Patents Examined by Brian Burn
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Patent number: 5894074Abstract: A process for preparing amines of the general formula (I)X(--CH.sub.2 --NR.sup.1 R.sup.2).sub.n (I)whereR.sup.1 and R.sup.2 are preferably methyl, X is preferably 1,4-butylene and n is preferably 2, comprises reacting nitriles of the general formula (II)(R.sup.1 R.sup.2 N--CH.sub.2 --).sub.n-m X(--CN).sub.m (II)where R.sup.1, R.sup.2 and X are each as defined above and m is an integer from 1 to n,with secondary amines of the general formula (III)HNR.sup.1 R.sup.2 (III)where R.sup.1 and R.sup.2 are each as defined above,and hydrogen at from 50 to 250.degree. C. and from 5 to 350 bar in the presence of a palladium catalyst comprising, based on the total weight of the catalyst, from 0.1 to 10% by weight of Pd and from 0.01 to 10% by weight of at least one further metal selected from groups IB and VII of the Periodic Table, cerium and lanthanum on a support.Type: GrantFiled: March 31, 1998Date of Patent: April 13, 1999Assignee: BASF AktiengesellschaftInventors: Eberhard Fuchs, Boris Breitscheidel, Rainer Becker, Horst Neuhauser
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Patent number: 5574189Abstract: This invention relates to an improvement in a process for the production of amines and particularly secondary amines by the hydrogenation of aliphatic and aromatic nitriles. The improvement resides in the use of a multi-metallic catalyst, preferably a bimetallic catalyst comprising nickel or cobalt in combination with rhodium, ruthenium or palladium. Optionally, the catalyst is carried on an alumina support.Type: GrantFiled: February 2, 1995Date of Patent: November 12, 1996Assignee: Air Products and Chemicals, Inc.Inventors: Gamini A. Vedage, John N. Armor
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Patent number: 5567724Abstract: The present invention provides a method of inhibiting .beta.-amyloid toxicity in brain cells. The method includes administering to the cells an amount of an alkaline phosphatase inhibitor which is pharmacologically effective to reduce degeneration in the cells. Methods of treatment of peripheral neuropathy are also provided using acid or alkaline phosphatase inhibitors.Type: GrantFiled: June 1, 1994Date of Patent: October 22, 1996Assignee: Cortex Pharmaceuticals, Inc.Inventors: Judith A. Kelleher, David D. Eveleth
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Patent number: 5559270Abstract: An improved process of synthesizing gasoline soluble polyolefinic amines or polyether amines comprising the steps of reacting polyolefinic halides or polyether halides with polyamines in a specific sequence of reactions; distilling off non-reactive polyamine; neutralizing the reaction mixture; recovering polyamine(s) and water; and separating polyolefinic amines from the solids with simple filtration or centrifuge or decanting.Type: GrantFiled: December 15, 1994Date of Patent: September 24, 1996Assignee: Petrokleen, Ltd.Inventors: Donald E. Koehler, William J. Claffey
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Patent number: 5559241Abstract: A process for the preparation of sterile sodium amoxycillin characterized by the fact that a solution of amoxycillin trihydrate in a mixture of methyl alcohol and a lower C.sub.2 -C.sub.5 alcohol is reacted in a sterile ambient, optionally in the presence of a suitable amine, with a solution of a suitable salifying agent selected from the group consisting of an alcoholate or carboxylate of sodium in methyl acetate followed by separation of the precipitate is described.Type: GrantFiled: September 15, 1995Date of Patent: September 24, 1996Assignee: Instituto Biochimico Italiano Giovanni Lorenzini S.p.A.Inventors: Giordano B. Corsi, Alberto Brandt, Loredana Cecchetelli
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Patent number: 5556837Abstract: The present invention is broadly directed to treatment of an addictive disease or disorder. In particular, the invention relates to inhibiting or reversing the biochemical and neurophysiological changes that correlate with behavioral changes of addictive diseases or disorders. The method of the invention comprises administering to a subject suspected of suffering from an addictive disease or disorder an amount of brain-derived factor (BDNF) or neurotrophin-4 (NT-4), or both, effective to reverse behavioral changes that are associated with the addictive disease or disorder. In a specific Example, administration of BDNF or NT-4 inhibits or reverses increased expression of tyrosine hydroxylase and glial ibrillary acidic protein in the ventral tegmental area of the brain, and inhibits or reverses increased levels of cyclic-AMP-dependent protein kinase activity in the nucleus accumbens.Type: GrantFiled: August 1, 1994Date of Patent: September 17, 1996Assignees: Regeneron Pharmaceuticals Inc., Yale UniversityInventors: Eric J. Nestler, Melissa T. Berhow, Dana Beitner-Johnson, David S. Russell, Ronald M. Lindsay
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Patent number: 5557011Abstract: Process for the preparation of diamines of the general formula I ##STR1## in which A denotes a C.sub.1 -C.sub.20 alkylene chain optionally mono- to penta-substituted by C.sub.1 -C.sub.4 alkyl,R.sup.1, R.sup.2 denote C.sub.1 -C.sub.20 alkyl, C.sub.1 -C.sub.20 hydroxyalkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.4 -C.sub.20 alkylcycloalkyl, C.sub.4 -C.sub.20 cycloalkylalkyl, phenyl, C.sub.7 -C.sub.20 phenylalkyl, C.sub.1 -C.sub.20 alkoxyalkyl, C.sub.7 -C.sub.20 phenoxyalkyl or together a saturated or unsaturated C.sub.2 -C.sub.6 alkylene chain optionally monosubstituted, disubstituted, or trisubstituted by C.sub.1 -C.sub.4 alkyl and optionally interrupted by oxygen or nitrogen,by the reaction of dinitriles of the general formula IINC--A--CN (II),in which A has the aforementioned meaning,with secondary amines of the general formula II ##STR2## in which R.sup.1 and R.sup.2 have the aforementioned meanings, with hydrogen at temperatures ranging from 50.degree. to 200.degree. C.Type: GrantFiled: November 15, 1994Date of Patent: September 17, 1996Assignee: BASF AktiengesellschaftInventors: Tom Witzel, Eberhard Fuchs
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Patent number: 5554794Abstract: The invention includes a compound of formula I ##STR1## where R' is hydrogen, an alkyl, or aryl group; R"O is derived from R"OH which is a polyether mono-ol or hydrocarbyl mono-ol; and R"' independently is a hydrogen, an alkyl group or a substituted alkyl group. The invention also includes an unleaded fuel composition containing a compound of formula I and a process for making the compound of formula I.Type: GrantFiled: August 18, 1994Date of Patent: September 10, 1996Assignee: Shell Oil CompanyInventor: Thomas H. Johnson
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Patent number: 5554649Abstract: A controlling agent for fabric pest insects characterized by containing, as an active ingredient, a carboxylic acid ester represented by the formula (I): ##STR1## wherein R represents an allyl or propargyl group, Y represents a hydrogen atom or a methyl group, and when Y is a hydrogen atom, X represents an isobutenyl, 2,2-difluorovinyl or 2-chloro-2-fluorovinyl group, and when Y is a methyl group, X represents a methyl group.Type: GrantFiled: December 19, 1994Date of Patent: September 10, 1996Assignee: Sumitomo Chemical Company, Limited.Inventors: Takao Ishiwatari, Kazunori Tsushima
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Patent number: 5550297Abstract: A process for catalytic preparation of alcohols or amines by reaction of esters, fatty acids, or nitriles with hydrogen at elevated temperature and pressure. The unreduced catalyst contains, per 100 parts by weight of CuO, 40 to 130 parts by weight of ZnO, 2 to 50 parts by weight of Al.sub.2 O.sub.3, and optionally 0.5 to 8 parts by weight of oxide of Mn, Mo, V, Zr, and/or alkaline earth metal. It has a BET total area of 80 to 175 m.sup.2 /g of catalyst in the unreduced state, and 75% to 95% of the BET total area is formed by pores having a radius r.sub.p .ltoreq.15 nm.Type: GrantFiled: February 16, 1995Date of Patent: August 27, 1996Assignee: Hoechst AktiengesellschaftInventors: Gerhardt Horn, Carl D. Frohning
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Patent number: 5550106Abstract: A low buffer nutritional composition which is useful to reduce the incidence of colonization of pathogenic bacteria.Type: GrantFiled: March 4, 1994Date of Patent: August 27, 1996Assignee: Bristol-Myers Squibb CompanyInventors: Bryon W. Petschow, Yung-Hsiung Lee
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Patent number: 5550157Abstract: Method of controlling fresh water mussels of the Dreissenidae family (zebra and quagga mussels) by direct contact with peracetic acid or indirectly by application to an environment where control is desired. The biofouling of environments, such as fresh water intakes, conduits and storage systems of power and water treatment systems, and of processing streams of industrial plants, is thereby reduced or eliminated.Type: GrantFiled: June 15, 1994Date of Patent: August 27, 1996Assignees: FMC Corporation, The Research Foundation of the State University of N.Y.Inventors: Alexander M. Vegega, Claudio E. Manissero
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Patent number: 5545754Abstract: p-Amino-phenols are advantageously prepared by catalytic hydrogenation of the aromatic nitro compounds on which they are based in a reaction medium of aqueous sulphuric acid in the sense of a Bamberger rearrangement at elevated temperature by a procedure in which the reaction medium additionally contains a water-miscible organic solvent.Type: GrantFiled: November 26, 1991Date of Patent: August 13, 1996Assignee: Bayer AktiengesellschaftInventors: Alexander Klausener, Heinz Landscheidt, Heinz-Ulrich Blank
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Patent number: 5348870Abstract: An ester is caused to act on a 2-substituted-3-hydroxycarboxylic acid ester as a racemate in the presence of hydrolase under substantially anhydrous conditions to effect a transesterification resulting in the resolution.The compound thus resolved is converted to an optically active 2,6-cis-2,5,6-substituted-1,3-dioxan-4-one and the resulting compound is recrystallized to give optically active 5,6-anti-2,5,6-substituted-1,3-dioxan-4-one and 5,6-syn-2,5,6-substituted-1,3-dioxan-4-one. Thus an optically active compound having plural chiral centers.Further, an optically active 2,5,6-substituted-1,3-dioxan-4-one obtained by transesterification and recrystallization is reacted with an alcohol to produce an optically active 2-substituted-3-hydroxycarboxylic acid ester.Type: GrantFiled: March 23, 1993Date of Patent: September 20, 1994Assignee: Chisso CorporationInventors: Kazutoshi Miyazawa, Naoyuki Yoshida
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Patent number: 5245081Abstract: The preparation of N,N-disubstituted m-aminophenols from resorcinol, which is reacted, in a first step, with primary amines to form N-monosubstituted m-aminophenols, which are treated in situ, in a second step, with alkylating agents to form N,N-disubstituted m-aminophenols.Type: GrantFiled: May 22, 1992Date of Patent: September 14, 1993Assignee: BASF AktiengesellschaftInventors: Manfred Hauptreif, Helmut Reichelt
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Patent number: 5147529Abstract: Magnetic particles used as a solid support are placed in reaction vessels and stepped sequentially past successive magnets for separation.Type: GrantFiled: August 10, 1988Date of Patent: September 15, 1992Assignee: E. I. Du Pont de Nemours and CompanyInventors: Ching-Cherng Lee, James E. Davis
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Patent number: 4999041Abstract: The use of diphenyl ether derivatives of the general formula I ##STR1## where A is a radical ##STR2## where R.sup.1 is hydrogen, an alkali metal or alkaline earth metal ion, substituted or unsubstituted ammonium, alkyl of from 1 to 4 carbon atoms or alkoxycarbonylalkyl of a total of 1 to 6 carbon atoms and R.sup.2 is alkyl of from 1 to 4 carbon atoms, for the desiccation and abscission of plant organs.Type: GrantFiled: December 18, 1989Date of Patent: March 12, 1991Assignee: BASF AktiengesellschaftInventors: Klaus Grossmann, Helmut Walter, Bruno Wuerzer
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Patent number: 4992092Abstract: The present invention provides a method for protecting a gramineous crop from injury caused by a pyridine imidazolinone herbicidal compound by applying to the crop a chemical safener in a non-phytotoxic antidotal amount.Type: GrantFiled: December 30, 1988Date of Patent: February 12, 1991Assignee: American Cyanamid CompanyInventors: Jeffrey H. Birk, Timothy Malefyt