Abstract: The present invention relates to a process for the minimization of volatile organic sulphur byproducts in dimethyl sulfate quaternization of amines made with hypophosphorous acid, which leads to the formation of an odor stable product.
Type:
Grant
Filed:
December 23, 2003
Date of Patent:
February 5, 2008
Assignee:
Akzo Nobel N.V.
Inventors:
Elliot Band, Maurice Dery, William Joyce, Jeffrey Earl Telschow, Biing Ming Su, Michael Engel, John Nowak, Claude Peterson, Harold Providence, Phuong-Nga Trinh, Sandra Urquhart
Abstract: This invention encompasses novel methods of preparing sibutramine and sibutramine derivatives, and stereomerically pure sibutramine derivatives in particular. Examples of sibutramine derivatives include, but are not limited to, sibutramine metabolites such as desmethylsibutramine and didesmethylsibutramine. The invention further encompasses novel compounds useful in the synthesis of sibutramine derivatives.
Type:
Grant
Filed:
August 20, 2003
Date of Patent:
May 17, 2005
Assignee:
Sepracor Inc.
Inventors:
Chris Hugh Senanayake, Zhengxu Han, Dhileepkumar Krishnamurthy, Derek Pflum
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