I2) with formic acid (COOH) in a molar ratio of molecular iodine (I2): formic acid (COOH) of no less than 1.01:1, in a solvent medium, introducing into the solvent medium a compound being a donor of organic cation RxN+ in an amount providing the molar ratio of the donor of organic cation RxN+: molecular iodine (I2) of no less than 1.01:1, and maintaining the reaction mixture at a temperature of not less than 20° C.
    Type: Grant
    Filed: June 1, 2020
    Date of Patent: January 21, 2025
    Assignee: SAULE S.A.
    Inventors: Kasjan Misztal, Konrad Wojciechowski, Olga Malinkiewicz, Zbigniew Miara
  • Patent number: 12195417
    Abstract: The invention relates to a fatty amide which is a di- or triamide based on a polyether diamine or triamine which can be used as organogelator and in particular as rheology additive, said amide comprising a specific mixture of hydroxylated fatty acids and short hydroxylated acids. The invention also relates to a formulation composition using said fatty amide as rheology additive and to its use with this aim in coating, adhesive or PVC plastisol compositions and in particular transparent or non-transparent mastic compositions. Said rheology additive has the advantage of not needing a specific activation process before use, in contrast to the other known fatty amide additives based on hydrogenated castor oil derivatives.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: January 14, 2025
    Assignee: Arkema France
    Inventors: Dmitri Colesnic, Vincent Leroy, Laurent Lepinay
  • Patent number: 12178914
    Abstract: A lyophilisate of treosulfan is described which possesses favourable characteristics in terms of a short reconstitution time and a high purity and stability and which is particularly useful in the treatment of cancer and for conditioning therapy before transplantation of bone marrow or blood stem cells.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: December 31, 2024
    Assignee: Medac Gesellschaft Für Klinische Spezialpräparate MBH
    Inventor: Sebastian Bialleck
  • Patent number: 12180142
    Abstract: A composition including a N-[4-[[4-(diethyl amino) phenyl](2,5-disulfophenyl)methylene]-2,5-cyclohexadien-1-ylidene]-N-ethylethanaminium sodium salt, where the N-4-4-(diethylamino)phenyl (2,5-disulfophenyl)methylene-2,5-cyclohexadien-1-ylidene-N-ethylethanaminium sodium salt is at least 90% of the weight of such composition. A method of making the composition by a process including sulphonating 2-chlorobenzaldehyde, treatment with sodium sulphite and subsequent basification, a condensation step, an oxidation step and a purification step comprising utilizing HPLC to monitor the sulphonating step, the treatment step, the condensation step, and/or the oxidation step, to determine when one or more reactions of such sulphonating step, treatment step, condensation step, and/or oxidation step are substantially complete and ending such one or more reactions on the basis of the HPLC monitoring.
    Type: Grant
    Filed: February 22, 2024
    Date of Patent: December 31, 2024
    Assignee: Rising Pharma Holdings, Inc.
    Inventors: Vimal Kavuru, Kamalkishore Pati
  • Patent number: 12162817
    Abstract: Improvements in catalyst systems and associated processes for the conversion of glycolaldehyde to monoethanolamine are disclosed. The catalyst systems exhibit improved selectivity to this desired product and consequently reduced selectivity to byproducts such as diethanolamine and ethylene glycol. These beneficial effects are achieved through the use of acids, and particularly Lewis acids, as co-catalysts of the reductive amination reaction, in conjunction with a hydrogenation catalyst.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: December 10, 2024
    Assignee: ARCHER-DANIELS-MIDLAND COMPANY
    Inventors: James Brazdil, Chi-Cheng Ma
  • Patent number: 12122739
    Abstract: An integrated, co-product capable process is provided for producing taurine in particular with optionally one or both of monoethanolamine and diethanolamine from one or more sugars, comprising pyrolyzing one or more sugars to produce a crude pyrolysis product mixture including glycolaldehyde and formaldehyde; optionally removing formaldehyde from the crude pyrolysis product mixture, then combining the crude pyrolysis product mixture with an aminating agent in the presence of hydrogen and further in the presence of a catalyst to produce at least monoethanolamine from the crude pyrolysis product mixture; optionally recovering diethanolamine from the crude reductive amination product, sulfating at least a portion to all of the monoethanolamine product to produce 2-aminoethyl hydrogen sulfate ester; and sulfonating the 2-aminoethyl hydrogen sulfate ester to produce taurine.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: October 22, 2024
    Assignee: ARCHER-DANIELS-MIDLAND COMPANY
    Inventors: James Brazdil, Chi-Cheng Ma
  • Patent number: 12116336
    Abstract: The present invention relates to a method for recycling and/or disposal of halocarbons, particularly fluorinated alkanes, such as trifluoromethane, by reacting said halocarbons with sulfur trioxide, particularly to form halide sulfonic acids and sulfur dioxide.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: October 15, 2024
    Assignee: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventors: Timo Ott, Christian Diaz-Urrutia, Matthias Vogt
  • Patent number: 12084398
    Abstract: The present invention relates to a process for preparing a surfactant composition based on glycine betaine ester salt, and to the composition thus obtained. The invention also relates to the uses of said composition. A subject of the invention is also a product comprising the abovementioned composition.
    Type: Grant
    Filed: November 25, 2019
    Date of Patent: September 10, 2024
    Assignee: SURFACTGREEN
    Inventors: Freddy Pessel, Francis Galle, Pierre-Yves Divet, Xavier Roussel
  • Patent number: 12071400
    Abstract: The present invention describes a selective glycerol oxidation process comprising a set of steps. In the first step, a glycerol-containing raw material and an oxidizing agent are fed into a reaction vessel containing an iron oxide-containing catalyst. Subsequently, the glycerol-containing raw material, the oxidizing agent, and said iron oxide-containing catalyst are brought into contact at a temperature in the range of 100 to 350° C., wherein the glycerol-oxidation reaction occurs.
    Type: Grant
    Filed: November 12, 2019
    Date of Patent: August 27, 2024
    Assignees: PETRÓLEO BRASILEIRO S.A.—PETROBRAS, UNIVERSIDADE FEDERAL DE MINAS GERAIS—UFMG
    Inventors: Marcio De Figueiredo Portilho, Victor Augusto Araujo De Freitas, Luiz Carlos Alves De Oliveira
  • Patent number: 12071401
    Abstract: A calcium carboxylate is prepared by reacting water, calcium oxide, and a compound of formula (I): wherein R is a C1-C3 alkyl and R1 is a C1 or C2 alkyl. The reaction solution is heated to remove an amount of a co-product from the reaction solution. The calcium carboxylate may be recovered in a solid form from the reaction solution.
    Type: Grant
    Filed: September 1, 2023
    Date of Patent: August 27, 2024
    Assignee: NIACET CORPORATION
    Inventors: Kelly Brannen, David J. Harrigan, Donal S. Tunks, Stanley A. Sojka
  • Patent number: 12060323
    Abstract: The present invention relates to a 6-hydroxy-3-hexenyl alkoxymethyl ether compound of the following general formula (1): HOCH2CH2CH=CHCH2CH2OCH2OCH2R1 (1), R1 representing a hydrogen atom, an n-alkyl group having 1 to 9 carbon atoms, or a phenyl group; and also relates to a process for preparing a 3,13-octadecadien-1-ol compound of the following formula (6): CH3(CH2)3CH—CH(CH2)8CH?CHCH2CH2OH (6) from the 6-hydroxy-3-hexenyl alkoxymethyl ether compound (1).
    Type: Grant
    Filed: April 19, 2023
    Date of Patent: August 13, 2024
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Yuki Miyake, Takeshi Kinsho, Yusuke Nagae
  • Patent number: 12060312
    Abstract: The objective of the present invention is to provide a method for producing an isocyanate compound safely and efficiently. The method for producing an isocyanate compound according to the present invention is characterized in comprising the steps of irradiating a high energy light to a halogenated methane at a temperature of 15° C. or lower in the presence of oxygen, and further adding a primary amine compound to be reacted without irradiating a high energy light.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: August 13, 2024
    Assignees: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, AGC INC.
    Inventors: Akihiko Tsuda, Takashi Okazoe
  • Patent number: 12054471
    Abstract: The present invention pertains to novel thiocycloheptyne derivatives of general formula (I): and in particular to thiacycloalkynesulfoimine derivatives and their synthesis. The invention also relates to the use of the novel thiocycloheptyne derivatives in coupling reactions with linkers and drugs. The invention further relates to the use of the novel thiocycloheptynes in bioorthogonal (copper-free) click reactions. The invention further pertains to the use of the novel thiocycloheptyne derivatives in the generation of advanced multifunctional drug delivery systems (drug-loaded) nanoparticles.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: August 6, 2024
    Assignee: Cristal Delivery B.V.
    Inventors: Josephus Johannes Weterings, Cristianne Johanna Ferdinand Rijcken