Abstract: An orthopedic implant can comprise a structural body, a plug and a frangible connection. The structural body can comprise a first surface, a second surface opposing the first surface, and a through-bore extending from the first surface to the second surface. The through-bore can have a bore surface. The structural body can be formed of a porous material. The plug can be disposed in the through-bore. The frangible connection can link the bore surface and the plug. A method of manufacturing an orthopedic implant can comprise producing a porous structural body having a port, producing a plug for positioning in the port, and producing a plurality of frangible crosspieces within the port to connect the plug to the structural body.

Abstract: Fixation device for fixation of leaflets of a heart valve includes an elongate central member defining a longitudinal axis of the fixation device and first and second arms rotatable about at least one arm hinge point between an open position and a closed position. The fixation device further includes a first gripping element rotatable about a first gripping element axis of rotation to capture a first leaflet of a heart valve between the first gripping element and the first arm. The fixation device further includes a second gripping element rotatable about a second gripping element axis of rotation to capture a second leaflet of a heart valve between the second gripping element and the second arm. At least one of the first gripping element axis of rotation and the second gripping element axis of rotation is variably offset from the arm hinge point by an axis offset distance defined along the longitudinal axis.

Abstract: A nasal tissue implant for reconstruction and tissue engineering of nasal tissue in a subject includes a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The tissue scaffold component conforms to a portion of the subject's nasal region and defines at least a portion of the subject's nasal anatomy. A method of making an implantable nasal tissue implant for reconstructing a portion of a nasal anatomy of a human or other animal subject is also provided that includes laser sintering or three-dimensional (3D) printing a biocompatible polymeric material to form a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. Again, the tissue scaffold component substantially conforms to a nasal region specific to the human or other animal subject.

Abstract: An apparatus including a joint spacer for treatment of a joint of a human subject. The joint spacer includes a bioresorbable stent having compressed and expanded configurations and a covering that covers an external surface of the stent. The joint spacer is configured to be inserted into a space of the joint, and is shaped, when the bioresorbable stent is in the expanded configuration, to provide mechanical support to the joint until the bioresorbable stent resorbs into a body of the subject. Treating a joint of a human subject includes inserting a joint spacer into a space of the joint while a bioresorbable stent of the joint spacer is in a compressed configuration, and transitioning the bioresorbable stent to an expanded configuration within the joint, such that the joint spacer provides mechanical support to the joint until the bioresorbable stent resorbs into a body of the subject.

Abstract: Systems and methods for providing assistance with human motion, including hip and ankle motion, are disclosed. Sensor feedback is used to determine an appropriate profile for actuating a wearable robotic system to deliver desired joint motion assistance. Variations in user kinetics and kinematics, as well as construction, materials, and fit of the wearable robotic system, are considered in order to provide assistance tailored to the user and current activity.

Abstract: The disclosure describes an annuloplasty device that includes a wire configured to extend around at least part of an annulus of a cardiac or vascular valve, such as at least partially around a circumference of the annulus, and a plurality of anchors. The anchors of the plurality of anchors are configured to engage the wire and anchor the wire to the annulus. The wire is configured to urge at least some anchors of the plurality of anchors toward each other in a radially inward direction to decrease a distance between valve leaflets that extend from the annulus.

Abstract: Assemblies are provided for positioning within a lumen comprising a stent graft; and a sensor positioned on the stent graft. Within certain aspects the sensors are wireless sensors, and include for example one or more fluid pressure sensors, contact sensors, position sensors, pulse pressure sensors, blood volume sensors, blood flow sensors, chemistry sensors (e.g., for blood and/or other fluids), metabolic sensors (e.g., for blood and/or other fluids), mechanical stress sensors and/or temperature sensors.

Abstract: An orthopedic device with a hydraulic damping device, a valve with a valve seat and a valve body that is subjected to a closing force. The closing force is applied via a valve spring that is pre-loaded towards the valve seat. A fluid connection between the hydraulic damping device and the valve seat is provided. The valve features an adjustment device for adjusting the preload of the valve spring.

Abstract: This invention is directed to an expandable stent for implantation in a body lumen, such as an artery, and a method for making it from a single length of tubing. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common axis and interconnected by one or more links. A Y-shaped member is comprised of a U-shaped member and a link having a curved portion and a straight portion to improve the flexibility and thereby improve the fatigue performance of the Y-link junction.

Abstract: An implantable composition, method of making and using the implantable composition is provided. The implantable composition comprising a first set of fibers and a second set of fibers, the first set of fibers manufactured to have a first binding surface, the second set of fibers manufactured to have a second binding surface, the first binding surface of the first set of fibers configured to bind at least at or near the second binding surface of the second set of fibers and the second set of fibers configured to bind at least at or near the first binding surface of the first set of fibers.

Abstract: There is provided an acetabular cup liner for a total hip replacement (THR) prosthesis comprising an inner surface with a hemispherical portion having a radius of curvature. The hemispherical portion is disposed about a centerline and it intersects a hemisphere plane perpendicular to the centerline so that the intersection of the hemispherical portion and the plane define a circle having a radius equal to the radius of curvature. The liner further comprises a capture portion continuous with the hemispherical portion that has the same radius of curvature as the hemispherical portion and connects with the hemispherical portion at the hemispherical plane along a first arc of the circle on the plane, and extends a first distance out of the plane. The liner further comprises an insertion portion continuous with the hemispherical portion. The insertion region is connected with the hemispherical portion along a second arc of the circle on the plane.

Abstract: Nasal implant obtained by additive manufacturing, comprising a main portion and a return portion connected by an intermediate portion, the main and return portions forming an angle of between 25° and 90°, said implant is made from a biocompatible ceramic of synthetic origin; said implant has an average macroporosity characterized by: a density of material of between 20% and 95% by volume, said density of material being higher in said intermediate portion than in said main portion; cavities defining sections of cavities, said sections of cavities each having a diameter of between 0.3 mm and 1 mm; said sections of cavities each having an area and a form substantially equal over the entire implant.

Abstract: A prosthetic heart valve having a cuff attached to a stent provides a seal for preventing paravalvular leakage. The cuff may be constructed from known sealing materials to fill in and around paravalvular leakage gaps, while continuously collapsing down into a low profile volume within the stent. The cuff has a first cuff portion positioned on the luminal surface of the stent and a second cuff portion. The second cuff portion has a deployed configuration in which a region of the second cuff portion is spaced from the abluminal surface of the stent and an initial configuration different from the deployed configuration.

Abstract: An implant can include a flexible body made of a non-bioresorbable hydrogel material. The implant can also include a radiopaque marker located within the flexible body, where the body and the radiopaque marker can be implanted in a body cavity to mark the cavity in a radiographic image of the cavity.

Abstract: An implant (30) for a mammalian bone joint (3) for spacing a first bone (2) of the joint from a second bone (1) of the joint while allowing translational movement of the second bone in relation to the first bone is described. The implant comprises (a) a distal part (31) configured for intramedullary engagement with an end of the second bone, (b) a proximal part (34) having a platform (15) configured for non-engaging abutment of an end of the first bone and translational movement thereon, and (c) an articulating coupling (10, 16) provided between the distal and proximal ends allowing controlled articulation of the first and second bones. The bone-abutting platform is shaped to conform to and translate upon the end of the first bone. A kit for assembly to form the implant of the invention, and the use of the implant to treat osteoarthritis in a bone joint, are also described.

Abstract: In one embodiment, the present disclosure relates to an acetabular implant system with a liner and a sleeve. The liner includes a convex outer surface shaped to correspond to an interior of an acetabular cup and has an equatorial region and a polar region. The convex outer surface includes a plurality of liner engagement features thereon. The sleeve includes an inner surface with a plurality of sleeve engagement features thereon. The inner surface of the sleeve is sized to be flush with the convex outer surface of the liner. When the sleeve is engaged with the liner, the liner engagement features engage the sleeve engagement features.

Abstract: A method of augmenting a bone defect in proximity to an acetabulum, comprising: implanting an acetabular cup implant into a bone; after implanting the acetabular cup implant, driving a drill bit into the bone so as to form a first void having a geometry corresponding to that of the drill bit; and inserting a void filler into the void formed by the drill bit such that a portion of the void filler is in a working relationship with the acetabular cup implant and another portion of the void filler is disposed within the void.

Abstract: A method of preventing paravalvular leakage includes concurrent delivery of a heart valve prosthesis and an annular sealing component. During delivery, the sealing component is moved from a first position to a second position of the heart valve prosthesis which is longitudinally spaced apart from the first position of the heart valve prosthesis. The sealing component is secured around the heart valve prosthesis at the second position by a contoured outer surface of the heart valve prosthesis. The sealing component may be a flexible ring or may be a cylindrical flexible sleeve having a plurality of ribs longitudinally extending over the cylindrical sleeve. The ribs operate to deploy the sealing component such that at least a portion of the cylindrical sleeve buckles outwardly away from the outer surface of the heart valve prosthesis.

Abstract: A total knee implant prosthesis is disclosed. The total knee implant prosthesis includes a tibial component including a pair of bearing surfaces and a post positioned between the bearing surfaces, and a femoral component configured to rotate relative to the tibial component. The femoral component includes a pair of condyles sized and shaped to articulate on the bearing surfaces and a cam positioned between the pair of condyles. The cam engages the post at a first contact point when the femoral component is at 0 degrees of flexion and engages the post at a second contact point located lateral of the first contact point when the femoral component is at a first degree of flexion greater than 0 degrees. The cam is disengaged from the post when the femoral component is at a second degree of flexion greater than the first degree of flexion.

Abstract: Medical devices that include a tubular member with a plurality of braided filaments, each filament crossing another of the filaments at a respective crossing point forming sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm, the pores have an average pore size that is less than or equal to about 500 microns when the tubular member is in an expanded state, the filaments possessing antithrombogenic surfaces to increase antithrombogenicity of the medical device with pores substantially free of webs formed by antithrombogenic material, such that fewer than 5% of the crossing points have webs formed by antithrombogenic material thereby permitting the pores to be substantially free of webs.