Abstract: Coenzyme A-independent transacylase is required for the release of free arachidonic acid, and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme inhibits the production of these inflammatory mediators and will be of therapeutic utility in a broad range of allergic and inflammatory diseases and disorders. Compounds are described herein which inhibit the action of CoA-IT and are therefore useful in the treatment of disease states caused thereby.
Type:
Grant
Filed:
August 6, 1993
Date of Patent:
July 15, 1997
Assignees:
SmithKline Beecham Corporation, The Johns Hopkins University
Inventors:
James David Winkler, Floyd Harold Chilton, III, Deirdre Mary Bernadette Hickey
Abstract: This invention relates broadly to a novel ambient-temperature process for making aquatic animal feed including fish and crustaceans and to the aquatic animal feed so produced.