Patents Examined by Bong-Sook Baek
  • Use of alkylated semi-synthetic glycosaminoglycosan ethers for the treatment of dental disorders
    Patent number: 8951990
    Abstract: Described herein are methods for treating a dental disorder in a subject comprising administering to the subject an effective amount of a modified hyaluronan or a pharmaceutically acceptable salt or ester thereof, wherein said hyaluronan or its pharmaceutically acceptable salt or ester comprises at least one sulfate group and the primary C-6 hydroxyl proton of at least one N-acetyl-glucosamine residue is substituted with a C1-C10 unsubstituted alkyl group or fluoroalkyl group.
    Type: Grant
    Filed: January 7, 2013
    Date of Patent: February 10, 2015
    Assignee: University of Utah Research Foundation
    Inventors: Glenn Prestwich, Jianxing Zhang, Sr., Thomas P. Kennedy, Narayanam Rao
  • Pharmaceutical carrier composition and pharmaceutical composition
    Patent number: 8937085
    Abstract: The present invention relates to a pharmaceutical carrier composition and a pharmaceutical composition comprising said pharmaceutical carrier composition. The pharmaceutical composition comprises: (a) at least 20% (w/w) of the composition of a sugar or a sugar alcohol; (b) one or more pharmaceutically acceptable excipients; (c) one or more pharmaceutically active ingredients in their base form; and (d) water up to 100% (w/w). The present pharmaceutical composition is especially resistant against flocculation, clumping and/or precipitation at room temperature during prolonged time-periods such as one or more years.
    Type: Grant
    Filed: February 13, 2008
    Date of Patent: January 20, 2015
    Assignee: Dafra Pharma N.V.
    Inventor: Frans Herwig Jansen
  • Polyphenol-rich extract from plant material
    Patent number: 8906957
    Abstract: A process is provided for preparing (1) a first composition obtained by extracting a plant material with a single phase mixture of water and at least a first organic solvent under agitation so as to obtain a first extract rich in polyphenol oligomers, wherein the first composition is the first extract, and (2) a second composition obtained by extracting at least a portion of the first extract with a biphasic mixture of water and at least a second organic solvent under agitation so as to obtain a second extract rich in polyphenol monomers, dimers, and trimers, wherein the second composition is the second extract. Food products, mendicants, and cosmetics containing the first composition or the second composition are also provided.
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: December 9, 2014
    Assignee: Kraft Foods R & D, Inc.
    Inventors: Wolfram Steffan, Kelly Duffin-Maxwell, Allan Bradbury
  • Pre-compacted calcium-containing compositions
    Patent number: 8906411
    Abstract: A pre-compacted materiel comprising one or more calcium-containing compounds and one or more sugar alcohols, wherein the calcium-containing compound having a polycrystallic porous structure. The pre-compacted material is preferably obtained by roller compaction and is suitable for use in the further processing of the pre-compacted material into composition like e.g. tablets.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: December 9, 2014
    Assignee: Takeda Nycomed AS
    Inventors: Poul Egon Bertelsen, Peder Mohr Olsen
  • Microbicidal and antiparasitic compositions
    Patent number: 8865235
    Abstract: Pharmaceutical or dermo-dermo-cosmetic compositions for topical and intravaginal application for treatment of human and veterinary affections caused by anaerobic organisms or parasites comprising quassinoids or plant extracts containing these phytochemicals, in effective amounts. Such compositions can be administered topically or intravaginally to patients in need thereof in various pharmaceutical dosage forms.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: October 21, 2014
    Assignee: Life Science Investments, Ltd.
    Inventors: Christian Diehl, Silvia Chami De Diehl
  • Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
    Patent number: 8859580
    Abstract: The present invention relates to compounds defined by formula I wherein the groups R1 to R3, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11?-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.
    Type: Grant
    Filed: November 14, 2008
    Date of Patent: October 14, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Frank Himmelsbach, Matthias Eckhardt, Bradford S. Hamilton, Armin Heckel, Joerg Kley, Thorsten Lehmann-Lintz, Herbert Nar, Stefan Peters, Annette Schuler-Metz, Matthias Zentgraf
  • (2S,3R)-N-(2((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide novel salt forms, and methods of use thereof
    Patent number: 8846715
    Abstract: The present invention relates to (2S,3R)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms thereof, methods for its preparation, novel intermediates, and methods for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central and autonomic nervous systems.
    Type: Grant
    Filed: July 22, 2013
    Date of Patent: September 30, 2014
    Assignee: Targacept, Inc.
    Inventors: Merouane Bencherif, Lisa Benson, Gary Maurice Dull, Nikolai Federov, Gregory J. Gatto, Kristen G. Jordan, Anatoly A. Mazurov, Lan Miao, Julio A. Munoz, Inigo Pfeiffer, Sondra Pfeiffer, Teresa Phillips
  • Amino acid vitamin ester compositions for controlled delivery of pharmaceutically active compounds
    Patent number: 8828960
    Abstract: The invention relates to pharmaceutical compositions that provide sustained-release of a pharmaceutically active compound and to methods of treating or preventing a condition in an animal by administering the pharmaceutical compositions to the animal. When the pharmaceutical compositions are administered to an animal by injection, they form a drug depot that releases the pharmaceutically active compound over time. The pharmaceutical compositions can also be administered orally.
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: September 9, 2014
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Yerramilli V.S.N. Murthy, Michael Atkinson
  • Spiropiperidine compounds
    Patent number: 8822486
    Abstract: A compound of the formula: or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition, and a method for treating diabetes.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: September 2, 2014
    Assignee: Eli Lilly and Company
    Inventors: Chafiq Hamdouchi, Jayana Pankaj Lineswala, Pranab Maiti
  • Modulation of bacterial quorum sensing with synthetic ligands
    Patent number: 8815943
    Abstract: The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for naturally occurring bacterial quorum sensing ligands in a ligand-protein binding system; that is, they imitate the effect of natural ligands and produce an agonistic effect. In another embodiment, the compounds of the present invention are able to act in a manner which disturbs or inhibits the naturally occurring ligand-protein binding system in quorum sensing bacteria; that is, they produce an antagonistic effect. The compounds of the present invention comprise N-acylated-homoserine lactones (AHLs) comprised of a wide range of acyl groups.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: August 26, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Helen E. Blackwell, Grant D. Geske, Jennifer C. O'Neill
  • Methods and compositions for promoting bone and joint health
    Patent number: 8815306
    Abstract: Methods and compositions that can be used to promote bone and joint health through amelioration, stabilization and repair of damage associated with various pathophysiological conditions are disclosed.
    Type: Grant
    Filed: March 14, 2008
    Date of Patent: August 26, 2014
    Assignee: Metaproteomics, LLC
    Inventors: Matthew L. Tripp, Veera Konda, Anu Desai, Amy J. Hall, Jeffrey S. Bland
  • Use of a pyridine compound for the preparation of a medicament for the treatment of skin lesions
    Patent number: 8809360
    Abstract: The present invention relates to use of a pyridine compound of the following formula [I]: wherein R is a substituted pyridyl group having the following formula: R0 is a C1-6 alkoxy-C1-6 alkyl group, R1 and R2 are the same or different and a C1-6 alkoxy group, X is a group of the formula: ?N— or a group of the formula: Ring A is a saturated or unsaturated 10-membered nitrogen-containing hetero-bicyclic group optionally having a substituent(s), the dotted line means the presence or absence of a double bond, or a pharmaceutically acceptable salt thereof for the preparation of a medicament for treatment of skin lesion.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: August 19, 2014
    Assignee: Mitsubishi Tanabe Pharma Corporation
    Inventors: Tamotsu Takagi, Atsuko Naotsuka
  • Purine and pyrimidine CDK inhibitors and their use for the treatment of autoimmune diseases
    Patent number: 8809350
    Abstract: The present invention relates to the use of an inhibitor of CDK2 and/or CDK7 and/or CDK9, or a pharmaceutically acceptable salt thereof, in the preparation of a medicament for treating a disease associated with antinuclear antibodies, wherein the inhibitor of CDK2 and/or CDK7 and/or CDK9 or pharmaceutically acceptable salt thereof is administered in an amount sufficient to down-regulate the levels of antinuclear antibodies. A further aspect of the invention relates to a combination comprising an inhibitor of CDK2 and/or CDK7 and/or CDK9, or a pharmaceutically acceptable salt thereof, and methylprednisolone, and its use in the treatment of diseases associated with antinuclear antibodies, such as SLE.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: August 19, 2014
    Assignee: Cyclacel Limited
    Inventors: Ariela Benigni, Carla Zoja, Giuseppe Remuzzi, Athos Gianella-Borradori
  • Purified phospholipid-non-steroidal anti-inflammatory drug associated compositions and methods for preparing and using same
    Patent number: 8802656
    Abstract: A new pharmaceutical composition is disclosed comprising a purified phospholipid-selective and/for nonselective non-steroidal, anti-inflammatory drug associated complex and methods for making and using same. A screening method for identifying compounds that form phospholipid associated complexes is also disclosed.
    Type: Grant
    Filed: October 12, 2005
    Date of Patent: August 12, 2014
    Assignee: The Board of Regents of the University of Texas System
    Inventor: Lenard Lichtenberger
  • Metabolic syndrome-improving agent and medicine, supplement, functional food and food additive containing the same
    Patent number: 8802723
    Abstract: A metabolic syndrome relieving agent that is free from a problem of side effects and can be taken for a long term is provided. Aurapten is used as an agent for relieving a metabolic syndrome. Since aurapten has functions of activating PPAR? and PPAR?, promoting the secretion of adiponectin in adipocytes and inhibiting the generation of VLDLs in hepatic cells, it is possible to prevent or treat diseases such as insulin resistance, hyperinsulinism, type 2 diabetes, obesity, visceral fat obesity, hypertension, hyperlipemia, arteriosclerosis and the like and thus prevent or treat the metabolic syndrome. Also, as understood from the fact that citrus fruits such as a hassaku orange, a sweet summer orange or the like containing aurapten have been eaten for many years, they have no problems in terms of safety and have a low calorie content, and therefore, they can be taken for a long term.
    Type: Grant
    Filed: January 20, 2006
    Date of Patent: August 12, 2014
    Assignee: ARKRAY, Inc.
    Inventor: Takao Sasaki
  • Conjugates of synthetic TLR agonists and uses therefor
    Patent number: 8790655
    Abstract: The invention provides TLR agonists and conjugates thereof useful in vaccines and to prevent, inhibit or treat a variety of disorders including pathogen infection and asthma.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: July 29, 2014
    Assignee: The Regents of The University of California
    Inventors: Dennis A. Carson, Howard B. Cottam, Wolfgang Wrasidlo, Christina C. N. Wu, Gregory A. Daniels
  • Methods and compositions for treating a disease condition in a subject
    Patent number: 8788041
    Abstract: Methods for treating a disease condition in a subject are provided. The subject methods are characterizing by enhancing at least one symptom of the disease condition in a manner effective to cause the subject to mount a compensatory response effective to treat the disease condition. Also provided are compositions, kits and systems for practicing the subject methods.
    Type: Grant
    Filed: September 20, 2010
    Date of Patent: July 22, 2014
    Assignee: Palo Alto Investors
    Inventors: Anthony Joonkyoo Yun, Patrick Yuarn-Bor Lee
  • Phosphorus binder composition for treatment of hyperphosphatemia
    Patent number: 8759398
    Abstract: The present invention relates to oral pharmaceutical products which are useful for binding phosphorus in ingesta, and inhibiting absorption of phosphorus from the gastrointestinal tract of subjects. A method for binding phosphorus in ingesta and inhibiting its absorption from the gastrointestinal tract is also provided. The pharmaceutical products and methods of the present invention are particularly useful in the treatment of hyperphosphatemia of chronic uremia and reducing serum phosphorus levels in patients requiring such therapy.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: June 24, 2014
    Assignee: Biolink Life Sciences, Inc.
    Inventor: Deanna J. Nelson
  • Combination of brimonidine and timolol for topical ophthalmic use
    Patent number: 8748425
    Abstract: Disclosed are pharmaceutical compositions comprising brimondine and timolol for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated for glaucoma and associated conditions such as elevated intraocular pressure in the eyes of humans.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: June 10, 2014
    Assignee: Allergan Sales, LLC
    Inventors: Chin-Ming Chang, Gary J. Beck, Cynthia C. Pratt, Amy L. Batoosingh
  • Phenolic hydrazone macrophage migration inhibitory factor inhibitors
    Patent number: 8742173
    Abstract: Provided are various compounds of Formula (I): Also provided are pharmaceutical compositions comprising the above compounds. Additionally, methods of inhibiting macrophage migration inhibitory factor (MIF) activity in a mammal are provided, as are methods of treating or preventing inflammation in a mammal. Further provided are methods of treating a mammal having sepsis, septicemia, and/or endotoxic shock. Also provided are methods of treating a mammal having an autoimmune disease, and methods of treating a mammal having a tumor.
    Type: Grant
    Filed: March 13, 2012
    Date of Patent: June 3, 2014
    Assignee: The Feinstein Institute for Medical Research
    Inventor: Yousef Al-Abed