Patents Examined by Brian J. Gangle
  • Schistosoma vaccine
    Patent number: 9283264
    Abstract: The method for large scale production of a full length Schistosomal paramyosin coiled coil dimer composition is carried out by providing a composition comprising recombinant paramyosin, contacting the composition with a strand separation agent to remove paramyosin fragments and other contaminants. The purified paramyosin is used in vaccines for humans and bovine animals to induce immunity against schistosomal infection.
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: March 15, 2016
    Assignee: Rhode Island Hospital
    Inventors: Jonathan Kurtis, Mario Jiz, Haiwei Wu, Sunthorn Pond-Tor
  • Methods for the treatment of hepatitis B and hepatitis D infections
    Patent number: 9284556
    Abstract: It is disclosed a method for the treatment of hepatitis B (HBV) infection or HBV/hepatitis D (HDV) co-infection, the method comprising administering to a subject in need of treatment a first pharmaceutically acceptable agent that removes the hepatitis B surface antigen from the blood and a second pharmaceutically acceptable agent which stimulates immune function.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: March 15, 2016
    Inventors: Michel Bazinet, Andrew Vaillant
  • Stable formulations of polypeptides and uses thereof
    Patent number: 9265834
    Abstract: Formulations are provided that contain single variable domains with a good solubility and good stability under different storage, transportation and stress conditions. The formulations are useful as pharmaceutical formulation. The formulation comprises an aqueous carrier with a pH of 5.5 to 8.0, a buffer selected from the group consisting of histidine pH 6.0-6.5, hepes pH 7.0-8.0, MES pH 6.0, succinate pH 6.0-6.5 and acetate pH 5.5-6.0; an excipient; and/or a surfactant selected from polysorbate 80, polysorbate 20 and poloxamers. The formulation is further characterized that it has an inorganic salt concentration of 150 mM or lower.
    Type: Grant
    Filed: August 12, 2013
    Date of Patent: February 23, 2016
    Assignee: Ablynx N.V.
    Inventors: Ann Brige, Christine Labeur, Veronique De Brabandere, Marc Lauwereys
  • Anti-PCSK9 antibodies, formulations, dosing, and methods of use
    Patent number: 9266961
    Abstract: The invention provides anti-PCSK9 antibodies, formulations, dosing regimens, and methods of using the same.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: February 23, 2016
    Assignee: Genentech, Inc.
    Inventors: Yan Wu, Cecilia Pui Chi Chiu, Daniel K. Kirchhofer, Andrew Peterson, Ganesh A. Kolumam, Monica Kong Beltran, Paul Moran, Wei Li, Xanthe M. Lam, Lin Luis, Ada Hui
  • Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use
    Patent number: 9266944
    Abstract: The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: February 23, 2016
    Assignee: EPITOPIX LLC
    Inventors: Daryll A. Emery, Darren E. Straub, Lisa L. Herron-Olson, Laura Wonderling
  • Multipurpose gel for vaginal dryness with direct and delayed effect
    Patent number: 9248151
    Abstract: The present invention relates to topical vaginal compositions in gel form containing immune mediators, growth factors, chemotactic factors and antibacterial/antiviral factors extracted from bovine colostrum, and optionally other ingredients with complementary activity.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: February 2, 2016
    Assignee: ZAMBON S.P.A.
    Inventors: Alberto Bartorelli, Maria Rosa Gobbi
  • Combination of SEMA-4D inhibitors and immunomodulators to inhibit tumors and metastases
    Patent number: 9243068
    Abstract: Provided herein are methods for inhibiting, delaying, or reducing tumor growth and metastases of plexin-B1-expressing cancer cells in a subject, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D) in combination with an effective amount of at least one other immune modulating therapy.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: January 26, 2016
    Assignee: VACCINEX, INC.
    Inventors: Elizabeth E. Evans, Ernest S. Smith, Maurice Zauderer
  • Use of a food additive based on at least one phytonutrient for stimulating vaccine immunity against apicomplexa in animals
    Patent number: 9241981
    Abstract: The invention relates to the use of a food additive comprising at least one phytonutrient in order to stimulate vaccine immunity against apicomplexa in non-human monogastric animals, such as poultry or pigs, or in ruminants, such as a cattle, sheep or goats.
    Type: Grant
    Filed: January 31, 2012
    Date of Patent: January 26, 2016
    Assignees: PANCOSMA S.A., THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE
    Inventors: David Bravo, Hyun Lillehoj
  • Conjugated proteins
    Patent number: 9234192
    Abstract: The present invention relates to modified therapeutic proteins, such as e.g. coagulation factors. In particular, the present invention relates to conjugated Factor VIII molecules such as e.g. FVII, FVIII, or FIX comprising a hydrophobic side group.
    Type: Grant
    Filed: February 9, 2011
    Date of Patent: January 12, 2016
    Assignee: Novo Nordisk A/S
    Inventors: Jens Buchardt, Carsten Behrens
  • Methods of stimulating protective immunity employing Dengue viral antigens
    Patent number: 9234009
    Abstract: Compositions that include at least a portion of at least one pathogen-associated molecular pattern and at least a portion of at least one member selected from the group consisting of a Den1 viral envelope protein, a Den2 viral envelope protein, a Den3 viral envelope protein and a Den4 viral envelope protein are employed in methods to stimulate a protective immune response in a subject.
    Type: Grant
    Filed: September 23, 2014
    Date of Patent: January 12, 2016
    Assignee: VaxInnate Corporation
    Inventors: Thomas J. Powell, Valerian Nakaar, Langzhou Song, James W. Huleatt, William F. McDonald, Duane D. Hewitt
  • Antimicrobial cationic peptides and formulations thereof
    Patent number: 9227999
    Abstract: Compositions and methods for making and using therapeutic formulations of antimicrobial cationic peptides are provided. The antimicrobial cationic peptide formulations may be used, for example, in the treatment of microorganism-caused infections, which infections may be systemic, such as a septicemia, or may be localized, such as in acne or an implanted or indwelling medical device.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: January 5, 2016
    Assignee: Carrus Capital Corporation
    Inventors: Timothy J. Krieger, Patricia J. McNicol
  • Bacterial ribonucleic acid cell wall compositions and methods of making and using them
    Patent number: 9220765
    Abstract: The present invention relates to novel bacterial and mycobacterial compositions containing RNA and cell walls, and methods for making and using these compositions. These compositions have immune stimulating and anti-cancer activity.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: December 29, 2015
    Assignee: BIONICHE UROLOGY IP INC.
    Inventors: Nigel C. Phillips, Danbing Ke, Zdenek Richard Holan, Mario C. Filion, Mohamed Elrafih, Iqubal Velji
  • spp. polypeptides and methods of use
    Patent number: 9221899
    Abstract: The present invention provides isolated polypeptides isolatable from a Yersinia spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: December 29, 2015
    Assignee: EPITOPIX LLC
    Inventors: Daryll A. Emery, Darren E. Straub, Laura Wonderling
  • Detecting infection in reduced pressure wound treatment
    Patent number: 9215994
    Abstract: Provided is a method of detecting infection in a wound caused by an infecting organism at a wound site. Also provided is a system for detecting an infection in a wound at a wound site. Additionally, a porous pad comprising luciferase is provided.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: December 22, 2015
    Assignee: KCI Licensing, Inc.
    Inventors: Amy K. McNulty, Deepak V. Kilpadi, George Hutchinson, Nancy Price
  • DinQ-sRNA type I toxin-antitoxin system for plasmid maintenance
    Patent number: 9217152
    Abstract: The present invention relates to the use of a dinQ-sRNA type I toxin-antitoxin systems for plasmid maintenance. An embodiment of the present invention relates to the use of the dinQ-sRNA type I toxin-antitoxin system for the manufacture of a plasmid selection system. In another embodiment of the present invention is the sRNA selected from the group consisting of agrA and agrB. Aspects of the present invention also relates to medical uses of the plasmid selection system.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: December 22, 2015
    Assignee: Oslo Universitetssykehus HF
    Inventors: Ragnhild Weel-Sneve, James Booth, Magnar Bjoras, Knut Ivan Kristiansen
  • Use of IL-17D for the treatment and prevention of cancers
    Patent number: 9205131
    Abstract: The present invention relates to the treatment and prevention of cancers, particularly cancers whose growth is reduced or inhibited by immunostimulatory therapy, by the administration of interleukin-17D (IL-17D), compounds that can increase the production, half-life, or activity of IL-17D, or compositions that contain IL-17D.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: December 8, 2015
    Assignee: The Regents of the University of California
    Inventor: Jack Bui
  • Methods for treating hair loss disorders
    Patent number: 9198911
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: December 1, 2015
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Raphael Clynes
  • Methods for the treatment of hepatitis B and hepatitis D infections
    Patent number: 9200283
    Abstract: It is disclosed a method for the treatment of hepatitis B (HBV) infection or HBV/hepatitis D (HDV) co-infection, the method comprising administering to a subject in need of treatment a first pharmaceutically acceptable agent that removes the hepatitis B surface antigen from the blood and a second pharmaceutically acceptable agent which stimulates immune function.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: December 1, 2015
    Inventors: Michel Bazinet, Andrew Vaillant
  • Method for purifying human granulocyte-colony stimulating factor from recombinant
    Patent number: 9193761
    Abstract: The present invention provides a method for purifying a large amount of human granulocyte-colony stimulating factors (hG-CSFs) from a recombinant E. coli with high yield and purity. According to the method of the present invention, human granulocyte-colony stimulating factor, identical to the native form expressed in the human body, can be easily purified with high yield and purity without an additional activation process. In particular, according to the purification method of the present invention, hG-CSF variants expressed in E. coli are efficiently removed to obtain physiologically active hG-CSFs with high purity.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: November 24, 2015
    Assignee: HANMI SCIENCE CO., LTD
    Inventors: Sung Chul Choi, Jin Ki Kim, Young Hak Oh, Jong Soo Lee
  • Inactivated bacterial cell formulation
    Patent number: 9192659
    Abstract: The invention relates to the use of lactic acid-producing bacteria to boost the immune system.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: November 24, 2015
    Assignee: Ganeden Biotech, Inc.
    Inventors: Sean Farmer, Michael A. Bush, David Keller