Abstract: The present invention relates to iodinated resins. It relates in particular to a process for preparing a polyiodide-resin wherein an anion exchange resin is contacted with a material capable of donating a member absorbable by the resin so as to convert the resin to the polyiodide-resin. The absorbable member is selected from the group consisting of I2 and polyiodide ion having a valence of ?1. In the process, conversion of the anion exchange resin to the polyiodide-resin is effected at elevated temperature and/or elevated pressure, the elevated temperature being about 100° C. or higher, the elevated pressure being greater than atmospheric pressure. The present invention also relates to a substance comprising an iodine (impregnated) resin as produced by the above process.
Abstract: The invention relates to a method for treating Syndrome X, or inhibiting the onset of symptoms of Syndrome X in a patient, and includes administering a therapeutically effective amount of a salt of at least one alkylated and cross-linked polymer, or a copolymer thereof, the polymer salt formed as a product of the reaction of one or more polymers, or salts and copolymers thereof, having a repeat unit that is essentially: where n is a positive integer and each R, independently, is H or a C1–C8 alkyl group; at least one aliphatic alkylating agent; and a cross-linking agent. Long term administration of the cross-linked polyamine salts of the invention increases HDL levels and decreases LDL levels in patients. The invention also provides for administration of the polymer salt colesevelam, in combination with an HMG-CoA reductase inhibitor; the combined administration is effective in further lowering serum total-cholesterol and LDL-cholesterol levels beyond that achieved by either agent alone.
Abstract: This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperatures ranging from cold to body temperature for long periods of time. The formulations are capable of being uniformly delivered from drug delivery systems at an exit shear rate of between about 1 to 1×10?7 reciprocal second.
Type:
Grant
Filed:
February 3, 2000
Date of Patent:
August 21, 2007
Assignee:
Alza Corporation
Inventors:
Stephen A. Berry, Pamela J. Fereira, Houdin Dehnad, Anna Muchnik
Abstract: A coating for a medical device, particularly for a drug eluting stent, is described. The coating can include a polyacrylate, a blend of polyacrylates, or a blend of the polyacrylate with other polymers, for example, poly(ethylene-co-vinyl alcohol).
Type:
Grant
Filed:
June 21, 2002
Date of Patent:
July 24, 2007
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Wouter E. Roorda, Ni Ding, Stephen D. Pacetti, Eugene T. Michal, Ashok A. Shah, Syed F. A. Hossainy
Abstract: The invention relates to topical delivery of bioactive agents. More particularly, the invention relates to anhydrous formulations for percutaneous absorption. The invention provides formulations that allow efficient topical delivery of high concentrations of bioactive substances for percutaneous absorption. The formulations according to the invention are generally non-irritating to the skin.
Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
Type:
Grant
Filed:
February 1, 2002
Date of Patent:
June 26, 2007
Assignee:
Pfizer Inc
Inventors:
Marshall D. Crew, William J. Curatolo, Dwayne T. Friesen, Michael Jon Gumkowski, Douglas A. Lorenz, James A. S. Nightingale, Roger B. Ruggeri, Ravi M. Shanker
Abstract: The present invention relates to leave-on compositions for personal care comprising trimethylsilylalkylsilsesquioxanes, particularly trimethylsilyl-n-octylsilsesquioxanes (Caprylyl Trimethicones). Said trimethylsilylalkylsilsesquioxanes are especially useful in formulating emulsions.
Type:
Grant
Filed:
October 24, 2001
Date of Patent:
June 26, 2007
Assignee:
Clariant Finance (BVI) Limited
Inventors:
Gary E. LeGrow, W. Leonard Terry, Jr., Ray Figueroa, Peter Klug, Waltraud Simsch, Angelika Turowski
Abstract: Pharmaceutical compositions of a particularly effective sparingly soluble glycogen phosphorylase inhibitor are disclosed, as well as methods of making such compositions and dosage forms from such compositions.
Type:
Grant
Filed:
March 21, 2003
Date of Patent:
June 26, 2007
Assignee:
Pfizer Inc
Inventors:
Marshall D. Crew, Dwayne T. Friesen, Bruno C. Hancock, Chris Macri, James A. S. Nightingale, Ravi M. Shankar
Abstract: A novel rapid-melt composition, including methods of making the same, and methods of using the same for the delivery of prophylactic and therapeutic active materials to a mammal. The rapid-melt compositions are formed by molding or compression, with an additional heating step being preferred.
Abstract: Extremely hydrophobic nitric oxide (NO) releasing polymers are disclosed. The extremely hydrophobic NO-releasing polymers provided are extensively cross-linked polyamine-derivatized divinylbenzene diazeniumdiolates. These polymers can be loaded with extremely high NO levels and designed to release NO in manners than mimic natural biological systems. The NO-releasing extremely hydrophobic polymers provided can maintain a sustained NO release for periods exceeding nine months. Also provided are related medical devices made using these NO-releasing extremely hydrophobic polymers.
Type:
Grant
Filed:
July 17, 2003
Date of Patent:
June 5, 2007
Assignee:
Medtronic Vascular, Inc.
Inventors:
Anthony L. Fitzhugh, Robert Cafferata, Larry K. Keefer
Abstract: A gel composition and cosmetic composition and the like that can excel in pigment and/or filler uniformity and stability and can have a good outer appearance even when further comprising a relatively large amount of pigments. A gel composition is formed by combining at least one ingredient chosen from pigments and fillers, wherein the at least one ingredient has been surface-treated by at least one water-repellent oil-repellent agent, and at least one gelling agent comprising at least one polyacrylamide-based polymer.
Abstract: Propofol solubilised in aqueous micellar preparations of poloxamers is stable at low concentrations and that such preparations are effective administration forms for Propofol.
Abstract: The present invention features a novel therapy for effecting acute treatment of migraine headache. The therapy involves intravenous administration of valproate and is equal to and in some respects superior to previously-known therapies for abortive treatment of prolonged moderate to severe acute migraine headache.
Abstract: The present invention is concerned with controlled release compositions for oral administration comprising galantamine; and with processes of preparing such controlled release compositions.
Type:
Grant
Filed:
December 20, 1999
Date of Patent:
January 9, 2007
Assignee:
Janssen Pharmaceutica N.V.
Inventors:
John Paul McGee, Paul Marie Victor Gilis, Marc Maurice Germain De Weer, Valentin Florent Victor de Condé, Herman Johannes Catherina de Bruijn, Frederic Anne Rodolf Van Dycke
Abstract: A dosage form comprising a resin/resinate combination is described. Said dosage form allows optimization of the release rate profile of active ingredients.
Type:
Grant
Filed:
March 26, 2002
Date of Patent:
December 26, 2006
Assignee:
Rohm and Haas Company
Inventors:
Lyn Hughes, Simon Andrew Bellamy, Christina Hann
Abstract: The present invention features a novel therapy for effecting acute treatment of migraine headache. The therapy involves intravenous administration of valproate and is equal to and in some respects superior to previously-known therapies for abortive treatment of prolonged moderate to severe acute migraine headache.
Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
Type:
Grant
Filed:
July 30, 2001
Date of Patent:
October 3, 2006
Inventors:
William J. Curatolo, Dwayne T. Friesen, Michael J. Gumkowski, Douglas A. Lorenz, James A. S. Nightingale, Roger B. Ruggeri, Ravi M. Shanker
Abstract: A substantially taste masked liquid pharmaceutical composition containing a pharmaceutically effective amount of an unpleasant tasting drug dissolved or dispersed in an aqueous excipient base, said excipient base comprising polyvinyl pyrrolidone and/or copolyvidone, and high molecular weight polyethylene glycol.
Type:
Grant
Filed:
December 7, 2001
Date of Patent:
September 5, 2006
Assignee:
Unilab Pharmatech, Ltd.
Inventors:
Joyce Bedelia B. Santos, Rita Josefina M. Santos, Kennie U. Dee
Abstract: Method and system of producing microparticles loaded with biologically active drugs, including proteins such as ICAM-1, for controlled release of the drugs in a nasal passageway. The method includes introducing a drug/polymer feed solution and an emulsifier into a first mixing chamber to create an emulsion, then mixing a cross-linking agent together with the emulsion under controlled conditions to create microparticles loaded with the drug. The system includes a first mixing chamber, in which the emulsion is created, having a first port for introducing the drug/polymer solution, and a second port angled substantially perpendicular to the first port for introducing the emulsifier. A second mixing chamber adjacent to the first mixing chamber receives the emulsion and either contains a cross-linking agent or receives a stream of a cross-linking agent to solidify the microparticles.
Type:
Grant
Filed:
April 22, 2002
Date of Patent:
August 8, 2006
Inventors:
David C. Bomberger, Paul G. Catz, Mark I. Smedley, Paul C. Stearns
Abstract: Pharmaceutical compositions that have excellent storage stability even though they include a active component that is susceptible to degradation in an acidic environment are disclosed. The stabilized pharmaceutical composition of the invention includes a ring-opened 7-substituted-3,5-dihydroxyheptanoic or a ring-opened 7-substituted-3,5-dihydroxyheptenoic acid, or a pharmaceutically acceptable salt thereof, as an active component and a stabilizing effective amount of at least one amido-group containing polymeric compound or at least one amino-group containing polymeric compound, or combination thereof; wherein the stabilized pharmaceutical composition does not contain a stabilizing effective amount of another stabilizer or a combination of other stabilizers.