Abstract: A therapeutic agent delivery system that includes a catheter having a proximal end and an opposite distal end. The catheter has a body with a lumen defined therein. The body of the catheter includes a non-bulbous region having a substantially uniform outer diameter and a bulbous region made from an elastically deformable material. While in a first state the bulbous region has a maximum outer diameter greater than the substantially uniform outer diameter of the non-bulbous region; and while in a second state the maximum outer diameter of the bulbous region is reduced relative to that while in the first state.

Abstract: A syringe assembly is disclosed which includes a syringe body defining a first fluid reservoir and a fluid outlet. A plunger assembly includes a plunger rod and a plunger. The plunger is supported on a distal end of the plunger rod and defines a second fluid reservoir. The plunger is movable within the syringe body from a retracted position to an advanced position to eject fluid from the first fluid reservoir. A piercing member is supported on a distal end of the plunger rod within the second fluid reservoir. The piercing member is movable to pierce the plunger to eject fluid from the second fluid reservoir when a predetermined force is applied to the plunger in the advanced position.

Abstract: A medical device for the injection of a product. The device includes a body receiving an injection needle and a container containing the product to be injected; an arrangement for holding the needle in an injection position; an arrangement for holding the container in a position permitting injection; and, a piston engaged in the container. The device also includes first and second actuators which make it possible, at the end of the injection, to respectively release the arrangement for holding the needle before, or simultaneously to, the release of the arrangement for holding the container. A container support is mounted slidably on the body and is displaceable relative to the latter in order to perform the injection. The container support is held in a standby position before injection with the needle being held in the injection position.

Abstract: A multiple component cartridge includes a barrel defining a chamber and a longitudinal axis. A first plunger is disposed within the chamber and in sealing engagement with the barrel. The first plunger includes at least one member and is movable relative to the barrel such that the at least one member is configured for movement relative to the first plunger to facilitate passage of at least a first component through the first plunger. A second plunger is disposed within the chamber and in sealing engagement with the barrel. The second plunger includes at least one member and is movable relative to the barrel such that the at least one member of the second plunger is configured for movement relative to the second plunger to facilitate passage of at least a second component through the second plunger.

Abstract: A device for imparting a combination of therapies to a user's body or body parts has a first battery-powered array submerged into a liquid contained in a first reservoir and a second battery-powered array submerged into a liquid contained in a second reservoir. Each array has one or more degradable electrodes that release ions into the liquid in the reservoir. The electrodes can be copper, zinc, steel, silver, nickel, or a combination thereof. The solution in the reservoir may contain positively or negatively charged medicament ions. During a therapy session, the device is operated in one or both of an electrolysis mode and an iontophoresis mode. Direct current is applied to one or more of the electrodes depending on the mode selected and other session parameters.

Abstract: A surgical instrument having a tissue vitality comparator is provided to view images of tissue relative to the surgical instrument and compare the images with predetermined reference images. The surgical instrument includes a pair of jaws for capturing tissue and one or more light sources 14 illuminating the captured tissue. The surgical instrument additionally includes a light pipe with fiber optic imaging bundle having a first end for viewing the tissue between the jaws and a second end on a handle portion of the surgical instrument for observing the tissue. A tissue comparison chart having a plurality of reference images is provided on the handle of the surgical instrument for comparison with the image observed through the second end of the light pipe with fiber optic imaging bundle.

Abstract: A catheter-insertion assembly includes a catheter with a proximal end and a distal end, a needle with a proximal end and a beveled distal end forming a sharp distal point, and an obturator with a proximal end and a distal end. The distal end of the obturator includes at least one bend. The bend allows the distal end of the obturator to protect the catheter from the sharp distal point of the needle during insertion of the needle through the catheter.

Abstract: Methods and apparatus for translating a continuous-delivery delivery profile into a plurality of periodic bolus deliveries.

Abstract: The present disclosure relates to a seal assembly for a cannula. The cannula includes a housing having a proximal portion and a distal portion. The seal assembly is located in the proximal portion of the housing and includes a first seal including a first tri-slit, a second seal disposed co-axially and proximal to the first seal and including a second tri-slit, and a third seal disposed co-axially to the first seal and the second seal and including a central opening. A cap is coupled to the proximal portion of the housing and adjacent the third seal and includes a plurality of suture retaining features, such as tabs, for management of sutures during surgery. Fluid leakage out of the cannula, during surgery, is substantially reduced due to the leakage being limited to a channel defined by the first tri-slit, the second tri-slit, and the central opening.

Abstract: A device for assisting recovery from dysphagia, and a method of preventing and/or treating dysphagia. The device includes a catheter suitable for insertion into the body of a patient, for the introduction of nutrients to the stomach of said patient, and electrodes located on a surface of the catheter, the electrodes being positioned such that when the catheter is inserted into a patient the electrodes are in a suitable position for applying electrical pharyngeal stimulation.

Abstract: A needle shroud assembly (10) comprises a barrel (16), a needle shroud (18) captively telescoped relative to the forward end of the barrel for movement between retracted and extended positions and is biased towards said extended position by a spring (25). A separate locking element (42) is mounted within the barrel moveable between a safe position (as seen in FIG. 5) in which it prevents or limits retraction movement of said needle shroud (18), and a live position in which it is clear of the rearward path of the needle shroud (18). The locking member is moved from its safe position to its live position by means of an externally operable actuating member (54), having a cam (52) which cooperates with a cam surface (46) on the locking element (42). The cam (52) is driven back to its original position by the rearward end of the shroud (18) as it moves to the fully retracted position.

Abstract: Ultrasonic, sonic or vibratory energy, delivered non-invasively, minimally invasively or invasively (e.g. surgically), is utilized to provide direct cleaning action at or to the location of the implanted device such as a prosthetic heart valve with undesirable deposits of at least some amount thereon or therein. Such ultra-sound energy may be aided by the use of a drug in association or cooperation with the acoustic irradiation. The “cleaning” acoustic energy may optionally be delivered under the guidance of an imaging modality and may be delivered in a timed or gated manner such that the valve occluders or leaflets are in a preferred position (assuming they are functioning) during exposures.

Abstract: A vascular access port is described that is elongate in form. A distal end is coupled to a tube which leads into a body lumen. A proximal end has a head thereon with a septum which can be repeatedly penetrated by a needle and reseal, for repeated administration of medications or other compositions through the port and into the body of the patient. A wing is attached to the body that has two positions including a streamlined first position for implantation and a wider second position for stabilization of the port after implantation. A stay is preferably also provided to abut the wing when in the second position to keep the wing in the second position when fully deployed.

Abstract: A device, system and method deliver an agent to a soft mass, such as an area of the body, and more specifically the brain. One aspect includes creation of one or more channels, tunnels or grooves in tissue using a relatively small diameter, minimally-invasive stylet and then removing the stylet prior to infusion. The stylet-created channels become paths of increased hydraulic conductivity, through which the infusate will tend to flow and produce a predictable infusion pattern. Infusate will be carried into these channels with relatively low resistance, and then infuse outward from these channels into the surrounding tissue. By carefully positioning these channels, one can control and modify the preferred paths and duration of distribution.

Abstract: A holding device for locking the head of a syringe piston on a pusher has arms connected to respective pinions pivotable and translationally displaceable so that the corresponding arm is involved in the same motion between a rest position, in which the arms are closed and pressed against the pusher, and an open position, in which the arms are opened and remote therefrom, the translation is carried out prior to rotation during the movement toward the open position or in reverse order toward the rest position. The holding device also has a control member and means for converting a part of the control member movement by transmitting it to at least one pinion as a translation movement, which are translationally locked, and means for converting a part of the control member movement by transmitting it to at least one pinion as a rotation movement.

Abstract: A device for regulating the flow rate of a medical liquid includes a body provided with elements associated with corresponding parts connected together but torsionally free, at least one of the parts including a plurality of recesses acting as flow regulator able to modify the flow rate of the liquid directed towards the patient by rotating the parts about a common axis of rotation. Between the parts a seal element enables the recesses to be selectively connected together via communication elements, so achieving flow rate regulation. Transverse sealers are provided between the seal element and at least the second part of the parts which are interconnected but torsionally free. The transverse sealers preventing the escape of liquid from the recesses and from the body of the device following a relative movement or misalignment between the parts in a plane perpendicular to the axis of rotation or along this latter during flow regulation or following any angular misalignment of the parts relative to the axis.

Abstract: Apparatus for the aspiration of a fluid from an individual, the apparatus comprising a port in fluid communication with the atmosphere; a catheter having a proximal end arranged to be inserted into the body of an individual and having a distal end; a one-way valve; and a fluid passage switch reversibly movable between a first position in which the distal end of the catheter is in fluid communication with the port and a second position in which the distal end of the catheter is in fluid communication with the one-way valve, the one-way valve being arranged to permit fluid flow there through in a direction from the distal end of the catheter. The apparatus may be used for both the aspiration of fluid from within the body and instillation of fluid into the body.

Abstract: Some embodiments of a medical infusion pump system include a drive system that advances a piston rod to dispense medicine to the patient in a safe and energy efficient manner.

Abstract: An apparatus and method for securing a catheter within a target area of the anatomy are disclosed. The catheter includes a passage or opening through which a suture filament may be routed. The suture filament can be secured relative to anatomical tissue to retain the catheter within a desired region. After the catheter has been used to complete the desired medical procedure, the suture filament may be released, permitting the catheter to be easily withdrawn from the anatomy. The catheter may include a biodegradable tip, which when absorbed by the body would enable the catheter to be removed. Biodegradable suture filaments and other components may also be used to facilitate the release of the catheter from the anatomy.

Abstract: A feeding device configured for insertion into the gastrointestinal tract of a patient, and dynamic movement through the gastrointestinal tract toward the jejunum. The device includes an elongate tubular member having a plurality of distal projections disposed on an exterior surface thereof. The projections extend radially outwardly from the exterior surface of the tubular member a distance sufficient to engage an interior surface of the gastrointestinal tract during peristaltic contractions therein, and are configured to promote ingress of the device in response to the contractions. At least some of the projections are soluble under bodily conditions at the gastrointestinal tract, thereby facilitating removal of the feeding device.