Patents Examined by Blessing Fubara
  • Patent number: 8691259
    Abstract: A biocompatible tissue repair stimulating implant or “scaffold” device is used to repair tissue injuries, particularly injuries to ligaments, tendons, and nerves. Such implants are especially useful in methods that involve surgical procedures to repair injuries to ligament, tendon, and nerve tissue in the hand and foot. The repair procedures may be conducted with implants that contain a biological component that assists in healing or tissue repair.
    Type: Grant
    Filed: November 16, 2005
    Date of Patent: April 8, 2014
    Assignee: DePuy Mitek, LLC
    Inventors: Steven M. Bowman, Izi Bruker, Alireza Rezania, Mora Carolynne Melican, Francois Binette, Julia Hwang
  • Patent number: 8623413
    Abstract: The present invention is directed to medical devices and pharmaceutical compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less than about 40° C., as determined by differential scanning calorimetry.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: January 7, 2014
    Assignee: Ethicon, Inc.
    Inventors: Aruna Nathan, Joel Rosenblatt, Steven C. Arnold
  • Patent number: 8592487
    Abstract: This invention relates to novel compounds that are hydroxyethylamino sulfonamide derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel hydroxyethylamino sulfonamide derivatives that are derivatives of darunavir. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering a human immunodeficiency virus (HIV) protease inhibitor, such as darunavir.
    Type: Grant
    Filed: April 28, 2009
    Date of Patent: November 26, 2013
    Assignee: Concert Pharmaceuticals, Inc.
    Inventor: Scott L. Harbeson
  • Patent number: 8586082
    Abstract: The present invention relates to solid pharmaceutical dosage forms which can be administered orally and comprise 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide in amorphous form and/or thermodynamically metastable crystal modification and have rapid release of active ingredient, and to process for the production thereof, the use thereof as medicament, the use thereof for the prophylaxis, secondary prophylaxis and/or treatment of disorders, and to the use thereof for producing a medicament for the prophylaxis, secondary prophylaxis and/or treatment of disorders.
    Type: Grant
    Filed: September 21, 2006
    Date of Patent: November 19, 2013
    Assignee: Bayer Intellectual Property GmbH
    Inventor: Klaus Benke
  • Patent number: 8586076
    Abstract: This invention relates to fat containing consumable food products comprising ?-cyclodextrin. The food products have reduced levels of bioavailable fat but have substantially the same fat, cholesterol and caloric content as a like food without ?-cyclodextrin. The invention also relates to methods for reducing the bioavailability of fats in fat containing food products without reducing caloric intake as determined by bomb calorimetry and to methods for increasing high density lipoproteins in a subject and reducing or controlling weight by administering the food products of this invention.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: November 19, 2013
    Assignee: SOHO Flordis International Pty Ltd
    Inventors: Joseph D. Artiss, Catherine Jen
  • Patent number: 8580281
    Abstract: Provided is a medicated patch containing a medicinal agent and an adhesive base material and having an acid value of no greater than 28, where the medicinal agent is varenicline or a pharmaceutically acceptable salt of varenicline.
    Type: Grant
    Filed: February 9, 2009
    Date of Patent: November 12, 2013
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Kumi Morimoto, Akio Takeuchi, Takashi Yasukochi, Kaori Yamaguchi, Kenji Ishigaki
  • Patent number: 8580230
    Abstract: A material useful as a MRI contrast agent used for medical imaging, drug delivery platform or other functions are provided as a class of non-gadolinium and non-iron oxide based materials that comprise Prussian blue materials or analogue materials. The materials may be used as T1-weighted and/or T2-weighted MRI contrast agents for imaging, including cellular imaging, in clinical diagnosis and biomedical research applications. The agent is a compound created from Prussian blue materials that is non-toxic, and can be internalized by cells through endocytosis. The Prussian blue materials may also be used for drug delivery applications. The Prussian blue materials may be administered orally to a subject in either medical imaging or drug delivery applications or dual modality MRI-Fluorescence imaging agent.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: November 12, 2013
    Assignee: Kent State University
    Inventors: Songping D. Huang, Soumitra Basu, Anatoly K. Khitrin, Mohammadreza Shokouhimehr, Eric Scott Soehnlen
  • Patent number: 8580533
    Abstract: The present invention provides methods for enhancing chemical reactions of molecules, e.g., biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g., solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: November 12, 2013
    Assignee: Waters Technologies Corporation
    Inventors: Edouard S. P. Bouvier, Bruce J. Compton, John C. Gebler, Martin Gilar, Ying-Qing Yu, Peter Jeng-Jong Lee, Elizabeth K. Brown
  • Patent number: 8580284
    Abstract: Abstract Provided is an oil-based cosmetic preparation which retains a smooth feel. Provided is an oil-based cosmetic preparation containing the following components (A), (B), and (C): (A) a cellulose derivative having a cellulose skeleton in a main chain, in which 67 mol % or more in total hydroxyl groups are substituted with a group —O-M-R, wherein M represents CH2 or a carbonyl group C?O, and R represents a straight or branched alkyl or alkenyl group having 3 to 40 carbon atoms; (B) an ester oil which is liquid at 25° C.; and (C) a hydrocarbon oil which is liquid at 25° C., in which a weight ratio (B)/(C) of the component (B) to the component (C) is 8/1 to 1/4.
    Type: Grant
    Filed: September 24, 2009
    Date of Patent: November 12, 2013
    Assignee: Kao Corporation
    Inventors: Eiko Tamura, Kouji Ohsaki, Kazuo Kuwahara, Kazuhiro Ishikawa, Kenko Kurita, Yu Saito
  • Patent number: 8574557
    Abstract: Present invention provides a composition for a cosmetic comprising a fluorine-containing silicone polymer having a three-dimensional, cross-linked structure, prepared by addition polymerizing the following (A), (B) and (C) and containing 10 to 30 mass % of the fluorine atoms, relative to a total mass of (A) to (C), (A) a vinyl group-containing organopolysiloxane represented by the following formula (1): (B) an organohydrogenpolysiloxane represented by the following formula (2): and (C) an organopolysiloxane having a reactive group on one end alone and represented by the following formula (3), and further comprising (D) a low viscosity silicone oil with a dynamic viscosity of 50 mm2/s or less at 25 degrees C.
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: November 5, 2013
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Chihiro Hayakawa, Hiromasa Yamaguchi
  • Patent number: 8568760
    Abstract: Hydrophobic ?(1?4)glucopyranose polymers useful for the preparation of implantable or injectable medical articles are described. The hydrophobic ?(1?4)glucopyranose polymer includes pendent groups having hydrocarbon groups and terminal amine or hydroxyl groups. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo. Matrices including and capable of releasing a bioactive agent in vivo are also described.
    Type: Grant
    Filed: December 30, 2010
    Date of Patent: October 29, 2013
    Assignee: Surmodics, Inc.
    Inventor: Emily R. Rolfes Meyering
  • Patent number: 8568748
    Abstract: The present invention relates to a pharmaceutical formulation in colloidal form for topical application for the therapy and prophylaxis of pathological changes of the skin and/or integumentary structures of the skin and/or mucous membranes, including mucous membranes of the digestive tract, uro-genital tract and bronchial system and/or conjunctiva, containing a lipophilic phase in a quantity of 1-10% by weight, a mixture of surfactant and co-surfactant in a quantity of 1-50% by weight, a hydrophilic phase in a quantity of 40-80% by weight and, as active ingredient, cyclosporin and/or derivatives thereof in a concentration of 0.1-20% by weight.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: October 29, 2013
    Assignee: JAGOTEC AG
    Inventors: Johannes Wohlrab, Reinhard Neubert, Konstanze Jahn
  • Patent number: 8562966
    Abstract: Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: October 22, 2013
    Assignee: Massachusetts Institute of Technology
    Inventors: Gregory T. Zugates, Andreas Zumbuehl, Robert S. Langer, Daniel Griffith Anderson
  • Patent number: 8563040
    Abstract: Compositions are provided which stimulate bone growth. Also provided are methods for utilizing the compositions for filling in bone defects, promoting rapid fusion of bone fractures, grafts, and bone-prostheses, and promoting strengthening of osteoporotic bones.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: October 22, 2013
    Assignee: Marfly 2, LP
    Inventor: J. Alexander Marchosky
  • Patent number: 8563025
    Abstract: The present application teaches a coating having a biologically compatible compound conjugated to, or blended with, a polymer, wherein the polymer includes at least one olefin-derived unit and at least one unit derived from a vinyl alcohol, an allyl alcohol, or derivatives thereof.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: October 22, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Eugene T. Michal, Syed F. A. Hossainy, Ashok Shah
  • Patent number: 8557266
    Abstract: A synergistic antimicrobial composition comprising: (a) a hydroxymethyl-substituted phosphorus compound selected from the group consisting of tetrakis(hydroxymethyl)phoshponium salts and tris(hydroxymethyl)phosphine; and (b) tris(hydroxymethyl)nitromethane.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: October 15, 2013
    Assignee: Dow Global Technologies LLC
    Inventor: Bei Yin
  • Patent number: 8557231
    Abstract: Poly(?-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: October 15, 2013
    Assignee: Massachusetts Institute of Technology
    Inventors: Robert S. Langer, David M. Lynn, David Putnam, Mansoor M. Amiji, Daniel G. Anderson
  • Patent number: 8552063
    Abstract: Here the inventors provide a composition for topical application to the skin of animal comprising stearidonic acid in combination with one or octadecatrienoic acids (CODTAs). Preferably the composition comprises echium oil as a source of the stearidonic acid, and a plant lipid as a source of octadecatrienoic acid, such as borage oil (Borago officinalis), wheat germ oil (Triticum vulgare) rosehip oil (refined; Rosa mosqueta), jacaranda oil (Jacandra mimosi folia), and/or calendula oil (Calendula officinalis). The composition of the invention increases collagen I secretion and thus has particular utility for promoting collagen production in skin.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: October 8, 2013
    Assignee: E.S.L.I. Limited
    Inventor: Clifford Spencer
  • Patent number: 8545821
    Abstract: Cosmetic compositions comprising water-redispersible polymers are provided, as well as methods for using such compositions in cosmetics that afford powder-to-liquid and moisture-resistant benefits. These cosmetics can provide easier portability, as well as long wear benefits when topically applied to the skin or hair.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: October 1, 2013
    Assignee: Avon Products, Inc.
    Inventors: Prithwiraj Maitra, Wendy Chan
  • Patent number: RE44578
    Abstract: Pharmaceutical compositions that have excellent storage stability even though they include a active component that is susceptible to degradation in an acidic environment are disclosed. The stabilized pharmaceutical composition of the invention includes a ring-opened 7-substituted-3,5-dihydroxyheptanoic or a ring-opened 7-substituted-3,5-dihydroxyheptenoic acid, or a pharmaceutically acceptable salt thereof, as an active component and a stabilizing effective amount of at least one amido-group containing polymeric compound or at least one amino-group containing polymeric compound, or combination thereof; wherein the stabilized pharmaceutical composition does not contain a stabilizing effective amount of another stabilizer or a combination of other stabilizers.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: November 5, 2013
    Assignee: TEVA Pharmaceutical Industries, Ltd.
    Inventors: Michael Fox, Ivo Dorossiev