Patents Examined by Brian Davis
  • Patent number: 7411093
    Abstract: The present invention relates to compounds of formula (I) wherein R1 is as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: August 12, 2008
    Assignee: Hoffman-La Roche Inc.
    Inventors: Markus Boehringer, Daniel Hunziker, Bernd Kuhn, Bernd Michael Loeffler, Hans Peter Marty, Patrizio Mattei, Robert Narquizian
  • Patent number: 7384979
    Abstract: This invention relates to a series of substitituted amino acids of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are small molecules which bind to the erythropoietin receptor and compete with the natural ligand for binding to this receptor.
    Type: Grant
    Filed: May 30, 2006
    Date of Patent: June 10, 2008
    Assignee: Ortho McNeil Pharmaceutical, Inc.
    Inventors: Peter J. Connolly, William V. Murray, Steven K. Wetter, Sigmond Johnson, Victor T. Bandurco, Jacqueline Bussolari
  • Patent number: 7381845
    Abstract: A process for hydrogenating nitrile functions present in organic compounds over at least one heterogeneous catalyst, in which the hydrogenation is carried out in the presence of an ionic liquid, is described.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: June 3, 2008
    Assignee: BASF Aktiengesellschaft
    Inventors: Verena Weiskopf, Till Gerlach, Kirsten Wenz
  • Patent number: 7378553
    Abstract: The present invention provides isolated N-methyl-3-(3-methylphenoxy)-3-phenylpropylamine hydrochloride, and preparation thereof as well as of N-methyl-3-(4-methylphenoxy)-3-phenylpropylamine hydrochloride and of N-methyl-3-phenoxy-3-phenylpropylamine hydrochloride. The invention further provides the use of the above compounds as reference markers and/or reference standards during the synthesis of Atomoxetine. Also provided is a method of limiting the amounts of the impurities 3FT (3-fluorotoluene), 4FT (4-fluorotoluene), and FB (fluorobenzene) in the 2-fluorotoluene starting material used in the synthesis of Atomoxetine Hydrochloride. The purity of the Atomoxetine Hydrochloride product is ensured by determining the amounts of 3FT, 4FT, and FB in the 2-fluorotoluene starting material with the marker 3-ATM HCl.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: May 27, 2008
    Assignee: Teva Pharmaceutical Fine Chemicals S.r.l.
    Inventors: Eugenio Castelli, Alessandra Vailati
  • Patent number: 7378555
    Abstract: The present invention is to prepare efficiently 2?-amino-5?-hydroxypropiophenone corresponding to the AB-ring part of camptothecin (CPT) skeleton and a tricyclic ketone corresponding to the CDE-ring part in order to provide efficiently CPT by the total synthesis, which is a starting material for irinotecan hydrochloride and various kinds of camptothecin derivatives, and to provide stably CPT and its derivatives.
    Type: Grant
    Filed: September 8, 2006
    Date of Patent: May 27, 2008
    Assignee: Kabushiki Kaisha Yakult Honsha
    Inventors: Takanori Ogawa, Hiroyuki Nishiyama, Miyuki Uchida, Seigo Sawada
  • Patent number: 7368598
    Abstract: Provided herein are processes for conversion of methane to acetic acid. In one embodiment, the processes are for direct, selective conversion of methane to acetic acid in a single step.
    Type: Grant
    Filed: July 19, 2005
    Date of Patent: May 6, 2008
    Assignee: University of South California
    Inventor: Roy A. Periana
  • Patent number: 7365231
    Abstract: The present invention provides the diaminophenyladamantane derivatives with antitumor activities and the preparation method therefore. The method includes a step of reacting an aromatic diol with at least one 5-halo-2-nitrophenol in the presence of at least one inorganic base in an organic solvent with a relatively high boiling point.
    Type: Grant
    Filed: April 21, 2005
    Date of Patent: April 29, 2008
    Assignee: National Taiwan University of Science & Technology
    Inventor: Yaw-Terng Chern
  • Patent number: 7361789
    Abstract: The present invention relates to novel dihydronaphthalene compounds, compositions, methods for using the same, and processes for preparing the same. The present invention also relates to novel total synthesis approaches for preparing these compounds. In addition, the present invention relates to methods of producing quantities of isomers of these compounds and separating and purifying them using chiral separation techniques. The present invention also relates to methods of producing quantities of a single isometric compound without the need for chiral separation techniques.
    Type: Grant
    Filed: July 27, 2005
    Date of Patent: April 22, 2008
    Assignee: Amgen Inc.
    Inventors: Qi Yan, Carlos Orihuela, Bo Shen, Ying Chen, Xin Wang, John Ng, Ruizhi Ji, Pengzu Zhou
  • Patent number: 7358397
    Abstract: The present invention relates to halogenated 4-aminophenols and to halogenated 4-(phenyidiazenyl)phenols, to a process for their preparation and to the use of the halogenated 4-hydroxyphenols for preparing active ingredients, especially in pharmaceuticals and agrochemicals.
    Type: Grant
    Filed: September 3, 2004
    Date of Patent: April 15, 2008
    Assignee: LANXESS Deutschland GmbH
    Inventors: Karen Peilstöcker, Albrecht Marhold, Jens-Peter Joschek
  • Patent number: 7358399
    Abstract: A process is described for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propaneamine comprising substitution of the sulfonyloxy group of the compound of the formula in which the substituents R and R? have the meanings stated in the description, in a solvent comprising an ionic liquid, to yield the tertiary amine of the formula and the subsequent deprotection thereof.
    Type: Grant
    Filed: October 6, 2005
    Date of Patent: April 15, 2008
    Assignee: Chemi SPA
    Inventors: Stefano Turchetta, Umberto Ciambecchini, Pietro Massardo
  • Patent number: 7358359
    Abstract: Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: April 15, 2008
    Assignee: University of Washington
    Inventors: Niels H. Andersen, Jason Bowman
  • Patent number: 7355078
    Abstract: Provided are processes for preparing tomoxetine comprising reacting N-methyl-3-hydroxy-3-phenylpropylamine with dimethylsulfoxide (DMSO) and 2-fluorotoluene in the presence of an alkali base to form tomoxetine. Also provided is the conversion of said tomoxetine into atomoxetine or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: April 8, 2008
    Assignee: Teva Pharmaceutical Fine Chemicals S.r.l.
    Inventors: Eugenio Castelli, Giuseppe Lo Monaco, Silvia Mantovani, Paola Daverio, Paolo Riva, Alessandra Vailati, Stefano Bianchi
  • Patent number: 7355077
    Abstract: A process for preparing tolterodine with high purity.
    Type: Grant
    Filed: October 26, 2005
    Date of Patent: April 8, 2008
    Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
    Inventors: Sundaram Venkataraman, Vijayavitthal Thippannachar Mathad, Kikkuru Srirami Reddy, Neti Srinivasan, Chinta Raveendra Reddy, Muthulingam Arunagiri, Routhu Lalitha Kumari
  • Patent number: 7351866
    Abstract: The invention provides a method for manufacturing a tertiary amine, including reacting a tertiary amine with an alcohol and a primary or secondary amine in a reactor loaded with a film type catalyst, controlling the superficial velocity of liquid in the reactor at 0.1 cm/s or more.
    Type: Grant
    Filed: January 29, 2007
    Date of Patent: April 1, 2008
    Assignee: Kao Corporation
    Inventors: Atsushi Hirota, Toru Nishimura
  • Patent number: 7342135
    Abstract: 3(4),7(8)-bis(aminomethyl)bicyclo[4.3.0]nonane and a process for its preparation, wherein bicyclo[4.3.0]nona-3,7-diene is reacted with synthesis gas in a homogeneous organic phase in the presence of transition metal compounds of Group VIII of the Periodic Table containing complex-bound organophosphorus compounds, and excess organophosphorus compound, at temperatures of 70 to 160° C. and pressures of 5 to 35 MPa, and the 3(4),7(8)-bisformylbicyclo[4.3.0]nonane thus obtained is reductively aminated.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: March 11, 2008
    Assignee: Celanese Chemicals Europe GmbH
    Inventors: Helmut Springer, Paolo Bavaj
  • Patent number: 7342136
    Abstract: A process for preparing long chain internal fatty tertiary amines, quaternary amines and amine oxides via the selection of long chain internal olefins.
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: March 11, 2008
    Assignee: Procter & Gamble Company
    Inventors: Corey James Kenneally, Jeffrey John Scheibel
  • Patent number: 7342133
    Abstract: The invention relates to substituted amino compounds, to processes for their preparation, to pharmaceutical formulations containing these compounds and to the use of these substances in the preparation of pharmaceutical formulations, especially for the treatment or inhibition of depression, anxiety, pain and urinary incontinence, and to related methods of treating or inhibiting these disorders.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: March 11, 2008
    Assignee: Gruenenthal GmbH
    Inventors: Petra Bloms-Funke, Elmar Friderichs, Ivars Graudums, Hagen-Heinrich Hennies, Achim Kless, Klaus Schiene, Oswald Zimmer
  • Patent number: 7339079
    Abstract: Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed.
    Type: Grant
    Filed: June 17, 2005
    Date of Patent: March 4, 2008
    Assignees: The Regents of the University of California, Oregon Health & Science University
    Inventors: Thomas S. Scanlan, Matthew E. Hart, David K. Grandy, James R. Bunzow
  • Patent number: 7335789
    Abstract: A process for the preparation of compounds of formula (I): HO-A-ONO2??(I) wherein A is a C2-C6 alkylene chain, the compounds of formula (I) being synthesized by nitration of the corresponding alkanediols with “stabilized” nitric acid is herein disclosed. The process is safer to operators and allows to obtain advantageous yields on an industrial scale.
    Type: Grant
    Filed: November 6, 2003
    Date of Patent: February 26, 2008
    Assignee: Dipharma S.p.A.
    Inventors: Nevio Francescutti, Tiziano Scubla, Fausto Gorassini, Graziano Castaldi
  • Patent number: 7332634
    Abstract: The invention relates to a continuously operated process for the purification by distillation of the 1,2-propylene glycol formed as by-product in the synthesis of propylene oxide, wherein the mixture formed in the synthesis which contains the 1,2-propylene glycol is separated in a dividing wall column into low-, intermediate- and high-boiling fractions and the 1,2-propylene glycol is taken off as intermediate boiler at the side offtake of the column.
    Type: Grant
    Filed: July 22, 2003
    Date of Patent: February 19, 2008
    Assignee: BASF Aktiengesellschaft
    Inventors: Peter Bassler, Hans-Georg Goebbel, Joaquim Henrique Teles, Peter Rudolf